Life Sciences Commons^™

Dose Dependent Effects Of Caffeine On Cognitive Performance And Neuronal Activation, Stephan Albrecht, Helen Morris, Michelle Vieyra

Journal of the South Carolina Academy of Science

Many students assume that the more caffeine you drink, the better your cognitive performance. Over-consumption of caffeine has many negative effects, so if there are no dose related cognitive benefits to large amounts of caffeine, then college students should limit their intake. This study looked at whether ingesting a medium dose (200 mg) versus a lower dose (100 mg) of caffeine improved short term memory as measured by Flanker and n-back tests, compared to a control group. In addition, we looked at whether larger doses of caffeine produced a difference in neuronal activation during these tests as measured by functional …

Fourier Analysis Of Phase Resetting Curves Of Neural Oscillators, Robert A. Raidt, Sorinel A. Oprisan

Journal of the South Carolina Academy of Science

We investigated the impact of changes in biologically relevant control parameters, such as the shape of an external perturbation or the conductance values of an individual model neuron, on the shape of the phase resetting curve (PRC) of that neuron. For that purpose, PRCs were generated for groups of Morris-Lecar (ML) model neurons with different conductance values but similar firing periods (within 0.005ms) using external rectangular, triangular, or trapezoidal perturbations of varying areas. These PRCs were numerically described and analyzed as a series of coefficient values using a Fourier Discrete Sine Transform (DST). We found that changes in the shape …

A Review Of “An Ethical Market In Human Organs,” By Charles A. Erin And John Harris, And A Proposed Solution To The Current Organ Shortage, Rachel Rattenni Fcrh '14

The Fordham Undergraduate Research Journal

In 2005, an Israeli man named Nick Rosen answered an ad in his local Tel Aviv newspaper searching for someone interested in selling a kidney. Through funding from the broker who placed the ad, Rosen was flown to New York and set up with a dialysis patient from Brooklyn. After Rosen and the dialysis patient passed a simple procedure for the screening of illegal organ sales by saying the two were old friends, the successful transplant surgery was performed at the esteemed Mount Sinai Medical Center in New York. The Brooklyn resident walked away never again needing to go on …

The Influence Of Snowmobile Trails On Coyote Movements During Winter In High-Elevation Landscapes, Eric M. Gese, Jennifer L. Burghardt Dowd, Lise M. Aubry

Wildland Resources Faculty Publications

Competition between sympatric carnivores has long been of interest to ecologists. Increased understanding of these interactions can be useful for conservation planning. Increased snowmobile traffic on public lands and in habitats used by Canada lynx (Lynx canadensis) remains controversial due to the concern of coyote (Canis latrans) use of snowmobile trails and potential competition with lynx. Determining the variables influencing coyote use of snowmobile trails has been a priority for managers attempting to conserve lynx and their critical habitat. During 2 winters in northwest Wyoming, we backtracked coyotes for 265 km to determine how varying snow characteristics influenced coyote movements; …

Identifying Potential Cancer Driver Genes By Genomic Data Integration., Yong Chen, Jingjing Hao, Wei Jiang, Tong He, Xuegong Zhang, Tao Jiang, Rui Jiang

College of Science & Mathematics Departmental Research

Cancer is a genomic disease associated with a plethora of gene mutations resulting in a loss of control over vital cellular functions. Among these mutated genes, driver genes are defined as being causally linked to oncogenesis, while passenger genes are thought to be irrelevant for cancer development. With increasing numbers of large-scale genomic datasets available, integrating these genomic data to identify driver genes from aberration regions of cancer genomes becomes an important goal of cancer genome analysis and investigations into mechanisms responsible for cancer development. A computational method, MAXDRIVER, is proposed here to identify potential driver genes on the basis …

Integrating Human Omics Data To Prioritize Candidate Genes., Yong Chen, Xuebing Wu, Rui Jiang

College of Science & Mathematics Departmental Research

BACKGROUND: The identification of genes involved in human complex diseases remains a great challenge in computational systems biology. Although methods have been developed to use disease phenotypic similarities with a protein-protein interaction network for the prioritization of candidate genes, other valuable omics data sources have been largely overlooked in these methods.

