Life Sciences Commons^™

Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad

Mansoura Medical Journal

Background Schistosomiasis is a prevalent fibrotic disease characterized by inflammation and fibrous tissue deposition around Schistosoma eggs trapped in the hepatic tissue. This work aimed to evaluate the anti-fibrotic and anti-parasitic effects of fucoidan during the chronic phase of experimental schistosomiasis-mansoni in mice. Methods Sixty female Swiss albino mice were allocated into six groups; non-infected unmanaged mice group, infected unmanaged mice group, non-infected fucoidanmanaged mice group, infected fucoidan-managed mice group, infected PZQ-managed mice group, and infected combined fucoidan and PZQ managed mice. Every liver tissue was examined parasitologically, histopathologically, and by anti-transforming growth factor-beta (TGF-β) immunohistochemically. Serum was used to …

Application Of Milan System In Cytological Diagnosis Of Salivary Gland Lesions And Its Association With Histopathology, Asmaa Sabry Gad, Heba Salah Eldin Hany, Wagdi Fawzi Elkashef, Mie Ali Mohamed

Mansoura Medical Journal

Background: Salivary gland harbors a wide variety of non-neoplastic & neoplastic conditions that show heterogenicity in the same tumor tissue. The Milan System for Reporting Salivary Gland Cytology was designated to offer a standardized universally accepted reporting format for Salivary Gland FNAC. Aim: To apply Milan system for salivary gland and assess its accuracy by comparing the cytology and histopathology. Methods: In this retrospective study, the Milan system was applied on 81 FNAC cases referred to pathology lab at Oncology Centre Mansoura University during 5 years & compared results with postoperative biopsy. For cytological samples, Hematoxylin & Eosin-stained smears, cell …

The Impact Of Effective Diabetes Management On Reducing Burden In Elderly Patients: A Case-Control Study, Eslam Abdelhamid Mohamed, Mohamed A. Helaly, Ahmed Albehairy

Mansoura Medical Journal

Background and aim: Elderly individuals with diabetes mellitus (DM) are more prone to experiencing common geriatric syndromes, which include impaired cognition, dementia, frailty, falls, fractures, urinary incontinence, and disability. These can significantly impair their quality of life (QoL) and could conflict with anti-diabetic medication. Therefore, we aim to evaluate the impact of controlling diabetes on the overall burden of diabetes in the elderly. Materials and Methods: 100 elderly patients over sixty-five with type 2 diabetes mellitus (T2DM) were selected from Mansoura Specialized Medical Hospital (MSMH) between April 2022 and February 2023. The patients were divided into two groups: fifty diabetic …

Could Angiopioetin-1 & Angiopioetin-2 Be Considered A Predictor For Community Acquired Pneumonia Severity And Phenotypes, Magdy Mohamed Zedan, Nashwa Abusamra, Engy Osman, Rania Mohammed Emad Eldin Eldersy

Mansoura Medical Journal

Background: Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide and the role of biomarkers in pneumonia has been evaluated in many clinical areas. Angiopoietin-1 and Angiopoietin -2 are glycoproteins that play role in vascular development, angiogenesis, and permeability. Aim: To conduct a trial for phenotyping and endotyping of pneumonia using Angiopoietins-1 and Angiopoietin -2. Subjects and methods: This case-control study included 30 cases and 29 controls of matched age and sex. to investigate Angiopioetin-1 & -2 serum levels in both groups and then evaluated the possible association between serum Angiopoietin -1&-2 in different pneumonia phenotypes. Results: …

Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy

Mansoura Medical Journal

Background The role of vitamin D in the pathogenesis of rheumatoid arthritis is controversial. This study aims to assess the relation between vitamin D level and rheumatoid arthritis disease activity. Patients and methods This study was conducted on 80 rheumatoid arthritis (RA) patients beside 40 healthy persons. Vitamin D level was assessed in all participants. Rheumatoid activity was assessed using DAS28 (disease activity score). RA patients were classified according to DAS 28 into two groups: active group and remission group. Results The median for vitamin D level in RA group was 23.5ng/ml. There was no statistically significant difference in serum …

Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy

Mansoura Medical Journal

Background Laryngotracheal reconstruction (LTR) is a well-established surgical procedure for the management of pediatric subglottic stenosis, with rib cartilage grafts. This study was conducted to evaluate preoperative and intraoperative discrepancies of rib graft used in laryngotracheal reconstruction using ultrasonic criteria in terms of their height, thickness, and length. Methods This prospective cohort study was conducted on 10 pediatric patients who underwent LTR at Mansoura University Hospitals. Preoperative ultrasonography was performed on the right 4th, 5th, and 6th rib cartilages, measuring height, thickness, and length. These measurements were then directly compared with intraoperative dimensions of the harvested cartilage. Results There was …

Study Of Heat Shock Protein 70 In Serum Of Cancer Breast Patients, Dina Adel Denewer, Fatma Abbas Auf, Khaled M. Abdelwahab, Mona Elwassefy

Mansoura Medical Journal

Background Breast cancer (BC) is the most frequent malignancy affecting women worldwide. Heat shock proteins (HSPs) are a family of proteins that are important for the maintenance of cell homeostasis. HSPs have been overexpressed in many tumours, including BCs, lung, gastric, ovarian, endometrial and colon Aim To evaluate the relation between serum levels of HSP70 and BC in Egyptians and its impact on tumour characteristics and different histopathological types of BC. Methods This a case-control study conducted on 70 cases of newly diagnosed BC and the control group included 19 apparently healthy age and sex matched subjects. Full clinical examination …

Evaluation Of Safety And Efficacy Of Autologous Platelet-Rich Fibrin In The Treatment Of Psoriasis Vulgaris, Hajar Esamelddin, Maha Elgyyar, Mohamed Sultan

Mansoura Medical Journal

Background: Psoriasis is a chronic, immune-mediated dermatosis characterized by dysregulated cutaneous immunity. Platelet-rich fibrin (PRF), an autologous biomaterial concentrated with immunomodulatory cytokines and growth factors, presents a potential novel therapeutic approach by modulating localized inflammatory pathways. Objective: This study aimed to assess the efficacy and safety of a topical and intralesionally autologous PRF protocol in patients with localized plaque psoriasis. Methods: In a prospective single-arm trial, sixty adults with mild-to-moderate localized plaque psoriasis (BSA ≤10%, PASI ≤10) were enrolled. PRF was prepared from peripheral blood via low-speed centrifugation without anti-coagulant. Treatment involved bi-weekly intralesionally injections and topical massage of the …

Comparison Of Baumgaertner Reduction Quality Criteria , Chang Criteria And Ap3×Ml3 Classification And Their Ability To Predict Mechanical Complications Of Trochanteric Fractures Fixed With Proximal Femoral Nail, Amr Elhadidy Elhadidy, Ahmed Abdelbadie Ibrahim, Sallam Ibrahim Fawzy, Ehab Youssef Hassanin

Mansoura Medical Journal

Background Trochanteric fractures are common injuries among the elderly. Despite advances in fixation with proximal femoral nails (PFN), Mechanical complication remain significant. Several reduction quality systems have been proposed, but their predictive value and reproducibility remain debated. Aim To evaluate and compare the predictive value and reproducibility of Baumgaertner Reduction Quality Criteria (BRQC), Chang Reduction Quality Criteria (CRQC), and AP3×ML3 classification in patients with AO Foundation/Orthopaedic Trauma Association (AO/OTA) 31-A1 and 31-A2 trochanteric fractures fixed with PFN. Methods A prospective observational study was conducted on 146 patients with 31-A1 and A2 trochanteric fractures treated by PFN. Postoperative radiographs were assessed …

Association Of Uric Acid Index And Cardiovascular Risk In Egyptian Patients With Type 2 Diabetes, Reem Fathallah, Talaat Abdelaaty, Hend Ghallab, Shimaa M. Elrahmany

