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2007

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Articles 3451 - 3480 of 3598

Full-Text Articles in Life Sciences

Mda-7/Il-24, Novel Anticancer Cytokine: Focus On Bystander Antitumor, Radiosensitization And Antiangiogenic Properties And Overview Of The Phase I Clinical Experience (Review), Irina V. Lebedeva, Luni Emdad, Zao-Zhong Su, Pankaj Gupta, Moira Sauane, Devanand Sarkar, Michelle R. Staudt, Shi-Jian Liu, Mohiuddin M. Taher, Ruoyu Xiao, Paola Barral, Seok-Geun Lee, Dongning Wang, Nicollaq Vozhilla, Eun Sook Park, Lejuan Chatman, Habib Boukerche, Rajagopal Ramesh, Satoshi Inoue, Sunil Chada, Rong Li, Anthony L. De Pass, Parameshwar J. Mahasreshti, Igor P. Dmitriev, David T. Curiel, Adly Yacoub, Steven Grant, Paul Dent, Neil Senzer, John J. Nemunaitis, Paul B. Fisher Jan 2007

Mda-7/Il-24, Novel Anticancer Cytokine: Focus On Bystander Antitumor, Radiosensitization And Antiangiogenic Properties And Overview Of The Phase I Clinical Experience (Review), Irina V. Lebedeva, Luni Emdad, Zao-Zhong Su, Pankaj Gupta, Moira Sauane, Devanand Sarkar, Michelle R. Staudt, Shi-Jian Liu, Mohiuddin M. Taher, Ruoyu Xiao, Paola Barral, Seok-Geun Lee, Dongning Wang, Nicollaq Vozhilla, Eun Sook Park, Lejuan Chatman, Habib Boukerche, Rajagopal Ramesh, Satoshi Inoue, Sunil Chada, Rong Li, Anthony L. De Pass, Parameshwar J. Mahasreshti, Igor P. Dmitriev, David T. Curiel, Adly Yacoub, Steven Grant, Paul Dent, Neil Senzer, John J. Nemunaitis, Paul B. Fisher

Publications and Research

Subtraction hybridization applied to a ‘differentiation therapy’ model of cancer employing human melanoma cells resulted in the cloning of melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24). Initial studies confirm an inverse correlation between mda-7 expression and melanoma development and progression. Forced expression of mda-7 by means of a plasmid or via a replication incompetent adenovirus (Ad.mda-7) promotes growth suppression and induces apoptosis in a broad array of human cancers. In contrast, mda-7 does not induce growth suppressive or toxic effects in normal cells. Based on structure (containing an IL-10 signature motif), secretion by cells (including subsets of T-cells) and location on chromosome …

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Whole Genome Duplications And Contracted Breakpoint Graphs, Max A. Alekseyev, Pavel A. Pevzner Jan 2007

Whole Genome Duplications And Contracted Breakpoint Graphs, Max A. Alekseyev, Pavel A. Pevzner

Faculty Publications

The genome halving problem, motivated by the whole genome duplication events in molecular evolution, was solved by El-Mabrouk and Sankoff in the pioneering paper [SIAM J. Comput., 32 (2003), pp. 754–792]. The El-Mabrouk–Sankoff algorithm is rather complex, inspiring a quest for a simpler solution. An alternative approach to the genome halving problem based on the notion of the contracted breakpoint graph was recently proposed in [M. A. Alekseyev and P. A. Pevzner, IEEE/ACM Trans. Comput. Biol. Bioinformatics, 4 (2007), pp. 98–107]. This new technique reveals that while the El-Mabrouk–Sankoff result is correct in most cases, it does not hold in …

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Colored De Bruijn Graphs And The Genome Halving Problem, Max A. Alekseyev, Pavel A. Pevzner Jan 2007

Colored De Bruijn Graphs And The Genome Halving Problem, Max A. Alekseyev, Pavel A. Pevzner

Faculty Publications

Breakpoint graph analysis is a key algorithmic technique in studies of genome rearrangements. However, breakpoint graphs are defined only for genomes without duplicated genes, thus limiting their applications in rearrangement analysis. We discuss a connection between the breakpoint graphs and de Bruijn graphs that leads to a generalization of the notion of breakpoint graph for genomes with duplicated genes. We further use the generalized breakpoint graphs to study the Genome Halving Problem (first introduced and solved by Nadia El-Mabrouk and David Sankoff). The El-Mabrouk-Sankoff algorithm is rather complex, and, in this paper, we present an alternative approach that is based …

