Life Sciences Commons^™

Ephedrine Versus Norepinephrine Infusion For Prevention Of Haemodynamic Instability After Declamping Of The Aorta In Abdominal Aortic Aneurysm Repair, Mohamed Younes Yousef Abd Allah, Maha Younes Youssef Abd-Allah, Mohamed E. Elshehawi, Ka Awad

Mansoura Medical Journal

Background: During general anesthesia, hypotension is often experienced and is linked to both postoperative morbidity and death. Anesthesiologists have long had a hurdle while performing abdominal aortic aneurysm (AAA) repair, a high-risk treatment that increases vulnerability to hemodynamic disturbances during open surgery. A common vasopressor that is a combined α- and β-agonist, ephedrine is used to treat hypotension in general anesthesia. Conversely, norepinephrine has a favorable chronotropic impact on the heart in addition to acting as an agonist for both α and ß receptors. Aim of the work: Examine the differences in the effects of intravenous ephedrine hydrochloride and noradrenaline …

Serum Trefoil Factor 3 As A Diagnostic Marker Of Hepatocellular Carcinoma Related To Chronic Hepatitis C Cirrhosis, Mohammed El Hagrasy, Ashraf Omar, Hosam Abdel Twab, Ahmed Saed

Mansoura Medical Journal

Background: Liver cancer, specifically Hepatocellular Carcinoma (HCC), is a main cause of cancer-related deaths globally. Early detection of HCC is also a significant challenge. Our research aimed to examine serum trefoil factor 3 (TFF3) level compared to alpha-fetoprotein (AFP) in diagnosis and prognosis of HCC and other hepatitis C virus (HCV)-related liver diseases. Methods: This single-center prospective study was performed at a Specialized Medical Hospital, Faculty of Medicine, Mansoura University, over a duration of 6 months from May to October 2021. The study consisted of 35 cases with HCC on top of cirrhosis, 35 with HCV-induced cirrhosis, and 20 healthy …

Making Sense Of Big (Kinematic) Data: A Comprehensive Analysis Of Movement Parameters In A Diverse Population, Naomi Wilma Nunis

University of the Pacific Theses and Dissertations

OBJECTIVE

The purpose of this study was to determine how kinematic, big data can be evaluated using computational, comprehensive analysis of movement parameters in a diverse population.

METHODS

Retrospective data was collected, cleaned, and reviewed for further analysis of biomechanical movement in an active population using 3D collinear resistance loads. The active sample of the population involved in the study ranged from age 7 to 82 years old and respectively identified as active in 13 different sports. Moreover, a series of exercises were conducted by each participant across multiple sessions. Exercises were measured and recorded based on 6 distinct biometric …

Gut-Lung Axis Of The Microbiome Alterations After Ultrafine Particles And Ozone Inhalation, Md Habibul Hasan Mazumder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Air pollution poses a significant threat to public health. It is a mixture of particulate matter, gaseous substances, and other secondary substances. Despite epidemiological research indicating the interactive effects of various components of air pollution, existing studies and regulatory limits often focus on single-exposure scenarios. The emerging understanding of the microbiome’s role in regulating immune response, metabolism, and pathophysiology of various diseases points towards interactions between environmental exposures and microbial dysbiosis. In this dissertation, mice were exposed to relevant deposited doses of carbon black (CB) and ozone (O3), and lung inflammation as well as the lung-gut axis of the microbiome …

Spiking Neural Network That Maps From Generalized Coordinates To Cartesian Coordinates, Chloe K. Guie

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this thesis, I look to understand how insects compute task-level quantities by integrating range-fractionated sensory signals to create a sparse-spatial coding of Cartesian positions. I created biologically plausible 2-D and 3-D models of one species of the stick insect (Carausius morosus) leg and encoded the foot position through a spiking neural network. This model used spiking afferents from three angles of an insect leg which are integrated by one non-spiking interneuron. This model contains many dendritic compartments and one somatic compartment that encode the foot’s position relative to the body. The Functional Subnetwork Approach (FSA) was used …

Quantifying The Impacts Of Genetically Engineered Crops And Deep Soil C Cycling On The Sustainability Of Bioenergy Crop Production, Zoe Pagliaro

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bioenergy can help mitigate climate change by providing a carbon-neutral fuel source. However, multiple challenges exist to achieving carbon neutrality including converting lignocellulosic materials to fuel and enhancing soil C sequestration during the growth of the feedstocks. To address these challenges, there have been recent efforts to genetically modify feedstocks to produce more energy dense oils that increase fuel conversion efficiency and to cultivate deep-rooted perennial feedstocks that can enhance soil C storage. However, the C consequences and efficacy of these solutions remain largely uncertain.

