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2011

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Articles 541 - 570 of 5493

Full-Text Articles in Life Sciences

Heart And Ventilatory Measures In Crayfish During Copulation, Richard M. Cooper, Heidi Schapker Finucane, Megan Adami, Robin L. Cooper Nov 2011

Heart And Ventilatory Measures In Crayfish During Copulation, Richard M. Cooper, Heidi Schapker Finucane, Megan Adami, Robin L. Cooper

Biology Faculty Publications

Monitoring heart rate (HR) and ventilatory rate (VR) during defined sensory stimuli and during aggressive and submissive social interactions has provided additional information of a crayfish's physiological state which is not achieved by behavioral observations. In this study, the HR and VR of crayfish were monitored before, during and after the act of copulation in both heterosexual partners. The female crayfish abruptly reduces HR and VR during copulation but the male maintains HR and VR. After separation from copulation the female HR and VR are elevated, potentially paying back the O2 debt. The tight relationship with HR and VR …


Eating Frequency Is Higher In Weight Loss Maintainers And Normal-Weight Individuals Than In Overweight Individuals, Jessica L. Bachman, Suzanne Phelan, Rena R. Wing, Hollie A. Raynor Nov 2011

Eating Frequency Is Higher In Weight Loss Maintainers And Normal-Weight Individuals Than In Overweight Individuals, Jessica L. Bachman, Suzanne Phelan, Rena R. Wing, Hollie A. Raynor

Kinesiology and Public Health

Eating frequency has been negatively related to body mass index (BMI). The relationship between eating frequency and weight loss maintenance is unknown. This secondary analysis examined eating frequency (self-reported meals and snacks consumed per day) in weight loss maintainers (WLM) who had reduced from overweight/obese to normal weight, normal weight (NW) individuals, and overweight (OW) individuals. Data collected July 2006 to March 2007 in Providence, RI, included three 24-hour dietary recalls (2 weekdays, 1 weekend day) analyzed using Nutrient Data System for Research software from 257 adults (WLM n=96, 83.3% women aged 50.0±11.8 years with BMI 22.1±1.7; NW n=80, 95.0% …


Trails And Physical Activity: A Review, Heather A. Starnes, Philip J. Troped, David B. Klenosky, Angela M. Doehring Nov 2011

Trails And Physical Activity: A Review, Heather A. Starnes, Philip J. Troped, David B. Klenosky, Angela M. Doehring

Kinesiology and Public Health

To provide a synthesis of research on trails and physical activity from the public health, leisure sciences, urban planning, and transportation literatures. Methods: A search of databases was conducted to identify studies published between 1980 and 2008. Results: 52 studies were identified. The majority were cross-sectional (92*%) and published after 1999 (11%). The evidence for the effects of trails on physical activity was mixed among 3 intervention and 5 correlational studies. Correlates of trail use were examined in 13 studies. Several demographic (eg, race, education, income) and environmental factors (eg, land-use mix and distance to trail) were related to trail …


Perceived Built Environment And Physical Activity In U.S. Women By Sprawl And Region, Philip J. Troped, Kosuke Tamura, Heather A. Whitcomb, Francine Laden Nov 2011

Perceived Built Environment And Physical Activity In U.S. Women By Sprawl And Region, Philip J. Troped, Kosuke Tamura, Heather A. Whitcomb, Francine Laden

Kinesiology and Public Health

Background

A number of studies have demonstrated relationships between the perceived built environment and physical activity among adults. However, little is known about whether these associations differ by U.S. region and level of urban sprawl.

Purpose

To examine associations between the perceived built environment and physical activity in U.S. women by region and urban sprawl.

Methods

Nurses' Health Study II participants (N=68,968) completed four perceived neighborhood environment survey items in 2005. Logistic regression was used to estimate associations with meeting physical activity recommendations, adjusting for demographic and weight-status variables, and stratifying by region and sprawl. Data analyses were completed in …


Improving Commercial Fishing Access Rights In Western Australia, Department Of Fisheries Nov 2011

Improving Commercial Fishing Access Rights In Western Australia, Department Of Fisheries

Fisheries Occasional Publications

Access Rights Working Group Report to the Hon Norman Moore, MLC Minister for Fisheries


New Findings Emerge, Winston J. Craig Nov 2011

New Findings Emerge, Winston J. Craig

Lake Union Herald

No abstract provided.


