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Articles 151 - 180 of 1535
Full-Text Articles in Life Sciences
Formulation And Evaluation Of Fast Disintegrating Tablets Of Domperidone Using Chitosan-Glycine Conjugates As Superdisintegrant, Simran Kaur Zandu, Reena Kumari, Inderbir Singh
Formulation And Evaluation Of Fast Disintegrating Tablets Of Domperidone Using Chitosan-Glycine Conjugates As Superdisintegrant, Simran Kaur Zandu, Reena Kumari, Inderbir Singh
The Thai Journal of Pharmaceutical Sciences
Purpose: The present research was envisaged to employ chitosan-glycine conjugates as superdisintegrant for developing fast disintegrating tablets of domperidone. Materials and Methods: Chitosan-glycine conjugates were prepared by physical mixing and microwave-assisted technique. Micromeritic study, Fourier transform infrared, scanning electron microscopy, and X-ray diffraction methods were employed for characterizing the powdered conjugates. The formulated FDTs were evaluated for wetting time, water absorption ratio, disintegration time, in vitro drug release, and other tablet parametric tests. Results and Discussion: The effective pore radius of unadulterated chitosan was found to be 18.45±1.27 μm whereas the chitosan-glycine conjugates prepared by physical technique and microwave technique …
Development And Radiosynthesis Of A Novel Bifunctional Tri-Γ-Glutamic Acid Polypeptide For Gallium-68 Labeling, Wanchai Chongcharoen, Shuichi Shiratori
Development And Radiosynthesis Of A Novel Bifunctional Tri-Γ-Glutamic Acid Polypeptide For Gallium-68 Labeling, Wanchai Chongcharoen, Shuichi Shiratori
The Thai Journal of Pharmaceutical Sciences
Radiosynthesis of a novel bifunctional chelator for gallium-68 (Ga-68) chelation has been fabricated through peptide synthesis. Using of solid phase peptide synthesizer, linear structure of three repeating unit of glutamic acid was primarily generated. Protecting group of tert-butyl in intermediate was then cleaved and eventually yield as tri-γ-glutamic acid polypeptide (tri- γ-GAP). Mass spectrometry revealed m/z was 406.1378 that well corresponded with proposed structure of three repeating unit of glutamic acids. To label Ga-68 with synthesized tri-γ-GAP, the elution of 68GaCl3 was chelated to tri-γ-GAP with high temperature condition. It was subsequently purified through Sep-Pak C18 cartridge. Radio thin-layer chromatography …
Characterization Of Acyclovir-Isonicotinamide Cocrystal By Solvent Evaporation Method With Ethanol And Glacial Acetic Acid, Hansen Pradana Sutedjo, Agnes Nuniek Winantari, Roisah Nawatila
Characterization Of Acyclovir-Isonicotinamide Cocrystal By Solvent Evaporation Method With Ethanol And Glacial Acetic Acid, Hansen Pradana Sutedjo, Agnes Nuniek Winantari, Roisah Nawatila
The Thai Journal of Pharmaceutical Sciences
Background: Acyclovir is used as the first-line therapy for genital herpes simplex virus, but acyclovir has low solubility and bioavailability. Acyclovir has a water solubility of 2.5 mg/ml at 37°C and belongs to Class IV according to the bioavailability classification system. Cocrystalization is a technology that can be used to improve the solubility of materials by modifying the physical properties of materials, such as melting points, stability, mechanical properties, and polymorphisms of materials. Materials and Method: This study aims to prepare cocrystal of acyclovir with isonicotinamide as coformer using different solvents, namely, ethanol and glacial acetic acid by solvent evaporation …
Doxepin Accelerates The Healing Process Of Burn Wounds In Mice, Elham Saberzadeh, Mohsen Zabihi, Ehsan Motaghi, Fatemeh Shishehbor
Doxepin Accelerates The Healing Process Of Burn Wounds In Mice, Elham Saberzadeh, Mohsen Zabihi, Ehsan Motaghi, Fatemeh Shishehbor
The Thai Journal of Pharmaceutical Sciences
