Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Biology (13)
- Ecology and Evolutionary Biology (11)
- Biochemistry, Biophysics, and Structural Biology (9)
- Biochemistry (7)
- Physical Sciences and Mathematics (6)
-
- Animal Sciences (4)
- Genetics and Genomics (4)
- Social and Behavioral Sciences (4)
- Agriculture (3)
- Environmental Sciences (3)
- Microbiology (3)
- Amino Acids, Peptides, and Proteins (2)
- Behavior and Ethology (2)
- Bioinformatics (2)
- Biotechnology (2)
- Cell and Developmental Biology (2)
- Chemicals and Drugs (2)
- Chemistry (2)
- Economics (2)
- Environmental Health and Protection (2)
- Environmental Monitoring (2)
- Environmental Policy (2)
- Enzymes and Coenzymes (2)
- Evolution (2)
- Genetics (2)
- Immunology and Infectious Disease (2)
- International and Area Studies (2)
- Laboratory and Basic Science Research (2)
- Medicinal-Pharmaceutical Chemistry (2)
- Keyword
-
- DAX-1 (4)
- Breast cancer (3)
- CmvIL-10 (3)
- Human cytomegalovirus (3)
- ABC transporter (2)
-
- Belding's ground squirrels (2)
- Cancer (2)
- Climate Change (2)
- HCMV (2)
- LuxS (2)
- MetNI (2)
- NR0B1 (2)
- Nuclear hormone receptor (2)
- Quorum Sensing (2)
- Squirrel (2)
- UL111A (2)
- ABC Transporter (1)
- ABC-Transporter (1)
- AI-2 (1)
- ATPase Assays (1)
- Accountability (1)
- Amazon (1)
- Amazon Rainforest (1)
- Amphibians (1)
- Analogs (1)
- Anisotropy (1)
- Anura (1)
- Apoptosis (1)
- Arctic seals (1)
- Arginine (1)
Articles 1 - 30 of 38
Full-Text Articles in Life Sciences
Role Of Toll-Like Receptor 2 In Macrophage Recognition And Response To Borrelia Burgdorferi, Yukiye A. Koide
Role Of Toll-Like Receptor 2 In Macrophage Recognition And Response To Borrelia Burgdorferi, Yukiye A. Koide
Master's Theses
Lyme disease is the most common vector-borne disease in the US and will experience an uptick as the insect host, the ixodid tick, gains habitat with climate change. The causative agent of Lyme disease, Borrelia burgdorferi, is recognized by Toll-like receptor 2 (TLR2), which initiates the innate immune response. Here, I used ELISA and SEAP detection assays to determine that knocking out TLR2 in THP-1 macrophages reduces the amount of NFkB activation, as well as IL-10 and IL-1β secretion. Then, I used fluorescence microscopy and Incucyte assays to quantify the amount of phagocytosis performed by wild-type and knock-out THP-1 cells. …
Covalent Inhibition Of Enzyme Sortase A As A New Pathway Against Bacterial Resistance Of Staphylococcus Aureus, Umyeena Bashir
Covalent Inhibition Of Enzyme Sortase A As A New Pathway Against Bacterial Resistance Of Staphylococcus Aureus, Umyeena Bashir
Master's Theses
The continued rise of antibiotic-resistant bacteria, such as MRSA (methicillin-resistant Staphylococcus aureus), has made the discovery of novel antibiotics critical. While bacteriostatic and bactericidal antibiotics inevitably exert evolutionary pressure on bacteria to develop resistance, small molecules that target mechanisms of bacterial virulence present a promising alternative for treatment. Sortase A (Srt A), a cysteine protease of S. aureus, promotes bacterial virulence by covalently attaching proteins such as pilin to the bacterial surface, enabling bacterial adhesion to mammalian cells. Inhibitory studies of this enzyme have gained prominent interest as a new pathway for drug development since blocking this enzyme's ability to …
Nanodiscs: A Novel Approach To The Study Of The Methionine Abc Transporter System, Michael T. Winslow
Nanodiscs: A Novel Approach To The Study Of The Methionine Abc Transporter System, Michael T. Winslow
Master's Theses
Membrane transporter proteins play the vital role of moving compounds in and out of the cell and are essential for all living organisms. ATP Binding Cassette (ABC) family transporters function both as importers and exporters in prokaryotes. MetNI is an E. coli Type I ABC transporter responsible for the uptake of methionine into the cytosol from the cell periplasmic space through the cell membrane to maintain intracellular methionine pools. ABC transporters, like other membrane proteins, are most often mechanistically and structurally studied in vitro, solubilized by detergents. However, detergent micelles may affect the conformational changes of membrane proteins relative to …