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Computer Simulation Of Glioma Growth And Morphology, Hermann B. Frieboes, John S Lowengrub, S Wise, X Zheng, Paul Macklin, Elaine L. Bearer, Vittorio Cristini Jan 2007

Computer Simulation Of Glioma Growth And Morphology, Hermann B. Frieboes, John S Lowengrub, S Wise, X Zheng, Paul Macklin, Elaine L. Bearer, Vittorio Cristini

Faculty, Staff and Student Publications

Despite major advances in the study of glioma, the quantitative links between intra-tumor molecular/cellular properties, clinically observable properties such as morphology, and critical tumor behaviors such as growth and invasiveness remain unclear, hampering more effective coupling of tumor physical characteristics with implications for prognosis and therapy. Although molecular biology, histopathology, and radiological imaging are employed in this endeavor, studies are severely challenged by the multitude of different physical scales involved in tumor growth, i.e., from molecular nanoscale to cell microscale and finally to tissue centimeter scale. Consequently, it is often difficult to determine the underlying dynamics across dimensions. New techniques …

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Structure And Biosynthesis Of Heat-Stable Antifungal Factor (Hsaf), A Broad-Spectrum Antimycotic With A Novel Mode Of Action, Fengan Yu, Kathia Zaleta-Rivera, Xiangcheng Zhu, Justin Huffman, Jeffrey C. Millet, Steven D. Harris, Gary Yuen, Xing-Cong Li, Liangcheng Du Jan 2007

Structure And Biosynthesis Of Heat-Stable Antifungal Factor (Hsaf), A Broad-Spectrum Antimycotic With A Novel Mode Of Action, Fengan Yu, Kathia Zaleta-Rivera, Xiangcheng Zhu, Justin Huffman, Jeffrey C. Millet, Steven D. Harris, Gary Yuen, Xing-Cong Li, Liangcheng Du

Department of Plant Pathology: Faculty Publications

A screen for antifungal compounds from Lysobacter enzymogenes strain C3, a bacterial biological control agent of fungal diseases, has previously led to the isolation of heat-stable antifungal factor (HSAF). HSAF exhibits inhibitory activities against a wide range of fungal species and shows a novel mode of antifungal action by disrupting the biosynthesis of a distinct group of sphingolipids. We have now determined the chemical structure of HSAF, which is identical to that of dihydromaltophilin, an antifungal metabolite with a unique macrocyclic lactam system containing a tetramic acid moiety and a 5,5,6-tricyclic skeleton. We have also identified the genetic locus responsible …

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Black Walnut, Charles Michler, Keith Woeste, Paula Pijut Jan 2007

Black Walnut, Charles Michler, Keith Woeste, Paula Pijut

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Black walnut (Juglans nigra L.), also known as eastern black walnut or American walnut, is a fine hardwood species in the family Juglandaceae, section Rhysocaryon (Manning 1978). In general, J. nigra will not cross with species in the sections Cardiocaryon or Trachycaryonv, but J. nigra will cross with J. ailantifolia (Cardiocaryon) (Williams 1990). Juglans nigra will also hybridize to some extent with other Juglans species (Dioscaryon and Rhysocaryon), and one hybrid is recognized: J. nigra × J. regia = J. x intermedia Carr. (USDA-NRCS 2004). Native to the deciduous forests of the eastern United States …

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Pines, C. Plomion, D. Chagné, D. Pot, S. Kumar, P. L. Wilcox, R. D. Burdon, D. Prat, D. G. Peterson, J. Paiva, P. Chaumeil, G. G. Vendramin, F. Sebastiani, C. D. Nelson, C. S. Echt, O. Savolainen, T. L. Kubisiak, M. T. Cervera, N. De María, M. N. Islam-Faridi Jan 2007

Pines, C. Plomion, D. Chagné, D. Pot, S. Kumar, P. L. Wilcox, R. D. Burdon, D. Prat, D. G. Peterson, J. Paiva, P. Chaumeil, G. G. Vendramin, F. Sebastiani, C. D. Nelson, C. S. Echt, O. Savolainen, T. L. Kubisiak, M. T. Cervera, N. De María, M. N. Islam-Faridi

