Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

2025

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 12121 - 12150 of 12452

Full-Text Articles in Life Sciences

Developing A Prognostic Panel In Hormone Receptor Positive Breast Cancer; An Immunohistochemical Study With Clinicopathological Correlation, Shaimaa M Yussif, Reham Naguib, Nahed Soliman Jan 2025

Developing A Prognostic Panel In Hormone Receptor Positive Breast Cancer; An Immunohistochemical Study With Clinicopathological Correlation, Shaimaa M Yussif, Reham Naguib, Nahed Soliman

Mansoura Medical Journal

Introduction

Breast cancer is a heterogeneous disease with a wide range of clinical, histological, and molecular characteristics. Various diagnostic methods have been used to ascertain prognosis by evaluating various clinicopathological data, such as tumor size, nodal stage, hormone receptor status, and human epidermal growth factor 2 (HER2) status, metastasis, tumor grade and lymphovascular emboli. Accurate substratification of prognostic groups with varying clinical outcomes is needed. This is particularly valid for cases of hormone receptor-positive breast cancer. The purpose of this study is to examine the immunohistochemical expression of a set of markers in hormone positive breast carcinoma cases and test …


Clinical Features And Prognosis Of Acute Kidney Injury In Hospital-Admitted Patients With Covid-19 In Egypt: A Single-Center Experience, Hoda M. M. Abdulaziz, Aya Ahmed Mohamed Elsayed, Elshahat A. Yousef Jan 2025

Clinical Features And Prognosis Of Acute Kidney Injury In Hospital-Admitted Patients With Covid-19 In Egypt: A Single-Center Experience, Hoda M. M. Abdulaziz, Aya Ahmed Mohamed Elsayed, Elshahat A. Yousef

Mansoura Medical Journal

Background While COVID-19 primarily manifests clinically as a respiratory disease, it can also impact other organs, such as the kidneys. Acute kidney injury (AKI) is frequently seen in hospital-admitted patients with COVID-19 and is linked to poorer outcomes. This research sought to explore the rate, contributing elements, and consequences of AKI in individuals with COVID-19. Methods Data from 236 COVID-19-infected patients hospitalized at wards and intensive care units (ICUs) dedicated to isolation between September 2020 and February 2021 were analyzed. Comparisons between patients with and without AKI were done using statistical tests as appropriate. Binary logistic regression analyses were performed …


The Effect Of Intraoperative Facet Joint Denervation In The Prophylaxis Of Back Pain After Spinal Fixation: A Randomized Prospective Controlled Single-Blind Study, Mohamed Ali Abbas, Ahmed Zaghlol, Ayman M Ismail, Hamdy Nabwi, Mohamed Ismail, Ahmed Sameh Nada, Mona Mokhtar, Ahmed Shaker Elakhras Jan 2025

The Effect Of Intraoperative Facet Joint Denervation In The Prophylaxis Of Back Pain After Spinal Fixation: A Randomized Prospective Controlled Single-Blind Study, Mohamed Ali Abbas, Ahmed Zaghlol, Ayman M Ismail, Hamdy Nabwi, Mohamed Ismail, Ahmed Sameh Nada, Mona Mokhtar, Ahmed Shaker Elakhras

Mansoura Medical Journal

Background: Failed back surgery syndrome (FBSS) remains a significant challenge after fixation procedures of the spine. The present research assessed the efficacy of intraoperative facet joint denervation in preventing postoperative back pain in individuals undergoing spinal fixation. Methods: A randomized retrospective controlled single-blind study was carried out on 70 patients requiring spinal fixation assigned to two equal groups: Group A: intraoperative facet joint denervation was performed, while Group B was a control group. Pain levels were evaluated utilizing the visual analog scale (VAS) for 7 days following surgery. Follow-up visits occurred at 2 weeks, 1, 3, and 6 months. The …


Urinary Kidney Injury Molecule-1 As A Biomarker For Detection Of Albuminuria And Retinopathy Among Patients With Type 2 Diabetes Mellitus, Amr Y. El Feky, Yehia M. Ghanem, Talaat A. Abdelaaty, Magdy M. Elbordeny, Rabab H. Neanaa Jan 2025

Urinary Kidney Injury Molecule-1 As A Biomarker For Detection Of Albuminuria And Retinopathy Among Patients With Type 2 Diabetes Mellitus, Amr Y. El Feky, Yehia M. Ghanem, Talaat A. Abdelaaty, Magdy M. Elbordeny, Rabab H. Neanaa

