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Mannan-Binding Lectin; Rainbow-Trout; Immunoglobulin Receptor; Channel Catfish; Immune-Response; Salmo-Gairdneri; Hepatic-Uptake; Cross-Linking; Affinity; Antibody
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Full-Text Articles in Animal Sciences
The Strength Of B Cell Interaction With Antigen Determines The Degree Of Igm Polymerization, Jm Ye, Es Bromage, Sl Kaattari
The Strength Of B Cell Interaction With Antigen Determines The Degree Of Igm Polymerization, Jm Ye, Es Bromage, Sl Kaattari
VIMS Articles
The induction of variable disulfide polymerization of IgM in the trout (Oncorhynchus mykiss) and its effect on its half-life were examined. An association between greater Ab affinity and increased disulfide polymerization was first indicated by the observation of this increased IgM disulfide polymerization during the process of affinity maturation. A direct association between Ab affinity and disulfide polymerization was then established by the fractionation of individual sera into high- and low-affinity subpopulations, which also resulted in the partitioning of high and low degrees of disulfide polymerization. The ability of high-affinity B cells to produce more highly polymerized Abs upon Ag …