METHODS: With this understanding, we proposed a method called BRIDGE to prioritize candidate genes by integrating disease phenotypic similarities with such omics data as protein-protein interactions, gene sequence similarities, gene expression patterns, gene ontology annotations, and gene pathway memberships. BRIDGE utilizes a multiple regression model with lasso penalty to …

Post-Fire Interactions Between Soil Water Repellency, Islands Of Fertility, And Bromus Tectorum Invasibility, Kaitlynn Jane Fernelius

Theses and Dissertations

An intrinsic link exists between soil moisture and soil nitrogen. Factors that increase or decrease soil moisture can have a profound effect on soil nitrogen cycling, which may have later repercussions in the plant community. Post-fire soil water repellency is one factor that can limit soil moisture acquisition and may indirectly affect nitrogen cycling and weed invasion in woody islands of fertility. Plots centered on burned Juniperus osteosperma trees were either left untreated or treated with a surfactant to ameliorate water repellency. Two years later, soils were excavated from the untreated and treated field plots. In the greenhouse, half of …

On The Origin Of Phenotypic Variation: Novel Technologies To Dissect Molecular Determinants Of Phenotype, Francesco Vallania

All Theses and Dissertations (ETDs)

This thesis describes the conception, design, and development of novel computational tools, theoretical models, and experimental techniques applied to the dissection of molecular factors underlying phenotypic variation. The first part of my work is focused on finding rare genetic variants in pooled DNA samples, leading to the development of a novel set of algorithms, SNPseeker and SPLINTER, applied to next-generation sequencing data. The second part of my work describes the creation of a reporter system for DNA methylation for the purpose of dissecting the genetic contribution of tissue-specific patterns of DNA methylation across the genome. Finally the last part of …

Divergent Antibody Subclass And Specificity Profiles But Not Protective Hla-B Alleles Are Associated With Variable Antibody Effector Function Among Hiv-1 Controllers, Jennifer I. Lai, Anna F. Licht, Anne-Sophie Dugast, Todd Suscovich, Ickwon Choi, Chris Bailey-Kellogg, Galit Alter, Margaret E. Ackerman

Dartmouth Scholarship

Understanding the coordination between humoral and cellular immune responses may be the key to developing protective vaccines, and because genetic studies of long-term HIV-1 nonprogressors have associated specific HLA-B alleles with spontaneous control of viral replication, this subject group presents an opportunity to investigate relationships between arms of the adaptive immune system. Given evidence suggesting that cellular immunity may play a role in viral suppression, we sought to determine whether and how the humoral immune response might vary among controllers. Significantly, Fc-mediated antibody effector functions have likewise been associated with durable viral control. In this study, we compared the effector …

U.S. Drought Monitor, December 17, 2013, Mark D. Svoboda

United States Agricultural Commodities in Drought Archive

Drought map of U.S. for December 17, 2013 (12/17/13) plus: U.S. crop areas experiencing drought (map), Approximate percentage of crop located in drought, by state (bar graph), Percent of crop area located in drought, past 52 weeks (line graph) for: Corn, Soybeans, Hay, Cattle, Winter wheat.

Valproic Acid Causes Proteasomal Degradation Of Dicer And Influences Mirna Expression, Zhaiyi Zhang, Paolo Convertini, Manli Shen, Xiu Xu, Frédéric Lemoine, Pierre De La Grange, Douglas A. Andres, Stefan Stamm

Molecular and Cellular Biochemistry Faculty Publications

Valproic acid (VPA) is a commonly used drug to treat epilepsy and bipolar disorders. Known properties of VPA are inhibitions of histone deacetylases and activation of extracellular signal regulated kinases (ERK), which cannot fully explain VPA's clinical features. We found that VPA induces the proteasomal degradation of DICER, a key protein in the generation of micro RNAs. Unexpectedly, the concentration of several micro RNAs increases after VPA treatment, which is caused by the upregulation of their hosting genes prior to DICER degradation. The data suggest that a loss of DICER protein and changes in micro RNA concentration contributes to the …