Wound healing following a skin burn is still a concern due to poor effectiveness and the side effects of the available topical and systemic drugs. Doxepin hydrochloride is an approved antidepressant drug (Application No.: 022036) which is effective for the treatment of moderate pruritus in patients with eczema and atopic dermatitis. The current study has evaluated the effect of topical and systemic doxepin to improve the histopathologic process of second-degree burn wound in mice. The mice were divided into six groups (n = 6), including topical normal saline group, topical glycerin group, positive control group (topical phenytoin), topical doxepin 5% …
In Silico Approach For Hepatoprotective Activity Of Piper Crocatum Leaf Toward Cytochrome P450 2e1 Protein, I. Nyoman Ehrich Lister, Chrismis Novalinda Ginting, Ermi Girsang, Wahyu Widowati, Ika Adhani Sholihah
In Silico Approach For Hepatoprotective Activity Of Piper Crocatum Leaf Toward Cytochrome P450 2e1 Protein, I. Nyoman Ehrich Lister, Chrismis Novalinda Ginting, Ermi Girsang, Wahyu Widowati, Ika Adhani Sholihah
The Thai Journal of Pharmaceutical Sciences
Liver plays important roles in metabolism of harmful xenobiotics. Prolonged exposure to chemicals, daily dietary supplements, or pharmaceutical drugs may cause liver damage or hepatotoxicity. Acetaminophen is a well-known pharmaceutical drug causing hepatotoxicity through generation of reactive metabolite called N-acetyl-p-benzoquinone imine through Cytochrome P450 2E1 (CYP2E1) metabolism. In the present study, we intended to predict the possible hepatoprotective properties of red betel (Piper crocatum) leaves. Quantitative structure activity relationship (QSAR) was used to predict the antioxidant and anti-inflammatory potential of major compounds of red betel, namely, eugenol, isoeugenol, chavibetol, hydroxychavicol, and allylpyrocatechol. Molecular docking was performed to analyze binding mode …
Comparative Evaluation Of The Hepatoprotective Activity Of Methanol Leaf Extracts Of Pterocarpus Santalinoides Dc Obtained By Cold Maceration And Soxhlet Extraction Techniques, Thelma Ebele Ihedioha, Isaac Uzoma Asuzu, Aruh Ottah Anaga, John Ikechukwu Ihedioha
Comparative Evaluation Of The Hepatoprotective Activity Of Methanol Leaf Extracts Of Pterocarpus Santalinoides Dc Obtained By Cold Maceration And Soxhlet Extraction Techniques, Thelma Ebele Ihedioha, Isaac Uzoma Asuzu, Aruh Ottah Anaga, John Ikechukwu Ihedioha
The Thai Journal of Pharmaceutical Sciences
Objectives: This study compared the hepatoprotective activity of Pterocarpus santalinoides cold maceration extract (PSCME) with P. santalinoides Soxhlet extract (PSSE). Materials and Methods: Phytochemical constituents of both extracts were determined. 45 albino rats, randomly assigned into 9 groups (1–9) of 5 rats each, were used for the study. Liver damage was induced in groups 1–8 using carbon tetrachloride (CCl4). Group 1 served as untreated control, Groups 2–7 were treated with 50, 250 or 500 mg/kg PSCME or PSSE, Group 8 was treated with 100 mg/kg silymarin, while Group 9 served as normal control. Treatment was done orally for 15 days. …
Teaching And Learning Of Smoking Cessation And Tobacco Control In The Pharmacy Program: A Cross-Sectional Survey Study, Pantira Parinyarux, Adinat Umnuaypornlert, Kornkaew Chanthapasa
Teaching And Learning Of Smoking Cessation And Tobacco Control In The Pharmacy Program: A Cross-Sectional Survey Study, Pantira Parinyarux, Adinat Umnuaypornlert, Kornkaew Chanthapasa
The Thai Journal of Pharmaceutical Sciences
Introduction: Pharmacists play an important role in smoking cessation programs. A lack of knowledge among pharmacy students can create a barrier to providing smoking cessation support. Pharmacy training programs should integrate smoking cessation techniques into the core curriculum. Objective: We aimed to explore the current teaching practices for smoking cessation and tobacco control in pharmacy curricula in Thailand. Methods: A questionnaire surveying tobacco control curricula and teaching techniques were distributed to faculty members in all 19 pharmacy departments in Thailand. Results: Twenty-nine faculty members participated in this study. Most pharmacy programs start teaching smoking cessation and tobacco control in the …
