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Amino Acids And N-Acetyl-Aspartyl-Glutamate As Neurotransmitter Candidates In The Monkey Retinogeniculate Pathways, Ricardo A. Molinar-Rode
Amino Acids And N-Acetyl-Aspartyl-Glutamate As Neurotransmitter Candidates In The Monkey Retinogeniculate Pathways, Ricardo A. Molinar-Rode
Dissertations, Theses, and Capstone Projects
The lateral geniculate nucleus (LGNd) receives chemically identified inputs from brain stem structures, the thalamus and visual cortex. The identity of the neurotransmitter(s) in the retinal input, however, is unknown.
To investigate the possibility that some amino acids and certain dipeptides, such as N-acetyl-aspartyl-glutamate (NAAG), fulfill this function, changes in their concentration were measured in the optic tract, parvocellular and magno-cellular segments of the LGNd, superior colliculus and visual cortex of six monkeys (Macaca fascicularis), seven days after right optic tractotomy. The LGNd was studied also in two additional macaques, three months after occipital lobectomy. Tissue was frozen within five …