Animal Sciences Commons^™

Xenopus Interferon Complex: Inscribing The Amphibiotic Adaption And Species-Specific Pathogenic Pressure In Vertebrate Evolution?, Yun Tian, Jordan Jennings, Yuanying Gong, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

Several recent studies have revealed previously unknown complexity of the amphibian interferon (IFN) system. Being unique in vertebrate animals, amphibians not only conserve and multiply the fish-like intron-containing IFN genes, but also rapidly evolve amniote-like intronless IFN genes in each tested species. We postulate that the amphibian IFN system confers an essential model to study vertebrate immune evolution in molecular and functional diversity to cope with unprecedented pathophysiological requirement during terrestrial adaption. Studies so far have ascribed a potential role of these IFNs in immune regulation against intracellular pathogens, particularly viruses; however, many knowledge gaps remain elusive. Based on recent …