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Articles 31 - 60 of 1535
Full-Text Articles in Life Sciences
Antidiabetic Study And Teratogenicity Evaluation Of Ethanolic Extract Of Chromolaena Odorata Linn., Indah Solihah, Yuni Fitriani, Meutia Reni Noprida, Herlina, Riana Sari Puspita Rasyid, Tri Suciati
Antidiabetic Study And Teratogenicity Evaluation Of Ethanolic Extract Of Chromolaena Odorata Linn., Indah Solihah, Yuni Fitriani, Meutia Reni Noprida, Herlina, Riana Sari Puspita Rasyid, Tri Suciati
The Thai Journal of Pharmaceutical Sciences
There is considerable interest in herbal medicine in developing antidiabetic alternative therapy based on plant-derived compounds that would reduce oral hypoglycemic agent-related adverse effects while staying safe during pregnancy. The purpose of this in vivo study was to evaluate the ethanolic extract of Chromolaena odorata L. leaves (ECOL) in alloxan-induced diabetes and its teratogenic effect. The hypoglycemic impact of ECOL increased when the extract dose was raised. Three doses of ECOL (125, 250, and 500 mg/kg body weight) showed a 27.29%, 34.68%, and 52.24% hypoglycemic effect, respectively. While, the standard insulin (1 IU/kg BW) group shown a 31.38% hypoglycemic effect …
Synthesis And In Silico Study Of New Azetidinones Against Non-Small Cell Lung Cancer By Egfr Inhibition, Jainey P. James, T. C. Aiswarya, Swetha P. Shenoy, Vinod Devaraji
Synthesis And In Silico Study Of New Azetidinones Against Non-Small Cell Lung Cancer By Egfr Inhibition, Jainey P. James, T. C. Aiswarya, Swetha P. Shenoy, Vinod Devaraji
The Thai Journal of Pharmaceutical Sciences
Background: Lung cancer is alarmingly increasing and therapies targeting receptors such as human epidermal growth factor have been found to be emerging in treating lung cancer. Many studies report azetidinone bearing compounds to be cytotoxic. This work aims to prove the anti-lung cancer action of synthesized azetidinones that are through epidermal growth factor receptor (EGFR) inhibition. Materials and Methods: Novel azetidinone derivatives were synthesized from Schiff bases; molecular docking analyzed the interactions with EGFR, and pharmacophore modeling revealed the features responsible for the possible interactions. Moreover, the compounds with good docking scores were selected for anti-lung cancer study by MTT …
Impact Of A Digital Educational Program On The Health Literacy And Perceived Drug Teratogenic Risk Of Diabetic Pregnant Women Attending A Malaysian Teaching Hospital, Sami Al-Shakhshir, Syed Azhar Sulaiman, Mohd Pazudin Ismail, Mahmoud S. Alhaddad, Yaser Mohammed Al-Worafi, Islam M. Ashram
Impact Of A Digital Educational Program On The Health Literacy And Perceived Drug Teratogenic Risk Of Diabetic Pregnant Women Attending A Malaysian Teaching Hospital, Sami Al-Shakhshir, Syed Azhar Sulaiman, Mohd Pazudin Ismail, Mahmoud S. Alhaddad, Yaser Mohammed Al-Worafi, Islam M. Ashram
The Thai Journal of Pharmaceutical Sciences
ABSTRACTObjectives: The study aimed to identify the impact of clinical pharmacist’s digital educational program on health literacy and drug teratogenicity risk among Malaysian diabetic pregnant women. Methods: A quasi-experimental study was undertaken at the antenatal clinic at Universiti Sains Malaysia Hospital (HUSM) in Malaysia. The study was carried out with 138 diabetic pregnant women who were conveniently interviewed to measure their health literacy and teratogenic risk perceptions before and after educational program which was conducted using WhatsApp application. Descriptive and inferential analyses were performed using SPSS version 22. P-values of less than 0.05 were considered significant. Results: Most participants had …
Citrus Aurantium Peels Secondary Metabolites Prevents Cell Senescence On Human Fibroblasts Cells By In Vitro And Bioinformatics Studies, Nur Dina Amalina, Sri Wahyuni, Harjito H, Meiny Suzery, Bambang Cahyono
Citrus Aurantium Peels Secondary Metabolites Prevents Cell Senescence On Human Fibroblasts Cells By In Vitro And Bioinformatics Studies, Nur Dina Amalina, Sri Wahyuni, Harjito H, Meiny Suzery, Bambang Cahyono
The Thai Journal of Pharmaceutical Sciences
