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Full-Text Articles in Poultry or Avian Science
Transcriptome Analyses Of Liver In Newly-Hatched Chicks During The Metabolic Perturbation Of Fasting And Re-Feeding Reveals Thrspa As The Key Lipogenic Transcription Factor, Larry A. Cogburn, Nares Trakooljul, Xiaofei Wang, Laura E. Ellestad, Tom E. Porter
Transcriptome Analyses Of Liver In Newly-Hatched Chicks During The Metabolic Perturbation Of Fasting And Re-Feeding Reveals Thrspa As The Key Lipogenic Transcription Factor, Larry A. Cogburn, Nares Trakooljul, Xiaofei Wang, Laura E. Ellestad, Tom E. Porter
Biology Faculty Research
Background
The fasting-refeeding perturbation has been used extensively to reveal specific genes and metabolic pathways that control energy metabolism in the chicken. Most global transcriptional scans of the fasting-refeeding response in liver have focused on juvenile chickens that were 1, 2 or 4 weeks old. The present study was aimed at the immediate post-hatch period, in which newly-hatched chicks were subjected to fasting for 4, 24 or 48 h, then refed for 4, 24 or 48 h, and compared with a fully-fed control group at each age (D1-D4).
Results
Visual analysis of hepatic gene expression profiles using hierarchical and K-means …