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Full-Text Articles in Life Sciences
Regulation Of Amyloid Oligomer Binding To Neurons And Neurotoxicity By The Prion Protein-Mglur5 Complex, Flavio H. Beraldo, Valeriy G. Ostapchenko, Fabiana A. Caetano, Andre L. S. Guimaraes, Giulia D. S. Ferretti, Nathalie Daude, Lisa Bertram, Katiane O. P. C. Nogueira, Jerson L. Silva, David Westaway, Neil R. Cashman, Vilma R. Martins, Vania F. Prado, Marco A. M. Prado
Regulation Of Amyloid Oligomer Binding To Neurons And Neurotoxicity By The Prion Protein-Mglur5 Complex, Flavio H. Beraldo, Valeriy G. Ostapchenko, Fabiana A. Caetano, Andre L. S. Guimaraes, Giulia D. S. Ferretti, Nathalie Daude, Lisa Bertram, Katiane O. P. C. Nogueira, Jerson L. Silva, David Westaway, Neil R. Cashman, Vilma R. Martins, Vania F. Prado, Marco A. M. Prado
Anatomy and Cell Biology Publications
The prion protein (PrPC) has been suggested to operate as a scaffold/receptor protein in neurons, participating in both physiological and pathological associated events. PrPC, laminin, and metabotropic glutamate receptor 5 (mGluR5) form a protein complex on the plasma membrane that can trigger signaling pathways involved in neuronal differentiation. PrPC and mGluR5 are co-receptors also for -amyloid oligomers (AOs) and have been shown to modulate toxicity and neuronal death in Alzheimer's disease. In the present work, we addressed the potential crosstalk between these two signaling pathways, laminin-PrPC-mGluR5 or AO-PrPC-mGluR5, as well as their interplay. Herein, we demonstrated that an existing complex …
The Atp2c2 Gene As Transcribed From A Novel Transcriptional Start Site In Pancreatic Acinar Cells, Caitlin M. Sullivan
The Atp2c2 Gene As Transcribed From A Novel Transcriptional Start Site In Pancreatic Acinar Cells, Caitlin M. Sullivan
Electronic Thesis and Dissertation Repository
Strict regulation of cytosolic Ca2+ is essential to regulated exocytosis and proper pancreatic acinar cell function, controlled in part by pumps that shuttle Ca2+ out of the cytosol. Our laboratory identified a novel isoform of Secretory Ca2+ ATPase 2 (SPCA2) containing only the carboxy terminus. Pancreatic SPCA2, is an approximately 17-20 kDa, protein encoded by the Atp2c2 gene and is completely absent in Mist1-/- acini.. The focus of this thesis was to understand transcriptional regulation of Atp2c2 in the pancreas. Pancreatic Atp2c2 appears to be transcribed from an alternative transcriptional start site (TSS) and is regulated …
Regulation Of Trpm2 Channels By Fyn Kinase, Matthew L. Johnston
Regulation Of Trpm2 Channels By Fyn Kinase, Matthew L. Johnston
Electronic Thesis and Dissertation Repository
TRPM2 is a calcium-permeable non-selective cation channel that acts as a mediator of cell death in response to oxidative stress. It has been shown that oxidative stress increases TRPM2 tyrosine phosphorylation and activation – an effect that is blocked by PP2, a non-specific inhibitor of Src family kinases. However, the kinase and target TRPM2 tyrosine residue(s) involved have not yet been identified. Here, we investigated the potential regulation of TRPM2 by Fyn. Intracellular application of recombinant Fyn potentiated TRPM2 currents in HEK293 cells expressing inducible TRPM2 (TRPM2-HEK293 cells). Further, a physical interaction between Fyn and TRPM2 was demonstrated by co-immunoprecipitation …