Disruption Of Play Behavior Influences Development Of Caution In Juvenile Ground Squirrels, William Ryan
Disruption Of Play Behavior Influences Development Of Caution In Juvenile Ground Squirrels, William Ryan
Master's Theses
Play behavior is ubiquitous among young mammals and has a variety of important influences on early development. I evaluated possible influences of social play behavior on the development of temperament in juvenile Belding’s ground squirrels (Urocitellus beldingi), using the caution/boldness spectrum as a measure of temperament. I disrupted the play behavior of juvenile U. beldingi by walking toward juveniles at play until the play interactions stopped. I used undisrupted juveniles and juveniles whose non-play behavior was disrupted at regular intervals as controls. Caution was measured with behavioral tests during which a human intruder walked toward a squirrel and recorded the …
Mechanisms Of Substrate Selectivity And Transport By Escherichia Coli Atp- Binding Cassette (Abc) Transporter Metni, Yuchun Chen
Mechanisms Of Substrate Selectivity And Transport By Escherichia Coli Atp- Binding Cassette (Abc) Transporter Metni, Yuchun Chen
Master's Theses
ABC transporters are central in many cellular functions including nutrient uptake, signal transduction membrane assembly, and cellular detoxification. Both structural and functional studies have revealed insights into the high-affinity uptake mechanism of the MetNI methionine ABC transporter. Using the energy from ATP binding and hydrolysis, the MetNI-Q system can import L-Met, D-Met, and other methionine derivatives against concentration gradients. Many mechanistic studies of ABC transporter propose a model in which cognate binding proteins sequester substrates in the periplasm and deliver them to the transporter. In contrast, recent in vivo and crystallographic studies of MetNI-Q suggest that some substrates may be …
Examination Of Methylation Status And Occupancy Of Dna Methylation Modifying Proteins On Regulatory Regions Of The Dax-1 Gene, Caroline P. Riedstra
Examination Of Methylation Status And Occupancy Of Dna Methylation Modifying Proteins On Regulatory Regions Of The Dax-1 Gene, Caroline P. Riedstra
Master's Theses
Epigenetic modifications influence gene expression and thereby play a pivotal role in development and disease. Misregulation and mutations in the DAX-1 gene, or Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X chromosome, gene 1, have been implicated in Adrenal Hypoplasia Congenita (AHC) and Dosage Sensitive Sex Reversal (DSS). The orphan nuclear hormone receptor DAX-1 is expressed predominantly in tissues such as the testes, ovaries, breast, adrenal cortex, and lung. Critically, DAX-1 may serve as an indicator of aberrant growth in these tissues. Here we hypothesize that DAX-1 is epigenetically regulated, specifically in cancer cells, thereby reducing its …
Investigating The Mechanism Of The Escherichia Coli Atp-Binding Cassette (Abc) Transporter Metni, Matthew Foronda
Investigating The Mechanism Of The Escherichia Coli Atp-Binding Cassette (Abc) Transporter Metni, Matthew Foronda
Master's Theses
Chemical homeostasis is a baseline requirement for any cell to survive. ATP-binding cassette (ABC) transporters play a vital role in homeostasis by importing nutrients and exporting toxins against their concentration gradients by utilizing the energy of ATP hydrolysis. Malfunctioning ABC transporters cause a variety of health problems, including cystic fibrosis, Stargardt’s disease (vision loss), and the development of drug-resistant tumors. An important step in solving these medical issues is to first understand the structure and mechanism of ABC transporters. Various studies have made great strides in depicting the structure and details of different ABC transporters and their mechanisms, however, many …
Testing The Climatic Variability Hypothesis With Coastal And Inland Populations Of Mimulus Guttatus And Implications For These Populations Under Climate Change, Alec Chiono
Master's Theses