To examine the C consequences of enhancing oil content of bioenergy feedstocks, I examined the …

Ubiquitination Of The Protocadherin-Γa3 Variable Cytoplasmic Domain Modulates Cell-Cell Interaction, Albert Ptashnik, Nicole Lamassa, Aliya Mambetalieva, Emily Schnall, Mike Bucaro, Greg R. Phillips

Publications and Research

The family of ∼60 clustered protocadherins (Pcdhs) are cell adhesion molecules encoded by a genomic locus that regulates expression of distinct combinations of isoforms in individual neurons resulting in what is thought to be a neural surface “barcode” which mediates same-cell interactions of dendrites, as well as interactions with other cells in the environment. Pcdh mediated same-cell dendrite interactions were shown to result in avoidance while interactions between different cells through Pcdhs, such as between neurons and astrocytes, appear to be stable. The cell biological mechanism of the consequences of Pcdh based adhesion is not well understood although various signaling …

Evaluating The Relative Influence Of Soil Water Potential, Soil Moisture, And Vapor Pressure Deficit On Semi-Arid Vegetation Dynamics, Kayla R. Jamerson

Graduate Student Theses, Dissertations, & Professional Papers

Knowledge of vegetation’s response to soil water availability and atmospheric demand is critical to understanding the impact of climate change on semi-arid ecosystems. However, limited field-based research has been conducted to assess the relative importance of these drivers and previous research has simplified the assessment of soil water availability by relying on soil volumetric water content (VWC) as a primary control on plant growth, which, as opposed to soil water potential (Ψsoil), does not account for the effects of soil texture on plant available water. To address these gaps, we compared remotely sensed indicators of vegetation response to field based …

Relationship Between Reproductive And Bone Biomarkers And Osteoarthritis In Zoo Asian (Elephas Maximus) And African (Loxodonta Africana) Elephants, Daniella E Chusyd, Janine L Brown, Lilian Golzarri-Arroyo, Stephanie L Dickinson, Virginia B Kraus, Jessica Siegal-Willott, Timothy M Griffin, Janet L Huebner, Katie L Edwards, David B Allison, Steven N Austad

Children’s Nutrition Research Center Staff Publications

Osteoarthritis (OA) is common in zoo Asian (Elephas maximus) and African (Loxodonta africana) elephants. This study investigated the relationship between confirmed or suspected OA with ovarian cyclicity, gonadotropins, progestagens, luteinizing hormone (LH), follicular stimulating hormone (FSH), and collagen type I (CTX-I) in zoo elephants. In Asian elephants, odds of having confirmed or suspected OA decreased with cycling (OR = 0.22, P = 0.016; OR = 0.29, P = 0.020, respectively), however, not when adjusted for age (odds ratio [OR] = 0.31, P = 0.112; OR = 0.58, P = 0.369, respectively). In African elephants, none of …

Conditioning On Parental Mating Types Can Reduce Necessary Assumptions For Mendelian Randomization, Keisuke Ejima, Nianjun Liu, Luis Miguel Mestre, Gustavo De Los Campos, David B Allison

Children’s Nutrition Research Center Staff Publications

Mendelian randomization (MR) has become a common tool used in epidemiological studies. However, when confounding variables are correlated with the instrumental variable (in this case, a genetic/variant/marker), the estimation can remain biased even with MR. We propose conditioning on parental mating types (a function of parental genotypes) in MR to eliminate the need for one set of assumptions, thereby plausibly reducing such bias. We illustrate a situation in which the instrumental variable and confounding variables are correlated using two unlinked diallelic genetic loci: one, an instrumental variable and the other, a confounding variable. Assortative mating or population admixture can create …

Table Of Contents

Human–Wildlife Interactions

This is the table of contents.

