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Lesioning Of The Nucleus Of The Hippocampal Commissure Followed By Food Deprivation Stress In Birds Demonstrates Simultaneous Involvement In Both The Hypothalamo-Pituitary-Adrenal Axis And The Hypothalamo-Pituitary-Thyroid Axis, Michael Thomas Kidd Jr.
Graduate Theses and Dissertations
The hypothalamo-pituitary-adrenal (HPA) axis is the regulatory system for the neuroendocrine stress response within vertebrates. Within the HPA axis corticotropin releasing hormone (CRH) is a major regulator and driving hormone. A structure named the nucleus of the hippocampal commissure (NHpC) has been found to contain CRH neurons and also these neurons respond to early food deprivation stress significantly prior to the paraventricular nucleus (PVN), the major driving nucleus of the classic neuroendocrine HPA axis. The objective of this study was to perform a knock down of the NHpC via electrolytic lesioning, thus eliminating a significant portion of its population of …