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The Effect Of Heavy Metal Stress On Avian Proximal Tubule Urate Secretion, Carla L. Maffeo
The Effect Of Heavy Metal Stress On Avian Proximal Tubule Urate Secretion, Carla L. Maffeo
Honors Scholar Theses
In both humans and birds, urate is an important antioxidant when maintained at normal plasma concentrations. Though human kidneys primarily reabsorb filtered urate, while those of birds perform mostly secretion, both maintain urate levels at ~300microM. The importance of maintaining urate levels within the homeostatic range was observed when the study of several prominent diseases revealed an association with hyperuricemia.
This study examined the effect of elevated zinc concentration on avian urate secretion. Here, acute exposure of chicken proximal tubule epithelial cells (cPTCs) to zinc stress had no effect on urate secretion, but prolonged zinc-induced cellular stress inhibited active transepithelial …