Attractants For Insects Such As Flies: United States Patent, Quinn Et Al.- November 2011, Brian P. Quinn, David A. Carlson, Christopher J. Geden, Ulrich R. Bernier, Matthew M. Booth, Jerome Hogsette Nov 2011

Attractants For Insects Such As Flies: United States Patent, Quinn Et Al.- November 2011, Brian P. Quinn, David A. Carlson, Christopher J. Geden, Ulrich R. Bernier, Matthew M. Booth, Jerome Hogsette

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

A composition containing at least two members of the group consisting of propionic acid, benzoic acid, 2,6-dimethoxyphenol, 2-acetylpyrrole, 2-hydroxy-3-methyl-2-cyclopentanone, 2-methyltetrahydrofuran-3-one, and 3-methylbutanal; and water, and optionally a carrier or carrier material. The composition is useful for attracting insects (e.g., flies). A method for attracting insects (e.g., flies) involving treating an object or area with an insect attracting effective amount of the composition described herein.


The Nuclear Pore Complex Mediates Binding Of The Mig1 Repressor To Target Promoters, Nayan J. Sarma, Thomas D. Buford, Terry Haley, Kellie Barbara-Haley, George M. Santangelo, Kristine A. Willis Nov 2011

The Nuclear Pore Complex Mediates Binding Of The Mig1 Repressor To Target Promoters, Nayan J. Sarma, Thomas D. Buford, Terry Haley, Kellie Barbara-Haley, George M. Santangelo, Kristine A. Willis

Faculty Publications

All eukaryotic cells alter their transcriptional program in response to the sugar glucose. In Saccharomyces cerevisiae, the best-studied downstream effector of this response is the glucose-regulated repressor Mig1. We show here that nuclear pore complexes also contribute to glucose-regulated gene expression. NPCs participate in glucose-responsive repression by physically interacting with Mig1 and mediating its function independently of nucleocytoplasmic transport. Surprisingly, despite its abundant presence in the nucleus of glucose-grown nup120Δ or nup133Δ cells, Mig1 has lost its ability to interact with target promoters. The glucose repression defect in the absence of these nuclear pore components therefore appears …


Functional Dissection Of The Glucose Signaling Pathways That Regulate The Yeast Glucose Transporter Gene (Hxt) Repressor Rgt1, David J. Jouandot Ii, Adhiraj Roy, Jeong-Ho Kim Nov 2011

Functional Dissection Of The Glucose Signaling Pathways That Regulate The Yeast Glucose Transporter Gene (Hxt) Repressor Rgt1, David J. Jouandot Ii, Adhiraj Roy, Jeong-Ho Kim

Faculty Publications

The yeast Rgt1 repressor is a bifunctional protein that acts as a transcriptional repressor and activator. Under glucose-limited conditions, Rgt1 induces transcriptional repression by forming a repressive complex with its corepressors Mth1 and Std1. Here, we show that Rgt1 is converted from a transcriptional repressor into an activator under high glucose conditions and this occurs through two independent but consecutive events mediated by two glucose signaling pathways: (1) disruption of the repressive complex by the Rgt2/Snf3 pathway; (2) phosphorylation of Rgt1 by the cAMP-dependent protein kinase (cAMP-PKA) pathway. Rgt1 is phosphorylated by PKA at four serine residues within its amino-terminal …


Nebline, November/December 2011 Nov 2011

Nebline, November/December 2011

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Feature: Avoid Guessing About Holiday Food Safety

Farm Views

Horticulture

Food & Fitness

Home & Family Living

Environmental Focus

Urban Agriculture

4-H & Youth

Community Focus

Extension Calendar

Nutrition Education Program

Family and Community Education (FCE) Clubs

and other extension news and events


A History Of Low Back Pain Associates With Altered Electromyographic Activation Patterns In Response To Perturbations Of Standing Balance, Jesse V. Jacobs, Sharon M. Henry, Stephanie L. Jones, Juvena R. Hitt, Janice Y. Bunn Nov 2011

A History Of Low Back Pain Associates With Altered Electromyographic Activation Patterns In Response To Perturbations Of Standing Balance, Jesse V. Jacobs, Sharon M. Henry, Stephanie L. Jones, Juvena R. Hitt, Janice Y. Bunn