Enrichment And Training Improve Cognition In Rats With Cortical Malformations, Kyle R. Jenks, Marcella M. Lucas, Ben A. Duffy, Ashlee A. Robbins, Barjor Gimi, Jeremy M. Barry, Rod C. Scott

Dartmouth Scholarship

Children with malformations of cortical development (MCD) frequently have associated cognitive impairments which reduce quality of life. We hypothesized that cognitive deficits associated with MCD can be improved with environmental manipulation or additional training. The E17 methylazoxymethanol acetate (MAM) exposure model bears many anatomical hallmarks seen in human MCDs as well as similar behavioral and cognitive deficits. We divided control and MAM exposed Sprague-Dawley rats into enriched and non-enriched groups and tested performance in the Morris water maze. Another group similarly divided underwent sociability testing and also underwent Magnetic Resonance Imaging (MRI) scans pre and post enrichment. A third group …

Diversity Of Cultivable Bacteria Involved In The Formation Of Macroscopic Microbial Colonies (Cave Silver) On The Walls Of A Cave In Slovenia, Blagajana Herzog Velikonja, Rok Tkavc, Lejla Pašić

International Journal of Speleology

Karstic caves often support white, yellow, grey or pink microbial colonies that are termed ‘cave silver’ by speleologists. Using various sample pre-treatments and culture media, a wide variety of bacteria associated with these colonies were recovered from a cave in Slovenia, Pajsarjeva jama. Decreasing the inoculum size resulted in significant increases in viable counts, while pre-treatments had the opposite effect with the exception of microwave irradiation. While all growth media yielded viable counts, the maximal counts were observed on a low-nutrient TWA medium.

Based on the 16S rRNA gene sequence of OTU representatives, the majority of the 80 isolates examined …

Phospholipase D- And Phosphatidic Acid-Mediated Signaling In Plant Response To Abscisic Acid And Reactive Oxygen Species, Liang Guo

Dissertations

The Arabidopsis genome has 12 phospholipase D (PLD) genes that are classified into six types, PLDα, PLDβ, PLDγ, PLDδ, PLDε, and PLDζ, based on sequence similarities, domain structures, and biochemical properties. Phosphatidic acids (PA) produced by PLDs have been identified as important lipid signaling molecules in cell growth, development, and stress responses. This study was undertaken to determine the role of PLD and PA in plant response to abscisic acid (ABA) and reactive oxygen species (ROS). The lipid mediator PA was found to interact with sphingosine kinases (SPHKs) in Arabidopsis. Two unique SPHK cDNAs were cloned and expressed. Both SPHKs …

Dog Behavior Co-Varies With Height, Bodyweight And Skull Shape, Paul D. Mcgreevy, Dana Georgevsky, Johanna Carrasco, Michael Valenzuela, Deborah L. Duffy, James A. Serpell

Eidonomy Collection

Dogs offer unique opportunities to study correlations between morphology and behavior because skull shapes and body shape are so diverse among breeds. Several studies have shown relationships between canine cephalic index (CI: the ratio of skull width to skull length) and neural architecture. Data on the CI of adult, show-quality dogs (six males and six females) were sourced in Australia along with existing data on the breeds’ height, bodyweight and related to data on 36 behavioral traits of companion dogs (n = 8,301) of various common breeds (n = 49) collected internationally using the Canine Behavioral Assessment and Research Questionnaire …

Studies On Two Polyherbal Formulations (Zpto And Zto) For Comparison Of Their Antidyslipidemic, Antihypertensive And Endothelial Modulating Activities, Nauman Aziz, Malik Hassan Mehmood, Anwarul Hassan Gilani

Department of Biological & Biomedical Sciences

Background

Cardiovascular disorders (CVDs) are the leading cause of disease burden worldwide. Apart from available synthetic drugs used in CVDs, there are many herbal formulations including POL-10 (containing 10 herbs), which have been shown to be effective in animal studies but POL-10 was found to cause tachycardia in rodents as its side effect. This study was designed to modify the composition of POL-10 for better efficacy and/or safety profile in CVDs.

