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Full-Text Articles in Animal Sciences
Feline Lentivirus: Molecular Analysis And Epidemiology In Southern African Lions, Hayley Rebecca Adams
Feline Lentivirus: Molecular Analysis And Epidemiology In Southern African Lions, Hayley Rebecca Adams
Doctoral Dissertations
Feline immunodeficiency virus is a retrovirus of domestic cats causing significant lifelong infection. Infection has also been detected in nondomestic species, including African lions. It is endemic in certain populations in east and southern Africa. Infection leads to immunologic dysfunction and immunosuppressive disease in domestic cats; however, little research exists about the pathogenic effects of infection in lions and its epidemiological impact on free-ranging and captive populations. Little is known about the lentivirus in these populations at the molecular and host level. Analysis of the virus from these populations is necessary for development of detection assays that are both sensitive …
Antimicrobial Activity Screening Of Recombinant And Synthetic Varasin A Defensin From The Hard Tick Dermacentor Variabilis Against Various Bacteria, Julia A. Sharp
Biological Sciences Theses & Dissertations
Hematophagous arthropods, such as ticks and mosquitoes, rely on their innate immune system for defense against pathogens ingested in a blood meal as well as those acquired through injury. In response to pathogen recognition, the production of antimicrobial peptides, such as defensin, is typically upregulated. Varisin, a defensin, is thought to be a key component in the immunocompetence of the hard tick D. variabilis against Borrelia burgdorferi, the causative agent of Lyme disease. To study the antimicrobial effects of varisin, recombinant varisin was expressed by both insect cells and E coli. Purification of the protein followed by enterokinase treatment yielded …
Evidence For Disease Mediated Extinction: Correlation Between An Introduced Pathogen And Extinction Of Rattus Macleari On Christmas Island, Kelly B. Wyatt
Evidence For Disease Mediated Extinction: Correlation Between An Introduced Pathogen And Extinction Of Rattus Macleari On Christmas Island, Kelly B. Wyatt
Biological Sciences Theses & Dissertations
The Durham Collection and the Cambridge and Oxford University Museums provided the materials to investigate the possibility that the extinction of indigenous rats of Christmas Island was a result of disease introduced by infected ship rats (R. rattus) in 1899. The collections of H.E. Durham in 1901-1902 reveal that R. macleari was present on Christmas Island up to then and includes specimens of R. rattus together with specimens that exhibit characteristics of both R. rattus and R. macleari. Durham's notes indicate both R. rattus and R. macleari specimens were heavily infected with trypanosomes at the time of collection. In …
Chronic Acetaminophen Treatment Influences Indices Of Reactive Oxygen Species Accumulation In The Aging Fisher 344 X Brown Norway Rat Aorta, Sarath Meduru
Theses, Dissertations and Capstones
We have previously reported that aging in the Fisher 344 X Brown Norway (FBN) rat aorta is characterized by increased levels of ROS and alterations in cell signaling. Acetaminophen was found to scavenge free radicals in recent ischemia-reperfusion studies. Here we examined if chronic treatment with a therapeutic dose of acetaminophen attenuates age-associated increase in aortic ROS accumulation and signaling. FBN rats (27 month old; n=8) were subjected to 6 months of treatment with a therapeutic dose of acetaminophen (30mg/kg/day), with age-matched untreated FBN rats as controls. Protein oxidation levels were altered in control and treated aortae compared to aortae …
Trophic Ecology And Growth Dynamics Of Striped Bass (Morone Saxatilis) In Chesapeake Bay, With Reference To Mycobacteriosis, Kathleen Anne Mcnamee
Trophic Ecology And Growth Dynamics Of Striped Bass (Morone Saxatilis) In Chesapeake Bay, With Reference To Mycobacteriosis, Kathleen Anne Mcnamee
Dissertations, Theses, and Masters Projects
No abstract provided.
Optimization Of Porcine Buccal Mucosa For In Vitro Evaluation, Upendra D. Kulkarni
Optimization Of Porcine Buccal Mucosa For In Vitro Evaluation, Upendra D. Kulkarni
University of the Pacific Theses and Dissertations
Porcine buccal mucosa has been extensively used as in vitro model to study the permeability of drugs and assess their potential to deliver through buccal route. Porcine buccal mucosa is found to be very similar to human oral mucosa in structure and function. However, the in vitro permeation studies across porcine buccal mucosa show high variability which is mostly due to the various experimental and biological variables that are often overlooked while conducting such studies.
The precise nature of the permeability barrier offered by the various tissue layers of buccal mucosa was investigated in this study. It was observed that …