Meat Science Commons^™

Mesh-Informed Enrichment Analysis And Mesh-Guided Semantic Similarity Among Functional Terms And Gene Products In Chicken, Gota Morota, Timothy M. Beissinger, Francisco Peñagaricano

Department of Animal Science: Faculty Publications

Biomedical vocabularies and ontologies aid in recapitulating biological knowledge. The annotation of gene products is mainly accelerated by Gene Ontology (GO) and more recently by Medical Subject Headings (MeSH). Here we report a suite of MeSH packages for chicken in Bioconductor and illustrate some features of different MeSH-based analyses, including MeSH-informed enrichment analysis and MeSH-guided semantic similarity among terms and gene products, using two lists of chicken genes available in public repositories. The two published data sets that were employed represent (i) differentially expressed genes and (ii) candidate genes under selective sweep or epistatic selection. The comparison of MeSH with …