Tradeoffs May Counteract Effects Of Telecommunication Towers On Osprey Nesting, Gage R. Barnes, Kate G. Slankard, John B. Hewlett, Andrea K. Darracq

Human–Wildlife Interactions

The number of telecommunication towers (TCTs) throughout the United States has and continues to increase exponentially. Increased TCT placement has been implicated in local population increases in platform nesting birds such as ospreys (Pandion haliaetus). However, osprey use of artificial structures can cause conflicts with humans because of economic costs and risks to human safety. Managers require better information regarding the effect of artificial nesting surfaces, such as TCTS, on osprey reproduction to make informed decisions regarding species conservation and to mitigate potential conflicts. The objective of our study was to evaluate the influence of TCTs on osprey …

Do Trap-Neuter-Return (Tnr) Practices Contribute To Human–Coyote Conflicts In Southern California?, Danielle M. Bucklin, Jennifer M. Shedden, Niamh M. Quinn, Robert Cummings, Paul Stapp

Human–Wildlife Interactions

One possible contributor to the unusually high number of conflicts between coyotes (Canis latrans) and people in urban southern California, USA, may be the abundance of free-roaming domestic cats (Felis catus; cats) subsidized by feeding and augmented by trap-neuter-return (TNR) programs. To determine if coyotes regularly prey on and consume cats, we combined visual and molecular-genetic approaches to identify prey items in stomachs of 311 coyotes from Los Angeles County and Orange County, provided to the South Coast Research and Extension Center, in Irvine, California, between June 2015 and December 2018. We detected cat remains in …

Habituated, Tolerant, Or Salt-Conditioned Mountain Goats And Human Safety, Richard B. Harris, Kurt Aluzas, Laura Balyx, Jami Belt, Joel Berger, Mark Biel, Tonya Chilton-Radandt, Steeve D. Côté, Julie Cunningham, Adam Ford, Patti Happe, Chad P. Lehman, Kim Poole, Clifford G. Rice, Kirk Safford, Wesley Sarmento, Laura Wolf

Human–Wildlife Interactions

Interactions between humans and wildlife include a number of consumptive and non-consumptive forms. In some cases, the increased demand for wildlife viewing can precipitate new human–wildlife conflicts. Mountain goats (Oreamnos americanus; goats) are native to a number of North American mountain ranges from southeastern Alaska to southwestern Montana, USA. Goat habitat typically consists of steep terrain and cold weather habitats, which has left them particularly vulnerable to climate change. Their alpine environments also make them vulnerable to disturbance by aircraft and land-based motorized human activity. We reviewed and characterized situations in which goats in close proximity to humans …

Conflict Animals, Or Conflict People—That Is The Question, Vincenzo Penteriani

Human–Wildlife Interactions

Managing conflictual sce­narios involving large carnivores is generally addressed from an animal-centric perspective. This is rather contradic­tory because such conflicts are mostly triggered by human conduct that acts on animal’s instinc­tive behaviors. Shifting conflict miti­gation perspectives to human behaviors may thus provide a more consistent management strategy than focusing only on animals. For example, human habituation and anthropogenic food conditioning are 2 main conflict drivers that mostly depend on human behavior. Thus, an approach that addresses the human dimension aspects of these conflicts needs to be reinforced. I offer 6 points to consider in prioritizing management to mitigate human–bear conflicts …

Hwi Monograph Series

Human–Wildlife Interactions

The HWI Monograph Series includes open access publications on wild pigs, black bears, deer, and a forthcoming title on free-ranging domestic cats.

An Unmanned Aircraft System For Marking Live Power Lines To Prevent Bird Collisions, Mattheuns D. Pretorius, Lourens Leeuwner, Kaajial Durgapersad, Constant Hoogstad, Peter Beckedahl, Michael D. Michael, Kishaylin Chetty

Human–Wildlife Interactions

Collisions with overhead power lines represent a significant cause of mortality for a number of large bird species worldwide. Certain threatened species are severely impacted by power line collisions, particularly those for which there are no other known significant threats. In South Africa, bird collisions with overhead power line cables, including collisions with phase conductors and shield wires, contribute significantly to annual threatened bird species mortalities associated with Eskom power lines. The most practical mitigation measure is to attach bird anti-collision devices as markers on the cables. Current marking methods involve installations by hand, where linemen are hoisted up to …

