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Full-Text Articles in Animal Sciences
Obesity, Metabolic Hormone Signaling, And Granulosa Cell Gene Expression, Elizabeth Mack
Obesity, Metabolic Hormone Signaling, And Granulosa Cell Gene Expression, Elizabeth Mack
Department of Animal Science: Dissertations, Theses, and Student Research
It has become increasingly clear that female obesity is associated with a myriad of adverse side effects including abnormal female reproduction due, in part, to amenorrhea and anovulatory infertility. The lethal yellow (LY) mouse possesses a deletion mutation which results in ectopic expression of agouti and adult-onset obesity. Furthermore, LY mice exhibit premature loss of fertility, which has been associated with progressive obesity making the LY mouse line an excellent model to study the effects of obesity-dependent factors on ovarian function. In the current study blood serum and granulosa cells were obtained from LY (Ay/a) and age-matched B6 controls (C57BL/6J) …