Mansoura Medical Journal

Background: Diabetic retinopathy (DR) and diabetic kidney disease (DKD) are prevalent microvascular complications of type 2 diabetes mellitus (T2DM). The objective of this study was to examine the potential relevance of urinary kidney injury molecule-1 (uKIM-1) as a marker of DKD and DR in cases who have T2DM. Methods: A cross-sectional study has been performed among 60 cases with T2DM. They were subdivided into 30 patients with albuminuria and 30 patients without albuminuria. Sociodemographic data, fundus examination, laboratory investigations involving fasting blood glucose (FBG), fasting insulin, HbA1c, HOMA-IR, lipid profile, creatinine, and urinary albumin to creatinine ratio (ACR) have been …


Split-Dose Versus Single-Dose Bowel Preparation For Colonoscopy: A Single Center Study, Mohamed Adel, Seham Seif, Hany Shabana, Asmaa Gameel Jan 2025

Split-Dose Versus Single-Dose Bowel Preparation For Colonoscopy: A Single Center Study, Mohamed Adel, Seham Seif, Hany Shabana, Asmaa Gameel

Mansoura Medical Journal

Background Colonscopy is now the gold standard for colorectal screening. Colon preparation is an important parameter for adequate bowel examination. Detection of small colorectal polyps which are precusors for colorectal adenocarcinoma needs effective bowel cleansing. Aim we performed a prospective randomized controlled trail to compare bowel cleanliness, compliance, tolerability, and patient satisfaction of a single regimen versus a split regimen for colonoscopy. Results The number of detected polyps was statistically significantly higher in the split method group as compared to the single method group (p= 0.040).Also, the prevalence features of ulcerative colitis was statistically significantly higher in the split method …


Thyroid Peroxidase Antibody (Tpo Ab) Can Be Used As A Marker For Persistence Of Symptoms Of Hypothyroidism In Patients With Primary Hypothyroidism Despite Normal Tsh Level: Cross-Sectional Study, Gehad Mohamed Aldamsisy, Mohamed Ghoniem Mohamed, Mohammed Mofreh, Ahmed Albehairy Jan 2025

Thyroid Peroxidase Antibody (Tpo Ab) Can Be Used As A Marker For Persistence Of Symptoms Of Hypothyroidism In Patients With Primary Hypothyroidism Despite Normal Tsh Level: Cross-Sectional Study, Gehad Mohamed Aldamsisy, Mohamed Ghoniem Mohamed, Mohammed Mofreh, Ahmed Albehairy

Mansoura Medical Journal

Background Primary hypothyroidism is one of the most prevalent endocrine conditions. Some hypothyroid patients treated with an acceptable dose of levothyroxine report continuing symptoms including fatigue, depression, and weight gain, despite having a TSH level in the lower half of the normal range. Aim to evaluate why some hypothyroid patients on levothyroxine continue to have residual symptoms despite apparently adequate replacement& laboratory euthyroid status? Patients and methods 111 Adult male and female ranging from (18-65) years with primary hypothyroidism and normal TSH taking adequate levothyroxine dose were divided into 2 groups. Group1: Hypothyroid patients with persistent symptoms despite normal TSH …


Does A Preoperative Caffeine Tablet Affect The Characteristics Of Post-Dural Puncture Headache In Caesarian Section Under Spinal Anesthesia?, Mahmoud Abdelfattah, Karim Ali Awad, Ahmed Amin Eisa, Abdullah Elsayed Abdullah Gheith, Shimaa Abd El-Satar Mohamed Jan 2025

Does A Preoperative Caffeine Tablet Affect The Characteristics Of Post-Dural Puncture Headache In Caesarian Section Under Spinal Anesthesia?, Mahmoud Abdelfattah, Karim Ali Awad, Ahmed Amin Eisa, Abdullah Elsayed Abdullah Gheith, Shimaa Abd El-Satar Mohamed

Mansoura Medical Journal

Background: The current study aim was to evaluate the effectiveness of administering caffeine tablets before surgery in preventing post-dural puncture headache (PDPH) in adult patients who underwent cesarian delivery with spinal anesthesia (SA). Methods: This randomized controlled study (RCT) enrolled patients aged 18–45 years who underwent elective caesarian section under SA. Patients were allocated to receive either a caffeine or placebo tablet prior to SA. Those in the intervention group received a 200 mg caffeine tablet, while those in the control group received a placebo. The primary outcome measured was the incidence of PDPH, with secondary outcomes including the severity …