Exercise and Sport Studies: Faculty Publications

People with a history of low back pain (LBP) exhibit altered responses to postural perturbations, and the central neural control underlying these changes in postural responses remains unclear. To characterize more thoroughly the change in muscle activation patterns of people with LBP in response to a perturbation of standing balance, and to gain insight into the influence of early- vs. late-phase postural responses (differentiated by estimates of voluntary reaction times), this study evaluated the intermuscular patterns of electromyographic (EMG) activations from 24 people with and 21 people without a history of chronic, recurrent LBP in response to 12 directions of …


Racing Start Safety: Head Depth And Head Speed During Competitive Backstroke Starts, Brian V. Wright, Andrew C. Cornett, Josh C. White, Alexander P. Willmott, Joel M. Stanger Nov 2011

Racing Start Safety: Head Depth And Head Speed During Competitive Backstroke Starts, Brian V. Wright, Andrew C. Cornett, Josh C. White, Alexander P. Willmott, Joel M. Stanger

Kinesiology Faculty Publications

Research on competitive swim start safety has focused on starts involving a dive from above the water surface. The purpose of this study was to determine the depths, speeds, and distances attained when executing backstroke starts, which begin in the water, and to investigate whether or not these variables are a function of age. Backstroke starts (n = 122) performed in 1.22 m of water during competition were stratified according to age group (8&U, 9-10, 11-12, 13-14, and 15&O). Dependent measures were maximum depth of the center of the head (MHD), head speed at maximum head depth (SPD), and distance …


Folic Acid Supplementation Improves Vascular Function In Professional Dancers With Endothelial Dysfunction, Anne Z. Hoch, Paula E. Papanek, Aniko Szabo, Michael E. Widlansky, David D. Gutterman Nov 2011

Folic Acid Supplementation Improves Vascular Function In Professional Dancers With Endothelial Dysfunction, Anne Z. Hoch, Paula E. Papanek, Aniko Szabo, Michael E. Widlansky, David D. Gutterman

Exercise Science Faculty Research and Publications

Objective

To determine if folic acid supplementation improves vascular function (brachial artery flow-mediated dilation [FMD]) in professional dancers with known endothelial dysfunction.

Design

Prospective cross-sectional study.

Setting

Academic institution in the Midwestern United States.

Subjects

Twenty-two professional ballet dancers volunteered for this study.

Main Outcome Measures

Subjects completed a 3-day food record to determine caloric and micronutrient intake. Menstrual status was determined by interview and questionnaire. Endothelial function was determined as flow-induced vasodilation measured by high-frequency ultrasound of the brachial artery. A change in brachial diameter of

Results

Sixty-four percent of dancers (n = 14) had abnormal brachial artery FMD …


Spinal Locomotor Inputs To Individually Identified Reticulospinal Neurons In The Lamprey, James T. Buchanan Nov 2011

Spinal Locomotor Inputs To Individually Identified Reticulospinal Neurons In The Lamprey, James T. Buchanan

Biological Sciences Faculty Research and Publications

Locomotor feedback signals from the spinal cord to descending brain stem neurons were examined in the lamprey using the uniquely identifiable reticulospinal neurons, the Müller and Mauthner cells. The same identified reticulospinal neurons were recorded in several preparations, under reduced conditions, to address whether an identified reticulospinal neuron shows similar locomotor-related oscillation timing from animal to animal and whether these timing signals can differ significantly from other identified reticulospinal neurons. Intracellular recordings of membrane potential in identified neurons were made in an isolated brain stem-spinal cord preparation with a high-divalent cation solution on the brain stem to suppress indirect neural …


Procedure And Checklist For Water Vaccination Of Meat Turkey Flocks, David D. Frame Nov 2011

Procedure And Checklist For Water Vaccination Of Meat Turkey Flocks, David D. Frame

All Current Publications

Vaccination for certain diseases is an important component of the health management program for commercial meat turkey production. Because of logistical challenges almost all routine vaccination of meat turkey flocks is administered through the drinking water.


Buying And Feeding The Family Milk Cow, Allen Young Nov 2011

Buying And Feeding The Family Milk Cow, Allen Young

All Current Publications

This publication lists characteristics of cow breeds, how to choose the right breed for your needs, how to maintain the animal, and how to control and monitor milk production.


Winterizing Your Horse's Feet, Scott Mckendrick, James Keyes, Karmella Dolecheck Nov 2011

Winterizing Your Horse's Feet, Scott Mckendrick, James Keyes, Karmella Dolecheck

All Current Publications

This publication gives tips and instructions on winterizing horse's feet in order to keep them safe and healthy.