Synthesis, Molecular Docking, And Biological Evaluation Of Novel 2-(3-Chlorophenyl) Quinoline-4-Carboxamide Derivatives As Potent Anti-Breast Cancer And Antibacterial Agents, Kailas W. Shinde, Prashant S. Kharkar, Chetan P. Shah, Shrimant V. Rathod
Synthesis, Molecular Docking, And Biological Evaluation Of Novel 2-(3-Chlorophenyl) Quinoline-4-Carboxamide Derivatives As Potent Anti-Breast Cancer And Antibacterial Agents, Kailas W. Shinde, Prashant S. Kharkar, Chetan P. Shah, Shrimant V. Rathod
The Thai Journal of Pharmaceutical Sciences
Objectives: The study aims to synthesize and to evaluate the anti-breast cancer and antibacterial activity of some novel quinoline-4-carboxamide derivatives. Materials and Methods: A series of novel quinoline analogs 6a-6j with varied substituent (X = H, F, OCH3, NO2) were synthesized from aniline through multi-step reactions in good yields. All analogues were confirmed by spectral characterization, namely, FT-IR, MS, 1H-NMR, and 13C-NMR. All the molecules were evaluated for their anticancer activity against a breast cancer cell line, MDA-MB-231 by MTT assay, and antibacterial activity against Gram-positive bacteria (Staphylococcus aureus 6538p and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas …
Doxorubicin Modulates P-Glycoprotein Transcription Differently During Caco-2 Differentiation, Udomsak Udomnilobol, Suree Jianmongko
Doxorubicin Modulates P-Glycoprotein Transcription Differently During Caco-2 Differentiation, Udomsak Udomnilobol, Suree Jianmongko
The Thai Journal of Pharmaceutical Sciences
P-glycoprotein (P-gp) is an efflux transporter protecting cells from various chemical threats. Upregulation of P-gp expression, mediated by reactive oxygen species (ROS), has been reported in doxorubicin-treated cells. However, during cell differentiation cellular redox status may vary. This study investigated the influence of cell differentiation on doxorubicin-mediated P-gp expression in Caco-2 cells, and its relation to cellular redox status. During 21-day culture, Caco-2 cells were divided into pre-, during-, and post-differentiation, based on total cell numbers, percentage of G0/G1 cells, and alkaline phosphatase activity. Our study demonstrated that Caco-2 cells were in a more reduced state on differentiation. At low …
Evaluation Of Acute Oral Toxicity Of Methanolic Fractions Of Sesbania Grandiflora Linn. Roots In Albino Mice, N. S. Vinay, S. Babitha, R. Nandeesh, S. Paramesh, E. Manjunath, J. P. Geetha, V. P. Veerapur, B. Swetha, H. V. Keerthi Prasanth
Evaluation Of Acute Oral Toxicity Of Methanolic Fractions Of Sesbania Grandiflora Linn. Roots In Albino Mice, N. S. Vinay, S. Babitha, R. Nandeesh, S. Paramesh, E. Manjunath, J. P. Geetha, V. P. Veerapur, B. Swetha, H. V. Keerthi Prasanth
The Thai Journal of Pharmaceutical Sciences
Introduction: Although Sesbania grandiflora Linn. roots have valuable pharmacological effects, the comprehensive awareness about its toxicity potential has been lacking. Objectives: The objectives of the study were to assess the acute oral toxicity of methanolic fraction of S. grandiflora root (MFSGR). Materials and Methods: The female albino mice were divided into two groups (n = 5), one group served as normal control while the other treated with MFSGR (2000 mg/kg, p.o). Both the groups of mice were observed for 14 days for various parameters according to the Organization for Economic Cooperative and Development guidelines 425 TG. Results: Oral administration of …