Direct-Acting Antivirals For Chronic Hepatitis C Virus Infection In Children With Malignancy: A Review Of Current Evidence And Clinical Insights, Ashrakat Galal Aboelfotoh, Ahmad Darwish Mohamad, Ahmed Megahed Hassan Jan 2025

Direct-Acting Antivirals For Chronic Hepatitis C Virus Infection In Children With Malignancy: A Review Of Current Evidence And Clinical Insights, Ashrakat Galal Aboelfotoh, Ahmad Darwish Mohamad, Ahmed Megahed Hassan

Mansoura Medical Journal

In children, hepatitis C virus (HCV) remains a serious health concern, especially those receiving cancer treatment, where repeated blood transfusions and immunosuppression significantly increase the risk of infection. The use of direct-acting antivirals (DAAs) represents a turning point in HCV management, delivering high cure rates with fewer side effects than previous therapies. In this review, we explore the latest insights into HCV epidemiology, transmission, and pathophysiology in pediatric patients, with particular attention to those facing malignancy. We will discuss the mechanisms of action, approved treatment regimens, and safety profiles of DAAs, focusing on combinations like sofosbuvir/ledipasvir in the oncology setting. …


Impacts Of Age And Androgen Level On Albino Rat Meibomian Gland: Light & Electron Microscopic Study, Amira A. Hamid, Nawal A. Hasanin, Hanaa A. Khalaf, Walaa H. E. Hamed Jan 2025

Impacts Of Age And Androgen Level On Albino Rat Meibomian Gland: Light & Electron Microscopic Study, Amira A. Hamid, Nawal A. Hasanin, Hanaa A. Khalaf, Walaa H. E. Hamed

Mansoura Medical Journal

Background: Histological changes in albino rats meibomian glands in relation to age and androgen level. Aim of the work: The current research attempted to assess the impact of age and androgen level on histological structure of meibomian gland . Material and methods: Three groups of adult male albino rats were used ,each group comprised ten rats, group I: six months, group II: one year and group III : two years, Each animal at proper age was weighed , anaesthetized and blood samples were collected for estimation of dehydro-epiandrosterone (DHEA) hormone . The eyelids of each rat were dissected and prepared …


D-Dimer As A Bio-Marker For Assessment Of Disease Activity In Rheumatoid Arthritis Patients, Ahmed Othman, Amir A. Youssef, Y. Tera, Yasmin Adel Jan 2025

D-Dimer As A Bio-Marker For Assessment Of Disease Activity In Rheumatoid Arthritis Patients, Ahmed Othman, Amir A. Youssef, Y. Tera, Yasmin Adel

Mansoura Medical Journal

Background Rheumatoid arthritis (RA) is considered the most common inflammatory joint disorder. It can lead to early morbidity, mortality and increased incidence of functional disability. Achieving rapid remission in early disease appears to be a beneficial strategy in preventing work disability in RA patients. The lack of specificity of commonly used inflammatory markers prompted the investigation of novel ones for estimating disease activity in RA. D-dimer has been one of these new markers, as RA is known to induce a hypercoagulable state. Aim This study aimed to investigate the possibility of utilizing D-dimer as a potential marker for assessing RA …


Pulsed Radiofrequency Of Suprascapular Nerve Versus Radiofrequency Ablation Of Articular Branches Of The Shoulder For Intractable Shoulder Pain: A Randomized Controlled Study, Elsayed M. Elemam, Mahmoud M. Alseoudy, Ahmed R. Abourezk Jan 2025

Pulsed Radiofrequency Of Suprascapular Nerve Versus Radiofrequency Ablation Of Articular Branches Of The Shoulder For Intractable Shoulder Pain: A Randomized Controlled Study, Elsayed M. Elemam, Mahmoud M. Alseoudy, Ahmed R. Abourezk

Mansoura Medical Journal

BackgroundChronic shoulder pain is frequent in the community and can cause considerable functional impairment. The suprascapular nerve (SSN) is responsible for approximately 70% of the sensory innervation to the shoulder joint.Objectives: This randomized controlled trial aimed to compare the efficacy of pulsed radiofrequency treatment of the SSN with thermal radiofrequency ablation of the articular branches of the shoulder among patients with persistent shoulder pain.Methods 82 patients were randomly allocated into two equal groups; group PRF included patients who underwent pulsed radiofrequency of the suprascapular nerve, and group TRF included patients who underwent thermal radiofrequency ablation of articular terminal branches of …


Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus, Amr Y. El Feky, Talaat A. Abdelaaty, Azza A. Ismail, Rania M. Elsharkawy, Mohamed F. Amara, Shimaa M. Elrahmany Jan 2025

Relationship Between Serum Micro-Rna 192 And 29c And Kidney Disease In Subjects With Type 2 Diabetes Mellitus, Amr Y. El Feky, Talaat A. Abdelaaty, Azza A. Ismail, Rania M. Elsharkawy, Mohamed F. Amara, Shimaa M. Elrahmany

Mansoura Medical Journal

Background Diabetic kidney disease (DKD) is a frequent and serious complication of type 2 diabetes mellitus (T2DM). This study aimed to assess the relationship between micro- RNA (miRNA)-192 and miRNA-29c expression and DKD in patients with T2DM. Patients and methods A case-control study was conducted with 160 participants: 40 T2DM patients with DKD, 40 T2DM patients without DKD, and 80 healthy controls. Plasma levels of miRNA-192 and miRNA-29c were quantified using quantitative reverse transcription PCR. Diagnostic accuracy was assessed via ROC curve analysis. Multivariate logistic regression identified predictors of DKD. Results Micro RNA-192 expression was significantly elevated while miRNA-29c expression …


Predictive Value Of Procalcitonin In Patients With Hepatitis C Virus Related Liver Cirrhosis And Sepsis, Omar Abdallah, Elshimaa Saad Eleraky, Doaa A. A. Abdeldayem, Mohamed Hossam El-Dein Zaghloul, Mohamed El-Saadany Jan 2025

Predictive Value Of Procalcitonin In Patients With Hepatitis C Virus Related Liver Cirrhosis And Sepsis, Omar Abdallah, Elshimaa Saad Eleraky, Doaa A. A. Abdeldayem, Mohamed Hossam El-Dein Zaghloul, Mohamed El-Saadany

Mansoura Medical Journal

Infection is a major source of morbidity and mortality in patients with liver cirrhosis. In about 30% of patients, bacterial infection is present on admission or develop during hospitalisation. Early detection of bacterial infection in patients with decompensated cirrhosis remain a major challenge, where time plays a crucial role. This study was conducted aiming to find the prognostic value of PCT in the patients with liver cirrhosis presenting with sepsis. During the period from June 2021 to December 2021, 75 subjects were enrolled. 50 patients with Hepatitis-C Virus (HCV) cirrhosis with sepsis. 25 patients had compensated cirrhosis while the other …


The Effect Of Parathyroidectomy Compared To Pharmacological Treatment On Biochemical Markers And Quality Of Life Among Maintenance Hemodialysis Patients With Secondary Hyperparathyroidism, Ahmed Bahie, Dina Abd El Halim Shahin, Magdy Elsaid Abd Elmagid Samour, Elshahat Ali Ahmed Mohamed Yousef Jan 2025

The Effect Of Parathyroidectomy Compared To Pharmacological Treatment On Biochemical Markers And Quality Of Life Among Maintenance Hemodialysis Patients With Secondary Hyperparathyroidism, Ahmed Bahie, Dina Abd El Halim Shahin, Magdy Elsaid Abd Elmagid Samour, Elshahat Ali Ahmed Mohamed Yousef

Mansoura Medical Journal

Background One-third of maintenance hemodialysis (HD) patients develop severe secondary hyperparathyroidism (SHPT). Parathyroidectomy (PTx) is recommended for resistant SHPT, but calcimimetics have reduced the need for surgery. Aim of the work: to compare biochemical and QoL parameters in HD patients with SHPT who underwent PTx to those treated medically. Subject and methods in a cross-sectional study, 200 maintenance HD patients in two equal groups: A (patients on medical treatment) and B (PTx patients). In Group A, 32 patients received Cinacalcet. A thorough history, anthropometrics, clinical examination, Electrocardiography and full laboratory tests including serum calcium (sCa), phosphorus (sPhos), intact parathormone (iPTH) …


Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad Jan 2025

Antifibrotic Effects Of Fucoidan Compound On Experimental Hepatic Schistosomiasis, Eman Alaa Eldin Nazir Mohamed, Nairmen Nabih Ahmed, Suzan Hassan Elgendy, Zeinab Mohamed Ahmed Gawesh, Soha Ibrahim Awad

