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Full-Text Articles in Life Sciences
Evolution Of Picornaviruses: Impacts Of Recombination And Selection, Nicole Noel Lewis-Rogers
Evolution Of Picornaviruses: Impacts Of Recombination And Selection, Nicole Noel Lewis-Rogers
Theses and Dissertations
Picornaviruses are responsible for some of the most common and debilitating diseases affecting humans and animals worldwide. The objectives of this dissertation research were (1) estimate phylogenetic relationships among 11 picornavirus genera and within three species: foot-and-mouth disease virus (FMDV: Aphthovirus) which afflicts cloven-hoofed animals and human rhinovirus A and B (HRV: Enterovirus) which cause the common cold; (2) better understand the impact recombination has on genomic organization and evolution; (3) characterize where positive and purifying selection has occurred in proteins and how selection has influenced phenotype. The dissertation includes four studies. The first chapter provides an overview of the …
Domain Duplication, Darwinian Selection, And The Origin Of The Globulin Seed Storage Proteins, Nathaniel S. Cannon
Domain Duplication, Darwinian Selection, And The Origin Of The Globulin Seed Storage Proteins, Nathaniel S. Cannon
Theses and Dissertations
The seed storage globulins found among virtually all spermatophytes comprise a multi-gene family of proteins with ancient evolutionary origins. The two main groups of storage globulins include the legumins (11S) and vicilins (7S), both of which play a main role in protein deposition and storage in the seed endosperm. Composed of two cupin domains (bicupin), these proteins have been recently noted not only for their close structural relationships among the two subfamilies (7S and 11S) but also for their similarity to other proteins such as germin-like proteins (GLP's), bacterial oxalate decarboxylases, and other cupin containing proteins. Previous studies have investigated …