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Articles 1 - 11 of 11
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Spread And Interaction Of Epidemics And Information On Adaptive Social Networks, Yunhan Long
Spread And Interaction Of Epidemics And Information On Adaptive Social Networks, Yunhan Long
Dissertations, Theses, and Masters Projects
The spread of diseases and opinions has profoundly affected the development of human societies. The structure of the underlying social network may change as a result of individuals changing their social connections in response to an ongoing epidemic or opinion spreading, either for self protection or as an expression of personal values. The interaction of spreading processes and the underlying network structure has been a focus of many recent studies. In this dissertation, we construct models to better incorporate heterogeneous responses to disease spread and attempted opinion spread.;We first model the simultaneous spread of an epidemic and awareness about the …
Langevin, Population Density And Moment-Based Modeling Of Local And Global Aspects Of Intercellular Calcium Signaling, Xiao Wang
Dissertations, Theses, and Masters Projects
Markov chain models of the coupled gating of intracellular calcium (Ca 2+) channels are often used to study the stochastic dynamic of local Ca2+ release events and whole cell Ca2+ homeostasis. However, the runtime of the Markov chain description of Ca2+ channel gating is exponential in the number of Ca2+ channel states and may thus result in a combinatorial state space explosion when the number of channel states is large. This dissertation presents several novel stochastic modeling approaches that capture important aspects of Ca 2+ signaling while improving computational efficiency. This dissertation presents several novel stochastic modeling approaches that capture …
Automated Reductions Of Markov Chain Models Of Calcium Release Site Models, Yan Hao
Automated Reductions Of Markov Chain Models Of Calcium Release Site Models, Yan Hao
Dissertations, Theses, and Masters Projects
Markov chain models have played an important role in understanding the relationship between single channel gating of intracellular calcium (Ca2+) channels, specifically 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs), and the stochastic dynamics of Ca2+ release events, known as Ca2+ puffs and sparks. Mechanistic Ca2+ release site models are defined by the composition of single channel models whose transition probabilities depend on the local calcium concentration and thus the state of the other channels. Unfortunately, the large state space of such compositional models impedes simulation and computational analysis of the whole cell Ca2+ signaling in which the stochastic dynamics of …
A Versatile Imaging System For In Vivo Small Animal Research, Jianguo Qian
A Versatile Imaging System For In Vivo Small Animal Research, Jianguo Qian
Dissertations, Theses, and Masters Projects
In vivo small animal imaging has become an essential technique for molecular biology studies. However, requirements of spatial resolution, sensitivity and image quality are quite challenging for the development of small-animal imaging systems. The capabilities of the system are also significant for carrying out small animal imaging in a wide range of biological studies. The goal of this dissertation is to develop a high-performance imaging system that can readily meet a wide range of requirements for a variety of small animal imaging applications. Several achievements have been made in order to fulfill this goal.;To supplement our system for parallel-hole single …
Novel Use Of A Natural Isotope Signature To Track Recruitment And Evaluate Age Determination Methods For The 2002 Year Class Of American Shad In The York River, Sally A. Upton
Dissertations, Theses, and Masters Projects
No abstract provided.
Probability Density Methods For Modeling Local And Global Aspects Of Intracellular Calcium Signaling, G. S. Blair Williams
Probability Density Methods For Modeling Local And Global Aspects Of Intracellular Calcium Signaling, G. S. Blair Williams
Dissertations, Theses, and Masters Projects
Considerable insight into intracellular calcium (Ca) responses has been obtained through the development of whole cell models that are based on molecular mechanisms, e.g., the kinetics of intracellular Ca channels and the feedback of Ca upon these channels. However, a limitation of most deterministic whole cell models to date is the assumption that channels are globally coupled by a single [Ca], when in fact channels experience localized "domain" Ca concentrations. More realistic stochastic Monte Carlo simulations are capable of representing individual domain Ca concentrations but suffer from increased computational demand. This dissertation introduces a novel probability approach which captures important …
Markov Chain Models Of Calcium Puffs And Sparks, Jeffrey R. Groff
Markov Chain Models Of Calcium Puffs And Sparks, Jeffrey R. Groff
Dissertations, Theses, and Masters Projects
Localized cytosolic Ca2+ elevations known as puffs and sparks are important regulators of cellular function that arise due to the cooperative activity of Ca2+-regulated inositol 1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RyRs) co-localized at Ca2+ release sites on the surface of the endoplasmic reticulum or sarcoplasmic reticulum. Theoretical studies have demonstrated that the cooperative gating of a cluster of Ca2+-regulated Ca 2+ channels modeled as a continuous-time discrete-state Markov chain may result in dynamics reminiscent of Ca2+ puffs and sparks. In such simulations, individual Ca2+-release channels are coupled via a mathematical representation of the local [Ca2+] and exhibit "stochastic Ca2+ …
Markov Chain Models Of Instantaneously Coupled Intracellular Calcium Channels, Hilary Deremigio
Markov Chain Models Of Instantaneously Coupled Intracellular Calcium Channels, Hilary Deremigio
Dissertations, Theses, and Masters Projects
Localized calcium elevations known as calcium puffs or sparks are cellular signals arising from cooperative activity of clusters of inositol 1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RyRs) located at calcium release sites on the endoplasmic or sarcoplasmic reticulum membrane. When Markov chain models of these intracellular calcium-regulated calcium channels are coupled via a mathematical representation of the calcium microdomain, simulated calcium release sites may exhibit the phenomenon of "stochastic calcium excitability" where the IP3Rs or RyRs open and close in a concerted fashion. Although the biophysical theory relating the kinetics of single channels to the collective phenomena of puffs and …
Effects Of Molecular Motion On Deuteron Magic Angle Spinning Nmr Spectra, Yuanyuan Huang
Effects Of Molecular Motion On Deuteron Magic Angle Spinning Nmr Spectra, Yuanyuan Huang
Dissertations, Theses, and Masters Projects
Solid state deuteron NMR experiments, especially magic angle spinning (MAS) and off-magic angle spinning (OMAS), are developed to explore dynamical systems. A theoretical discussion of interactions relevant for spin-1 nuclei is presented. Practical aspects of MAS/OMAS experiments are described an detail. The dominant quadrupolar coupling interaction in deuteron NMR has been simulated and the effects of multiple-frame molecular motions on MAS/OMAS spectra are taken into account in this calculation. Effects of chemical shift anisotropy are also simulated, and shown to be small under conditions of rapid sample spinning.;Two numerical methods, direct integration and an efficient simulation routine based on Floquet …
The Effects Of Total Body Proton Irradiation On The Peripheral Plasma Corticosterone Concentration And The Ultrastructure Of The Zona Fasciculata In Mus Musculus, Robert James Young
The Effects Of Total Body Proton Irradiation On The Peripheral Plasma Corticosterone Concentration And The Ultrastructure Of The Zona Fasciculata In Mus Musculus, Robert James Young
Dissertations, Theses, and Masters Projects
No abstract provided.
Effects Of High-Energy X-Rays On The Reproduction Of Urosalpinx Cinerea, Kenneth Allen Leon
Effects Of High-Energy X-Rays On The Reproduction Of Urosalpinx Cinerea, Kenneth Allen Leon
Dissertations, Theses, and Masters Projects
No abstract provided.