Mansoura Medical Journal

Background Schistosomiasis is a prevalent fibrotic disease characterized by inflammation and fibrous tissue deposition around Schistosoma eggs trapped in the hepatic tissue. This work aimed to evaluate the anti-fibrotic and anti-parasitic effects of fucoidan during the chronic phase of experimental schistosomiasis-mansoni in mice. Methods Sixty female Swiss albino mice were allocated into six groups; non-infected unmanaged mice group, infected unmanaged mice group, non-infected fucoidanmanaged mice group, infected fucoidan-managed mice group, infected PZQ-managed mice group, and infected combined fucoidan and PZQ managed mice. Every liver tissue was examined parasitologically, histopathologically, and by anti-transforming growth factor-beta (TGF-β) immunohistochemically. Serum was used to …


Application Of Milan System In Cytological Diagnosis Of Salivary Gland Lesions And Its Association With Histopathology, Asmaa Sabry Gad, Heba Salah Eldin Hany, Wagdi Fawzi Elkashef, Mie Ali Mohamed Jan 2025

Application Of Milan System In Cytological Diagnosis Of Salivary Gland Lesions And Its Association With Histopathology, Asmaa Sabry Gad, Heba Salah Eldin Hany, Wagdi Fawzi Elkashef, Mie Ali Mohamed

Mansoura Medical Journal

Background: Salivary gland harbors a wide variety of non-neoplastic & neoplastic conditions that show heterogenicity in the same tumor tissue. The Milan System for Reporting Salivary Gland Cytology was designated to offer a standardized universally accepted reporting format for Salivary Gland FNAC. Aim: To apply Milan system for salivary gland and assess its accuracy by comparing the cytology and histopathology. Methods: In this retrospective study, the Milan system was applied on 81 FNAC cases referred to pathology lab at Oncology Centre Mansoura University during 5 years & compared results with postoperative biopsy. For cytological samples, Hematoxylin & Eosin-stained smears, cell …


The Impact Of Effective Diabetes Management On Reducing Burden In Elderly Patients: A Case-Control Study, Eslam Abdelhamid Mohamed, Mohamed A. Helaly, Ahmed Albehairy Jan 2025

The Impact Of Effective Diabetes Management On Reducing Burden In Elderly Patients: A Case-Control Study, Eslam Abdelhamid Mohamed, Mohamed A. Helaly, Ahmed Albehairy

Mansoura Medical Journal

Background and aim: Elderly individuals with diabetes mellitus (DM) are more prone to experiencing common geriatric syndromes, which include impaired cognition, dementia, frailty, falls, fractures, urinary incontinence, and disability. These can significantly impair their quality of life (QoL) and could conflict with anti-diabetic medication. Therefore, we aim to evaluate the impact of controlling diabetes on the overall burden of diabetes in the elderly. Materials and Methods: 100 elderly patients over sixty-five with type 2 diabetes mellitus (T2DM) were selected from Mansoura Specialized Medical Hospital (MSMH) between April 2022 and February 2023. The patients were divided into two groups: fifty diabetic …


Could Angiopioetin-1 & Angiopioetin-2 Be Considered A Predictor For Community Acquired Pneumonia Severity And Phenotypes, Magdy Mohamed Zedan, Nashwa Abusamra, Engy Osman, Rania Mohammed Emad Eldin Eldersy Jan 2025

Could Angiopioetin-1 & Angiopioetin-2 Be Considered A Predictor For Community Acquired Pneumonia Severity And Phenotypes, Magdy Mohamed Zedan, Nashwa Abusamra, Engy Osman, Rania Mohammed Emad Eldin Eldersy

Mansoura Medical Journal

Background: Community-acquired pneumonia (CAP) is a major cause of morbidity and mortality worldwide and the role of biomarkers in pneumonia has been evaluated in many clinical areas. Angiopoietin-1 and Angiopoietin -2 are glycoproteins that play role in vascular development, angiogenesis, and permeability. Aim: To conduct a trial for phenotyping and endotyping of pneumonia using Angiopoietins-1 and Angiopoietin -2. Subjects and methods: This case-control study included 30 cases and 29 controls of matched age and sex. to investigate Angiopioetin-1 & -2 serum levels in both groups and then evaluated the possible association between serum Angiopoietin -1&-2 in different pneumonia phenotypes. Results: …


Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy Jan 2025

Relation Between Serum Vitamin D Level And Disease Activity In Rheumatoid Arthritis, Mohamed Hussein Salem, Nahed Abdullah Hassan, Adel Ibrahim Abdelsalam, Fatma Hamdy

