Life Sciences Commons^™

Cystic Fibrosis: An Ecological Review, Christopher Bozer

Student Works

This article focuses on the mechanisms of cystic fibrosis and the resulting microbial dysbiosis created through this disease. Through mutations in the CFTR gene, chloride ion proteins become dysfunctional, and mucus secreted in the lungs become thick and heavy, allowing infectious and pathogenic bacteria to thrive. 16s rRNA has been the primary method of sequencing the lung microbiome. Researchers have relied on bronchoscopies to collect proper samples. It can be concluded through current research that chloride ion dysfunction allows for an abnormal lung environment to develop. This abnormal environment allows for chronic infection of the lungs, and the formation of …