Nest Predation And Circulating Corticosterone Levels Within And Among Species, Joseph J. Fontaine, Elena Arriero, Hubert Schwabl, Thomas E. Martin Nov 2011

Nest Predation And Circulating Corticosterone Levels Within And Among Species, Joseph J. Fontaine, Elena Arriero, Hubert Schwabl, Thomas E. Martin

Wildlife Biology Faculty Publications

Variation in the risk of predation to offspring can influence the expression of reproductive strategies both within and among species. Appropriate expression of reproductive strategies in environments that differ in predation risk can have clear advantages for fitness. Although adult-predation risk appears to influence glucocorticosteroid levels, leading to changes in behavioral and life-history strategies, the influence of offspring-predation risk on adult glucocorticosteroid levels remains unclear. We compared total baseline corticosteronc concentrations in Gray-headed Juncos (Junco hyemalis dorsalis) nesting on plots with and without experimentally reduced risk of nest predation. Despite differences in risk between treatments, we failed to find differences …


Alarm-Calling And Response Behaviors Of The Black-Tailed Prairie Dog In Kansas, Lloyd W. Towers Iii Nov 2011

Alarm-Calling And Response Behaviors Of The Black-Tailed Prairie Dog In Kansas, Lloyd W. Towers Iii

Master's Theses or Doctor of Nursing Practice

Prairie dogs (Cynomys spp.) use alarm calls to warn offspring and other kin of predatory threats. Dialects occur when vocalizations contain consistent differences among populations not isolated by geographic barriers. The Gunnison’s prairie dog (C. gunnisoni) has dialects in its alarm calls. The objectives of my study were to: (1) assess if the black-tailed prairie dog (C. ludovicianus) responded differently to alarm calls from other colonies than it did to alarm calls from its own colony, and (2) detect dialects, if they existed, in the alarm calls of the black-tailed prairie dog. The study included 8 black-tailed prairie dog colonies …


Dung Beetle Ecology: Habitat And Food Preference, Hypoxia Tolerance, And Genetic Variation, Sean Doyle Whipple Nov 2011

Dung Beetle Ecology: Habitat And Food Preference, Hypoxia Tolerance, And Genetic Variation, Sean Doyle Whipple

Department of Entomology: Dissertations, Theses, and Student Research

Four studies were conducted on dung beetles (Coleoptera: Scarabaeidae), which are insects of great ecological and economic importance. Range management practices were found to impact dung beetle diversity and abundance. While sampling on organic and conventionally managed ranches in Nebraska, 93% (5,767) of total dung beetle capture was from the organically managed ranch. Only 480 dung beetles (7% of total) were collected from the conventionally managed ranch. Results indicated that organic ranching had increased numbers and diversity of dung beetles.

Comparison of the attractiveness of native and exotic herbivore, carnivore, and omnivore dung yielded 9,089 dung beetles from 15 species. …


Gravesoil Microbial Community Structure During Carcass Decomposition, Amy E. Maile Nov 2011

Gravesoil Microbial Community Structure During Carcass Decomposition, Amy E. Maile

Department of Entomology: Dissertations, Theses, and Student Research

Dead bodies placed on soil represent unique challenges for investigators. Although processes in soils can be used to estimate postmortem interval, we know very little about how carcasses and insects affect gravesoil microbial communities.

To address this, the current project was composed of two experiments. Experiment one was conducted to investigate the effect of surface type on carcass decomposition and evaluate soil ecology methods. Experiment two was conducted to investigate the presence of an insect population (Lucilia sericata Meigen) on gravesoil microbial communities. Both experiments were conducted in a laboratory setting using freshly killed mouse carcasses. Mouse carcasses were …


Habitat Use And Abundance Patterns Of Sandhill Cranes In The Central Platte River Valley, Nebraska, 2003–2010, Todd Joseph Buckley Nov 2011

Habitat Use And Abundance Patterns Of Sandhill Cranes In The Central Platte River Valley, Nebraska, 2003–2010, Todd Joseph Buckley

School of Natural Resources: Dissertations, Theses, and Student Research

The Central Platte River Valley (CPRV) in Nebraska is an important spring stopover area for the midcontinent population of sandhill cranes. Alterations to crop rotation and loss habitat in the CPRV pose a risk to the population. Personnel drove designated routes in the CPRV from 2003–2010 to record the presence of cranes in agricultural fields and estimate abundance. I developed and evaluated models to predict habitat use and flock sizes. Alfalfa was predicted to receive the highest use followed by corn, soybeans, winter wheat, grassland, and shrubland. Use of all habitats and flock size increased as field area increased. Flock …


