Life Sciences Commons^™

Lymphocyte Proteomics For Monitoring Long Term Immune System Dynamics, Michaela Mccown

Undergraduate Honors Theses

Time dependent change in lymphocytes provides a necessary background for monitoring the development of Chronic Lymphocytic Leukemia from asymptomatic to malignant. Several bulk proteomics studies characterize differences between tumor cells and healthy B cells, yet the transition to symptomatic disease is not well understood. This could be shown by a longitudinal study beginning with asymptomatic patients if the rare tumor cells in early stages can be isolated from small volume blood draws and effectively characterized with few cells, such as was done here using healthy B cells to provide a baseline for such studies to discriminate routine fluctuation from pathogenic …