How climate shapes the niche of a species is a core interest in evolution and ecology. Research on the evolution of climatic niches can inform us on the historical relationship between organisms and their climate, and, in an era of great environmental change, what that relationship may look like in the future. In this study, I tested an essential idea in the history of climate niche research, the Climatic Variability Hypothesis, by comparing the thermal niche breadth of coastal and inland populations of Mimulus guttatus. Using thermal performance results from this experiment, I also forecasted how the suitability of …
Assessing Seasonal Changes In Body Condition For Spotted (Phoca Largha), Ringed (Pusa Hispida), And Bearded (Erignathus Barbatus) Seals, Michelle Hartwick
Assessing Seasonal Changes In Body Condition For Spotted (Phoca Largha), Ringed (Pusa Hispida), And Bearded (Erignathus Barbatus) Seals, Michelle Hartwick
Master's Theses
Anthropogenic global warming is causing unprecedented changes to occur within Arctic ecosystems. As sea ice continues to decline in both thickness and extent, ice-adapted species will be particularly affected. Specifically, Arctic seals are reliant on sea ice during critical life-history stages and many of their preferred prey depend on reliable patterns in annual sea ice cover. Thus, ongoing changes will likely affect the ability of Arctic seals to carry out key life-history tasks and maintain positive energy balance. One way to assess energy reserves is through examination of body condition. For seals, this is often done by measuring overall blubber …
Assessing Methods For Determining Reference Conditions For Riparian Restoration In Santa Clara County, Claire Mallen
Assessing Methods For Determining Reference Conditions For Riparian Restoration In Santa Clara County, Claire Mallen
Master's Theses
Valley Water is the primary water wholesaler and flood control agency in Santa Clara County, providing services to 1.9 million residents. The operation and maintenance of infrastructure for water supply and flood control often require work within legally protected natural resources such as riparian ecosystems. Riparian ecosystems are dynamic and diverse ecosystems that provide our society with valuable services such as wildlife habitat, water quality, and recreation. However, the threat of human development on native ecosystems has led to the degradation and loss of 85-98% of riparian ecosystems nationwide. Today, federal, state, and regional laws mitigate further impacts to riparian …
Evaluating Methods To Reduce Humpback Whale (Megaptera Novaeamgliae) Ship Strike Mortality In Nearshore Feeding Habitats Within The San Francisco Bay, Alisa Keenan
Master's Theses
Across our world’s oceans, whales are perpetually stuck and killed by large ships. Sea-based commercial trade is increasing on a global scale; therefore, more large ships are circumnavigating through biologically important whale habitats. This is of grave concern to marine resource managers, especially in the United States where major shipping corridors overlap critical whale habitat. It is feared that in these areas with high whale density, ship strikes are reducing populations of whales to levels below what is sustainable for threatened and endangered species, thereby hindering the recovery of depleted whale populations. Humpback whales, a species that is federally-listed as …
Investigating The Relationship Between Hormone Receptors Dax-1 And Estrogen Receptor Within Prostate Cancer Cell Lines, Meghana G. Vijayraghavan
Investigating The Relationship Between Hormone Receptors Dax-1 And Estrogen Receptor Within Prostate Cancer Cell Lines, Meghana G. Vijayraghavan
Master's Theses
Prostate cancer (PCa) is estimated to be the second leading cause of cancer-related deaths among men in the United States in 2019. While most prostate tumors rely on androgens for growth signaling, there are subsets of tumors that become androgen-resistant, therefore resisting conventional androgen-depravation therapy. Consequently, research has focused on targeting different hormone receptors for novel therapeutics. One such receptor is Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX-1). DAX-1 is known to interact with other hormone receptors, such as androgen receptor (AR) and estrogen receptors (ERs) to suppress the proliferative effects …
