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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Testing Predicted Specificity Determinants In The Dihydrofolate Reductase Enzyme Family, Seema J. Patel
Testing Predicted Specificity Determinants In The Dihydrofolate Reductase Enzyme Family, Seema J. Patel
Theses, Dissertations and Culminating Projects
Dihydrofolate Reductase (DHFR) is an essential enzyme for most organisms, ranging from bacteria to humans. DHFR has essential functions in DNA biosynthesis and cell replication; as a result, cell growth can be inhibited by the inhibition of DHFR. Evaluating the use of well-known DHFR inhibitors is becoming essential in treating infections in the developing world as DHFR is a known target of antibacterial and antiparasitic drugs. Understanding determinants of DHFR inhibitor specificity in terms of amino acid sequence and structure will allow repurposing or designing of new compounds that selectively target DHFR from the pathogenic organism of interest over the …
The Role Of Stress-Activated Protein Kinases In Parasites, Tamara Kreiss
The Role Of Stress-Activated Protein Kinases In Parasites, Tamara Kreiss
Theses, Dissertations and Culminating Projects
Lymphatic filariasis and leishmaniasis are neglected tropical diseases that are caused by nematode and protozoal parasites. These diseases cause disfiguration, leaving their host socially marked, and in some cases cause more severe disease that can lead to death. These infections, which tend to persist for long periods of time, also lead to bacterial and fungal co-infections, which further exacerbate the disease. Currently there are insufficient treatment options. Current therapies are often too expensive, have toxicity associated with them and are subjected to growing resistance amongst parasite populations. In this thesis I investigated two potential drug targets. The first, is the …