Pharmacognostic And Chromatographic Evaluation Of Male And Female Flowers Of Coscinium Fenestratum For Berberine Content And Its Effect On Antioxidant Activity, T. S. Roopashree, Kuntal Das, N. Prashanth, K. Rakesh Kumar
Pharmacognostic And Chromatographic Evaluation Of Male And Female Flowers Of Coscinium Fenestratum For Berberine Content And Its Effect On Antioxidant Activity, T. S. Roopashree, Kuntal Das, N. Prashanth, K. Rakesh Kumar
The Thai Journal of Pharmaceutical Sciences
Coscinium fenestratum (CF) (Gaertn.) Colebr., [Family: Menispermaceae] is an endangered species of dioecious liana found in Western Ghats of India. The present investigation aimed with systematic analytical studies on the macroscopic, microscopic examination of male and female CF flowers, various solvent extractions, accompanied by phytochemical screening through chemical tests, identification of Berberine alkaloids, antioxidant activity, and Berberine quantification byhigh-performance thin-layer chromatography (HPTLC) process. Two different amounts of solvents (10 ml and 20 ml) with two different time intervals, that is, 15 min and 25 min, respectively, were used for extraction. Results revealed that both flowers had their own unique characters. …
Anthraquinones Extracted From Rubia Cordifolia Linn As Potential Ligands To Treat Alzheimer’S Disease, Pottella Srinivasulu, Janga Ramesh Babu, T.N.V. Ganesh Kumar, Padarthi Pavan Kumar, S. Vidyadhara
Anthraquinones Extracted From Rubia Cordifolia Linn As Potential Ligands To Treat Alzheimer’S Disease, Pottella Srinivasulu, Janga Ramesh Babu, T.N.V. Ganesh Kumar, Padarthi Pavan Kumar, S. Vidyadhara
The Thai Journal of Pharmaceutical Sciences
Objective: The present investigation aims to predict the pharmacokinetic aspects and assessing the anti-Alzheimer’s activity using both molecular docking platform and ex vivo pharmacological studies on muscle contraction. Materials and Methods: 2-Methyl Anthraquinone (MAQ) and Quinizarine (QNZ) were isolated from Rubia cordifolia L., and evaluated for absorption, distribution, metabolism, excretion, and toxicity. Molecular docking was performed with the help of Mcule software on five drug targets acetylcholinesterase enzyme (AChE), cyclin-dependent kinase5 (CDK5), glycogen synthase kinase 3β (GSK3β), monoamine oxidase (MAO-B), and β-secretase enzyme (BACE). The pharmacological activity was screened by recording the muscle contractions of chick ileum. Results: The selected …
Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib
Current Perspectives On The Therapeutic Potential Of Mitragyna Speciosa And Its Derivatives On Animal Model, Norsyifa Harun, Illa Syafiqah Johari, Rima Atria Japarin, Farah Wahida Suhaimi, Zurina Hassan, Mohammed Shoaib
The Thai Journal of Pharmaceutical Sciences
The plant Mitragyna speciosa Korth. is receiving increased attention as a therapeutic substitution for opioid use disorder (OUD). The active alkaloids constituents of the plant, particularly mitragynine and 7-hydroxymitragynine, have been shown to modulate opioid receptors, acting as agonists at mu-opioid receptors. Given this pharmacology, several studies have examined the abuse and dependence potential of M. speciosa and its alkaloids in various animal models of dependence. In addition to action on opioid receptors, the Mitragyna alkaloids also appear to exert diverse activities at other receptors in the central nervous system which may explain the complex pharmacological profile of these alkaloids. …
Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib
Evidence For Intravenous Self-Administration Of Mitragynine In Fentanyl-Dependent Rats, Norsyifa Harun, Zurina Hassan, Surash Ramanathan, Mohammed Shoaib
The Thai Journal of Pharmaceutical Sciences
