Life Sciences Commons^™

Acute Onset Of Bulbar And Ocular Paralysis: An Isolated Case, With Differential Diagnosis, Aziz Aghdassi, Robert D. Teasdall

Henry Ford Hospital Medical Journal

The diagnosis of botulism should be considered in all patients with the acute onset of cholinergic dysfunction and muscle weakness. The pupils are usually dilated, paralysis of ocular and bulbar muscles invariably occurs along with weakness of limb and axial muscles. This diagnosis is supported by the presence of a neuromuscular block and confirmed by the detection of toxin. Although the clinical presentation in this patient supported this diagnosis and a neuromuscular defect was present, no botulinum toxin was found. Not until Clostridium botulinum, type B organisms were cultured was the diagnosis of "probable botulism" made in this patient. Myasthenia …

Salicylate Effect On Platelets And Vascular Thrombosis In Rheumatoid Arthritis, Gilbert B. Bluhm, Jeanne M. Riddle, Donald G. Pica, Gordon D. Langejans

Henry Ford Hospital Medical Journal

Platelet surface activation was surveyed by electron microscopy (EM) in 40 patients with classical rheumatoid arthritis (RA) without clinical evidence of recent intravascular coagulation. Increased platelet surface activity (PSA) was noted in 8 of 25 females and 8 of 15 males (16 of 40 or 40%). Abnormal PSA failed to correlate with either the presence of rheumatoid nodules or the titer of rheumatoid factor. Hyperactive platelet populations, however, did tend to correlate with a serum urate level above 5 mg% (7 of 12 vs 9 of 28). Neither "low" nor "anti-inflammatory" levels of serum salicylate appear to afford protection from …

Quinidine-Induced Hepatitis And Thrombocytopenia, Mohsin Alam, Wolf F. C. Duvernoy, Sol D. Pickard, Paul L. Aronsohn

Henry Ford Hospital Medical Journal

Quindlne-induced hepatitis has received more attention only recently whereas quinidine-induced thrombocytopenia is well recognized. Over the past two years the authors saw four patients with quinidine-hepatitis accompanied by malaise, anorexia, fever in two patients and marked elevation of liver enzymes in all. Two patients had associated quinidine-induced thrombocytopenia of 81,000 and 6,600 platelets / cu mm, respectively. Liver biopsy in two patients revealed small foci of hepatocellular necrosis, Kupffer cell hyperplasia and Kupffer cells containing lipochrome. In one patient noncaseous granulomatous lesions were seen. Symptoms subsided and laboratory tests returned to normal rapidly on withdrawal of quinidine. In one patient, …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Uses Of Biofeedback: A Review Of Recent Research, Richard M. Lee, Scott E. Baldwin, Julia A. Lee

Henry Ford Hospital Medical Journal

Biofeedback refers to a special type of operant conditioning (ie, a category of learning) in which subjects acquire control over physiological processes through the feedback of information. Its methodology is based upon principles of behavioral science developed in the laboratory through experimentation. It has been conclusively demonstrated that humans (and other animals) can learn to control such actions as EKG parameters, blood pressure, body temperature, EEG, individual motor units, and glandular secretions. Clinically, biofeedback has been applied to a wide variety of psycho-physiologic disorders in which a measurable response requires alteration. The best established applications are tension and migraine headaches, …

Ultrasonic Versus Hand Filing Of The Human Root Canal System, Howard W. Scholz Jr.

Loma Linda University Electronic Theses, Dissertations & Projects

A comparison was made of ultrasonic filing versus hand filing using three solutions to flood the canals of 24 extracted human maxillary central incisors. A modified PR-30 Cavitron insert was used in a Cavitron 1010 unit for the ultrasonic filing. The clinical crown was removed with a diamond saw and water spray at the cemento-enamel junction. The two major groups were ultrasonic filing versus hand filing; the three subgroups were solution/solvents - 10% EDTA, 2.0% NaOCl, and distilled water.

After filing, the roots were grooved longitudinally with a high speed bur and cracked opened with a mallet and chisel. The …

The Effect Of Endodontic Therapy On The Incidence Of Radiation Caries In Dogs, James A. Abbott

Loma Linda University Electronic Theses, Dissertations & Projects

Endodontic therapy was evaluated as a possible control or prevention modality of radiation type dental caries in dogs. Two adult male dogs with permanent dentitions had endodontic therapy performed on alternating teeth in each jaw. The nontreated teeth served as controls.