Mansoura Medical Journal

Background The role of vitamin D in the pathogenesis of rheumatoid arthritis is controversial. This study aims to assess the relation between vitamin D level and rheumatoid arthritis disease activity. Patients and methods This study was conducted on 80 rheumatoid arthritis (RA) patients beside 40 healthy persons. Vitamin D level was assessed in all participants. Rheumatoid activity was assessed using DAS28 (disease activity score). RA patients were classified according to DAS 28 into two groups: active group and remission group. Results The median for vitamin D level in RA group was 23.5ng/ml. There was no statistically significant difference in serum …


Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy Jan 2025

Ultrasonic Criteria For The Selection Of Rib Graft For Laryngotracheal Reconstruction, Mohamed Abdulaziz Farah, Hazem Emam Amer, Ahmed Abdelfattah Elsobki, Mahitab M. Rashad Ghoneim, Ahmed Abdoo Elzhzahy

Mansoura Medical Journal

Background Laryngotracheal reconstruction (LTR) is a well-established surgical procedure for the management of pediatric subglottic stenosis, with rib cartilage grafts. This study was conducted to evaluate preoperative and intraoperative discrepancies of rib graft used in laryngotracheal reconstruction using ultrasonic criteria in terms of their height, thickness, and length. Methods This prospective cohort study was conducted on 10 pediatric patients who underwent LTR at Mansoura University Hospitals. Preoperative ultrasonography was performed on the right 4th, 5th, and 6th rib cartilages, measuring height, thickness, and length. These measurements were then directly compared with intraoperative dimensions of the harvested cartilage. Results There was …


Study Of Heat Shock Protein 70 In Serum Of Cancer Breast Patients, Dina Adel Denewer, Fatma Abbas Auf, Khaled M. Abdelwahab, Mona Elwassefy Jan 2025

Study Of Heat Shock Protein 70 In Serum Of Cancer Breast Patients, Dina Adel Denewer, Fatma Abbas Auf, Khaled M. Abdelwahab, Mona Elwassefy

Mansoura Medical Journal

Background Breast cancer (BC) is the most frequent malignancy affecting women worldwide. Heat shock proteins (HSPs) are a family of proteins that are important for the maintenance of cell homeostasis. HSPs have been overexpressed in many tumours, including BCs, lung, gastric, ovarian, endometrial and colon Aim To evaluate the relation between serum levels of HSP70 and BC in Egyptians and its impact on tumour characteristics and different histopathological types of BC. Methods This a case-control study conducted on 70 cases of newly diagnosed BC and the control group included 19 apparently healthy age and sex matched subjects. Full clinical examination …


Evaluation Of Safety And Efficacy Of Autologous Platelet-Rich Fibrin In The Treatment Of Psoriasis Vulgaris, Hajar Esamelddin, Maha Elgyyar, Mohamed Sultan Jan 2025

Evaluation Of Safety And Efficacy Of Autologous Platelet-Rich Fibrin In The Treatment Of Psoriasis Vulgaris, Hajar Esamelddin, Maha Elgyyar, Mohamed Sultan

Mansoura Medical Journal

Background: Psoriasis is a chronic, immune-mediated dermatosis characterized by dysregulated cutaneous immunity. Platelet-rich fibrin (PRF), an autologous biomaterial concentrated with immunomodulatory cytokines and growth factors, presents a potential novel therapeutic approach by modulating localized inflammatory pathways. Objective: This study aimed to assess the efficacy and safety of a topical and intralesionally autologous PRF protocol in patients with localized plaque psoriasis. Methods: In a prospective single-arm trial, sixty adults with mild-to-moderate localized plaque psoriasis (BSA ≤10%, PASI ≤10) were enrolled. PRF was prepared from peripheral blood via low-speed centrifugation without anti-coagulant. Treatment involved bi-weekly intralesionally injections and topical massage of the …


Comparison Of Baumgaertner Reduction Quality Criteria , Chang Criteria And Ap3×Ml3 Classification And Their Ability To Predict Mechanical Complications Of Trochanteric Fractures Fixed With Proximal Femoral Nail, Amr Elhadidy Elhadidy, Ahmed Abdelbadie Ibrahim, Sallam Ibrahim Fawzy, Ehab Youssef Hassanin Jan 2025

Comparison Of Baumgaertner Reduction Quality Criteria , Chang Criteria And Ap3×Ml3 Classification And Their Ability To Predict Mechanical Complications Of Trochanteric Fractures Fixed With Proximal Femoral Nail, Amr Elhadidy Elhadidy, Ahmed Abdelbadie Ibrahim, Sallam Ibrahim Fawzy, Ehab Youssef Hassanin