Aging is a medical problem affecting about 800 million people worldwide. However, the molecular mechanism of aging and aging-related disease has not yet been explored. Skin aging is a complex biological process primarily due to cellular senescence. Cellular senescence is an irreversible growth arrest that caused tissue to lose their cell-specific functionality, secreting pro-tumorigenic and pro-inflammatory cytokines, which eventually causes cancer. Citrus aurantium-derived secondary metabolites, including hesperidin, hesperetin, tangeretin, naringenin, nobiletin, and quercetin, are of vital importance to inhibiting aging due to their active properties. However, the effect of C. aurantium-derived secondary metabolites on the cells senescence and its molecular …
Synthesis, Docking Studies, Admet Prediction, And Antimicrobial Evaluation Of Coumarin-Oxadiazole Hybrids, Fabin Asmath Maziyuna, Abhishek Kumar, Pankaj Kumar
Synthesis, Docking Studies, Admet Prediction, And Antimicrobial Evaluation Of Coumarin-Oxadiazole Hybrids, Fabin Asmath Maziyuna, Abhishek Kumar, Pankaj Kumar
The Thai Journal of Pharmaceutical Sciences
The overuse and misuse of marketed antimicrobial agents developed drug resistance, which has become a significant problem worldwide. A series of new coumarinyl-oxadiazole Schiff base derivatives were designed and synthesized. These synthesized molecules synthesis of coumarinyl-oxadiazole schiff base derivatives (FP1-FP7) were characterized using Infrared spectroscopy, proton nuclear magnetic spectroscopy, and mass spectroscopy and evaluated for their antibacterial potential against Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strain by measuring minimum inhibitory concentration values. Among the synthesized compounds, FP6 was found to be the best antibacterial agent having concentration values of 3.12 and 6.25 μg/ml against …
The Synergistic Antitumor Effects Of Curcuma Longa And Phyllanthus Niruri Extracts On Promoting Apoptotic Pathways In Breast Cancer Stem Cells, Dedy Hermansyah, Delfitri Munir, Aznan Lelo, Agung Putra, Nur Dina Amalina, Iffan Alif
The Synergistic Antitumor Effects Of Curcuma Longa And Phyllanthus Niruri Extracts On Promoting Apoptotic Pathways In Breast Cancer Stem Cells, Dedy Hermansyah, Delfitri Munir, Aznan Lelo, Agung Putra, Nur Dina Amalina, Iffan Alif
The Thai Journal of Pharmaceutical Sciences
Breast cancer stem cells (BCSCs) develop apoptosis resistance by expressing pro- and anti-apoptotic protein including caspase-3, p53, and survivin. However, the induction of apoptosis is an important mechanism of action for many anticancer agents. Therefore, treatment using combination therapy was supposed to inhibit apoptosis resistance and increase the possibility of cancer apoptosis. This study aimed to investigate the effects of the combination Curcuma longa (CL) and Phyllanthus niruri (PN) extract on apoptosis induction. The single and combination cytotoxicity was analyzed using MTT assay. Apoptosis was measured by Annexin V-Propidium Iodide under flow cytometry. Caspase 3 expression was assessed by flow …
Carbon Dots: An Updated Overview On Their Synthesis, Properties, And Applications In Pharmaceutical And Biomedical Sciences, Earle Radha Rani, Majji Usharani, A. Lakshmi Usha
Carbon Dots: An Updated Overview On Their Synthesis, Properties, And Applications In Pharmaceutical And Biomedical Sciences, Earle Radha Rani, Majji Usharani, A. Lakshmi Usha
The Thai Journal of Pharmaceutical Sciences
Nowadays, carbon-based materials have acquired more attention in numerous fields including engineering, medicine, and pharmaceutics. As a new class of small carbon nanomaterials, carbon dots are developed due to their excellent physicochemical properties such as spherical shape, non-toxicity, cost effectiveness, facile, biocompatibility, and discrete particles <10 nm in diameter. In 2004, these carbon dots were first discovered accidentally during processing of single walled carbon nanotubes. Carbon dots have created huge excitement due to their advantages such as high water solubility, excellent biocompatibility, and resistance to photo bleaching. Carbon dots show unique properties such as photo stability, low toxicity, fluorescence, photo chemiluminescence, and electrochemiluminescence. Due to these properties, they have a wide range of applications in the field of bioimaging and drug delivery. Carbon dots are classified into two groups: Amorphous based carbon dots and graphene-based quantum dots with sp2 hybridization. The synthesis methods of carbon dots were reviewed along with their advantages and disadvantages. The applications of carbon dots in drug delivery, gene delivery, targeted drug delivery, crossing blood–brain barrier, and bio imaging were discussed.
Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery, Bhavin R. Choradiya, Sanjay B. Patil
Design, Development, And Characterization Of Brinzolamide And Brimonidine Tartrate Nanoemulsion For Ophthalmic Drug Delivery, Bhavin R. Choradiya, Sanjay B. Patil
The Thai Journal of Pharmaceutical Sciences
Aim: The current investigation work sums up the enumerating improvement and depiction of brinzolamide and brimonidine tartrate ophthalmic nanoemulsion giving widened helpful effect and improved visual penetration for treating glaucoma. Methodology: Nanoemulsion was formulated using polysorbate 80, castor oil and glycerol using the continuous emulsification technique. Preliminary batches were screened subject to in vitro medication release, globule size, zeta potential, and stability with regards to accelerated and long time. Nanoemulsions were evaluated for ex vivo optical irritancy using the hen’s egg chorioallantois membrane test model. Results: Screened nanoemulsion batches showed a low mean globule width (<220 nm), higher penetrability (>75%) in comparison with …
A New Antidiabetic Polyherbal Formulation For Diabetes, Sadish Kumar Shanmugam, Praveen Kumar Gaur, Deepak Kumar
A New Antidiabetic Polyherbal Formulation For Diabetes, Sadish Kumar Shanmugam, Praveen Kumar Gaur, Deepak Kumar
The Thai Journal of Pharmaceutical Sciences
Background: Synergism is a well-known concept in Herbal therapies. Polyherbal aqueous extract (PH-AE) containing Gymnema sylvestre (GS), Momordica charantia, Syzygium cumini, and Mangifera indica was evaluated for Antidiabetic activity. Objective: In our continuous research, an attempt has been made to explore GS aqueous extract (GS-AE) and its Polyherbal composite for diabetes to achieve greater efficacy. Methods: The antidiabetic activity was assessed in Streptozotocin induced diabetic rats and histopathological changes in Pancreas were documented after screening acute toxicity of both extracts. Results: Chromatographic separation and identification of GS-AE revealed the presence of Saponins and glycosides, which have also been confirmed in …
Diversity And Lipolytic Activity Of Lactic Acid Bacteria Isolated From Fermented Foods And Plant Materials In Thailand, Sujitra Techo, Nattakorn Kuncharoen, Somboon Tanasupawat
Diversity And Lipolytic Activity Of Lactic Acid Bacteria Isolated From Fermented Foods And Plant Materials In Thailand, Sujitra Techo, Nattakorn Kuncharoen, Somboon Tanasupawat
The Thai Journal of Pharmaceutical Sciences
Lactic acid bacteria (LAB) originated from fermented foods, are generally known to possess the lipolytic activity which provides the desirable flavor of the products. However, the researches on their lipolytic activity are limited. Therefore, LAB with lipolytic activity derived from traditional fermented foods and plants in Thailand were isolated and identified based on the phenotypic characteristics and 16S rRNA gene sequences. The isolates were identified as Lactiplantibacillus pentosus (four isolates), Lactiplantibacillus plantarum (three isolates), Limosilactobacillus fermentum (four isolates), Enterococcus hirae (two isolates), and each isolate of Lactiplantibacillus paraplantarum, Companilactobacillus tucceti, Companilactobacillus farciminis, Lacticaseibacillus porcinae, Lactobacillus amylovorus, Pediococcus pentosaceus, and Enterococcus …
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit
Complexity Of Implementing Harm Reduction Services In Community Hospitals: A Two-Phase Qualitative Study, Kanittha Nimsakul, Puckwipa Suwannaprom, Siritree Suttajit
The Thai Journal of Pharmaceutical Sciences
Objective: Regardless of effective harm reduction services (HRS) in Thanyarak Hospital, difficulties exist while implementing them in community hospitals. This study aimed to investigate the complexities of HRS implementation in two community hospitals in Mae Hong Son. Methods: Phase 1, in-depth interviews were conducted with 21 participants to investigate the complexity of HRS dissemination. An interview guide was developed from the seven domains of the Non-adoption, Abandonment, Scale-up, Spread, and Sustainability framework, and thematic analysis was used. Phase 2 involved two rounds of a Delphi technique with 17 experts to evaluate the HRS’s complexity level (complex, complicated, simple). Results: Although …
