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The Effects Of Adjacent Cell Fusion And Ultraviolet Radiation Exposure On Viral Plaque Formation With Herpes Simplex Virus Type I, Rebecca Conner
The Effects Of Adjacent Cell Fusion And Ultraviolet Radiation Exposure On Viral Plaque Formation With Herpes Simplex Virus Type I, Rebecca Conner
Masters Theses & Specialist Projects
In mammalian cell-virus systems, it has been observed that damage caused by exposure of the cell to ultraviolet radiation (UV) will result in an increase in viral plaque development rate. This phenomenon is termed the Large Plaque Effect (LPE). Apparently, viral plaque development increases at a faster rate for Herpes Simplex Virus (HSV) when it is assayed on certain UV-irradiated mammalian cells. The consequence of this increase in plaque development rate is that viral plaques appear larger on irradiated monolayers of cells when compared to plaques that developed on unirradiated cellular monolayers.
The cause of the LPE is not yet …