Play Behavior And The Development Of Boldness And Caution In Juvenile Belding’S Ground Squirrels (Urocitellus Beldingi), Madelene Shehan
Play Behavior And The Development Of Boldness And Caution In Juvenile Belding’S Ground Squirrels (Urocitellus Beldingi), Madelene Shehan
Master's Theses
The ubiquity of play among juvenile mammals suggests it provides adaptive benefits, potentially through influences on the development of temperament in young animals. Juvenile Belding’s ground squirrels (Urocitellus beldingi) must balance competing demands for boldness and caution imposed by the fundamental trade-off between their short active season and their vulnerability to predation. In this study, I evaluated whether play helps to facilitate the development of an appropriate balance between boldness and caution in juvenile U. beldingi.I observed the play behavior of juvenile U. beldingiand conducted flight-initiation distance tests to measure boldness-caution at the beginning and toward …
Frogs Hiding In Plain Sight: Phylogenetic Systematics Of Myanmar’S Occidozyga Species Complex, And The Identification Of A Novel Species, Allison Bogisich
Frogs Hiding In Plain Sight: Phylogenetic Systematics Of Myanmar’S Occidozyga Species Complex, And The Identification Of A Novel Species, Allison Bogisich
Master's Theses
Different species can be difficult to distinguish from one another when they are morphologically similar. Such cryptic species are the reason many anuran species go undetected. For this study, the taxonomic identity of the Occidozyga complex across Myanmar was investigated. An integrated approach was used combining molecular, morphological and phylogeographic data to better assess its taxonomy. Results indicate the presence of three new candidate species within Occidozyga, and three evolutionarily significant unit (ESU) lineages. Two mitochondrial gene fragments (16S, COI) and one nuclear gene fragment (Rhodopsin) were examined from DNA isolated from forty-seven preserved specimens from the California Academy …
Examining Genetic And Ecological Differentiation Of An Endemic Plant Species Found Across The Hawaiian Archipelago, Psychotria Mariniana, Tiffany L. Kho
Examining Genetic And Ecological Differentiation Of An Endemic Plant Species Found Across The Hawaiian Archipelago, Psychotria Mariniana, Tiffany L. Kho
Master's Theses
Speciation is a fundamental evolutionary process that remains poorly understood. Speciation ultimately begins with population divergence, so we can elucidate the complexities of speciation by first understanding the process and drivers of population divergence. To conduct population-level analyses, ecologists and evolutionary biologists have turned to island systems, primarily for their geographic orientation and high endemism. The Hawaiian archipelago is home to over 8,700 endemic species making it a great natural laboratory to study species diversification at the population level. The Hawaiian Psychotria (kōpiko, or wild coffee) make up 11 of these species and have been used to understand colonization and …
See The Forest For The Leaves: Foliar Fungal Community Composition And Volatile Organic Compound Production, Joshua Copeland
See The Forest For The Leaves: Foliar Fungal Community Composition And Volatile Organic Compound Production, Joshua Copeland
Master's Theses
Endophytes are microbes that live within plants without causing detectable illness. These microorganisms can emit volatile organic compounds (VOCs), airborne signaling molecules that can significantly affect plant growth. Despite the prevalence of endophytes and their VOCs, little is known about these factors important to plant health. With this in mind I isolated fungal endophytes from leaves of Populus trichocarpa and Populus fremontii, tree species with economic and environmental uses, to determine if endophyte communities are reserved between the closely related tree species and over seasons. Surface sterilized leaf fragments were plated onto malt extract agar and the resulting fungi were …
Naatm1: Examining The Mechanism Of A Heavy-Metal Abc Exporter, Dennis Hicks
Naatm1: Examining The Mechanism Of A Heavy-Metal Abc Exporter, Dennis Hicks