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack
The Successful Treatment Of Brevundimonas Diminuta Using Ceftriaxone, In A Patient On Continuous Ambulatory Peritoneal Dialysis: A Case Report And Literature Review, Sukrit Kanchanasurakit, Natnicha Woranithipokin, Piyakamol Teeranaew, Natthawee Kaewrattanapatthama, Chotirat Nakaranurack
The Thai Journal of Pharmaceutical Sciences
Brevundimonas diminuta (B. diminuta) is found in the health-care environment and in the community. At present, there are few reports of infections caused by this microorganism, especially in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). A 44-year-old woman undergoing CAPD was diagnosed with a B. diminuta infection. Ceftriaxone was given both intravenously and intraperitoneally. After treatment with ceftriaxone, the peritoneal dialysis fluid white cell count, neutrophil count, and symptoms improved. To the best of our knowledge, this is the first case report of a B. diminuta infection in a patient had undergoing CAPD in Thailand
Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease, S. Lavanya, Netal Patel, Arnav Purani, Kajal Patel
Impact Of Clinical Pharmacist Intervention On Medication Adherence In Patients With Cardiovascular Disease, S. Lavanya, Netal Patel, Arnav Purani, Kajal Patel
The Thai Journal of Pharmaceutical Sciences
Background: Cardiovascular diseases (CVDs) are a category of heart and blood vessel disorders that include coronary disorders, cerebrovascular diseases, rheumatic pain, and other conditions. One of the major risk factors for CVDs is high blood pressure (BP). Furthermore, it is poorly managed due to a lack of understanding of hypertension, a lack of proper primary care, and a lack of follow-up. The patient education improves the patient’s response to the disease and its management and their quality of life. Objectives: The objectives of this study were to evaluate the effect of clinical pharmacist intervention by the provision of patient counseling, …
Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design, Tejal Gandhi, Vaidehi Patel, Saloni Dalwadi, Vaishali Thakkar
Development And Optimization Of Polyherbal Formulation For Antiurolithiatic Activity Using Box Behnken Statistical Design, Tejal Gandhi, Vaidehi Patel, Saloni Dalwadi, Vaishali Thakkar
The Thai Journal of Pharmaceutical Sciences
Background: The objective of the present investigation was to design and evaluate the antiurolithiatic activity of extract of Tribulus terrestris, Bryophyllum pinnatum, and Cyperus rotundus on ethylene glycol-induced urolithiasis in Wistar albino rats using Box Behnken Design. To induce urolithiasis, 0.75% w/v ethylene glycol was administered orally to the rats for 28 days. Cystone 750 mg/kg was selected as the reference standard as a preventive dose. On the 28th day, urine discharged in 24 h was collected and subjected for estimation of various biochemical parameters which were evaluated using urine, serum, and kidney homogenate. The kidneys were also sectioned and …
Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E, Idara Asuquo Okon, Justin Atiang Beshel, Daniel Udofia Owu
Antioxidant Status, Antihyperlipidemic Activity, And Serum Electrolyte Levels In Dexamethasone-Induced Oxidative Stress In Wistar Rats Treated With Vitamin E, Idara Asuquo Okon, Justin Atiang Beshel, Daniel Udofia Owu
The Thai Journal of Pharmaceutical Sciences
Objectives: Dexamethasone (Dex) is an anti-inflammatory drug with serious side effects. The aim of this study was to investigate, antioxidants status, antihyperlipidemic activity, and serum electrolyte levels of rats treated with Vitamin E in Dex-induced oxidative stress. Materials and Methods: Wistar rats of both sexes were assigned to four groups (n = 6). The control group was fed with standard rat feed and water, while Dex group received 30 μg/kg of Dex. Vitamin E group received 300 IU/kg of vitamin E, while Dex + Vitamin E group received 30 μg/kg of Dex and 300 IU/kg of vitamin E. After 14 …
Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini
Silymarin And Oral Cancer: A Review On Clinical And Analytical Reports, Ramya Jonnalagadda, C. Vinodhini
The Thai Journal of Pharmaceutical Sciences
Oral cancer is the sixth-largest kind globally of cancer and a major health issue in India as well and affects a large population that is very vulnerable to recurrences and a lower survival rate among all the other malignancies. Milk thistle is a phytochemical herb of interest that has been used as folk medicine since ancient times. Due to its potential benefits, the pharmaceutical industrial world is widely using silymarin (an active component of milk thistle) for commercial preparations. Knowing the quantity and identity of active components is of utmost importance. Therefore, robust, accurate, and precise analytical methods are needed …
Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya
Edible Mushrooms: An Emerging Therapeutic Of Diabetes, Nilanjan Chakraborty, Anuron Banerjee, Sudeshna Nandi, Swagata Sarkar, Krishnendu Acharya
The Thai Journal of Pharmaceutical Sciences
Diabetes is the third most customary non-infectious disease occurring worldwide and leads to untimely disability and mortality. This metabolic disorder is characterized by impaired insulin secretions and high blood glucose levels. Among others, type 2 diabetes is the most common. Various chemical and biochemical hypoglycemic drugs are utilized to control and treat hyperglycemia but required further interventions to reduce their toxicity and side effects on the users. Edible mushrooms have been employed from ancient times to heal many diseases as it composed of anti-oxidant, alkaloids, fibers, triterpenoids, and other phytochemicals. The bioactive secondary metabolites of mushrooms can improve insulin resistance …
Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue
Determination Of Sugars And Amino Acids In Japanese Wine Using Core–Shell Liquid Chromatography Tandem Electrochemical Detection, Kana Yoshimura, Aiko Sano, Ryuichiro Suzuki, Shun-Ichi Mitomo, Yukiko Negishi, Toshiki Mutai, Florencio Arce Jr, Gerard Lee See, Takashi Tanikawa, Yutaka Inoue
The Thai Journal of Pharmaceutical Sciences
In this study, sugars (glucose, fructose, and sucrose) and amino acids in plum and yuzu wines were quantified with a new and simple method involving an electrochemical detector (ECD) and core–shell column (S-30/70 = Styrene/divinylbenzene – 5 tetramethyldiaminohexane). Analysis was conducted under the following conditions: A column temperature (40°C), flow rate (0.3 mL/min), injection volume (20 μL), and mobile phase (0.1 mol/L NaOH). Glucose, fructose, and sucrose had retention times of 14.68 min, 16.22 min, and 19.29 min, respectively, when measured using an ECD. When the sugar content was compared among the plum wines, plum wine A had the lowest …
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
Hemogram Results And Renal Function Before And After Administration Of Black Cumin Seed Oil In Healthy Volunteers, Titiek Hidayati, Akrom Akrom, Sagiran Sagiran, Indrayanti Indrayanti
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur
Formulation, Characterization, And Pharmacokinetic Study Of Methoteraxate-Quercetin Loaded Nanoparticles, Gyanesh Kumar Sahu, Harish Sharma, Swarnali Das Paul, Ajazuddin, Chanchal Deep Kaur
The Thai Journal of Pharmaceutical Sciences
Objectives: Methotrexate (MTX) is a biopharmaceutics classification system Class IV drug having potential cytotoxic action against cancer cells. However, short half-life and poor bioavailability have limited its application. The object of this work was to entrap MTX and an herbal bioenhancer in a nanoparticle system to improve its bioavailability. Methods: We prepared the nanoparticles (NPs) by emulsion solvent evaporation method with Eudragit RLPO (ERLPO) polymer. Results: The result revealed good in vitro properties with 110 to 228 nm particle size range. The percentage of drugs released from all the batches in 72 h was within the range of 82.71 to …
Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats, Muflihah Rizkawati, Mae Sri Hartati Wahyuningsih, Setyo Purwono, Dwi Aris Agung Nugrahaningsih, Abdul Karim Zulkarnain
Subchronic Dermal Toxicity Study Of Tithonia Diversifolia (Hemsley) A. Gray Gel Formulation In Wistar Rats, Muflihah Rizkawati, Mae Sri Hartati Wahyuningsih, Setyo Purwono, Dwi Aris Agung Nugrahaningsih, Abdul Karim Zulkarnain
The Thai Journal of Pharmaceutical Sciences
Background: Tithonia diversifolia has been widely developed as an anticancer therapy. Our previous study before showed that T. diversifolia was able to inhibit cell proliferation and collagen accumulation of keloid fibroblasts and decrease the index of rabbit scar hypertrophy. The acute dermal toxicity study of T. diversifolia gel formulation did not show toxic effect for 14 days and the LD50 was estimated more than 2%. However, toxicity data subchronic dermal toxicity study was not available for this T. diversifolia gel formulation. Objectives: Our study aimed to evaluate the subchronic dermal toxicity of T. diversifolia gel formulation in rats. Materials and …
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone
Preparation And Stability Of Fluocinolone Acetonide Premicroemulsion Concentrates And Microemulsions For Oral Lichen Planus Treatment, W. Muangsiri, P. Chukaewrungroj, Pornpen Werawatganone
The Thai Journal of Pharmaceutical Sciences
Purpose: Fluocinolone acetonide (FA) preparations were developed in the forms of premicroemulsion concentrates and microemulsions and their stabilities were evaluated. Materials and Methods: A pseudoternary diagram of clove oil, surfactant mixture (containing polysorbate80: Polyethylene glycol 400 [PEG400] at the ratio of 2:1), and water was constructed for the formulation of FA premicroemulsion concentrates and microemulsions. Physical properties and chemical stabilities of the preparations were monitored in the absence and presence of three antioxidants. Their beyond-use dates were determined. Results and Discussion: The premicroemulsion concentrates and microemulsions containing polysorbate 80, PEG400, and clove oil successfully improved FA solubility. Average diameters of …
Neuroprotective And Nootropic Evaluation Of Myristica Malabarica On Diabetes-Induced Cognitive Impairment In Experimental Animals: Promising For Controlling The Risk Of Alzheimer’S Disease, Kolguri Jagadeeshwar, Rajasekhar Reddy Alavala, Subhakar Raju Ravula, Umasankar Kulandaivelu, G.S.N. Koteswara Rao
Neuroprotective And Nootropic Evaluation Of Myristica Malabarica On Diabetes-Induced Cognitive Impairment In Experimental Animals: Promising For Controlling The Risk Of Alzheimer’S Disease, Kolguri Jagadeeshwar, Rajasekhar Reddy Alavala, Subhakar Raju Ravula, Umasankar Kulandaivelu, G.S.N. Koteswara Rao
The Thai Journal of Pharmaceutical Sciences
This study intends to explore the neuroprotective and memory-enhancing properties of Myristica malabarica (MM) leaf extracts on diabetic-induced cognitive decline rats. The models of Y maze and Morris water maze were selected for nootropic activity and neuroprotective properties were deliberate by assessing the levels of Ach, malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), catalase (CAT) and glutathione hormone (GSH) in diabetic rat brains. Significantly improved memory and learning with 100 mg/kg (P < 0.01) and 200 mg/kg (P < 0.001) of EAMM (L) and MAMM (L) in Y maze and Morris water maze models. Significant effect was observed in all the extracts with two doses when compared with diabetic control on day 75. The levels of AChE (P < 0.001), MDA (P < 0.01), and NO (P < 0.05) were decreased significantly and significantly raised (P < 0.01) levels of SOD, CAT, and GSH with MAMM (100 and 200 mg/kg) compared with disease control. Further studies on MM leaf are needed as evidence of cognitive impairment in defense against diabetes has been shown to expose its mode of action.
