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Comparative Transcriptomics Reveals Small Rna Composition And Differential Microrna Responses Underlying Interferon-Mediated Antiviral Regulation In Porcine Alveolar Macrophages, Jiuyi Li, Eric R. Sang, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang
Comparative Transcriptomics Reveals Small Rna Composition And Differential Microrna Responses Underlying Interferon-Mediated Antiviral Regulation In Porcine Alveolar Macrophages, Jiuyi Li, Eric R. Sang, Oluwaseun Adeyemi, Laura C. Miller, Yongming Sang
Agricultural and Environmental Sciences Faculty Research
Previous studies have shown that interferon-mediated antiviral activity is subtype-dependent. Using a whole transcriptome procedure, we aimed to characterize the small RNA transcriptome (sRNA-Seq) and specifically the differential microRNA (miRNA) responses in porcine alveolar macrophages (PAMs) upon antiviral activation during viral infection and interferon (IFN) stimulation. Data showed that near 90% of the qualified reads of sRNA were miRNAs, and about 10% of the other sRNAs included rRNA, snoRNA, snRNA, and tRNA in order of enrichment. As the majority of sRNA (>98%) were commonly detected in all PAM samples under different treatments, about 2% sRNA were differentially expressed between …