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Full-Text Articles in Life Sciences
Osteogenic Differentiation Of Electrostimulated Human Mesenchymal Stem Cells Seeded On Silk-Fibroin Films, Anil Sera Çakmak, Soner Çakmak, James White, Waseem Raja, David Kaplan, Menemşe Gümüşdereli̇oğlu
Osteogenic Differentiation Of Electrostimulated Human Mesenchymal Stem Cells Seeded On Silk-Fibroin Films, Anil Sera Çakmak, Soner Çakmak, James White, Waseem Raja, David Kaplan, Menemşe Gümüşdereli̇oğlu
Turkish Journal of Biology
Electric field is known as an important regulator to guide the development and regeneration of many tissues. The aim of this study was to investigate the osteogenic differentiation potential of human mesenchymal stem cells (hMSCs) cultivated on silk-fibroin films in response to different parameters, i.e. Frequency, voltage, distance between electrodes, and/or culture conditions (growth medium or osteogenic medium). Silk films were prepared in the presence of platinum wires to study the impact of exogenous electrostimulation on the cells for up to 14 days. The experimental groups can be defined as high voltage in osteogenic differentiation medium, low voltage in osteogenic …
Epigenetic Regulation Of Specific Transcription Factors In Osteogenicdifferentiation Of Mesenchymal Stem Cells, Milad Zadi Heydarabad, Mousa Vatanmakanian, Mina Nikasa, Majid Farshdousti Hagh
Epigenetic Regulation Of Specific Transcription Factors In Osteogenicdifferentiation Of Mesenchymal Stem Cells, Milad Zadi Heydarabad, Mousa Vatanmakanian, Mina Nikasa, Majid Farshdousti Hagh
Turkish Journal of Biology
An abundance of experiments have been performed to clarify the differentiation process of mesenchymal stem cells (MSCs). Osteogenic differentiation and in vitro conditions favoring these cell lineages have attracted the attention of many researchers. Moreover, the gene expression profile during MSC differentiation toward its main specialized cells (bone, cartilage, and adipose cells) has been mostly understood. In the last decades another layer of investigation has attempted to clarify the epigenetic mechanisms underlying MSC differentiation into its specialized cells. It has been shown that as MSCs progress through the differentiation process, more nonspecific genes undergo DNA methylation to prevent differentiation into …
Comparison Of The Osteogenic Differentiation Capacity Of Adipose Tissuederived Mesenchymal Stem Cells From Humans And Rats, Seçi̇l Erden Tayhan, Şeyma Taşdemi̇r, Sai̇me İsmet Deli̇loğlu Gürhan, Erol Mi̇r
Comparison Of The Osteogenic Differentiation Capacity Of Adipose Tissuederived Mesenchymal Stem Cells From Humans And Rats, Seçi̇l Erden Tayhan, Şeyma Taşdemi̇r, Sai̇me İsmet Deli̇loğlu Gürhan, Erol Mi̇r
Turkish Journal of Biology
Mesenchymal stem cells (MSCs) can be found in many types of adult tissues such as the bone marrow, adipose, placenta, liver, and periosteum. Recently, adipose tissue-derived MSCs (ADMSCs) have become one the most preferred MSC types because of their fast proliferation rate, abundance, and high plasticity for variable cell types. It is known that ADMSCs are able to differentiate into various cells, including osteoblasts, so they are quite promising for orthopedic clinical trials. The present study aimed to compare the osteogenic differentiation conditions of MSCs from human adipose tissue (hADMSC) and those of MSCs from rat adipose tissue (rADMSC). Therefore, …