Effects Of Growth Factor Deprivation On Mkn-45 Spheroid Cells, Özlem Türksoy, Gökhan Terzi̇oğlu

Turkish Journal of Biology

Background/aim: Serum and growth factor deprivation, a common cellular stressor in solid tumors, arises upon irradiation, chemotherapy, and antiangiogenesis. Spheroid body culture aims to enrich cancer stem cells by using low attachment conditions and some growth factors, such as basic fibroblast growth factor and epidermal growth factor to support the spheroid formation in serum-free spheroid culture. However, spheroid culture without any growth factors can imitate the tumor environment more realistically. In this study, we aimed to identify the effect of growth factor deprivation on the MKN-45 gastric cancer cell line in terms of stemness characteristics. Materials and methods: The spheroids …

Understanding Human Gut Bacterial Interactions And Their Role In Colonization Resistance Against Clostridioides Difficile Using Mini-Bioreactor Array And Caenorhabditis Elegans As Model Systems, Achuthan Ambat

Electronic Theses and Dissertations

No abstract provided.

Fungicide Sensitivity In P. Tritici-Repentis Diverse Population And Phenotyping Of Spelt Wheat For Multiple Diseases, Zunera Shabbir

Electronic Theses and Dissertations

Pyraclostrobin, a QoI fungicide, is extensively used in the management of fungal leaf spot diseases. In this study, 215 P. tritici-repentis isolates collected from wheat fields in South Dakota were evaluated for their sensitivity to Pyraclostrobin. Of 215 isolates, 48 isolates (22%) exhibited insensitivity based on G143A mutation and EC50 values using spore germination assay. Our results indicate reduced sensitivity to insensitivity to pyraclostrobin in some isolates suggesting regular monitoring of the P. tritici-repentis population to QoI fungicides is essential to track the evolution of insensitive population. Spelt wheat (Triticum spelta L.) is an ancient cereal that is gaining small …

Methods For Improving Potassium Fertilizer Recommendations For Corn In South Dakota, Andrew J. Ahlersmeyer

Electronic Theses and Dissertations

Corn (Zea mays L.) is a vital commodity in South Dakota’s agricultural sector. Optimal corn production occurs when there are sufficient mineral nutrients in the soil, especially potassium (K). Applications of K fertilizer are used when soil test K (STK) levels are deficient. Therefore, producers need reliable, thoroughly tested fertilizer recommendations to make profitable decisions and maintain environmental stewardship. South Dakota K fertilizer recommendations have not been updated in nearly 20 years. Simultaneously, changes in corn genetics, management practices, and climate patterns suggest that the critical soil test value (CSTV) for STK may have shifted in that same time frame. …

Effects Of Dietary Genistein And Fugacity Modelling In An Aquaculture System, Travis Schaeffer

Electronic Theses and Dissertations

Fish production from aquaculture has continued to grow over the past several decades, with finfishes being fed formulated, fish meal-based diets supporting most of that industry’s growth. However, increased demand and costs, coupled with static volume and erratic supplies of fish meal, has resulted in the use of alternative plant-derived protein sources. A common oilseed protein source is soybean meal (SBM), because of its protein content and amino acid profile; however, it also contains multiple anti-nutritional factors, including phytoestrogens. Phytoestrogens are naturally produced, estrogenmimicking compounds, with isoflavones receiving the most investigation as higher levels of these compounds occur within SBM. …

Effect Of Lighter (273 Kg) And Heavier (356 Kg) Initial Weight On Growth Performance Of Single-Source, Pre-Conditioned Beef Steers Fed A Single Growing-Finishing Diet, Thomas C. Norman

Electronic Theses and Dissertations

The objective of the study was to determine the influence that initial BW has on growth performance responses, efficiency of dietary net energy (NE) utilization, and carcass traits in feedlot steers. Light- and heavy-weight Charolais×Red Angus steers (n = 70) selected from a larger single-source group were used in a 209-d growing-finishing feedlot experiment at the Ruminant Nutrition Center, in Brookings, SD. On d-0 and d-1 weight and hip height (HH) measurements were collected for allotment purposes; the initial experimental weight was the average between d 0 and d 1 BW. Steers were assigned to two groups based on initial …

