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Renewed Selection For Heat Loss In Mice: Direct Responses And Correlated Responses In Feed Intake, Body Weight, Litter Size, And Conception Rate, J. M. Mcdonald, Merlyn K. Nielsen

Department of Animal Science: Faculty Publications

Divergent selection in mice was renewed in 3 independent replicates for high (MH) and low (ML) heat loss. An unselected control (MC) was maintained in all replicates. Heat loss was measured for individual male mice for 15 h, overnight in direct calorimeters. After 16 initial generations of selection followed by 26 generations of relaxed selection, divergent selection resumed for 9 generations. The realized selection applied was very close to the maximum possible selection according to the criteria and protocol. Selection differentials were greater for high than for low selection due to greater variation in the MH line. When corrected for …