Mansoura Medical Journal

Background The uric acid index (UAI) has recently gained recognition as a potential indicator for cardiovascular risk, particularly among middle-aged individuals. This research investigated the association between UAI levels and cardiovascular disease risk in Egyptian patients with type 2 diabetes (T2DM). Methods 200 individuals with T2DM were included in this cross-sectional analysis. The UAI was derived using the logarithmic formula: Ln [fasting triglycerides × fasting uric acid × fasting glucose ÷ 2]. To estimate the 10-year risk of cardiovascular events, the SCORE2-Diabetes was employed. Results The average serum uric acid level was 4.40 ± 1.48 mg/dL, and the mean UAI …

Evaluation Of Serum Zinc-To-Copper Ratio In Adults With Type 2 Diabetes And Its Association With Microvascular Complications, Magdy H. Megallaa, Shimaa M. Elrahmany, Rehab Safwat, Mohamed Zietoun

Mansoura Medical Journal

Background Zinc (Zn) and copper (Cu) are indispensable trace metals that contribute fundamentally to insulin biology, antioxidant defense, and vascular health. In this research, we sought to explore the association between the serum zinc-to-copper (Zn/Cu) ratio and microvascular complications among adults diagnosed with type 2 diabetes (T2DM). Methods For this case-control design, a total of 336 participants were selected and divided into two main groups: Group 1, comprising 224 patients with T2DM, and Group 2, consisting of 112 healthy subjects serving as controls. Group 1 was further stratified into two subgroups based on the presence of microvascular complications; Group 1A …

Sexual Dysfunction After Hysterectomy Based On Female Sexual Function, Elsayed M. Abd Elfattah, Amany A. Makroum, Mohamed A. Fekry, Mohamed Sayed Abdelhafez, Maher Shams, Ahmed El Mennayyer

Mansoura Medical Journal

Abstract Hysterectomy is the most common major gynecological surgical procedure. There are raised concerns regarding its impact on sexual function. Objective: This study aimed to assess the effects of vaginal, abdominal, and laparoscopic hysterectomy on women’s sexual functioning based on the female sexual function index (FSFI). Methods: This prospective Cohort study was conducted on 48 patients who underwent hysterectomy by different routes at the OB/GYN department at Mansoura University Hospitals, Mansoura, Egypt, aged between 25 and 49 years, from October 2024 to October 2025. The patients’ sociodemographic and clinical data were collected. The patients were asked to fill the FSFI …

Indications Of Hospitalization And Predictors Of Outcome Among Patients With Rheumatological Diseases Admitted To Mansoura Rheumatology And Immunology Unit, Hanan Mohamed Elberashi, Nibal Morad, Samar Tharwat

Mansoura Medical Journal

Background correction: Systemic autoimmune rheumatological diseases (SARDs) constitute a category of disorders that can affect several organs. SARDs are persistent, incapacitating illness characterized by significant morbidity and mortalityrates. Patients with SARDs necessitate hospitalization more frequently than the general population.

Aim: To determine the characteristics of patients hospitalized with SARDs at Mansoura University Hospital.

Materials and methods: This cross-sectional study was carried out on patients with different SARDs. The collected data

included patients’ sociodemographic data, autoimmune disease diagnoses, the onset and duration of the disease, rate of

readmission, the main cause of admission, the main organ affected at time of admission, …

Urinary Transferrin As A Marker For Diagnosis And Progression Of Diabetic Nephropathy: Short-Term Follow Up, Ghada El-Said Ahmed Ibrahim, Ibrahim Mohammed Adel Ibrahim Bakr, Amany Ragab Youssef Ahmed, Rasha Mahmoud Abdel Fattah

Mansoura Medical Journal

Background: One of the most serious and devastating effects of diabetes mellitus is diabetic nephropathy, which in many cases progresses to end-stage kidney disease (ESKD). Microalbuminuria is currently the gold standard biomarker for DN diagnosis. Microalbuminuria has a poor predictive value, though. Patients occasionally experienced progressive renal failure without microalbuminuria. A plasma protein called transferrin has a different ionic charge from albumin but is otherwise similar in weight. Aim: Our objectives were to evaluate urinary transferrin as a more accurate and earlier marker for the diagnosis of diabetic kidney disease and to investigate its relationship to the excretion of urinary …