Introduction: Kratom (Mitragyna speciosa Korth) is currently used as an alternative for the self-treatment of pain and management of opioid dependence and withdrawal. Due to the opioid-like effect of the plant’s active alkaloid, mitragynine (MG), the evaluation of its ability to maintain self-administration in animal models of opioid dependence appears to be great significance. Objectives: Here, the ability of MG to cross-substitute to the reinforcing effects of the synthetic narcotic fentanyl is investigated. Methods: Rats with implanted catheters were allowed to self-administer fentanyl (2.0 μg/kg/infusion) on a fixed-ratio 1 of schedule of reinforcement. Results: A significant increase in lever pressing …
Synthesis And Anti-Inflammatory Effects Evaluation Of 1,3 Substituted Isatin Derivatives, Farshid Hassanzadeh, Elham Jafari, Nahal Khayambashi, Valiollah Hajhashemi
Synthesis And Anti-Inflammatory Effects Evaluation Of 1,3 Substituted Isatin Derivatives, Farshid Hassanzadeh, Elham Jafari, Nahal Khayambashi, Valiollah Hajhashemi
The Thai Journal of Pharmaceutical Sciences
Objectives: Inflammation is a pathophysiological response of the body to a variety of agents including infections and physical injury leading to local accumulation of plasma fluid and blood cells. Isatin as a promising heterocyclic molecule has shown interesting biological profile. In this study, some derivatives of isatin containing both Schiff and mannich base fragments were synthesized in a three-step procedure. Methods: Benzohydrazide derivatives were prepared by reaction of benzoat derivatives with hydrazine hydrate. The Schiff bases were formed by treatment isatin with the benzo hydrazide derivatives. The corresponding mannich bases have been synthesized by the reaction of the Schiff bases …
Present Clinical Trial Regulatory System And Strategies For Improvement In Thailand, Charunee Krisanaphan, Rungpetch Sakulbumrungsil
Present Clinical Trial Regulatory System And Strategies For Improvement In Thailand, Charunee Krisanaphan, Rungpetch Sakulbumrungsil
The Thai Journal of Pharmaceutical Sciences
The study aimed to identify gaps and to develop strategies for improving the clinical trial regulatory system in Thailand. Two-step cross-sectional survey was conducted. The first questionnaire addressed the present situation and the expected system sent by mail. The participants were from the lists of ethics committee (EC) members available online and others obtained from Food and Drug Administration (FDA). The second questionnaire determined the strategies and methods to improve the regulatory system. The participants were the attendees at the Thailand Toward Excellence in Clinical Trials meeting. The first questionnaire with response rate of 26.9% showed that the present situation …
In Vitro Antioxidants And Anticancer Activity Of Crude Extract Isolates From Euphorbiaceae In Northern Thailand, Siwalee Rattanapunya, Wiriyaporn Sumsakul, Akharasit Bunsongthae, Samart Jaitia
In Vitro Antioxidants And Anticancer Activity Of Crude Extract Isolates From Euphorbiaceae In Northern Thailand, Siwalee Rattanapunya, Wiriyaporn Sumsakul, Akharasit Bunsongthae, Samart Jaitia
The Thai Journal of Pharmaceutical Sciences
The properties of Croton persimilis Müll.Arg. and Antidesma puncticulatum Miq.— interesting plant in the family Euphorbiaceae were investigated. The ethanol crude plant extracts were established for phytochemicals screening, antioxidants activities, anticancer in five important human cancer cell lines (MCF-7, MDA-MB-231, HeLa, HepG2, and NCI-H187), and cytotoxic activity in normal cell line (hTERT-HME1). The leaves extracts of C. persimilis Müll. Arg. contained flavonoids, saponins, terpenoids, and tannins. The total phenolic content properties were found in 43.40 ± 1.36 mg Gallic Acid Equivalents (GAE)/g crude extract. They also showed lowest antioxidant activity through 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay (IC50>1,000 μg/ml) and 2.4.2 …