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Pinus is the most important genus within the Family Pinaceae and also within the gymnosperms by the number of species (109 species recognized by Farjon 2001) and by its contribution to forest ecosystems. All pine species are evergreen trees or shrubs. They are widely distributed in the northern hemisphere, from tropical areas to northern areas in America and Eurasia. Their natural range reaches the equator only in Southeast Asia. In Africa, natural occurrences are confined to the Mediterranean basin. Pines grow at various elevations from sea level (not usual in tropical areas) to highlands. Two main regions of diversity are …

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Protecting Soil And Water In Forest Road Management, J. M. Grace Iii, B. D. Clinton Jan 2007

Protecting Soil And Water In Forest Road Management, J. M. Grace Iii, B. D. Clinton

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The National Forest road system is the network that supports public recreation, which has become the primary use of the public lands. The pattern of use of National Forest roads for recreation has increased dramatically since the late 1940s and is expected to continue to increase beyond the rates observed today. However, research over the past 60 years clearly presents forest roads as a major source of sediment and soil erosion from forest watersheds. Threats to healthy forests have received increased attention in the past decade. In particular, roads, road management, and travel management will likely be critical to addressing …

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Giving Voice To Wildlands Visitors: Selecting Indicators To Protect And Sustain Experiences In The Eastern Arctic Of Nunavut, Alan Watson, Brian Glaspell, Neal Christensen, Paul Lachapelle, Vicki Sahanatien, Frances Gertsch Jan 2007

Giving Voice To Wildlands Visitors: Selecting Indicators To Protect And Sustain Experiences In The Eastern Arctic Of Nunavut, Alan Watson, Brian Glaspell, Neal Christensen, Paul Lachapelle, Vicki Sahanatien, Frances Gertsch

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Many public land management agencies are committed to understanding and protecting recreation visitor experiences. Parks Canada is deeply committed to that objective for visitors to Canada’s National Parks. This 2004 study, informed by a 2003 qualitative study of visitor experiences and influences on those experiences at Auyuittuq National Park in Nunavut, worked to bring 50 potential elements of visitor experiences down to five articulated dimensions of the experience that is currently being received at this remote eastern arctic park. A hypothesized set of 17 influences on experiences, also reduced to just two factors with similar response patterns, and with some …

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Delivering The Science Synthesis: Fuelstools, Anne Black, Susan Perin Jan 2007

Delivering The Science Synthesis: Fuelstools, Anne Black, Susan Perin

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

To facilitate delivery and use of the Fuels Planning: Science Synthesis and Integration Project’s (Project) products, the Project team engaged in a series of technology transfer activities throughout the life of the project. These included bringing land managers into the design and development phase, funding and staffing a specific delivery phase, and conducting an external evaluation to focus future activities. Our plans were informed by concepts central to the diffusion of the innovation theory; in turn, our activities deepened our understanding of the theory and its application to fuels management.

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Dna Multiplex Hybridization On Microarrays And Thermodynamic Stability In Solution: A Direct Comparison, Daniel J. Fish, M. Todd Horne, Greg P. Brewood, Jim P. Goodarzi, Saba Alemayehu, Ashwini Bhandiwad, Robert P. Searles, Albert S. Benight Jan 2007

Dna Multiplex Hybridization On Microarrays And Thermodynamic Stability In Solution: A Direct Comparison, Daniel J. Fish, M. Todd Horne, Greg P. Brewood, Jim P. Goodarzi, Saba Alemayehu, Ashwini Bhandiwad, Robert P. Searles, Albert S. Benight

Chemistry Faculty Publications and Presentations

Hybridization intensities of 30 distinct short duplex DNAs measured on spotted microarrays, were directly compared with thermodynamic stabilities measured in solution. DNA sequences were designed to promote formation of perfect match, or hybrid duplexes containing tandem mismatches. Thermodynamic parameters DeltaH degrees , DeltaS degrees and DeltaG degrees of melting transitions in solution were evaluated directly using differential scanning calorimetry. Quantitative comparison with results from 63 multiplex microarray hybridization experiments provided a linear relationship for perfect match and most mismatch duplexes. Examination of outliers suggests that both duplex length and relative position of tandem mismatches could be important factors contributing to …

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Functional Interplay Between The B-Box 2 And The B30.2(Spry) Domains Of Trim5Α, Xi Ling, Byeongwoon Song, Shi-Hua Xiang, Joseph Sodroski Jan 2007

Functional Interplay Between The B-Box 2 And The B30.2(Spry) Domains Of Trim5Α, Xi Ling, Byeongwoon Song, Shi-Hua Xiang, Joseph Sodroski

