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Articles 31 - 33 of 33
Full-Text Articles in Life Sciences
Structure Of The Chicken Neuron-Glia Cell Adhesion Molecule, Ng-Cam: Origin Of The Polypeptides And Relation To The Ig Superfamily, Mark P. Burgoon
Structure Of The Chicken Neuron-Glia Cell Adhesion Molecule, Ng-Cam: Origin Of The Polypeptides And Relation To The Ig Superfamily, Mark P. Burgoon
Student Theses and Dissertations
The neuron-glia cell adhesion molecule, Ng-CAM, is a cell-surface glycoprotein expressed on neurons and Schwann cells in the chicken nervous system. It is expressed as a group of related components of ~200 kD, 135 kD, and 80 kD, which are detected at particular sites during development. Ng-CAM mediates a variety of functions that are known to be important in specific cell-cell interactions and the histogenesis of the nervous system, including neuron-neuron adhesion, neuron-glia adhesion, neurite fasciculation, and neuronal migration on glial cells. This thesis describes the characterization of cDNA that encode the entire Ng-CAM protein and the determination of the …
Laminin Potentiates Differentiation Of Pcc4uva Embryonal Carcinoma Into Neurons, T. M. Sweeney, Roy C. Ogle, C. D. Little
Laminin Potentiates Differentiation Of Pcc4uva Embryonal Carcinoma Into Neurons, T. M. Sweeney, Roy C. Ogle, C. D. Little
School of Medical Diagnostics & Translational Sciences Publications
The embryonal carcinoma PCC4uva differentiates into neurons in response to treatment with retinoic acid and dbcAMP. We used this in vitro model system to study the effects of laminin on early neural differentiation. Laminin substrata markedly potentiate neural differentiation of retinoic acid and dbcAMP-treated cultures. Only laminin induced more rapid neural cell body clustering, neurite growth and neurite fasciculation as compared to type IV collagen, type I collagen, and fibronectin substrata. Exogenous laminin substrata promoted greater cell attachment, cellular spreading and growth to confluence than type IV collagen, type I collagen, fibronectin and glass substrata. Laminin-induced effects were inhibited by …
Liver Cell Adhesion Molecules In Embryonic Development, Warren J. Gallin
Liver Cell Adhesion Molecules In Embryonic Development, Warren J. Gallin
Student Theses and Dissertations
Cell-cell adhesion is one of the essential processes for normal embryogenesis. The isolation and characterization of the neural cell adhesion molecule, N-CAM, provided the first substantial opportunity to study this process at a molecular level. Moreover, studies of N-CAM expression in embryos suggested that cell adhesion molecules may play a critical role in induction. This thesis describes the isolation of a glycoprotein, L-CAM, that mediates adhesion between liver cells, using an assay similar to the one used to isolate N-CAM. L-CAM was released from liver cell membranes by proteolysis with trypsin, and purified by ion-exchange chromatography, gel filtration chromatography and …