Fluid Properties Of Solvents And Oils Used In In Situ Forming Microparticles, Sai Myo Thu Rein, Torsak Intaraphairot
Fluid Properties Of Solvents And Oils Used In In Situ Forming Microparticles, Sai Myo Thu Rein, Torsak Intaraphairot
The Thai Journal of Pharmaceutical Sciences
In situ forming microparticle (ISM) has been recently used as the injectable drug delivery system prepared from polymeric non-aqueous phase in oil emulsion. Solvents and oils used in ISM including N-methyl pyrrolidone (NMP), 2-pyrrolidone (PYR), dimethyl sulfoxide (DMSO), glycofurol, triacetin, olive oil, camellia oil and isopropyl myristate (IPM) were evaluated for pH, density, viscosity, flow time, surface tension, contact angle, color distribution, injectability, antimicrobial activities and cytotoxicity. The most viscous camellia oil and olive oil showed the highest flow time with lowest color diffusion and lower injectability; thus, they were suitable for performing as external phase of ISM to prolong …
Metabolite Profiling And Activity Study Of Ethanol Extract Of Chrysophyllum Cainito L. Leaves In Increasing Bone Density In Male Mice, Burhan Ma’Arif, Kurniawan Hidayat Perdana Putra, Miftah Saiful ‘Arifin, Rukiana, Reyhan Amiruddin, Weka Sidha Bhagawan, Arief Suryadinata, Fidia Rizkia Inayatilah, Roihatul Muti’Ah, Agnis Aditama
Metabolite Profiling And Activity Study Of Ethanol Extract Of Chrysophyllum Cainito L. Leaves In Increasing Bone Density In Male Mice, Burhan Ma’Arif, Kurniawan Hidayat Perdana Putra, Miftah Saiful ‘Arifin, Rukiana, Reyhan Amiruddin, Weka Sidha Bhagawan, Arief Suryadinata, Fidia Rizkia Inayatilah, Roihatul Muti’Ah, Agnis Aditama
The Thai Journal of Pharmaceutical Sciences
Phytoestrogen is a group compound which has an estrogen-like structure or function. One of its roles was in the bone formation. Chrysophyllum cainito L. is a plant that contains phytoestrogen. The purpose of this research is to determine the metabolite profile and activity of1ethanolpextract of C. cainitoxleaves to increase trabecular femur bone density in male mice. The metabolite profiling analysis was done using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry/mass spectrometry and analyzed using Masslynx 4.1 software. Four doses of ethanol extract of C. cainito leaves were prepared for treatment. Which are 2,14,48, and 316 mg/ body weight (BW) mice/day …
Inhibition Of Phospholipase A2 And Prostaglandin Synthase Activities As Possible Mechanistic Insight Into The Anti-Inflammatory Activity Of Brenania Brieyi Methanol And Chloroform Fractions, Ifeoma Felicia Chukwuma, Victor Onukwube Apeh, Florence Nkechi Nworah, Chinelo Chinenye Nkwocha, John Emaimo, Lawrence Uchenna Sunday Ezeanyika, Victor Nwadiogo
Inhibition Of Phospholipase A2 And Prostaglandin Synthase Activities As Possible Mechanistic Insight Into The Anti-Inflammatory Activity Of Brenania Brieyi Methanol And Chloroform Fractions, Ifeoma Felicia Chukwuma, Victor Onukwube Apeh, Florence Nkechi Nworah, Chinelo Chinenye Nkwocha, John Emaimo, Lawrence Uchenna Sunday Ezeanyika, Victor Nwadiogo
The Thai Journal of Pharmaceutical Sciences
Objectives: The pharmacological basis of anti-inflammatory agents is geared toward maintaining body homeostasis. This study investigated the scientific underpinning and mechanisms of anti-inflammatory activity of root bark of Brenania brieyi. Material and Methods: The plant material was extracted with a mixture of methanol and chloroform (2:1) and fractionated with 0.2 volume water. Egg albumin-induced edema and cotton pellet-induced granuloma models were used to investigate anti-inflammatory activity while the possible mechanisms of actions were evaluated using standard methods. Results: Significant (P < 0.05) reduction in edema and granuloma tissue formation were recorded in fractions treated groups compared with the normal control. There was a significant (P < 0.05) inhibition of membrane hemolysis and phospholipase A2 (PLA2) activity by the fractions compared with the standard drugs, indomethacin, and prednisolone, respectively. Both fractions significantly (P < 0.05) inhibited prostaglandin (PG) synthase and nitric oxide radical activities compared with the control. However, varying doses of both fractions did not inhibit leukocyte migration compared with rats in indomethacin and control groups. The methanol fraction was found to be more potent in most of the tests. Conclusion: These results show that B. brieyi root bark has anti-inflammatory activity, and the potential underlying mechanisms of its action are inhibition of PLA2 and PG involved in inflammatory responses.