Incidence Of Pneumocystis Carinii Pneumonia In Treatment-Naïve Hiv-Infected Adult Patients Receiving Primary Pneumocystis Carinii Pneumonia Chemoprophylaxis With 48-Week Antiretroviral Initiation, Piroon Khamlee, Peerawong Werarak, Chankit Puttilerpong
Incidence Of Pneumocystis Carinii Pneumonia In Treatment-Naïve Hiv-Infected Adult Patients Receiving Primary Pneumocystis Carinii Pneumonia Chemoprophylaxis With 48-Week Antiretroviral Initiation, Piroon Khamlee, Peerawong Werarak, Chankit Puttilerpong
The Thai Journal of Pharmaceutical Sciences
Objective: The objective of the study was to determine the incidence of primary Pneumocystis carinii pneumonia (PCP) between patients who received and did not receive primary PCP chemoprophylaxis and investigate adverse drug reactions (ADRs) related to the chemoprophylaxis use. Method: A retrospective study was conducted in Siriraj Hospital, Thailand. Data were collected from HIV-infected adults, initiated with highly active antiretroviral therapy (HAART) with initial CD4+ <200 cells/mm3. Results: Overall, 217 patients had a median initial CD4+ of 83 cells/mm3 (interquartile range: 33.5–150.5) (range: 0–199), most of the initial HAART regimen was non-nucleoside reverse transcriptase inhibitors based containing tenofovir disoproxil fumarate (94.94%), and 104 patients (47.93%) received chemoprophylaxis. The incidence between patients who received and did not receive prophylaxis found no statistically significant difference (p = 0.133). Only one event was found in a severely immunocompromised patient who did not receive the prophylaxis. The absolute risk reduction of primary PCP incidence, and rate of ADRs was 0.89% (95% confidence interval, −0.84, 2.61) and 10.58% in patients who received the chemoprophylaxis, respectively. Conclusion: The initiation of HAART in HIV-infected patients who had the initial CD4+ cell count <200 cells/mm3 may impact on reducing the risk of developing primary PCP. Aside from the patients who received the prophylaxis, most of the adverse reactions were skin disorders.
Synthesis, Docking, And Molecular Dynamic Study Of Hydrazones Compounds To Search Potential Inhibitor For Breast Cancer Mcf-7, Jasril, Yuana Nurulita, Nur Afriana, Ihsan Ikhtiarudin, Neni Frimayanti
Synthesis, Docking, And Molecular Dynamic Study Of Hydrazones Compounds To Search Potential Inhibitor For Breast Cancer Mcf-7, Jasril, Yuana Nurulita, Nur Afriana, Ihsan Ikhtiarudin, Neni Frimayanti
The Thai Journal of Pharmaceutical Sciences
Introduction: Hydrazones have been reported for various biological activities, such as anticancer. The presence of the azomethine group (-NHN=CH-) makes these compounds as one of the important classes in many synthetic products. Objective: The aim of this work is to explore the potential of halogenated hydrazones series as breast cancer inhibitors. Methods: In this study, some series of halogenated hydrazones have been synthesized through condensation reaction between halogenated benzaldehydes and phenylhydrazine under microwave irradiation. The structures of the halogenated hydrazoes were confirmed by ultraviolet, fourier-transform infrared, NMR, and gas chromatography-mass spectrometry spectroscopic data. The in silico studies i.e. docking and …
Poly(Lactic-Co-Glycolic Acid) - Polyethylene Glycol Copolymer For Long-Acting Injectable: Synthesis, Characterization, And In-Vivo Study, Ravindra Kamble, Manasi Kulkarni, Swati Korake, Abhishek Pawar, Krishnat Dhekale
Poly(Lactic-Co-Glycolic Acid) - Polyethylene Glycol Copolymer For Long-Acting Injectable: Synthesis, Characterization, And In-Vivo Study, Ravindra Kamble, Manasi Kulkarni, Swati Korake, Abhishek Pawar, Krishnat Dhekale
The Thai Journal of Pharmaceutical Sciences
Aim: This work was aimed to develop a carrier system of poly(lactic-co-glycolic acid) (PLGA) by using polyethylene glycol (PEG) for longer action in various diseases by preparing a di-block copolymer by using Risperidone (RSP) as a drug. Methodology: PLG.