Minimal Structural Requirements Of Alkyl Γ-Lactones Capable Of Antagonizing The Cocaine-Induced Motility Decrease In Planarians, Debra Baker, Sean Deats, Peter Boor, James Pruitt, Oné R. Pagán Nov 2011

Minimal Structural Requirements Of Alkyl Γ-Lactones Capable Of Antagonizing The Cocaine-Induced Motility Decrease In Planarians, Debra Baker, Sean Deats, Peter Boor, James Pruitt, Oné R. Pagán

Biology Faculty Publications

We recently reported that the natural cyclic lactone, parthenolide, and related analogs prevent the expression of behavioral effects induced by cocaine in planarians and that parthenolide’s γ-lactone ring is required for this effect. In the present work, we tested a series of alkyl γ-lactones with varying chain length (1–8 carbons) to determine their ability to antagonize the planarian motility decrease induced by 200 μM cocaine. Alkyl lactones with up to a 4-carbon alkyl chain did not affect planarian motility or antagonized the cocaine-induced motility decrease; only the compound γ-nonalactone (a γ-lactone with a 5-carbon chain) was able to prevent the …


An Anomaly Of Pectinal Organs In Vaejovis Lapidicola (Scorpiones: Vaejovidae), Richard F. Ayrey Nov 2011

An Anomaly Of Pectinal Organs In Vaejovis Lapidicola (Scorpiones: Vaejovidae), Richard F. Ayrey

Euscorpius

Among specimens of Vaejovis lapidicola Stahnke, one female was found to have abnormally shaped pectines, both with only distal pectinal teeth. This rare, possibly teratological anomaly is documented and discussed.


The Update, November 2011, University Of Northern Iowa. College Of Humanities, Arts And Sciences. Nov 2011

The Update, November 2011, University Of Northern Iowa. College Of Humanities, Arts And Sciences.

Update

Inside this issue:

-- Bahamian Artist's Residency at UNI
-- Department News
-- KULT, UNI's Alternative
-- University of Northern Iowa Affiliates of the American Chemical Society
-- Student Spotlight, Department of Industrial Technology: Corey Moen
-- Fall Faculty and Staff Meeting
-- School of Music Events
-- 'Home' Project, Dean's Triangle
-- Physics Teaching Majors Present at 2011 AAPT Summer Meeting in Omaha Nebraska
-- Center For Holocaust and Genocide Update
-- Student Spotlight, School of Music: Rhys Talbot
-- Davis to Speak at National Convention
-- Beth Nybeck: Flight of Ideas: The Journey of a Nybeck Sculpture
-- …


Evolution Of Functionally Diverse Alleles Associated With Ptc Bitter Taste Sensitivity In Africa, Michael Campbell Nov 2011

Evolution Of Functionally Diverse Alleles Associated With Ptc Bitter Taste Sensitivity In Africa, Michael Campbell

Department of Biology Faculty Publications

Although human bitter taste perception is hypothesized to be a dietary adaptation, little is known about genetic signatures of selection and patterns of bitter taste perception variability in ethnically diverse populations with different diets, particularly from Africa. To better understand the genetic basis and evolutionary history of bitter taste sensitivity, we sequenced a 2,975 bp region encompassing TAS2R38, a bitter taste receptor gene, in 611 Africans from 57 populations in West Central and East Africa with diverse subsistence patterns, as well as in a comparative sample of 132 non-Africans. We also examined the association between genetic variability at this locus …


Laboratory Diagnosis Of Clostridium Difficile Infection: Can Molecular Amplification Methods Move Us Out Of Uncertainty?, Fred C. Tenover, Ellen Jo Baron, Lance R. Peterson, David Persing Nov 2011

Laboratory Diagnosis Of Clostridium Difficile Infection: Can Molecular Amplification Methods Move Us Out Of Uncertainty?, Fred C. Tenover, Ellen Jo Baron, Lance R. Peterson, David Persing

Biology Faculty Publications

The laboratory diagnosis of Clostridium difficile infection (CDI) continues to be challenging. Recent guidelines from professional societies in the United States note that enzyme immunoassays for toxins A and B do not have adequate sensitivity to be used alone for detecting CDI, yet the optimal method for diagnosing this infection remains unclear. Nucleic acid amplification tests (NAATs) that target chromosomal toxin genes (usually the toxin B gene, tcdB) show high sensitivity and specificity, provide rapid results, and are amenable to both batch and on-demand testing, but these tests were not universally recommended for routine use in the recent guidelines. …