Application Of Fluorotag In Quantification Of Metformin In Tablet Dosage Form And Biological Samples, Panikumar Durga Anumolu, Sunitha Gurrala, Sahitya Menkana, Ceema Mathew, Lavanya Srimantula
Application Of Fluorotag In Quantification Of Metformin In Tablet Dosage Form And Biological Samples, Panikumar Durga Anumolu, Sunitha Gurrala, Sahitya Menkana, Ceema Mathew, Lavanya Srimantula
The Thai Journal of Pharmaceutical Sciences
Background: New specific and sensitive spectrofluorimetric fluorotag method has been developed and validated for the quantification of metformin hydrochloride. Materials and Methods: The derivatization reaction was carried out using 1,2-naphthoquinone-4-sulfonic sulfonate as (NQS) fluorotag in the presence of strong alkaline medium (potassium hydroxide) to form the highly fluorescent product. The fluorescence was observed at emission wavelength 453 nm after excitation at 359 nm. The different experimental conditions affecting the reaction product formation and stability were carefully studied and optimized as 2% w/v of potassium hydroxide solution, 0.5% w/v NQS reagent. Results: At optimum reaction conditions, good linear relationship was found …
Preferences Of Thai Head Pharmacists For Pharmacy Technician Education: Certification Versus Bachelor’S Degree Program, Sukunta Muadthong, Nusaraporn Kessomboon, Tsutomu Kitajima, Kamolnut Muangyim, Surachat Ngorsuraches, Pattapong Kessomboon
Preferences Of Thai Head Pharmacists For Pharmacy Technician Education: Certification Versus Bachelor’S Degree Program, Sukunta Muadthong, Nusaraporn Kessomboon, Tsutomu Kitajima, Kamolnut Muangyim, Surachat Ngorsuraches, Pattapong Kessomboon
The Thai Journal of Pharmaceutical Sciences
Objective: This study aimed to investigate Thai hospital pharmacists’ preferences for a proposed bachelor’s degree curriculum for pharmacy technicians (PhTs), preparing PhTs to fill an advanced role in pharmacy, compared to the existing high vocational certificate (HVC) curriculum for PhTs. Methods: A labeled discrete choice experiment (DCE) questionnaire was sent by post to head pharmacists of 814 Thai Ministry of Public Health hospitals over a 2-month period. Respondents’ preferences for the proposed bachelor’s degree or the existing HVC of PhT were determined based on their selections among three attributes: Competency in pharmaceutical information services, competency in pharmaceutical inventory management, and …
Virgin Coconut Oil Ameliorates Arsenic Hepatorenal Toxicity And No-Mediated Inflammation Through Suppression Of Oxidative Stress In Rats, Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Arunaksharan Narayanankutty
Virgin Coconut Oil Ameliorates Arsenic Hepatorenal Toxicity And No-Mediated Inflammation Through Suppression Of Oxidative Stress In Rats, Ademola C. Famurewa, Ekenechukwu K. Maduagwuna, Chinyere Aloke, Sharon O. Azubuike-Osu, Arunaksharan Narayanankutty
The Thai Journal of Pharmaceutical Sciences
Background: Compelling evidence has implicated oxidative stress as a leading mechanism for arsenic (As)-induced pathologies. We evaluated antioxidant effect of virgin coconut oil (VCO) against arsenic-induced oxidative stress-mediated hepatorenal damage in rats. Methods: Rats were randomly divided into three groups: Control group, as group, and VCO + As group. VCO was orally administered before and along with arsenic (10 mg/kg body weight, orally) for 21 days. Subsequently, serum liver enzymes, albumin (ALB), creatinine, urea, antioxidant enzymes, malondialdehyde, and nitric oxide (NO) level were evaluated. The histology of the tissues was analyzed with standard procedures. Results: Arsenic caused marked increases in …
Screening Of Process Variables Using Box–Behnken Design In The Fabrication Of Berberine Hydrochloride-Loaded Transethosomes For Enhanced Transdermal Delivery, Koushlesh Kumar Mishra, Chanchal Deep Kaur
Screening Of Process Variables Using Box–Behnken Design In The Fabrication Of Berberine Hydrochloride-Loaded Transethosomes For Enhanced Transdermal Delivery, Koushlesh Kumar Mishra, Chanchal Deep Kaur
The Thai Journal of Pharmaceutical Sciences
Objective: The objective of the present work was to develop, optimize, and characterize berberine hydrochloride (BBN-HCl)-loaded transethosomes (TEs) for enhanced transdermal delivery. In this study, screening of formulation and process variables was conducted using Box–Behnken design approach to observe significant and insignificant influence on the TEs. Materials and Methods: The TEs was developed by homogenization technique (hot method). The optimized BBN-HCl-loaded TEs were evaluated for its vesicle size (VS), polydispersity index (PDI), zeta potential (ZP), loading capacity, and entrapment efficiency. Characterization was done by powder X-ray diffraction (P-XRD), differential scanning calorimetric (DSC), and transmission electron microscopy. Further, in vitro drug …