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United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
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A Peptide-Based Vaccine For Mycobacterium Avium Subspecies Paratuberculosis, Gaber S. Abdellrazeq, Mahmoud M. Elnaggar, J. P. Bannantine, David A. Schneider, Cleverson D. Souza, Julianne Hwang, Asmaa H.A. Mahmoud, Victoria Hulubei, Lindsay M. Fry, Kun-Taek Park, William C. Davis
A Peptide-Based Vaccine For Mycobacterium Avium Subspecies Paratuberculosis, Gaber S. Abdellrazeq, Mahmoud M. Elnaggar, J. P. Bannantine, David A. Schneider, Cleverson D. Souza, Julianne Hwang, Asmaa H.A. Mahmoud, Victoria Hulubei, Lindsay M. Fry, Kun-Taek Park, William C. Davis
United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications
Recent efforts to develop a live attenuated vaccine against Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of Johne’s disease (JD), revealed relA is important in Map virulence. Deletion of the relA gene impairs the ability of Map to establish a persistent infection. Analysis of the basis for this observation revealed infection with a relA deletion mutant (DrelA) elicits development of cytotoxic CD8 T cells (CTL) with the ability to kill intracellular bacteria. Further analysis of the recall response elicited by DrelA vaccination showed a 35 kDa membrane peptide (MMP) is one of the targets of the immune response, suggesting …