Nebraska Center for Virology: Faculty Publications

The retroviral restriction factors, TRIM5α and TRIMCyp, consist of RING and B-box 2 domains separated by a coiled coil from carboxy-terminal domains. These carboxy-terminal domains (the B30.2(SPRY) domain in TRIM5α and the cyclophilin A domain in TRIMCyp) recognize the retroviral capsid. Here we show that some B-box 2 changes in TRIM5α, but not in TRIMCyp, resulted in decreased human immunodeficiency virus (HIV-1) capsid binding. The phenotypic effects of these B-box 2 changes on the restriction of retroviral infection depended on the potency of restriction and the affinity of the TRIM5α interaction with the viral capsid, two properties specified by the …

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Characterization Of Human Immunodeficiency Virus Type 1 Monomeric And Trimeric Gp120 Glycoproteins Stabilized In The Cd4-Bound State: Antigenicity, Biophysics, And Immunogenicity, Barna Dey, Marie Pancera, Krisha Svehla, Yuuei Shu, Shi-Hua Xiang, Jeffrey Vainshtein, Yuxing Li, Joseph Sodroski, Peter D. Kwong, John R. Mascola, Richard Wyatt Jan 2007

Characterization Of Human Immunodeficiency Virus Type 1 Monomeric And Trimeric Gp120 Glycoproteins Stabilized In The Cd4-Bound State: Antigenicity, Biophysics, And Immunogenicity, Barna Dey, Marie Pancera, Krisha Svehla, Yuuei Shu, Shi-Hua Xiang, Jeffrey Vainshtein, Yuxing Li, Joseph Sodroski, Peter D. Kwong, John R. Mascola, Richard Wyatt

Nebraska Center for Virology: Faculty Publications

The human immunodeficiency virus type 1 exterior gp120 envelope glycoprotein is highly flexible, and this flexibility may contribute to the inability of monomeric gp120 immunogens to elicit broadly neutralizing antibodies. We previously showed that an S375W modification of a critical interfacial cavity central to the primary receptor binding site, the Phe43 cavity, stabilizes gp120 into the CD4-bound state. However, the immunological effects of this cavity-altering replacement were never tested. Subsequently, we screened other mutations that, along with the S375W alteration, might further stabilize the CD4-bound state. Here, we define a selected second cavity-altering replacement, T257S, and analyze the double mutations …

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Modulation Of Cd4 Co-Receptor Limits Spontaneous Autoimmunity When High-Affinity Transgenic Tcr Specific For Self-Antigen Is Expressed On A Genetically Resistant Background, Zsolt Illés, Hanspeter Waldner, Jay Reddy, Ana C. Anderson, Raymond A. Sobel, Vijay K. Kuchroo Jan 2007

Modulation Of Cd4 Co-Receptor Limits Spontaneous Autoimmunity When High-Affinity Transgenic Tcr Specific For Self-Antigen Is Expressed On A Genetically Resistant Background, Zsolt Illés, Hanspeter Waldner, Jay Reddy, Ana C. Anderson, Raymond A. Sobel, Vijay K. Kuchroo

Jay Reddy Publications

Myelin proteolipid protein (PLP) 139–151 is an immunodominant peptide that induces experimental autoimmune encephalomyelitis (EAE) in H-2s SJL/J mice. While PLP 139–151-specific TCR transgenic (tg) 4E3 mice develop fulminant spontaneous disease on the susceptible SJL/J background, spontaneous EAE is dramatically reduced on the H-2s congenic B10.S background. On this resistant background, we observed a high frequency of positively selected tg CD42CD82 (DN) thymocytes and peripheral DN tg T cells. Splenic DN tg T cells responded to anti-CD3 stimulation similarly to CD41 cells, but proliferative and cytokine responses to PLP 139–151 were blunted, implying that CD4 coreceptor down-regulation modulated …

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Hydrologic Connectivity And The Contribution Of Stream Headwaters To Ecological Integrity At Regional Scales, Mary C. Freeman, Catherine M. Pringle, C. Rhett Jackson Jan 2007

Hydrologic Connectivity And The Contribution Of Stream Headwaters To Ecological Integrity At Regional Scales, Mary C. Freeman, Catherine M. Pringle, C. Rhett Jackson