Indigenous Toxin Affects Cell Viability, While An Artificial Proteolytic Queueing Causes The Upregulation Of Specific Genes, Mohammed Salahuddin

Electronic Theses and Dissertations

Studying bacterial physiology is crucial to understand the fundamental mechanisms that govern bacterial growth, survival, and adaptation. This thesis combines two chapters investigating bacterial physiology by studying important cellular processes like bacterial toxin-antitoxin systems and proteolytic pathways. The first chapter involves studying bacterial toxin-antitoxin systems to understand the regulation and function of hypothetical toxin-antitoxin (TA) systems of bacteria and the effects of these TA systems on bacterial growth and survival. The emergence of these genetic modules in bacterial research and the unrevealing of some of their important roles in cell physiology in recent years has drawn much attention in scientific …

Control Of Persistent Environmental Listeria Monocytogenes Using Phenotypic And Genomic Approaches, Bhaswati Chowdhury

Electronic Theses and Dissertations

No abstract provided.

Diet And Management Strategies To Mitigate Decreased Feed Intake Associated With Terminal Implant Administration In Finishing Beef Steers, Alexandria M. Kelly

Electronic Theses and Dissertations

Terminal implant administration in beef steers often leads to decreased feed intake, leading to less growth. Our objective was to identify diet and management changes that can mitigate this decrease in feed intake. Single-sourced Angus x Simmental steers (n=27, initial BW= 385.1 ± 30.8 kg) were utilized in a completely randomized trial to assess the effects of animal movement and increased forage inclusion on rumination and feed intake after re-implanting. Steers were initially implanted with Synovex Choice (100 mg trenbolone acetate and 14 mg estradiol benzoate; Zoetis, Parsippany, NJ), then reimplanted 88 d later with Synovex Plus (200 mg trenbolone …

Evaluation Of Welded And Polished Stainless-Steel Surfaces In Supporting Sporeformer Biofilms In Dairy Plants, Taghreed Almalki

Electronic Theses and Dissertations

No abstract provided.

Evaluating Precision Supplementation Technology And Mathematical Nutrition Models For The Development Of Heifers Grazing Dormant Rangeland In Western South Dakota, Anna Katherine Dagel

Electronic Theses and Dissertations

The Great Plains supports about 40-50% of beef cattle production in the United States. Consequently, the beef cow-calf sector provides a large economic impact for states located within the Northern Great Plains (South Dakota Department of Agriculture, 2021). Producing profitable rangeland beef cattle through an economically efficient cowcalf operation presents several challenges. These challenges include providing adequate nutrition to meet the needs of growing heifers on rangelands, which requires additional labor and feed/supplement to achieve desired rates of gain and reach a target body weight, resulting in reproductive success. Implementation of precision livestock technology (PLT) and the use of precision …

Rumen-Protected Methionine Supplementation Improves Lactation, Oxidative Status, And Immune Response During A Subclinical Mastitis Challenge In Lactating Dairy Cows., Anita Paz Lopez

Electronic Theses and Dissertations

Mastitis is a significant problem in the dairy industry, posing numerous challenges for dairy farmers worldwide. Mastitis refers to the inflammation of the mammary gland, primarily caused by bacterial infections. This condition affects the health and well-being of dairy cows and has severe economic implications for farmers and overall dairy production. The prevalence of mastitis substantially threatens milk quality, productivity, and profitability, making it a top concern in the dairy industry. Preventing mastitis in cows is crucial for maintaining the herd's health and ensuring highquality milk production. Nutritional strategies have recently gained greater attention due to a direct impact on …

Identification Of Genes Expressed In The Anterior Pituitary Associated With Water Restriction In Beef Cattle, Himali Chathurika Wickramasinghe Vithana Arachchilage

Electronic Theses and Dissertations

Water is an essential nutrient and is required for growth, metabolism, lactation, and reproduction. Without water, livestock production would not be possible. Despite its importance, water requirements in livestock have not received much attention from the research community since the 1950s. The most recent edition of the Nutrient Requirements of Beef Cattle (8th edition) relies on literature from the 1950s or earlier for defining water requirements in beef cattle. Since the time these requirements were estimated, much has changed with regards to body size, genetics, and productivity of our livestock herds, including beef cattle. Global surface temperatures have increased in …