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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Acid Hydrolysis-Based Sugarcane Bagasse Biorefining For Levulinic Acid Production: Dynamic Mechanistic Modeling Under Varying Operating Conditions, Emília S. Lopes, Julio C.J. Gariboti, Luis H.Z. Feistel, Elmer Ccopa Rivera, Rubens Mac Iel Filho, Laura P. Tovar
Acid Hydrolysis-Based Sugarcane Bagasse Biorefining For Levulinic Acid Production: Dynamic Mechanistic Modeling Under Varying Operating Conditions, Emília S. Lopes, Julio C.J. Gariboti, Luis H.Z. Feistel, Elmer Ccopa Rivera, Rubens Mac Iel Filho, Laura P. Tovar
Faculty Publications
© 2020, AIDIC Servizi S.r.l. The study on the lignocellulosic material conversion into bio-based platform chemicals, such as levulinic acid (LA), is one of the most promising routes to promote the development of advanced biorefineries. In this work, a dynamic mechanistic model is developed to simulate the LA production from lignocellulosic material. A wide operating range is used to estimate the parameters of the reaction kinetics. Because multi-parameter estimation problem is complex, a genetic algorithm-based optimization procedure is used to determine the optimum parameters values. Measurements are obtained for various reaction times (0 - 45 min) temperatures (150 - 200 …
Ca2+ Extrusion By Ncx Is Compromised In Olfactory Sensory Neurons Of Omp-/- Mice, Hyun J. Kwon, Jae Hyung Koo, Frank Zufall, Trese Leinders-Zufall, Frank L. Margolis
Ca2+ Extrusion By Ncx Is Compromised In Olfactory Sensory Neurons Of Omp-/- Mice, Hyun J. Kwon, Jae Hyung Koo, Frank Zufall, Trese Leinders-Zufall, Frank L. Margolis
Faculty Publications
Background: The role of olfactory marker protein (OMP), a hallmark of mature olfactory sensory neurons (OSNs), has been poorly understood since its discovery. The electrophysiological and behavioral phenotypes of OMP knockout mice indicated that OMP influences olfactory signal transduction. However, the mechanism by which this occurs remained unknown. Principal Findings: We used intact olfactory epithelium obtained from WT and OMP-/- mice to monitor the Ca2+ dynamics induced by the activation of cyclic nucleotide-gated channels, voltage-operated Ca2+ channels, or Ca2+ stores in single dendritic knobs of OSNs. Our data suggested that OMP could act to modulate the Ca2+-homeostasis in these neurons …