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Full-Text Articles in Animal Sciences
Kdr-Lacz-Expressing Cells Are Involved In Ovarian And Testis-Specific Vascular Development, Suggesting A Role For Vegfa In The Regulation Of This Vasculature, Rebecca C. Bott, Debra T. Summers, Anna M. Fuller, Ryann M. Mcfee, Ningxia Lu, Renee M. Mcfee, Andrea S. Cupp
Kdr-Lacz-Expressing Cells Are Involved In Ovarian And Testis-Specific Vascular Development, Suggesting A Role For Vegfa In The Regulation Of This Vasculature, Rebecca C. Bott, Debra T. Summers, Anna M. Fuller, Ryann M. Mcfee, Ningxia Lu, Renee M. Mcfee, Andrea S. Cupp
Department of Animal Science: Faculty Publications
Our objectives were to evaluate kinase insert domain protein receptor (KDR)-β-galactosidase (LacZ) expression as a marker for vascular development during gonadal morphogenesis and to determine whether any novel non-angiogenic KDR-LacZ expression was present in mouse testes or ovaries. Gonads were collected from mice expressing LacZ driven by the Kdr promoter (KDRLacZ) from embryonic day 11 (E11) through postnatal day 60 (P60). At E11.5, mesonephric cells expressing KDR-LacZ seemed to migrate into the developing testis and surrounded developing seminiferous cords. Cells expressing KDR-LacZ appeared in the ovary with no apparent migration from the adjacent mesonephros, suggesting a different origin of endothelial …