Measuring The Potential Antioxidant Activity Of Methyl Gallate: Molecular Docking Study, Sutomo S, Mohammad Rizki Fadhil Pratama
Measuring The Potential Antioxidant Activity Of Methyl Gallate: Molecular Docking Study, Sutomo S, Mohammad Rizki Fadhil Pratama
The Thai Journal of Pharmaceutical Sciences
Objectives: This study aims to obtain predictions of the interactions that occur between methyl gallate and various antioxidant receptors while comparing it with gallic acid as its parent compound. Materials and Methods: The protein crystal structures of.
Assessment Of Antimicrobial Activity Of Moxifloxacin.Hcl From Gastro Retentive Formulations, Raghavendra Kumar Gunda, A. Vijayalakshmi, K. Masilamani
Assessment Of Antimicrobial Activity Of Moxifloxacin.Hcl From Gastro Retentive Formulations, Raghavendra Kumar Gunda, A. Vijayalakshmi, K. Masilamani
The Thai Journal of Pharmaceutical Sciences
Purpose: The objective of the present study is to assess the antimicrobial activity of gastroretentive formulation for moxifloxacin HCl and in vitro antimicrobial evaluation using the cup-plate method. Materials and Methods: Gastroretentive floating tabl.
Development And Validation Of Rp-Hplc Method For Simultaneous Determination Of Ondansetron Hydrochloride And Granisetron Hydrochloride In Their Admixtures With Pantoprazole Sodium, Al Montaser Hamed Bellah, Abdel Maaboud Ismail Mohamed, Niveen Abdel-Latif Mohamed
Development And Validation Of Rp-Hplc Method For Simultaneous Determination Of Ondansetron Hydrochloride And Granisetron Hydrochloride In Their Admixtures With Pantoprazole Sodium, Al Montaser Hamed Bellah, Abdel Maaboud Ismail Mohamed, Niveen Abdel-Latif Mohamed
The Thai Journal of Pharmaceutical Sciences
Objective: Development of rapid and sensitive high-performance liquid chromatography method for the quantification of ondansetron hydrochloride and granisetron hydrochloride in their admixtures with pantoprazole sodium in its dosage form using ketorolac .
The Effects Of Ball Mill Processing On The Physicochemical Properties Of Glutinous Rice Starch, Weeraya Tharanon, Jomjai Peerapattana
The Effects Of Ball Mill Processing On The Physicochemical Properties Of Glutinous Rice Starch, Weeraya Tharanon, Jomjai Peerapattana
The Thai Journal of Pharmaceutical Sciences
Glutinous rice starch (GRS) (Oryza sativa L.) is a product derived from a staple food that is commonly cultivated and consumed in Asia. This study investigates the effect of physical modification by planetary ball mill processing on some physicochemical .
Anti-Tyrosinase And Anti-Melanogenic Potential Of Shallots (Allium Ascalonicum) From Various Cultivation Sites In Thailand, Thidarat Phetmanee, Thaniya Wunnakup, Thitiya Lukkunaprasit, Fameera Madaka, Sukanya Settharaksa, Narisa Kamkaen, Nirun Vipunnqeun, Laksana Charoenchai
Anti-Tyrosinase And Anti-Melanogenic Potential Of Shallots (Allium Ascalonicum) From Various Cultivation Sites In Thailand, Thidarat Phetmanee, Thaniya Wunnakup, Thitiya Lukkunaprasit, Fameera Madaka, Sukanya Settharaksa, Narisa Kamkaen, Nirun Vipunnqeun, Laksana Charoenchai
The Thai Journal of Pharmaceutical Sciences
Objectives: The present study aimed to investigate the anti-tyrosinase effect of shallots (Allium ascalonicum) in Thailand and to prepare an optimised shallot extract for use as a skin-lightening agent. Materials and Methods: Aqueous and ethanolic shallo.