Master's Theses
ATP-Binding Cassette (ABC) Transporters are a superfamily of integral membrane proteins that have been found embedded in both the cellular membranes and internal organelles of all species yet analyzed (1). This extreme conservation throughout the tree of life is due to their vitally critical and broad task of transporting all manner of things into and out of the cell and related organelles. This broadness of responsibility has led to an abundant diversity of this family, which in turn, has allowed life to adapt to the many environments found on Earth. While the importance and variability of this family is abundantly …
Seeing Red: Analyzing Iucn Red List Data Of South And Southeast Asian Amphibians, Alexandra Gonzalez
Seeing Red: Analyzing Iucn Red List Data Of South And Southeast Asian Amphibians, Alexandra Gonzalez
Master's Theses
In the midst of the sixth mass extinction event which is currently underway, it appears that amphibians are one of the most impacted vertebrates. Over 6,500 amphibian species are listed on the IUCN Red List (an assessment tool which provides species’ conservation status, perceived threats, and distribution range). While it is well-known that populations under multiple stressors are more likely to undergo significant declines, there are little to no resources available for visualizing how these threats may work synergistically and interact within a species’ range. This is especially the case for Southeast Asian amphibians, which much less attention has been …
What’S At Steak? The Political Discourse Of Emissions Intensity And Implications Of Animal Agriculture, Kalyn Simon
What’S At Steak? The Political Discourse Of Emissions Intensity And Implications Of Animal Agriculture, Kalyn Simon
Master's Theses
This thesis analyzes the international discourse of greenhouse gas emissions in relation to livestock production. Specific government ministries, research institutes, and multilateral organizations are framing a new strategy to mitigate emissions by using emissions intensity metrics. Emissions intensity is a ratio comparing emissions produced per unit of animal product as oppose to measuring absolute emissions. This research is acknowledged as a win-win scenario which allows for a reduction of greenhouse gas emissions while continuing production more efficiently. This thesis outlines the emergence of this metric in international discourse and the implications this shift has on the livestock sector globally. Ultimately, …
The Role Of Orphan Nuclear Receptor Dax-1 (Nr0b1) In Human Breast Cancer Cells: Expression, Proliferation And Metastasis, Erin Dishington
The Role Of Orphan Nuclear Receptor Dax-1 (Nr0b1) In Human Breast Cancer Cells: Expression, Proliferation And Metastasis, Erin Dishington
Master's Theses
The orphan nuclear hormone receptor DAX-1 (Dosage Sensitive Sex Reversal, Adrenal Hypoplasia Congenita on the X Chromosome, gene 1) plays an important role in the development of adrenal and gonadal tissues and functions as a global negative-regulator of steroidogenesis. In addition, it is known to be involved in several diseases including some cancers. Herein, we describe our examination of the role of DAX-1 in breast cancer, specifically its influence on proliferation and metastasis and its expression during progressive stages of disease. In an effort to understand how DAX-1 influences breast cancer cell proliferation and metastasis, we used MCF7 breast cancer …
Phylogenetics, Biogeography, And Climate Niche Variation Of South Pacific And Hawaiian Psychotria, Elaine Zhang
Phylogenetics, Biogeography, And Climate Niche Variation Of South Pacific And Hawaiian Psychotria, Elaine Zhang
Master's Theses
Why do some species have broad geographic distributions, while other species are confined to a narrow distribution? Species age, ecological niche, or dispersal traits may help explain why some insular species are abundant and found on many islands, while others are rare and restricted to one island. In this study, I inferred a robust, time-calibrated phylogeny of the Hawaiian Psychotria, using two nuclear and eight chloroplast loci, sampling 67 individuals. I coupled my phylogenetic hypothesis with climatic data, ecological niche modeling, and morphological dispersal characteristics to explain the variation in number of islands occupied by each species. My inferred phylogeny …