Methods

To assess the antidyslipidemic, antihypertensive and endothelial modulatory properties of two herbal formulations, (ZPTO and ZTO) containing Z: Zingiber officinalis, P: Piper nigrum, T: Terminalia belerica and …

Contrast Negation Differentiates Visual Pathways Underlying Dynamic And Invariant Facial Processing, Pamela M. Pallett, Ming Meng

Dartmouth Scholarship

Abstract Bruce and Young (1986) proposed a model for face processing that begins with structural encoding, followed by a split into two processing streams: one for the dynamic aspects of the face (e.g., facial expressions of emotion) and the other for the invariant aspects of the face (e.g., gender, identity). Yet how this is accomplished remains unclear. Here, we took a psychophysical approach using contrast negation to test the Bruce and Young model. Previous research suggests that contrast negation impairs processing of invariant features (e.g., gender) but not dynamic features (e.g., expression). In our first experiment, participants discriminated differences in …

Table Of Contents

Professional Agricultural Workers Journal

No abstract provided.

Preface

Professional Agricultural Workers Journal

No abstract provided.

Plight Of Black Farmers In The Context Of Usda Farm Loan Programs: A Research Agenda For The Future, Shakara S. Tyler, Eddie A. Moore

Professional Agricultural Workers Journal

Black farmers remain an underdeveloped topic in academic literature. This historical study used a historical research methodology to assess the plight of Black farmers in the context of United States Department of Agriculture (USDA) farm loan programs and offered an array of future research recommendations. We investigated the severity of the plight of Black farmers in the context of USDA farm loan programs with an emphasis on effective and responsive leadership in relation to four elements: 1) legislative initiatives, 2) policy initiatives, 3) USDA structure and delivery systems, and the 4) Pigford v. Glickman class action and consent decree. We …

Socially Disadvantaged Farmer Issues Can Be Addressed When Diverse Frontline Agricultural Workers Proactively Work Together, Walter A. Hill, Jillian Hishaw, Tasha M. Hargrove

Professional Agricultural Workers Journal

This paper focuses on socially disadvantaged farmers (SDFs) and civil rights issues as it relates to the USDA. It also deals with Diversity Initiatives in the 2008 Farm Bill, and discusses an assessment by Jackson Lewis LLC of the USDA’s efforts to deal with the diversity initiatives. Redacted USDA case studies examined at the 2010 Professional Agricultural Workers Conference at Tuskegee University are presented. The findings revealed that at that time the 2008 Farm Bill Initiatives were not effectively being implemented. It was recommended that the USDA should: keep making the effort to reform or improve its civil rights practices; …

Community-University Partnerships For Change In The Black Belt South, Rosalind Harris

Professional Agricultural Workers Journal

This article explores issues related to community-university partnerships by examining

the unfolding of the Black Belt Initiative, a 21^st century mobilization within the Black Belt South to establish a Black Belt Regional Commission. The Black Belt Initiative provides an instructive and compelling case study. For instance, the very nature of the Black Belt Initiative’s beginnings through the provision of a grant by Senator Zell Miller of Georgia to the University of Georgia with the proviso that “poverty – not race be the guiding principle…” heightened the tension between historically black and white universities reflecting longstanding contestations around how problems …

Community Capital And Local Economic Development Efforts, Andrew A. Zekeri

Professional Agricultural Workers Journal

Actions by local groups and leaders constitute an essential but poorly understood element of many rural economic development efforts. Previous studies suggest that local development efforts can influence community changes, but questions remain about why localities differ in economic development efforts. Drawing upon community capital framework and human ecological theory, the purpose of this research was to examine the effects of community capital on economic development efforts in rural communities. Hierarchical regression results indicate that social capital, cultural capital, built capital significantly predict economic development effort to develop recreation and tourism and human services. Despite that, only built capital and …

The Fate Of Local Food Systems In The Global Industrialization Market: Food And Social Justice In The Rural South, Wylin D. Wilson, Reuben C. Warren, Stephen O. Sodeke, Norbert Wilson

Professional Agricultural Workers Journal

This paper investigates the connection between local food systems, health disparities, and social justice in the rural South. It begins with the relationship between food insecurity and health disparities that disproportionately affect racial and ethnic minority populations, and non-minority women and children. First, we discuss the concept of health disparities within the context of bioethics and public health ethics in order to explore the link between the food system and health as a social justice issue. Second, we define health disparities and discuss how they have historically plagued and disadvantaged racial minority populations. Third, we examine these disparities within the …

Abridged Submission Guidelines

Professional Agricultural Workers Journal

No abstract provided.