United States Geological Survey: Staff Publications

Cumulatively, headwater streams contribute to maintaining hydrologic connectivity and ecosystem integrity at regional scales. Hydrologic connectivity is the water-mediated transport of matter, energy and organisms within or between elements of the hydrologic cycle. Headwater streams compose over two-thirds of total stream length in a typical river drainage and directly connect the upland and riparian landscape to the rest of the stream ecosystem. Altering headwater streams, e.g., by channelization, diversion through pipes, impoundment and burial, modifies fluxes between uplands and downstream river segments and eliminates distinctive habitats. The large-scale ecological effects of altering headwaters are amplified by land uses that alter …

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The Science Of Targeting Within Landscapes And Watersheds To Improve Consevation Effectiveness, Todd Walter, Mike Dosskey, Madhu Khanna, Jim Miller, Mark Tomer, John Wiens Jan 2007

The Science Of Targeting Within Landscapes And Watersheds To Improve Consevation Effectiveness, Todd Walter, Mike Dosskey, Madhu Khanna, Jim Miller, Mark Tomer, John Wiens

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Our ernphasis in this chapter has been an the science that underlies efforts to target conservation efforts to enhance the effeciiveness (and cost-effectiveness) of management, mitigation and restoration.

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Georgeoral Immunization Of Rhesus Macaques With Adenoviral Hiv Vaccines Using Enteric-Coated Capsules, George T. Mercier, Pramod N. Nehete, Marco F. Passeri, Bharti N. Nehete, Eric A. Weaver, Nancy Smyth Templeton, Kimberly Schluns, Stephanie S. Buchl, K. Jagannadha Sastry, Michael A. Barry Jan 2007

Georgeoral Immunization Of Rhesus Macaques With Adenoviral Hiv Vaccines Using Enteric-Coated Capsules, George T. Mercier, Pramod N. Nehete, Marco F. Passeri, Bharti N. Nehete, Eric A. Weaver, Nancy Smyth Templeton, Kimberly Schluns, Stephanie S. Buchl, K. Jagannadha Sastry, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Targeted delivery of vaccine candidates to the gastrointestinal (GI) tract holds potential for mucosal immunization, particularly against mucosal pathogens like the human immunodeficiency virus (HIV). Among the different strategies for achieving targeted release in the GI tract, namely the small intestine, pH sensitive enteric coating polymers have been shown to protect solid oral dosage forms from the harsh digestive environment of the stomach and dissolve relatively rapidly in the small intestine by taking advantage of the luminal pH gradient. We developed an enteric polymethacrylate formulation for coating hydroxy-propyl-methyl-cellulose (HPMC) capsules containing lyophilized Adenoviral type 5 (Ad5) vectors expressing HIV-1 gag …

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Structural Definition Of A Conserved Neutralization Epitope On Hiv-1 Gp120, Tongqing Zhou, Ling Xu, Barna Dey, Ann J. Hessell, Donald Van Ryk, Shi-Hua Xiang, Xinzhen Yang, Mei-Yun Zhang, Michael B. Zwick, James Arthos, Dennis R. Burton, Dimiter S. Dimitrov, Joseph Sodroski, Richard Wyatt, Gary J. Nabel, Peter D. Kwong Jan 2007

Structural Definition Of A Conserved Neutralization Epitope On Hiv-1 Gp120, Tongqing Zhou, Ling Xu, Barna Dey, Ann J. Hessell, Donald Van Ryk, Shi-Hua Xiang, Xinzhen Yang, Mei-Yun Zhang, Michael B. Zwick, James Arthos, Dennis R. Burton, Dimiter S. Dimitrov, Joseph Sodroski, Richard Wyatt, Gary J. Nabel, Peter D. Kwong

Nebraska Center for Virology: Faculty Publications

The remarkable diversity, glycosylation and conformational flexibility of the human immunodeficiency virus type 1 (HIV-1) envelope (Env), including substantial rearrangement of the gp120 glycoprotein upon binding the CD4 receptor, allow it to evade antibody-mediated neutralization. Despite this complexity, the HIV-1 Env must retain conserved determinants that mediate CD4 binding. To evaluate how these determinants might provide opportunities for antibody recognition, we created variants of gp120 stabilized in the CD4-bound state, assessed binding of CD4 and of receptor-binding-site antibodies, and determined the structure at 2.3Å resolution of the broadly neutralizing antibody b12 in complex with gp120. b12 binds to a conformationally …

