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Full-Text Articles in Life Sciences

Validation Of Machine Vision And Action Sport Cameras For 3d Motion Analysis Model Reconstruction, John David Johnson, Michael Hales, Randy Emert Nov 2023

Validation Of Machine Vision And Action Sport Cameras For 3d Motion Analysis Model Reconstruction, John David Johnson, Michael Hales, Randy Emert

Faculty and Research Publications

The study investigated the feasibility of using action sport cameras for motion analysis research. Data acquired from two different marker-based motion capture systems and six different camera combinations were analyzed for motion reconstruction accuracy. Two different calibration procedures were used to determine the influence on marker position reconstruction. Static and dynamic calibration mean merit score differences between the reference and experimental camera systems were 0.4 mm and 1.3 mm, respectively. Angular displacement difference between the reference and experimental camera systems range between 0.1 and 2.0 degrees. A systematic bias (− 0.54 to 0.19 degrees) was determined between the reference and …


Effects Of Plyometric- And Cycle-Based High-Intensity Interval Training On Body Composition, Aerobic Capacity, And Muscle Function In Young Females: A Field-Based Group Fitness Assessment, A. J. Holmes, M. T. Stratton, A. R. Bailly, J. S. Gottschall, Y. Feito, P. L. Ha, A. Lavigne, K. Persaud, H. L. Gagnon, A. Krueger, A. Modjeski, T. A. Esmat, L. N. Harper, T. A. Vandusseldorp, Garrett Hester Aug 2023

Effects Of Plyometric- And Cycle-Based High-Intensity Interval Training On Body Composition, Aerobic Capacity, And Muscle Function In Young Females: A Field-Based Group Fitness Assessment, A. J. Holmes, M. T. Stratton, A. R. Bailly, J. S. Gottschall, Y. Feito, P. L. Ha, A. Lavigne, K. Persaud, H. L. Gagnon, A. Krueger, A. Modjeski, T. A. Esmat, L. N. Harper, T. A. Vandusseldorp, Garrett Hester

Faculty and Research Publications

High-intensity interval training (HIIT) is an effective alternative to moderate intensity continuous training for improvements in body composition and aerobic capacity; however, there is little work comparing different modalities of HIIT. The purpose of this study was to compare the effects of plyometric- (PLYO) and cycle-oriented (CYC) HIIT on body composition, aerobic capacity, and skeletal muscle size, quality, and function in recreationally trained females. Young (21.7 ± 3.1 yrs), recreationally active females were quasi-randomized (1:1 ratio) to 8 weeks of twice weekly PLYO (n = 15) or CYC (n = 15) HIIT. Body composition (four-compartment model), VO2peak …


Carbohydrate Rinse Fails To Enhance Cycling Performance Or Alter Metabolic And Autonomic Recovery In Recreational Cyclists, Cassie Williamson-Reisdorph, Emily Bechke, Cherilyn Mclester, Robert J. Buresh, Melinda Millard-Stafford, Zackery Green, Rasmus Rooks, Brett Nickerson, Brian Kliszczewicz Aug 2022

Carbohydrate Rinse Fails To Enhance Cycling Performance Or Alter Metabolic And Autonomic Recovery In Recreational Cyclists, Cassie Williamson-Reisdorph, Emily Bechke, Cherilyn Mclester, Robert J. Buresh, Melinda Millard-Stafford, Zackery Green, Rasmus Rooks, Brett Nickerson, Brian Kliszczewicz

Faculty and Research Publications

The purpose of the study was to examine the effects of carbohydrate (CHO) mouth rinsing on autonomic and metabolic recovery as well as cycling performance. Ten male recreational cyclists (age = 30 ± 6 years, VO2peak = 54.5 ± 8.1 mL·kg-1·min-1) completed a randomized, double-blind, placebo-controlled, crossover designed study. A CHO or a placebo (PLA) rinse was administered every 12.5% of a work to completion trial (75%Wmax). Heart rate variability (lnRMSSD), the respiratory exchange ratio, and plasma epinephrine, norepinephrine, insulin, glucose, free fatty acids (FFA), and lactate were measured pre- and post-exercise. The CHO rinse did not improve time to …


Effects Of Exogenous Application Of Plant Growth Regulators (Snp And Ga3) On Phytoextraction By Switchgrass (Panicum Virgatum L.) Grown In Lead (Pb) Contaminated Soil, Adrianne Beavers, Marina Koether, Thomas C. Mcelroy, Sigurdur Greipsson Oct 2021

