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Full-Text Articles in Poultry or Avian Science
Transcriptome Analyses Of Liver In Newly-Hatched Chicks During The Metabolic Perturbation Of Fasting And Re-Feeding Reveals Thrspa As The Key Lipogenic Transcription Factor, Larry A. Cogburn, Nares Trakooljul, Xiaofei Wang, Laura E. Ellestad, Tom E. Porter
Transcriptome Analyses Of Liver In Newly-Hatched Chicks During The Metabolic Perturbation Of Fasting And Re-Feeding Reveals Thrspa As The Key Lipogenic Transcription Factor, Larry A. Cogburn, Nares Trakooljul, Xiaofei Wang, Laura E. Ellestad, Tom E. Porter
Biology Faculty Research
Background
The fasting-refeeding perturbation has been used extensively to reveal specific genes and metabolic pathways that control energy metabolism in the chicken. Most global transcriptional scans of the fasting-refeeding response in liver have focused on juvenile chickens that were 1, 2 or 4 weeks old. The present study was aimed at the immediate post-hatch period, in which newly-hatched chicks were subjected to fasting for 4, 24 or 48 h, then refed for 4, 24 or 48 h, and compared with a fully-fed control group at each age (D1-D4).
Results
Visual analysis of hepatic gene expression profiles using hierarchical and K-means …
Transcriptional Profiling Of Liver During The Critical Embryo-To-Hatchling Transition Period In The Chicken (Gallus Gallus), Larry A. Cogburn, Nares Trakooljul, Chuming Chen, Hongzhan Huang, Cathy H. Wu, Wilfrid Carré, Xiaofei Wang, Harold B. White Iii
Transcriptional Profiling Of Liver During The Critical Embryo-To-Hatchling Transition Period In The Chicken (Gallus Gallus), Larry A. Cogburn, Nares Trakooljul, Chuming Chen, Hongzhan Huang, Cathy H. Wu, Wilfrid Carré, Xiaofei Wang, Harold B. White Iii
Biology Faculty Research
Background
Although hatching is perhaps the most abrupt and profound metabolic challenge that a chicken must undergo; there have been no attempts to functionally map the metabolic pathways induced in liver during the embryo-to-hatchling transition. Furthermore, we know very little about the metabolic and regulatory factors that regulate lipid metabolism in late embryos or newly-hatched chicks. In the present study, we examined hepatic transcriptomes of 12 embryos and 12 hatchling chicks during the peri-hatch period—or the metabolic switch from chorioallantoic to pulmonary respiration.
Results
Initial hierarchical clustering revealed two distinct, albeit opposing, patterns of hepatic gene expression. Cluster A genes …