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Structures Of The Ccr5 N Terminus And Of A Tyrosine-Sulfated Antibody With Hiv-1 Gp120 And Cd4, Chih-Chin Huang, Son N. Lam, Priyamvada Acharya, Min Tang, Shi-Hua Xiang, Syed Shahzad-Ul Hussan, Robyn L. Stanfield, James Robinson, Ian A. Wilson, Richard Wyatt, Carole A. Bewley, Peter D. Kwong Jan 2007

Structures Of The Ccr5 N Terminus And Of A Tyrosine-Sulfated Antibody With Hiv-1 Gp120 And Cd4, Chih-Chin Huang, Son N. Lam, Priyamvada Acharya, Min Tang, Shi-Hua Xiang, Syed Shahzad-Ul Hussan, Robyn L. Stanfield, James Robinson, Ian A. Wilson, Richard Wyatt, Carole A. Bewley, Peter D. Kwong

Nebraska Center for Virology: Faculty Publications

The CCR5 co-receptor binds to the HIV-l gp120 envelope glycoprotein and facilitates HIV-l entry into cells. Its N terminus is tyrosine-sulfated, as are many antibodies that react with the co-receptor binding site on gp120. We applied nuclear magnetic resonance and crystallographic techniques to analyze the structure of the CCR5 N terminus and that of the tyrosine-sulfated antibody 412d in complex with gp120 and CD4. The conformations of tyrosine-sulfated regions of CCR5 (α-helix) and 412d (extendedloop) are surprisingly different. Nonetheless, a critical sulfotyrosine on CCR5 and on 412d induces similar structural rearrangements in gp120. These results now provide a framework for …

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Inoculation Of Coffee Plants With The Fungal Entomopathogen Beauveria Bassiana (Ascomycota: Hypocreales), Francisco Posada, M. Catherine Aime, Stephen W. Peterson, Stephen A. Rehner, Fernando E. Vega Jan 2007

Inoculation Of Coffee Plants With The Fungal Entomopathogen Beauveria Bassiana (Ascomycota: Hypocreales), Francisco Posada, M. Catherine Aime, Stephen W. Peterson, Stephen A. Rehner, Fernando E. Vega

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The entomopathogenic fungus Beauveria bassiana was established in coffee seedlings afterfungal spore suspensions were applied as foliar sprays, stem injections, or soil drenches. Direct injection yielded the highest post-inoculation recovery of endophytic B. bassiana. Establishment, based on percent recovery of B. bassiana, decreased as time post-inoculation increased in all treatments. Several other endophytes were isolated from the seedlings and could have negatively influenced establishment of B. bassiana. The recovery of B. bassiana from sites distant from the point of inoculation indicates that the fungus has thepotential to move throughout the plant.

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How Will Global Climate Change Affect Parasite-Host Assemblages?, Eric P. Hoberg, Daniel R. Brooks Jan 2007

How Will Global Climate Change Affect Parasite-Host Assemblages?, Eric P. Hoberg, Daniel R. Brooks

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Parasites are integral components of the biosphere. Host switching correlated with events of episodic climate change is ubiquitous in evolutionary and ecological time. Global climate change produces ecological perturbations, which cause geographical and phenological shifts, and alteration in the dynamics of parasite transmission, increasing the potential for host switching. The intersection of climate change with evolutionary conservative aspects of host specificity and transmission dynamics, called ecological fitting, permits emergence of parasites and diseases without evolutionary changes in their capacity for host utilization.

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Nearctic Shrews, Sorex Spp., As Paratenic Hosts Of Soboliphyme Baturini (Nematoda: Soboliphymidae), S. V. Karpenko, N. E. Dokuchaev, Eric P. Hoberg Jan 2007

Nearctic Shrews, Sorex Spp., As Paratenic Hosts Of Soboliphyme Baturini (Nematoda: Soboliphymidae), S. V. Karpenko, N. E. Dokuchaev, Eric P. Hoberg

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Third-stage larvae (L3) of Soboliphyme baturini were discovered for the first time in shrews, Sorex cinereus and Sorex tundrensis from Alaska and the Nearctic. Shrews were found to be infected with L3 at Suloia Lake, southeastern Alaska, Togiak National Wildlife Refuge, southwestern Alaska, and at the Yukon-Charley Rivers National Preserve near the Yukon-Alaska border. Larvae in shrews from Alaska were morphologically indistinguishable from those known in both insectivores and arvicoline rodents from Russia. The occurrence of S. baturini in Alaskan insectivores further establishes shrews as important hosts in the transmission of S. baturini among mustelids and other carnivores and indicates …