Behavioral Determinants Of Biofortified Food Acceptance: The Case Of Orange-Fleshed Sweet Potato In Ghana, Chinonso E. Etumnu
Behavioral Determinants Of Biofortified Food Acceptance: The Case Of Orange-Fleshed Sweet Potato In Ghana, Chinonso E. Etumnu
Master's Theses
Biofortified foods are being introduced in sub-Saharan Africa as an important strategy to help address micronutrient malnutrition. However, there has been little research on factors that could play decisive roles in their successful introduction. This paper investigates the determinants of consumer acceptance of biofortified orange-fleshed sweet potato (OFSP) using data from a choice experiment conducted in Ghana. I find that OFSP is preferred to traditional white-fleshed and yellow-fleshed sweet potatoes as indicated by consumers' marginal willingness to pay for the three varieties. I also find that respondents' socio-economic characteristics do not have a significant effect on consumer acceptance of OFSP. …
The Role Of The State, Multinational Oil Companies, International Law & The International Community: Intersection Of Human Rights & Environmental Degradation Climate Change In The 21st Century Caused By Traditional Extractive Practices, The Amazon Rainforest, Indigenous People And Universal Jurisdiction To Resolve The Accountability Issue, Marcela Cabrera Luna
Master's Theses
Local, national and international conventions that protect indigenous sovereignty and their territories, where many of the resources are extracted from by multinational corporations (MNCs) particularly oil, the number one commodity of the world and cause of climate change, continue to be jeopardized because of the lack of a clear international legal framework that can protect them and potentially hold multinationals accountable for their actions. These practices are causing not only environmental issues to the indigenous and surrounding communities, but climate change is in fact, the real human rights issue of the 21st century and it affects everyone. By using …
The Roles Of Human Cytomegalovirus Us27 Gene Product During Virus Infection, Carolyn C. Tu
The Roles Of Human Cytomegalovirus Us27 Gene Product During Virus Infection, Carolyn C. Tu
Master's Theses
Human cytomegalovirus (HCMV) is a widespread pathogen that causes lifelong latent infection. Successful persistence of HCMV in healthy individuals involves extensive manipulation of host cellular functions and immune responses. HCMV encodes four genes for putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. The US28 gene product is a functional chemokine receptor that exhibits a variety of signaling outcomes. In contrast, the US27 gene product is an orphan with no known chemokine ligands. We have found that US27 triggers several biological effects: increased cellular proliferation, changes in gene expression, and enhanced signaling of cellular chemokine receptor CXCR4. Enhanced cell …
An Analysis Of Juvenile Chinook Salmon Outmigration Speed And Survival In Response To Habitat Features: Sacramento River From Knights Landing To Sacramento, California, Natalie N. Mcnair
An Analysis Of Juvenile Chinook Salmon Outmigration Speed And Survival In Response To Habitat Features: Sacramento River From Knights Landing To Sacramento, California, Natalie N. Mcnair
Master's Theses
Outmigration is an important life stage for Chinook salmon (Oncorhynchus tshawytscha) survival in the Sacramento River, and yet our understanding of their behavior and needs during this time is limited. To gain a better understanding of their survival and movement rates during outmigration, late fall run Chinook salmon smolts were tracked using acoustic telemetry techniques. Habitat features were measured and quantified throughout the study area to evaluate how Chinook salmon respond to key levee features including shade, instream woody material, and aquatic vegetation. The overall average movement speed through the entire study area was 0.77 m/s with an …
Transcriptional Regulation By Dax-1 In Pluripotent And Differentiated Cells, Alexandra C. Maramba