The Impact Of Selected Socioeconomic Factors On Asset Building In Rural Communities, Nii O. Tackie, Judith N. Aboagye, Gwendolyn J. Johnson, Millicent Braxton, Latanya Hunt-Haralson, Gertrude D. Wall

Professional Agricultural Workers Journal

The study examined the impact of selected socioeconomic factors on asset building. Using a questionnaire, data were obtained from a convenience sample of 204 participants from several Alabama Black Belt Counties, and analyzed using descriptive statistics and logit analysis. The results showed that a majority (64%) was willing to participate in an asset building program. Of this, an overwhelming majority (at most 70%) wanted to set up a small business; further their education, or purchase a home. In addition, one socioeconomic factor, age, had a statistically significant (p = 0.016) effect on willingness to participate in an asset building …

Environmental Regulation Of Tidal Wetland Microbial Communities And Associated Biogeochemistry, Ember Morrissey

Theses and Dissertations

Microbial communities play an essential role in carrying out the biogeochemical cycles that sustain life on Earth, yet we know very little about their ecology. One question of particular interest is how environmental conditions shape microbial community structure (i.e., the types of organisms found in the community and their relative abundance), and whether such changes in structure are related to biogeochemical function. It is the aim of this dissertation to address this question via the examination of carbon (C) and nitrogen (N) cycling in wetland ecosystems, which due to their diverse hydrology have a profound influence on biogeochemical cycles. With …

Cytotoxic Compounds From Invasive Giant Salvinia (Salvinia Molesta) Against Human Tumor Cells (Abstract), Shiyou Li, Ping Wang, Guangrui Deng, Wei Yuan, Zushang Su

NCPC Publications and Patents

Giant salvinia (Salvinia molesta) is one of the most noxious invasive species in the world. Our bioactivity-guided fractionation of ethanol extract of giant salvinia led to the isolation of 50 compounds. Of the six new compounds (1–6), salviniol (1) is a rare abietane diterpene with a new ferruginol-menthol coupled skeleton and both salviniside I (2) and salviniside II (3) are novel benzofuran glucose conjugates with unique 10-membered macrodiolide structures. Sixteen abietane diterpenes (1, 7–17, and 19–22) demonstrated in vitro activities …

Late Glacial And Holocene Record Of Climatic Change In The Southern Rocky Mountains From Sediments In San Luis Lake, Colorado, Usa, Fasong Yuan, Max R. Koran, Andrew Valdez

Biological, Geological, and Environmental Faculty Publications

Large rapid climate changes occurred over the last glacial cycle in the southwestern United States and elsewhere in many regions of the world. Some of these changes were attributed to alternations between stadial and interstadial conditions in the North Atlantic. But intense debate exists on how climate anomalies in the North Atlantic transmit to the southwest. Here we report a sediment record from San Luis Lake in southern Colorado, through analyses of grain size, magnetic susceptibility, Mg/Ca, total inorganic carbon, δ¹⁸O and δ¹³C, to indicate climatic and environmental changes in the southern Rocky Mountains over the …

Cleft Lip And Palate Repair: Bridging The Gap Between Genetics And Oral Health: An Individual Case Study, Duncan Perry

Honors Theses

Cleft Lip and Palate Syndrome (CL/P) is a condition that occurs in vitro, during fetal development. Because the majority of CL/P cases occur in underdeveloped nations, the families of CL/P patients are typically characterized by impoverished homes. These are the very people who cannot afford to pay for folic acid supplements, or reconstructive and reparative surgeries. Many families struggle under the extreme pressure of raising a child with CL/P. In these nations, the child often cannot receive the proper care they need, and usually are the product of unsuccessful surgeries. The stress of a CL/P patient is incredibly high, both …