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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Thermal And Microbial Effects On Brown Macroalgae: Heat Acclimation And The Biodiversity Of The Microbiome, Charlotte Tc Quigley
Thermal And Microbial Effects On Brown Macroalgae: Heat Acclimation And The Biodiversity Of The Microbiome, Charlotte Tc Quigley
Electronic Theses and Dissertations
This dissertation examines effects of stress on brown algal biology from a macroscopic scale by examining the whole aquaculture crops, and at a microscopic level by examining the macroalgal microbiome, across the vertical stress gradient of the intertidal zone and across the latitudes of their biogeographic ranges. Thermal stress negatively affected seedstock gametophytes of the kelp Alaria esculenta isolated from northern and southern locations in Maine. However, previous thermal stress had a positive effect on growth of the next-generation sporophytes. Alaria esculenta has potential as a kelp crop in Maine’s sea vegetable aquaculture sector and implementing this protocol may allow …
Identification Of Tnfaip8l1 Binding Partners Through Co-Immunoprecipitation And Mass Spectrometry, Audrey Hoyle
Identification Of Tnfaip8l1 Binding Partners Through Co-Immunoprecipitation And Mass Spectrometry, Audrey Hoyle
Honors College
The expanded understanding of the gene families and mechanisms governing tumorigenesis pathways has enormous potential for improving current cancer therapies and patient prognoses. One such gene family that participates in the regulation of tumorigenesis is the tumor necrosis factor alpha-induced protein 8 (TNFAIP8) gene family, which is comprised of four members: TNFAIP8, TNFAIP8L1, TNFAIP8L2, and TNFAIP8L3. The TNFAIP8L1 gene is thought to function as a tumor suppressor, but the mechanisms by which it exerts this function have yet to be elucidated. We hypothesize that the TNFAIP8L1 protein acts as a tumor suppressor through protein-protein …
Determining The Role Of Saly In Streptococcus Pyogenes Immune Evasion Using Fluorescence Microscopy, Taaniel Kiidli
Determining The Role Of Saly In Streptococcus Pyogenes Immune Evasion Using Fluorescence Microscopy, Taaniel Kiidli
Honors College
Streptococcus pyogenes, the etiologic agent for several life-threatening invasive diseases, utilizes numerous mechanisms to evade the host immune response and establish a successful infection causing a significant source of morbidity and mortality risks for patients. The bacterium is known to cause necrotizing fasciitis in both humans and zebrafish, with extensive necrotic damage to tissues but surprisingly lacking in an inflammatory response for a systemic infection. This suggests that the recruitment of inflammatory cells to the site of infection is inhibited. To observe this in real-time, we used the zebrafish model of Streptococcal pathogenesis to analyze immune cell recruitment in …