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First Observation Of Elaeophora Schneideri Wehr And Dikmans, 1935 (Nematoda:Filariidae) In Mule Deer From Nebraska, R. D. Mcknown, M. C. Sterner, D. W. Oates Jan 2007

First Observation Of Elaeophora Schneideri Wehr And Dikmans, 1935 (Nematoda:Filariidae) In Mule Deer From Nebraska, R. D. Mcknown, M. C. Sterner, D. W. Oates

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Between November 2000 and November 2005, approximately 200 mule deer (Odocoileus hemionus hemionus) and whitetailed deer (Odocoileus virginianus) from western Nebraska were extensively examined for the presence of Elaeophora schneideri, Wehr and Dikmans, 1935; three adult E. schneideri were detected from three mule deer. This represents the first documented occurrence of E. schneideri from wild deer in Nebraska.

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Introduction For Tom Armstrong, John Owens Jan 2007

Introduction For Tom Armstrong, John Owens

John Owens: Speeches and Appearances

Dr. Tom Armstrong is the USGS Senior Advisor for Global Change Programs. During his career at USGS, he has served as the principal for the Department of the Interior to the United States Climate Change Science Program, the United States Head of Delegation for the Arctic Monitoring and Assessment Program; Co-Lead for development of the Committee on Earth Observation Satellites response to the Global Climate Observing System Implementation Plan, the United States delegate to the United Nations Framework Council on Climate Change, advisor on USGS International Polar Year activities, and as Chair of the Science Sub-committee for the Department of …

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New Faculty Orientation Welcome, John Owens Jan 2007

New Faculty Orientation Welcome, John Owens

John Owens: Speeches and Appearances

It is a true pleasure to join Chancellor Perlman and Senior Vice Chancellor of Academic Affairs Couture in welcoming you to the University of Nebraska-Lincoln.

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Casnr Salute To Graduates, John Owens Jan 2007

Casnr Salute To Graduates, John Owens

John Owens: Speeches and Appearances

We appreciate your being with us this afternoon as we celebrate the accomplishments of tomorrow's graduates from the University of Nebraska-Lincoln. Thank you for attending, and congratulations to the new alumni! This ceremony is rapidly Becoming both a fixture and a tradition in the College of Agricultural Sciences and Natural Resources. As a matter of fact, it took the national "First Place Award" in a competition last year that was open to all the universities in the United States.

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Lead Presentation: The Game, John Owens Jan 2007

Lead Presentation: The Game, John Owens

John Owens: Speeches and Appearances

Good afternoon, everyone. The deans of the Institute of Agriculture and Natural Resources and I are pleased to be here with you today. We welcome you to IANR Shout It Out, the Institute of Agriculture and Natural Resources game that allows you to test your IANR and Nebraska knowledge, learn exciting new facts, and win prizes! Good luck to you all!

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Ianr Awards Luncheon: Dinsdale Family Faculty Awards, John Owens Jan 2007

Ianr Awards Luncheon: Dinsdale Family Faculty Awards, John Owens

John Owens: Speeches and Appearances

What a pleasure it is to come together here to recognize and celebrate outstanding work of members of our IANR community.

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Gudmundsen Sandhills Laboratory Open House, John Owens Jan 2007

Gudmundsen Sandhills Laboratory Open House, John Owens

John Owens: Speeches and Appearances

Please let me also extend a welcome to everyone attending today's Gudmundsen Sandhills Laboratory open house. It is wonderful to see you here, and it is great to be back. I know this is going to be a good, informative day, and I thank each and every member of our Institute of Agriculture and Natural Resources' community who has worked to make this open house a success. I have a special thank you for today's co-sponsors and exhibitors who are providing such useful information. And a sincere thank you to each of you attending today's open house. You’re the reason …

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Panhandle Research And Extension Center Feedlot Dedication Ceremony, John Owens Jan 2007

Panhandle Research And Extension Center Feedlot Dedication Ceremony, John Owens

John Owens: Speeches and Appearances

It is my very great privilege and pleasure to have this opportunity to welcome you to today's dedication. We look forward with great anticipation to the exciting, important research to enhance cattle feeding profitability this feedlot will provide. Approximately 34 percent of Panhandle agriculture's economic impact - about $350 million yearly - comes from cattle finishing.

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