Agriculture Commons^™

Metformin Uptake And Translocation In Chickpeas: Determination Using Liquid Chromatography−Mass Spectrometry, Brett Nespor, Anastasia Andrianova, Sean Pollack, Creighton Pfau, Muhammad Arifuzzaman, Nazrul Islam, Alena Kubatova, Khwaja Hossain

Chemistry Faculty Publications

Multiple chronic conditions (MCCs) such as diabetes, hypertension, heart disease, arthritis, asthma, and common respiratory problems are prevalent in over one-fourth of Americans, and separate drugs are prescribed to manage each of the diseases. The nutritive crop seeds loaded with multiple drugs could be a cheap and sustainable alternative to drugs produced by pharmaceutical companies. Our long-term goal is to produce chickpea seeds containing comparable dosages of multiple drugs regularly prescribed for managing MCC. In this work, we conducted experiments to understand the uptake and translocation of metformin into the tissues of chickpea to demonstrate the applicability of LC–HR-ToF-MS in …