Optimum Design Of Three-Phase Wound Rotor Induction Machine Using Giant Trevally Optimizer Technique, D. El-Hassanein, Abd Al Rahman Amin, Eid Gouda, Mohamed F. Kotb

Mansoura Engineering Journal

Conventional sizing methods for electric machines often result in large dimensions, excessive weight, even when following correct design principles. In this paper promising Giant Trevally Optimizer “GTO” is employed as a swarm intelligence-based optimization algorithm inspired by the social behavior of giant trevally, to design a three-phase wound rotor induction machine “3WRIM”. The optimization process targets four key objectives: maximizing efficiency , and minimizing weight per kilowatt “ ”, temperature rise , and the no-load current to phase current ratio . These objectives are optimized both simultaneously and individually while adhering to a set of practical design constraints. To validate …

Effect Of Raw Materials And Loop Length On Thermal Comfort Properties Of Pique Fleece Fabrics, Aya E. Elemam, Abd Elmonem Fouda, Ahmed S. Eldeeb, Rehab Abd Elkhalek

Mansoura Engineering Journal

Technological developments of knitting machines made it possible to produce evolved fabric structures to obtain various properties that suit consumer needs. Pique fleece is a variation of the special popular fleece knitted structure with aim of combining the features of pique and fleece structures. The aim of this research was to study the effect of yarns material type and loop length on thermal comfort properties of un-napped pique fleece fabrics that used as apparel textiles during transitional seasons. Two types of fleece yarn (100% cotton and 65% cotton/ 35%polyester) and three types of face and binding yarns (cotton, polyester and …

Towards A Framework To Integrate Smart Urban Agriculture Into City Planning In Egypt, Heba Adel Ahmed Hussein

Mansoura Engineering Journal

This study discusses challenges facing the expansion of urban agriculture in Egypt, investigates overcoming these challenges using smart solutions, and proposes a framework to integrate smart urban agriculture (SUA) into Egyptian cities’ plans. The proposed framework provides an insight into the aspects that should be considered before, during, and after transformation to SUA. This study could serve as a basis for the integration of smart agriculture into urban planning theories and practices, and as an inspiration for urban planners, designers, landscape architects, policymakers, and decision-makers to create strategies for promoting digital transformation in Egyptian cities.

The Impact Of Selected Winter Cover Crops On Soybean And Corn Yield, Seed Quality, And Economic Returns, Ashley Stockmaster

Theses and Dissertations

Cover crops are being used to reduce nutrient runoff from agricultural fields and to mitigate climate change. However, cover crops may reduce summer cash crop yields and affect seed quality early in adoption. Therefore, this study evaluated soybean and corn yield, seed quality, and a cost-benefit analysis following cover crops.

This study was conducted at the Illinois State University Research Farm and the Western Illinois University Research Farm to evaluate the impact of selected cover crops on soybean and corn yields and seed quality. The experimental design was a randomized block design replicated four times. Cover crop treatments consisted of …

Larval Environments Affect The Implementation Of The Sterile Insect Technique On Aedes Mosquitoes, Katherine G. Evans

Theses and Dissertations

Sterile Insect Technique (SIT) is an effective method for controlling pests and has been increasing in popularity to control Aedes mosquitoes. SIT involves inundating an area with sterilized male mosquitoes to reduce egg hatch and ultimately the number of wild adults. Previous research indicates that enacting mortality early in the larval life of Aedes mosquitoes can result in counter-productive effects, due to reduced competition among developing larvae. I hypothesize that the effectiveness of SIT at reducing adult populations is modified by densitydependent mortality and density-dependent growth among larvae. I performed two field-to-lab studies and developed an individual-based model to test …

Lower Extremity Individual Muscle Forces In Females During Loaded Hex-Bar Squat Jumps, Jadon Konkel

