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Changes In Myosin And Myosin Light Chain Kinase During Myogenesis, Stylianos P. Scordilis, J. Maurice Miles, Robert S. Adelstein, B. William Uhlendorf, Sigfrido Scarpa, Giulio L. Cantoni
Changes In Myosin And Myosin Light Chain Kinase During Myogenesis, Stylianos P. Scordilis, J. Maurice Miles, Robert S. Adelstein, B. William Uhlendorf, Sigfrido Scarpa, Giulio L. Cantoni
Biological Sciences: Faculty Publications
Myosins and myosin light chain kinases have been isolated from a cloned line of myoblasts (L5/A10) as this cell line undergoes differentiation toward adult muscle. At least three myosin isozymes were obtained during this developmental process. Initially a nonmuscle type of myosin was found in the myoblasts. The molecular weights of the myoblast light chains were 20 000 and 15 000. Myosin isolated from early myotubes had light chains with molecular weights of 20 000 and 19 500. Myosin isolated from myotubes which contained sarcomeres had light chains with molecular weights of 23 000, 18 500, and 16000. This last …