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The Roles Of Tid1, Ndj1, And Spo16 In Distributive Segregation During Saccharomyces Cerevisiae Meiosis, Ethan Atticus Shaw
The Roles Of Tid1, Ndj1, And Spo16 In Distributive Segregation During Saccharomyces Cerevisiae Meiosis, Ethan Atticus Shaw
Master's Theses
Meiosis is a specialized form of cell division in sexually reproducing eukaryotes. Crossovers are physical connections formed between homologous chromosomes during meiosis; these connections help ensure normal segregation of homologous chromosomes at meiosis I. However, the yeast Saccharomyces cerevisiae and other eukaryotes can still segregate homologs properly even in the absence of some crossovers. This is due to a backup mechanism known as distributive segregation, which correctly segregates non-crossover chromosomes at a higher rate than if segregation were completely random. To study distributive segregation, we have generated diploid yeast with one homeologous chromosome pair consisting of a Saccharomyces cerevisiae chromosome …