Transcriptional Regulation By Dax-1 In Pluripotent And Differentiated Cells, Alexandra C. Maramba
Master's Theses
DAX-1, an orphan nuclear hormone receptor, acts mainly as a repressor through transcriptional protein complexes. Its unique structure and specific expression raises questions as to what its precise interactions are and how it mediates its repressive function. While it is known to play a role in sexual development and adrenal insufficiency, expression in certain types of cancer suggests additional functions and interactions. Knock in of DAX-1 into a low-DAX-1 expressing cancer cell line has been previously observed to increase apoptosis, while, inversely, down in a high-DAX-1 expressing cancer cell line shows a decrease in apoptosis. Target genes that belong to …
Detection Of Hcmv Viral Il-10 (Vil-10) In Healthy Blood Donors, Vivian P. Young
Detection Of Hcmv Viral Il-10 (Vil-10) In Healthy Blood Donors, Vivian P. Young
Master's Theses
Human cytomegalovirus (HCMV) is widespread in the general population and can establish lifelong latency with expression of a limited subset of viral genes. The UL111A gene is expressed during both lytic and latent infection, and at least two protein isoforms are produced. During lytic infection, the full length transcript yields cmvIL-10, a potent immunosuppressive viral ortholog of human IL-10 (hIL-10). Alternative splicing of the UL111A transcript yields a truncated protein, LAcmvIL-10, which is expressed during both lytic and latent infection but with a limited range of immunosuppressive functions. The two viral cytokines, collectively termed viral IL-10 (vIL-10), are identical in …
Epigenetic Regulation Of Nuclear Hormone Receptor Dax-1, Michael B. Heskett
Epigenetic Regulation Of Nuclear Hormone Receptor Dax-1, Michael B. Heskett
Master's Theses
DAX-1 (NR0B1) is an orphan nuclear receptor that plays a key role in the development and maintenance of steroidogenic tissue in mammals. Dax-1 is also expressed in mouse embryonic stem (ES) cells and is required to maintain pluripotency. Duplication of the X-chromosome in the region containing the NR0B1 gene results in sex reversal, and mutations in NR0B1 cause adrenal hypoplasia congenita. DAX-1 has been observed to act as a corepressor of other nuclear receptors including androgen receptor (AR), estrogen receptor (ER), and steroidogenic factor 1 (SF-1). In addition to pluripotent ES cells, DAX-1 is primarily expressed in select tissues of …
Examining The Role Of Dax-1 In Regulation Of Cell Proliferation In Human Breast Cells, Amy E. Scandurra
Examining The Role Of Dax-1 In Regulation Of Cell Proliferation In Human Breast Cells, Amy E. Scandurra
Master's Theses
DAX-1 is a member of the Nuclear Hormone Receptor superfamily and acts as a transcriptional repressor. DAX-1 plays an important role in the development of adrenal and gonadal tissues. In addition to its role in normal cell development and differentiation, DAX-1 appears to have some influence on the progression of cancer. This work aims to examine the role of DAX-1 in regulation of proliferation in breast cancer. In our study, we have expressed DAX-1 in a DAX-1 deficient breast cancer cell line as well as knocked down DAX-1 expression in normal DAX-1 positive breast cells. Through these experiments, we were …
Land Grabs And Implications On Food Sovereignty And Social Justice In Senegal, Joanna Lafrancesca
Land Grabs And Implications On Food Sovereignty And Social Justice In Senegal, Joanna Lafrancesca
Master's Theses
This thesis focuses on the case study of Senegal to examine the implications of large- scale land acquisitions on the livelihoods of small-scale farmers. I investigate the diverse perspectives of market enthusiasts, human rights organizations, peasants, the state, and international financial organizations on large-scale land acquisitions. Based on primary research, I argue that the state of Senegal plays an active role in permitting “land grabs” and that they pose a threat to food sovereignty among Senegalese host communities. Lastly, I argue there needs to be a broader understanding of long-term consequences and risks to insure social justice in areas affected …