The dogs were irradiated with 7000 rad Cobalt-60 radiation fractionated over an eight week period. The dogs were killed at 60 and 182 days post-irradiation. The teeth were removed from the jaws and immersed in methylene blue dye, sectioned, and the dye penetration pattern photographed. Diffusion of the dye into the tooth structure was quantified and statistically analyzed.

A …

Human Placental Alkaline Phosphatase And Steroid Metabolism By Rat Adrenals, Allen G. Meier

Loma Linda University Electronic Theses, Dissertations & Projects

Human placental alkaline phosphatase was purified by butanol extraction, methanol precipitation and chromatography on DEAE-cellulose. The pH optimum was found to be 10.9. The enzyme was competitively inhibited by di-ethyl-p-nitrobenzyl-phosphonate and copper sulfate. An increase in enzymatic activity occurred in the presence of the phosphate ion (HPO₄) and ATP.

The enzyme was crystallized from a 40% saturated solution of ammonium sulfate and shown to be homogeneous by sedimentation analysis. Homogeneity of the enzyme was also demonstrated using poly-acrylamide-gel-electrophoresis. At a pH of 7.5% the electrophoretic pattern yielded a single band and showed no significant contamination.

The metabolic transformation …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Technetium Pyrophosphate Myocardial Scanning In Acute Myocardial Infarction, Arunkumar N. Mehta, Sidney Goldstein, Daniel S. Marks, Albert Kasenter, William R. Eyler

Henry Ford Hospital Medical Journal

Technetium 99m pyrophosphate (99mTCPyP) accumulates in recently infarcted myocardium and can be detected by external imaging techniques. This study was performed to evaluate the ability of this isotope to identify the presence of acute myocardial infarction. In 82 patients admitted to a coronary care unit with chest pain of varying etiology, scan was positive in all 13 patients with acute transmural myocardial infarction and in 23 of 27 patients with nontransmural myocardial infarction. The scan was negative in 37 of 42 patients without evidence of recent infarction. Four of the remaining five patients in this group had unstable angina pectoris. …

Intraoperative Transanal Fiberoptic Colonoscopy: Report Of Six Cases, Thomas A. Fox Jr., Peter A. Haas

Henry Ford Hospital Medical Journal

Intraoperative transanal fiberoptic colonoscopy is presented as an alternative to transcolonic procedures to remove colonic polyps, or to excise or biopsy other intraluminal lesions. This method should be considered when the standard transanal colonoscopy has failed. The results with this procedure have been excellent. The method also can be applied to patients who have colonic lesions and are to undergo elective procedures such as hysterectomy and cholecystectomy.

The Clinical Variations Of Hereditary Spastic Paraplegia In Four Families, Davood M. Danadoost, Charles E. Jackson, Robert D. Teasdall

Henry Ford Hospital Medical Journal

Hereditary spastic paraplegia was diagnosed in 19 patients belonging to four families. All had spastic gait and upper motor neuron signs in lower limbs. In family A, the disease was expressed in this manner, although one member had muscle wasting in an upper limb. There was additional involvement of the posterior columns in six of the eight affected members of family B and cerebellar ataxia was noted in upper limbs of three of them. Posterior columns were also involved in three of the four affected members of family C. The disease was transmitted in these three families by an autosomal …

Painless Dissecting Aneurysm Of The Thoracic Aorta: Report Of Eight Cases Masquerading As Gross Aortic Insufficiency, Severe Hypertension, Myocardial Infarction And Mediastinal Enlargement., Remigio Garcia, Peter Torbey, Daniel T. Anbe, Ellet H. Drake

Henry Ford Hospital Medical Journal

In a review of 68 patients with dissecting thoracic aorta aneurysm (DTAA), eight patients (11.7%) were found to have painless dissection. Three of the eight patients presented with gross aortic insufficiency (Al). Angiography on a fourth patient, who had severe hypertension, showed Type III DTAA. Three other patients had either dilatation of the ascending aorta or a possible mediastinal mass, according to chest roentgenograms. One patient received treatment for suspected myocardial infarction with cardiogenic shock. A high index of suspicion in patients with unexplained Al, severe hypertension and a mediastinal mass or dilatation of the ascending aorta, coupled with the …

Research Seminar — May 5,1977 — At Henry Ford Hospital

Henry Ford Hospital Medical Journal

No abstract provided.

