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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Cholesterol Conjugated Hdac Inhibitor As Novel Anticancer Agent, Paul Orefice, Jane Peterson, Bin Sun
Cholesterol Conjugated Hdac Inhibitor As Novel Anticancer Agent, Paul Orefice, Jane Peterson, Bin Sun
Undergraduate Research Posters 2014
Histone deacetylase (HDAC) inhibitors are a class of promising new multifunctional anticancer agents. These agents are able to affect multiple epigenetic changes in aberrant cells. In addition to regulating the gene expression and transcription via chromatin remodeling, HDAC inhibitors can also modulate a variety of cellular functions including proliferation, differentiation, and apoptosis. Vorinostat (SuberAniloHydroxamic Acid, SAHA), the first HDAC inhibitor approved by FDA, inhibited the metastasis of various cancer cells. However, SAHA distributes in cancer tissue and normal tissue in a similar level. It will be ideal to selectively delivery SAHA into cancer cells. Rapidly growing cancer cells have a …
Glycosylation Of Cyclooxygenase-2 (Cox-2) Influences The Migratory And Invasive Potential Of Cells, Fahad Algaly, Julia Hand, Mary B. Sevigny
Glycosylation Of Cyclooxygenase-2 (Cox-2) Influences The Migratory And Invasive Potential Of Cells, Fahad Algaly, Julia Hand, Mary B. Sevigny
Natural Sciences and Mathematics | Faculty Research Posters
Prostaglandins are bioactive lipids involved in many physiological functions such as maintenance of the cardiovascular, immune, renal, and central nervous systems. They also play a role in certain diseases like arthritis, cancer, and Alzheimer’s. Cyclooxygenase-2 (COX-2) is the enzyme that catalyzes the initial rate-limiting step in the pathway that converts arachidonic acid to prostaglandins. COX-2 exists as two glycoforms with the molecular weights of 72 and 74 kDa, the latter resulting from the addition of a high mannose chain to the Asn580 residue ~50% of the time. The over-expression of COX-2 is believed to be linked to cancer progression and …