Competencies: A Cure For Pre-Med Curriculum, Winston Anderson, Richard Amasino, Manuel Ares, Utpal Banerjee, Bonnie Bartel, Victor Corces, Catherine Drennan, Sarah C.R. Elgin, Irving Epstein, Ellen Fanning, Louis Guillette, Jo Handelsman, Graham Hatfull, Ronald Hoy, Darcy Kelley, Leslie Leinwand, Richard Losick, Yi Lu, David Lynn, Claudia Neuhauser, Diane O'Dowd, Toto Olivera, Pavel Pevzner, Rebecca Richards-Kortum, Jasper Rine, Robert Sah, Scott Strobel, Graham Walker, David Walt, Isiah Warner, Sue Wessler, Huntington Willard, Richard Zare Nov 2011

Competencies: A Cure For Pre-Med Curriculum, Winston Anderson, Richard Amasino, Manuel Ares, Utpal Banerjee, Bonnie Bartel, Victor Corces, Catherine Drennan, Sarah C.R. Elgin, Irving Epstein, Ellen Fanning, Louis Guillette, Jo Handelsman, Graham Hatfull, Ronald Hoy, Darcy Kelley, Leslie Leinwand, Richard Losick, Yi Lu, David Lynn, Claudia Neuhauser, Diane O'Dowd, Toto Olivera, Pavel Pevzner, Rebecca Richards-Kortum, Jasper Rine, Robert Sah, Scott Strobel, Graham Walker, David Walt, Isiah Warner, Sue Wessler, Huntington Willard, Richard Zare

Biology Faculty Research

No abstract provided.


Adaptive Evolution Of The Matrix Extracellular Phosphoglycoprotein In Mammals, Joao P. Machado, Warren E. Johnson, Stephen J. O'Brien, Vitor Vasconcelos, Agostinho Antunes Nov 2011

Adaptive Evolution Of The Matrix Extracellular Phosphoglycoprotein In Mammals, Joao P. Machado, Warren E. Johnson, Stephen J. O'Brien, Vitor Vasconcelos, Agostinho Antunes

Biology Faculty Articles

Background

Matrix extracellular phosphoglycoprotein (MEPE) belongs to a family of small integrin-binding ligand N-linked glycoproteins (SIBLINGs) that play a key role in skeleton development, particularly in mineralization, phosphate regulation and osteogenesis. MEPE associated disorders cause various physiological effects, such as loss of bone mass, tumors and disruption of renal function (hypophosphatemia). The study of this developmental gene from an evolutionary perspective could provide valuable insights on the adaptive diversification of morphological phenotypes in vertebrates.

Results

Here we studied the adaptive evolution of the MEPE gene in 26 Eutherian mammals and three birds. The comparative genomic analyses revealed a high degree …


Erect Wing Facilitates Context-Dependent Wnt/Wingless Signaling By Recruiting The Cell-Specific Armadillo-Tcf Adaptor Earthbound To Chromatin, Nan Xin, Hassina Benchabane, Ai Tian, Kerrie Nguyen, Lindsay Klofas, Yashi Ahmed Nov 2011

Erect Wing Facilitates Context-Dependent Wnt/Wingless Signaling By Recruiting The Cell-Specific Armadillo-Tcf Adaptor Earthbound To Chromatin, Nan Xin, Hassina Benchabane, Ai Tian, Kerrie Nguyen, Lindsay Klofas, Yashi Ahmed

Dartmouth Scholarship

During metazoan development, the Wnt/Wingless signal transduction pathway is activated repetitively to direct cell proliferation, fate specification, differentiation and apoptosis. Distinct outcomes are elicited by Wnt stimulation in different cellular contexts; however, mechanisms that confer context specificity to Wnt signaling responses remain largely unknown. Starting with an unbiased forward genetic screen in Drosophila, we recently uncovered a novel mechanism by which the cell-specific co-factor Earthbound 1 (Ebd1), and its human homolog jerky, promote interaction between the Wnt pathway transcriptional co-activators B-catenin/Armadillo and TCF to facilitate context-dependent Wnt signaling responses. Here, through the same genetic screen, we find an unanticipated requirement …