Early Vagotomies At Henry Ford Hospital: An Historical Vignette And A Follow-Up, James C. Gruenberg, Conrad R. Lam

Henry Ford Hospital Medical Journal

Over a one-year period beginning in April, 1946, nine transthoracic vagotomies were done at the Henry Ford Hospital. Three of the patients had had a partial gastrectomy previously and the operation was done for recurrent bleeding from marginal ulcers. Thirty years later, an attempt was made to ascertain the present condition of these patients. Long term follow-ups were possible on six patients and follow-ups of one, six and 14 years on the others. All nine patients had immediate relief of ulcer pain and cessation of bleeding if present. No subsequent drainage operation was required for the six patients with primary …

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Apical Closure Induction Using Bone Growth Factors And Mineral Trioxide Aggregate, Kenneth W. Tittle

Loma Linda University Electronic Theses, Dissertations & Projects

This study compared the ability of three different bone growth factor combinations with that of Ca(OH)₂ to stimulate apical closure as well as the effectiveness of Mineral Trioxide Aggregate (MTA) as an apical barrier. Fifty-six roots of second and fourth mandibular premolars of seven six- month old beagle dogs were used. Periradicular lesions were created over a four week period. The canals were cleaned and shaped and filled with Ca(OH)₂ for one week. They were then irrigated and received one of seven different treatments in a balanced design. Growth factors were placed in a carboxymethylcellulose carrier and delivered …

Analysis Of The Carbon-13 And Proton Nmr Spectra Of Bovine Chromaffin Granules, Edward P. Richards, Robert R. Sharp

Journal Articles

Natural abundance carbon-13 and proton NMR spectra of bovine chromaffin granules have been obtained and analyzed using computer simulation techniques. High resolution spectra show the presence of a fluid aqueous phase containing epinephrine, ATP and a random coil protein. The protein spectrum conrains unusually intense resonances due to glutamic acid and proline and has been simulated satisfactorily using the known amino acid composition of chromogranin A.

The lipid phase of chromaffin granules gives rise to intense, but very broad, resonances in the carbon-13 spectrum. Protons in the lipid phase are also observable as a very rapid component of the proton-free …

Dickey-Lincoln School Lakes Project Environmental Impact Statement: Appendix E: Aquatic Ecosystem And Fisheries Studies, Christoipher J. Schmitt, James R. Beltz, Normandeau Associates, Inc., New England Division, United States Army Engineer Division

Dickey-Lincoln School Lakes Project

Throughout this report, the following naming conventions will be used: the study area is the region of the Saint John River from Fort Kent to Ninemile Bridge and the drainage areas of all Saint John tributaries between Lincoln School and Ninemile Bridge within the United States, excluding the Allagash River drainage; the Dickey Lake Area is that region which would be inundated by the proposed Dickey Dam and the drainage areas of all rivers and streams (excluding the Saint John River) flowing into that proposed reservoir; the Lincoln School Reservoir area is that region which would be inundated by the …

Dickey-Lincoln School Lakes Project Environmental Impact Statement: Appendix C: Social And Economic Assessment, Edward C. Jordan, Roger Creighton

Dickey-Lincoln School Lakes Project

The purpose of this assessment of the social and economic impact of implementing the Dickey-Lincoln School Lakes Project, therefore, is not to flatly predict impacts. Rather, the intent is to provide information and judgments which can help people recognize the potential for changes and take appropriate steps to prepare for, accommodate, and adjust to those changes. Thus we hope that this report's success will be measured by how well it provides information with which local citizens and all others involved in this project can proceed with their planning and decision-making processes.

The Philosophy Of Drenching Sheep In Western Australia, G C De Chaneet

Journal of the Department of Agriculture, Western Australia, Series 4

Sheep of all classes are drenched more or less regularly throughout the agricultural areas of Western Australia.

Much of the drench is wasted because it is used in the wrong circumstances. This situation is probably a result of poor understanding of drenching.