In Silico Discovery Of Potential Diagnostic Biomarkers Of Lung Cancer, Ruzianisra Mohamed, Raja Nur Hidayah Raja Hasnan
In Silico Discovery Of Potential Diagnostic Biomarkers Of Lung Cancer, Ruzianisra Mohamed, Raja Nur Hidayah Raja Hasnan
The Thai Journal of Pharmaceutical Sciences
Introduction: Understanding hub genes implicated in lung cancer (LC) metastasis will help in finding effective ways to diagnose and cure cancer. Accurate identification of protein biomarkers helps in improving the prognosis of LC. Here, the focus of this.
Progress In Erectile Dysfunction Therapy Through Drug Delivery System, Mayuri Shitole, Shailesh Dugam, Rahul Tade, Neha Desai, Sopan Nangare
Progress In Erectile Dysfunction Therapy Through Drug Delivery System, Mayuri Shitole, Shailesh Dugam, Rahul Tade, Neha Desai, Sopan Nangare
The Thai Journal of Pharmaceutical Sciences
A man’s aptitude to acquire and continue an erection is frequently equated with masculinity and virility and can greatly influence men’s confidence. The sexual healthiness is a significant determinant of the worth of life. Erectile dysfunction (ED) a...
In Silico Screening Of Natural Compounds To Identify Lead As Interleukin 17a Receptor Blockers As Antihypertensive Agents, Jimish R. Patel, Hirak V. Joshi, Ujashkumar A. Shah, Jayvadan K. Patel
In Silico Screening Of Natural Compounds To Identify Lead As Interleukin 17a Receptor Blockers As Antihypertensive Agents, Jimish R. Patel, Hirak V. Joshi, Ujashkumar A. Shah, Jayvadan K. Patel
The Thai Journal of Pharmaceutical Sciences
Objectives: Nature gives disease and nature gives the medicine. Natural products have exhibited paramount sources of novel drugs. Due to this, natural products have gained a dominant role in drug design and discovery. Interleukin 17 (IL-17) is a potent p.
Chemical Composition Of The Essential Oil Of Several Iris Species, Olha Mykhailenko N/A, Volodymyr Kovalyov, Tetyana Orlova
Chemical Composition Of The Essential Oil Of Several Iris Species, Olha Mykhailenko N/A, Volodymyr Kovalyov, Tetyana Orlova
The Thai Journal of Pharmaceutical Sciences
The essential oil was obtained by a steam distillation from the dried leaves of Iris germanica L., Iris versicolor L., Iris graminea L., and Iris halophila Pall. (Iridaceae) and was investigated by a gas chromatography-mass spectrometry (GC/MS) method. I.
Anthelmintic Activity Of Mansoa Alliacea Against Pheretima Posthuma: In Vitro And In Silico Approach, D.S. N. B. K. Prasanth, S. K. Aminabee, Atmakuri Lakshmana Rao, Nayudu Teja, Koti Bhargavi, Chigurupati Monika, Boppudi Pujitha, Tera Sandhya, Agastya Lalitha, Siva Prasad Panda
Anthelmintic Activity Of Mansoa Alliacea Against Pheretima Posthuma: In Vitro And In Silico Approach, D.S. N. B. K. Prasanth, S. K. Aminabee, Atmakuri Lakshmana Rao, Nayudu Teja, Koti Bhargavi, Chigurupati Monika, Boppudi Pujitha, Tera Sandhya, Agastya Lalitha, Siva Prasad Panda
The Thai Journal of Pharmaceutical Sciences
Objectives: Mansoa alliacea has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our analysis work aims to distinguish phyto-derived anthelmintic substances from M. alliacea a.