Theses and Dissertations

The purpose of this study was to describe the individual muscle forces and contributions to extensor force occurring during the propulsive phase of unloaded jumps in females and explore how these are influenced by increasing loads using the hex bar modality. Ten, college-aged females (height: 1.66 ± 0.09 m; weight: 68.63 ± 9.66 kg) with weightlifting experience performed hexagonal bar squat jumps at bodyweight (BW), BW+20% and BW+40% of 1RM. Traditional motion capture techniques were employed to collect dominate lower limb kinematics and kinetics. Individual muscle forces were estimated utilizing Static Optimization in OpenSim using a Gait2392 musculoskeletal model. Muscle …

Nutrient Transport And Transformation In Anaerobic Co-Digestion Of Crop Residues And Swine Manure, Shelby Stoner

Theses and Dissertations

Cover crops may improve soil quality, water quality, soil health, reduce soil fertilizer use, and increase nutrient availability to cash crops. The benefits of cover crops are discussed due to the below ground presence of cover crops, but the aboveground biomass can serve as a source of sustainable energy through anerobic digestion. The nutrients in the above ground biomass can also be recycled and reused through land application of digestion effluent. We have tested anaerobic co-digestion of different biomass feedstocks: cover crops, soybean stalk, and corn stover with swine manure using both small and pilot scale digesters. Nutrients, specifically NPK, …

Site-Specific Modification Of Antibodies Utilizing Microbial Transglutaminase For Improved Immunoassay Performance, Emily Beitello

Theses and Dissertations

Immobilization strategies used for fixing antibodies to solid phase surfaces significantly contribute to the antigen capture capacity and influences the performance and sensitivity of immunoassays. Traditional methodologies result in the random orientation and/or the weak attachment of immobilized antibodies. Different formats of immunoassays scope in applicability to many fields of research and everyday use. Improving the efficiency of immobilizing antibodies in immunoassays is a beneficial endeavor to increase assay sensitivity. Here, we investigated the use of enzyme-mediated conjugation of antibodies to facilitate a highly oriented immobilization. Microbial transglutaminase (mTG) catalyzes the covalent bond formation between a plethora of primary amine …

A Novel Silver-Ruthenium-Based Antimicrobial Kills Gram-Negative Bacteria Through Oxidative Stress-Induced Macromolecular Damage, Patrick O. Tawiah

Theses and Dissertations

The rise in drug-resistant bacteria, together with the decline in antibiotic development, requires new strategies for infectious disease control. Gram-negative pathogens are particularly challenging to combat due to their outer membrane. This study highlights the effectiveness of the silver-containing antimicrobial AGXX® against the Gram-negative bacterium Escherichia coli. AGXX® is a promising silver coating that presumably kills bacteria through the generation of reactive oxygen species (ROS). However, neither AGXX®’s mode of action is fully understood, nor have its effects on Gram-negative bacteria or bacterial response and defense mechanisms towards AGXX® been studied in detail. Here, I report that the bactericidal …

Converting Cover Crop Biomass To Biogas And Volatile Fatty Acids, Tuba Yasmin Lubna

Theses and Dissertations

Cover crops are commonly used for their environmental benefits, including improved soil health and reduced soil erosion. However, there is limited use for the aboveground biomass, except for oilseed crops. The objectives of this study were to (1) characterize the selected winter cover crop biomass at three growth stages, (2) evaluate the biogas and volatile fatty acids (VFAs) yield, and (3) examine the concurrent alkali pretreatment and ensiling effects on biogas yield. Wild pennycress, golden pennycress, CoverCress^TM, annual ryegrass, cereal rye, pea, and clover biomass were harvested at three growth stages. Results showed that biogas yield increased with …

Stress And Behavior In Beef Calves During Weaning, Kathleen E. Tierney

Theses and Dissertations

Animal welfare in commercial livestock operations has been an increasing topic of concern. It is well known that stress can have significant behavioral and physiological repercussions. It is especially important in commercial operations to reduce stress, as animal efficiency is the leading priority. In an effort to reduce stress on animals and improve welfare in livestock operations, several studies have evaluated common husbandry practices. One of the most widely studied practices is weaning, which encapsulates the process of removing the young from the dam. Several studies have evaluated the effects of weaning on beef cattle through a variety of behavioral …