This article discusses the philosophy of drenching and attempts to relate this to the epidemiology of parasitism as it is currently understood.

Molecular Mobilities Of Soluble Components In The Aqueous Phase Of Chromaffin Granules, Edward P. Richards, Robert R. Sharp

Journal Articles

NMR relaxation times have been used to characterize molecular motion and intermolecular complexes in the aqueous phase of bovine chromaffin granules. Partially relaxed '3C and proton spectra have been obtained at 3 and 25°C. T1 measurements of five protonated carbons on epinephrine (C:, Cs, C6, CHOH and NCH3) give a correlation time of 0.15 (10 -9) s at 25°C for the catechol ring and methine carbon, while the effective correlation time for the NCH3 group is somewhat shorter due to its internal degree of rotational freedom. Resonances of protonated carbons on the soluble protein chromogranin give very similar correlation times: …

The Biochemistry Of Vascular Smooth Muscle In The Spontaneously Hypertensive Rat, John Edward Taylor

University of the Pacific Theses and Dissertations

Cyclic adenosine 3’,5’-monophosphate (cAMP) was first described as the mediator of the glycogenolytic effect of epinephrine and glucagon in the liver almost two decades ago. It has since been found that cAMP may mediate the effects of a number of hormones and neurohormones, and this observation has led to the development of the second messenger hypothesis of hormone action. According to the second messenger theory, the hormone or first messenger brings information to the cell, whereas, the second messenger (cAMP) transfers this information into intracellular events. More recent evidence has described the existence of an additional second messenger, cyclic guanosine …

Ryegrass Disease Could Spread, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

The disease annual ryegrass toxicity kills sheep and cattle grazing pastures which contain infected annual ryegrass. In Western Australia the first confirmed outbreak was in 1968 in the Gnowangerup area.

The disease has noe spread over a range of 450 kilometres and with a total area of perhaps 100 000 hectares. because annual ryegrass is the major sown pasture grass in W.A. the disease could spread throughout the South-West.

There are some precautions that can be taken.

A Biosystematic Investigation Of Medically Important Yeasts, Nancy Christiansen Ballot

University of the Pacific Theses and Dissertations

The purpose of this study is twofold: (1) conduct an epidemiological survey of yeasts found in clinical material; and (2) suggest an identification scheme that would identify yeasts of medical importance in the shortest possible time.

Recent Research On Cattle Worms : Research Round-Up, F C. Wilkinson, G. De Chaneet

Journal of the Department of Agriculture, Western Australia, Series 4

Summary of research carried out on cattle worms.

Some Basics Of Marron Production, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

marron are native to the South-West of Western Australia, and are keenly sought by inland fisher-men. However, supplies do not equal the apparent demand.

One solution is to cultivate marron in farm dams, or more intensively as a commercial enterprise.

This article suggests a few guidelines for marron production.

Studies On The Grooming Behavior And Morphology Of The Freshwater Prawn, Palaemonetes Kadiakensis, Bruce E. Felgenhauer

Masters Theses

No abstract provided.

Duck Plague Virus An Investigation Of Cytopathic Effects, In-Vitro Host Range, And Inhibition By Phosphonoacetic Acid, Ronald Attanasio

Biological Sciences Theses & Dissertations

Duck plague is a hemorrhagic, necrotic disease found exclusively in the order Anseriformes, family Anatidae (ducks, geese, swans). The etiologic agent has been reported to be a herpes-like virus. The Holland strain of duck plague was found to induce cytopathic effects in cell culture (perinuclear vacuolation followed by lysis). A simple reproducible plaque assay for quantitating the virus was developed. Under conditions of the plaque assay, one-hit kinetics were observed. The host range of duck plague virus in cell culture was found to include the order Galliformes, family Phasianidae (pheasants, quails and partridges). Duck plague virus-induced cell culture cytopathic effects …

Lumpy Wool May Increase By Dipping : Research Roundup, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

Lumpy wool, or mycotic dermatitis, is an infectious disease on the skin of the sheep caused by the bacterium Dermatophilus conglensis. The organism invades the wool and hair follicles, causing formation of skin lesions producing scabby material which binds the wool fibres into a hard mass.

Research shows that 'dipping' may increase the incidence of lumpy wool with some chemicals a greater risk than others.