Mansoura Medical Journal

Background Trochanteric fractures are common injuries among the elderly. Despite advances in fixation with proximal femoral nails (PFN), Mechanical complication remain significant. Several reduction quality systems have been proposed, but their predictive value and reproducibility remain debated. Aim To evaluate and compare the predictive value and reproducibility of Baumgaertner Reduction Quality Criteria (BRQC), Chang Reduction Quality Criteria (CRQC), and AP3×ML3 classification in patients with AO Foundation/Orthopaedic Trauma Association (AO/OTA) 31-A1 and 31-A2 trochanteric fractures fixed with PFN. Methods A prospective observational study was conducted on 146 patients with 31-A1 and A2 trochanteric fractures treated by PFN. Postoperative radiographs were assessed …


Association Of Uric Acid Index And Cardiovascular Risk In Egyptian Patients With Type 2 Diabetes, Reem Fathallah, Talaat Abdelaaty, Hend Ghallab, Shimaa M. Elrahmany Jan 2025

Association Of Uric Acid Index And Cardiovascular Risk In Egyptian Patients With Type 2 Diabetes, Reem Fathallah, Talaat Abdelaaty, Hend Ghallab, Shimaa M. Elrahmany

Mansoura Medical Journal

Background The uric acid index (UAI) has recently gained recognition as a potential indicator for cardiovascular risk, particularly among middle-aged individuals. This research investigated the association between UAI levels and cardiovascular disease risk in Egyptian patients with type 2 diabetes (T2DM). Methods 200 individuals with T2DM were included in this cross-sectional analysis. The UAI was derived using the logarithmic formula: Ln [fasting triglycerides × fasting uric acid × fasting glucose ÷ 2]. To estimate the 10-year risk of cardiovascular events, the SCORE2-Diabetes was employed. Results The average serum uric acid level was 4.40 ± 1.48 mg/dL, and the mean UAI …


Evaluation Of Serum Zinc-To-Copper Ratio In Adults With Type 2 Diabetes And Its Association With Microvascular Complications, Magdy H. Megallaa, Shimaa M. Elrahmany, Rehab Safwat, Mohamed Zietoun Jan 2025

Evaluation Of Serum Zinc-To-Copper Ratio In Adults With Type 2 Diabetes And Its Association With Microvascular Complications, Magdy H. Megallaa, Shimaa M. Elrahmany, Rehab Safwat, Mohamed Zietoun

Mansoura Medical Journal

Background Zinc (Zn) and copper (Cu) are indispensable trace metals that contribute fundamentally to insulin biology, antioxidant defense, and vascular health. In this research, we sought to explore the association between the serum zinc-to-copper (Zn/Cu) ratio and microvascular complications among adults diagnosed with type 2 diabetes (T2DM). Methods For this case-control design, a total of 336 participants were selected and divided into two main groups: Group 1, comprising 224 patients with T2DM, and Group 2, consisting of 112 healthy subjects serving as controls. Group 1 was further stratified into two subgroups based on the presence of microvascular complications; Group 1A …


Sexual Dysfunction After Hysterectomy Based On Female Sexual Function, Elsayed M. Abd Elfattah, Amany A. Makroum, Mohamed A. Fekry, Mohamed Sayed Abdelhafez, Maher Shams, Ahmed El Mennayyer Jan 2025

Sexual Dysfunction After Hysterectomy Based On Female Sexual Function, Elsayed M. Abd Elfattah, Amany A. Makroum, Mohamed A. Fekry, Mohamed Sayed Abdelhafez, Maher Shams, Ahmed El Mennayyer

Mansoura Medical Journal

Abstract Hysterectomy is the most common major gynecological surgical procedure. There are raised concerns regarding its impact on sexual function. Objective: This study aimed to assess the effects of vaginal, abdominal, and laparoscopic hysterectomy on women’s sexual functioning based on the female sexual function index (FSFI). Methods: This prospective Cohort study was conducted on 48 patients who underwent hysterectomy by different routes at the OB/GYN department at Mansoura University Hospitals, Mansoura, Egypt, aged between 25 and 49 years, from October 2024 to October 2025. The patients’ sociodemographic and clinical data were collected. The patients were asked to fill the FSFI …