Exploring Biostimulant Efficacy Under Limited Fertilizer And Water In Utah's Watermelon Production, Evan Christensen, Milena Oliveira, Prakriti Nepal, Youping Sun

Plants, Soils and Climate Student Research

The western U.S. has recently experienced some of the driest conditions on record, and Utah has been in a multi-year drought (2019-2023) that affected the agricultural sector, including vegetable producers. While vegetables are not a primary agricultural crop in Utah, they are still an important part of the horticultural economy with 763 farms growing 6,138 acres. As the fourth largest acreage vegetable crop in Utah (almost 10% of the acreage) watermelon and related crops in the gourd family Cucurbitaceae (nearly 36% of total vegetable acreage) are important to vegetable growers. Watermelon is a water-intensive crop and requires an adequate supply …

Seagrasses Are Most Vulnerable To Marine Heatwaves In Tropical Zones: Local-Scale And Broad Climatic Zone Variation In Thermal Tolerances, Nicole Said, Chanelle Webster, Simone Strydom, Natasha Dunham, Matthew P. Adams, Kathryn Mcmahon

Research outputs 2022 to 2026

Under a changing climate, it is imperative that we understand how species may respond to temperature impacts, which can differ among populations of the same species due to local drivers. Thermal tolerance data, which can be used to assess an organism's upper thermal limits, is valuable to identify species and/or populations' susceptibility to thermal stress. This study assessed the variation in thermal tolerance of six seagrass species at both broad latitudinal (c. 500–1000 km) and local scales (c. 25 km). Photosynthesis–temperature curves (15–45°C) were conducted, by measuring oxygen in closed incubation chambers, and thermal optima (Topt) was extracted. We found …

Contrasting Tropical Marine Herbivorous Fish Catches Between The Indo-Pacific And Western Atlantic, Lucas L. Lutzenkirchen, Sterling B. Tebbett, Helen F. Yan, David R. Bellwood

Research outputs 2022 to 2026

Ensuring food security in the Anthropocene presents a significant socio-ecological challenge, especially in rapidly changing coastal seascapes that sustain critical fisheries. Herbivorous fishes are essential for food and financial security through fisheries, however, their contributions to regional catches, and the factors influencing them, are not well understood. Analysing reported and reconstructed catch data across 69 Exclusive Economic Zones, we identify shallow-reef area and coastal population density as significant predictors of herbivorous fish catches. However, between-realm (i.e. Indo-Pacific vs. Western Atlantic) differences are marked, with rabbitfishes contributing disproportionately to herbivorous fishery catches. While rabbitfishes have the potential to support productive fisheries …

Scalable Fabrication Of High-Payload Dendrimer-Based Nanoparticles For Targeted Atherosclerosis Therapy, Huari Kou, Lin Qi, Da Huang, Jiandong Wu, Honglan Shi, Hu Yang

Chemistry Faculty Research & Creative Works

Nanoparticle-based therapeutics hold promise for the treatment of atherosclerosis, but challenges such as low drug-loading capacity and a lack of scalable, controllable production hinder their clinical translation. Flash nanoprecipitation, a continuous synthesis method, offers a potential solution for scalable and reproducible nanoparticle production. In this study, we employed a custom-designed multi-inlet vortex mixer to perform cross-linking reaction-enabled flash nanoprecipitation, facilitating controlled and scalable synthesis of cross-linked Poly amidoamine (PAMAM) dendrimer nanoparticles. Notably, this approach allows simultaneous nanoparticle cross-linking and drug loading in a single step. The mannose moiety enabled specific targeting of macrophages via mannose receptors, enhancing the localization of …

Every Publication Needs An Author Verified Tl;Dr Statement, Sarah Oerther, Daniel B. Oerther

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

No abstract provided.