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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Pacap-38 Signaling In Tetrahymena Thermophila Involves No And Cgmp, John Lucas, John Riddle, Janine Bartholomew, Brendan Thomas, Jason Forni, L. Emery Nickerson, Bradley Van Heukelum, Joshua Paulick, Heather G. Kuruvilla
Pacap-38 Signaling In Tetrahymena Thermophila Involves No And Cgmp, John Lucas, John Riddle, Janine Bartholomew, Brendan Thomas, Jason Forni, L. Emery Nickerson, Bradley Van Heukelum, Joshua Paulick, Heather G. Kuruvilla
Science and Mathematics Faculty Publications
Chemorepellents are signaling molecules, which have been shown to be important for mammalian neuronal development, and are presumed to have a role in protozoan defense. Tetrahymena thermophila represent a good model system in which to study repellents because of their ease of use in biochemical, behavioral, electrophysiological, and genetic analyses. In this study, we have used Tetrahymena as a model in which to study the chemorepellent, PACAP. Using behavioral and biochemical (EIA) assays, we have found that the NO/cGMP pathway plays an important role in PACAP signaling. An increase in intracellular calcium is also critical for PACAP avoidance, which appears …