Life Sciences Commons^™

Altered Gating Of KV1.4 In The Nucleus Accumbens Suppresses Motivation For Reward, Bernadette O'Donovan, Adewale Adeluyi, Erin L Anderson, Robert D. Cole, Jill R. Turner, Pavel I. Ortinski

Neuroscience Faculty Publications

Deficient motivation contributes to numerous psychiatric disorders, including withdrawal from drug use, depression, schizophrenia, and others. Nucleus accumbens (NAc) has been implicated in motivated behavior, but it remains unclear whether motivational drive is linked to discrete neurobiological mechanisms within the NAc. To examine this, we profiled cohorts of Sprague-Dawley rats in a test of motivation to consume sucrose. We found that substantial variability in willingness to exert effort for reward was not associated with operant responding under low-effort conditions or stress levels. Instead, effort-based motivation was mirrored by a divergent NAc shell transcriptome with differential regulation at potassium and dopamine …

Sex, Motivation, And Reversal Learning In The Common Marmoset (Callithrix Jacchus), Alyssa Carlotto

Masters Theses

This study examined the relationships between motivation and cognitive performance in male and female common marmosets (Callithrix jacchus). This question was driven by prior data from the Lacreuse lab showing a robust female impairment in reversal learning, as assessed by the number of trials needed to acquire a reversal following a simple discrimination between two stimuli. This thesis tested the hypothesis that the female impairment in reversal learning was mediated by deficits in motivation. Two sets of measures were used to test this hypothesis. I evaluated physical effort via testing on the progressive ratio (PR), a test that …

A Neural Network For Uncertainty Anticipation And Information Seeking, Jensen Kael White

Arts & Sciences Electronic Theses and Dissertations

In a world flooded with ‘click bait’, ‘alternative facts’, and ‘fake news’ one’s ability to seek out, discern, and value information is of utmost importance. Although contemporary phenomena, these cultural ills take advantage of an evolutionarily-preserved drive for humans and nonhuman animals to monitor for and pursue opportunities to gain information. Indeed, in a natural environment where rewards are scarce and can be risky, animals often seek sensory cues as a source of information about future outcomes. Interestingly, humans and nonhuman animals will seek sensory information that provides advance information that predicts an outcome even when this information does not …

Comparative Role Of Reward In Long-Term Peer And Mate Relationships In Voles, Nastacia L. Goodwin, Sarah A. Lopez, Nicole S. Lee, Annaliese K. Beery

Neuroscience: Faculty Publications

This is a contribution to SI: SBN/ICN meeting. In social species, relationships may form between mates, parents and their offspring, and/or social peers. Prairie voles and meadow voles both form selective relationships for familiar same-sex peers, but differ in mating system, allowing comparison of the properties of peer and mate relationships. Prairie vole mate bonds are dopamine-dependent, unlike meadow vole peer relationships, indicating potential differences in the mechanisms and motivation supporting these relationships within and/or across species. We review the role of dopamine signaling in affiliative behavior, and assess the role of behavioral reward across relationship types. We compared the …

Optimizing Cycle Exercise Performance During Normobaric Hypoxia Exposure, Cierra Brittany Ugale

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: The purpose of the present study was to examine whether implementing factors of OPTIMAL Theory: Enhanced Expectancies (EE), Autonomy Support (AS), and External Focus (EF) during a cycle exercise bout at a simulated altitude of 21,000 feet elevation had an effect on exercise performance and EPOC response in comparison to a control condition.

Methods: Sixteen participants (n = 8 women, n = 8 men) completed resting oxygen measurements (resting metabolic rate) between 6:00 A.M. and 8:00 A.M. Cycle exercise to fatigue at a constant workload was performed (100 W) while breathing air with reduced oxygen content to simulate exercising …

Vocal Expression Of Emotions In Mammals: Mechanisms Of Production And Evidence, Elodie Briefer

Elodie Briefer, PhD

Emotions play a crucial role in an animal’s life because they facilitate responses to external or internal events of significance for the organism. In social species, one of the main functions of emotional expression is to regulate social interactions. There has recently been a surge of interest in animal emotions in several disciplines, ranging from neuroscience to evolutionary zoology. Because measurements of subjective emotional experiences are not possible in animals, researchers use neurophysiological, behavioural and cognitive indicators. However, good indicators, particularly of positive emotions, are still lacking. Vocalizations are linked to the inner state of the caller. The emotional state …

A Cross-Training Program Does Not Alter Self-Reported Physical Activity Levels In Elementary School Children, Melody L. White, Matthew S. Renfrow, Richard S. Farley, Dana K. Fuller, Brandi M. Eveland-Sayers, Jennifer L. Caputo

Brandi M. Eveland-Sayers

International Journal of Exercise Science 11(5): 308-318, 2018. The purpose of the study was to examine the effects of a school-based cross-training program on body mass index (BMI), attitudes toward physical activity (ATPA), and physical activity (PA) levels of children in the 4^th and 5^th grades. Children (N = 118) were divided into control (n = 60) and experimental (n = 58) groups based on class availability. While the control group continued academic classes as usual, the experimental group participated in cross-training involving resistance training (RT), calisthenics, and stretching twice a week for 10 weeks. …

Effect Of Self-Selected Music On Affective Responses And Running Performance: Directions And Implications, Nile Brandt, Selen Razon

International Journal of Exercise Science

International Journal of Exercise Science 12(5): 310-323, 2019. The purpose of this study was to evaluate the effect of different types of music (i.e., self-selected, researcher-selected, and no music) on affective responses to an exercise task and the subsequent running performance, with an untrained population of college students in a field setting. Twenty-seven college students (17 female, 10 male, M_age = 22.11, SD = 5.12), ran one mile on three separate occasions and either listened to self-selected music, music selected by the researcher (i.e., Audiofuel), or no music at all. Affective responses were assessed before, during, and after …

The Effects Of Self-Presentation To Engage In Physical Activity, Duygu Gurleyik, Alison Ede, Deborah Feltz

International Journal of Exercise Science

International Journal of Exercise Science 12(5): 263-276, 2019. In order to improve physical activity levels, it has previously been suggested that the use of rewards can potentially have an impact on exercise behavior. One type of reward, the opportunity to present a good impression in the eyes of others (e.g., self-presentation), has not been previously examined in an experimental task. Therefore, the purpose of this study was to investigate if linking an exercise task to a prosocial, self-presentational reward in the form of a charitable giving opportunity influences the amount of effort expended in a single bout of exercise on …

Ventral Tegmental Area Astrocytes Orchestrate Avoidance And Approach Behavior, J. A. Gomez, J. M. Perkins, Gerard M.J. Beaudoin Iii, N. B. Cook, S. A. Quraishi, E. A. Szoeke, K. Thangamani, C. W. Tschumi, M. J. Wanat, A. M. Maroof, M. J. Beckstead, P. A. Rosenberg, C. A. Paladini

Biology Faculty Research

The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons and astrocytes, that coordinates behaviors by integrating activity from numerous afferents. Within neuron-astrocyte networks, astrocytes control signals from distinct afferents in a circuit-specific manner, but whether this capacity scales up to drive motivated behavior has been undetermined. Using genetic and optical dissection strategies we report that VTA astrocytes tune glutamatergic signaling selectively on local inhibitory neurons to drive a functional circuit for learned avoidance. In this circuit, astrocytes facilitate excitation of VTA GABA neurons to increase inhibition of dopamine neurons, eliciting real-time and learned avoidance behavior that is …