Indications Of Hospitalization And Predictors Of Outcome Among Patients With Rheumatological Diseases Admitted To Mansoura Rheumatology And Immunology Unit, Hanan Mohamed Elberashi, Nibal Morad, Samar Tharwat Jan 2025

Indications Of Hospitalization And Predictors Of Outcome Among Patients With Rheumatological Diseases Admitted To Mansoura Rheumatology And Immunology Unit, Hanan Mohamed Elberashi, Nibal Morad, Samar Tharwat

Mansoura Medical Journal

Background correction: Systemic autoimmune rheumatological diseases (SARDs) constitute a category of disorders that can affect several organs. SARDs are persistent, incapacitating illness characterized by significant morbidity and mortalityrates. Patients with SARDs necessitate hospitalization more frequently than the general population.

Aim: To determine the characteristics of patients hospitalized with SARDs at Mansoura University Hospital.

Materials and methods: This cross-sectional study was carried out on patients with different SARDs. The collected data

included patients’ sociodemographic data, autoimmune disease diagnoses, the onset and duration of the disease, rate of

readmission, the main cause of admission, the main organ affected at time of admission, …


Urinary Transferrin As A Marker For Diagnosis And Progression Of Diabetic Nephropathy: Short-Term Follow Up, Ghada El-Said Ahmed Ibrahim, Ibrahim Mohammed Adel Ibrahim Bakr, Amany Ragab Youssef Ahmed, Rasha Mahmoud Abdel Fattah Jan 2025

Urinary Transferrin As A Marker For Diagnosis And Progression Of Diabetic Nephropathy: Short-Term Follow Up, Ghada El-Said Ahmed Ibrahim, Ibrahim Mohammed Adel Ibrahim Bakr, Amany Ragab Youssef Ahmed, Rasha Mahmoud Abdel Fattah

Mansoura Medical Journal

Background: One of the most serious and devastating effects of diabetes mellitus is diabetic nephropathy, which in many cases progresses to end-stage kidney disease (ESKD). Microalbuminuria is currently the gold standard biomarker for DN diagnosis. Microalbuminuria has a poor predictive value, though. Patients occasionally experienced progressive renal failure without microalbuminuria. A plasma protein called transferrin has a different ionic charge from albumin but is otherwise similar in weight. Aim: Our objectives were to evaluate urinary transferrin as a more accurate and earlier marker for the diagnosis of diabetic kidney disease and to investigate its relationship to the excretion of urinary …


Optimum Design Of Three-Phase Wound Rotor Induction Machine Using Giant Trevally Optimizer Technique, D. El-Hassanein, Abd Al Rahman Amin, Eid Gouda, Mohamed F. Kotb Jan 2025

Optimum Design Of Three-Phase Wound Rotor Induction Machine Using Giant Trevally Optimizer Technique, D. El-Hassanein, Abd Al Rahman Amin, Eid Gouda, Mohamed F. Kotb

Mansoura Engineering Journal

Conventional sizing methods for electric machines often result in large dimensions, excessive weight, even when following correct design principles. In this paper promising Giant Trevally Optimizer “GTO” is employed as a swarm intelligence-based optimization algorithm inspired by the social behavior of giant trevally, to design a three-phase wound rotor induction machine “3WRIM”. The optimization process targets four key objectives: maximizing efficiency , and minimizing weight per kilowatt “ ”, temperature rise , and the no-load current to phase current ratio . These objectives are optimized both simultaneously and individually while adhering to a set of practical design constraints. To validate …


Effect Of Raw Materials And Loop Length On Thermal Comfort Properties Of Pique Fleece Fabrics, Aya E. Elemam, Abd Elmonem Fouda, Ahmed S. Eldeeb, Rehab Abd Elkhalek Jan 2025

Effect Of Raw Materials And Loop Length On Thermal Comfort Properties Of Pique Fleece Fabrics, Aya E. Elemam, Abd Elmonem Fouda, Ahmed S. Eldeeb, Rehab Abd Elkhalek

Mansoura Engineering Journal

Technological developments of knitting machines made it possible to produce evolved fabric structures to obtain various properties that suit consumer needs. Pique fleece is a variation of the special popular fleece knitted structure with aim of combining the features of pique and fleece structures. The aim of this research was to study the effect of yarns material type and loop length on thermal comfort properties of un-napped pique fleece fabrics that used as apparel textiles during transitional seasons. Two types of fleece yarn (100% cotton and 65% cotton/ 35%polyester) and three types of face and binding yarns (cotton, polyester and …