Effects Of Exogenous Application Of Plant Growth Regulators (Snp And Ga3) On Phytoextraction By Switchgrass (Panicum Virgatum L.) Grown In Lead (Pb) Contaminated Soil, Adrianne Beavers, Marina Koether, Thomas C. Mcelroy, Sigurdur Greipsson

Faculty and Research Publications

Soil lead (Pb) contamination is a major environmental and public health risk. Switch-grass (Panicum virgatum), a second-generation biofuel crop, is potentially useful for the long-term phytoremediation and phytoextraction of Pb contaminated soils. We evaluated the efficacy of a coor-dinated foliar application of plant growth regulators and soil fungicide and a chelator in order to optimize phytoextraction. Plants were grown in soil culture under controlled conditions. First, three exogenous nitric oxide (NO) donors were evaluated at multiple concentrations: (1) S-nitroso-N-acetylpenicillamine (SNAP); (2) sodium nitroprusside (SNP); and (3) S-nitrosoglutathione (GSNO). Second, the effect of SNP (0.5 µM) was examined further with the …


The Effects Of Aerobic-Resistance Training And Broccoli Supplementation On Plasma Dectin-1 And Insulin Resistance In Males With Type 2 Diabetes, Ayoub Saeidi, Mohammad Soltani, Ali Daraei, Hanieh Nohbaradar, Marjan Mosalman Haghighi, Nikoo Khosravi, Kelly E. Johnson, Ismail Laher, Anthony C. Hackney, Trisha Vandusseldorp, Hassane Zouhal Sep 2021

The Effects Of Aerobic-Resistance Training And Broccoli Supplementation On Plasma Dectin-1 And Insulin Resistance In Males With Type 2 Diabetes, Ayoub Saeidi, Mohammad Soltani, Ali Daraei, Hanieh Nohbaradar, Marjan Mosalman Haghighi, Nikoo Khosravi, Kelly E. Johnson, Ismail Laher, Anthony C. Hackney, Trisha Vandusseldorp, Hassane Zouhal

Faculty and Research Publications

BACKGROUND: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D). METHODS: Forty-four males with T2D were randomly allocated to four groups ( = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 …


Beyond The Kármán Gait: Knifefish Swimming In Periodic And Irregular Vortex Streets, Victor M. Ortega-Jiménez, Christopher P. Sanford May 2021

Beyond The Kármán Gait: Knifefish Swimming In Periodic And Irregular Vortex Streets, Victor M. Ortega-Jiménez, Christopher P. Sanford

Faculty and Research Publications

Neotropical freshwater fishes such as knifefishes are commonly faced with navigating intense and highly unsteady streams. However, our knowledge on locomotion in apteronotids comes from laminar flows, where the ribbon fin dominates over the pectoral fins or body bending. Here, we studied the 3D kinematics and swimming control of seven black ghost knifefish (Apteronotus albifrons) moving in laminar flows (flow speed U∞≈1-5 BL s-1) and in periodic vortex streets (U∞≈2-4 BL s-1). Two different cylinders (∼2 and ∼3 cm diameter) were used to generate the latter. Additionally, fish were exposed to an irregular wake produced by a free oscillating cylinder …


Isometric Versus Isotonic Contractions: Sex Differences In The Fatigability And Recovery Of Isometric Strength And High-Velocity Contractile Parameters, Phuong L. Ha, Benjamin E. Dalton, Michaela G. Alesi, Tyler M. Smith, Trisha Vandusseldorp, Yuri Feito, Garrett Hester May 2021

Isometric Versus Isotonic Contractions: Sex Differences In The Fatigability And Recovery Of Isometric Strength And High-Velocity Contractile Parameters, Phuong L. Ha, Benjamin E. Dalton, Michaela G. Alesi, Tyler M. Smith, Trisha Vandusseldorp, Yuri Feito, Garrett Hester

Faculty and Research Publications

The purpose of this study was to investigate potential sex differences in the fatigue- and recovery-induced responses of isometric strength and power, as well as select dynamic contractile parameters after isometric and isotonic plantar flexor (PF) contractions. Healthy males (n = 12; age = 21.8 ± 2.2 years) and females (n = 14; age = 21.4 ± 2.5 years) performed a 2-min maximal voluntary isometric contraction and 120 concentric isotonic (30% peak isometric torque) contractions of the PFs on separate visits. Isometric strength, isotonic power, as well as torque- and velocity-related parameters were recorded before, immediately after, and throughout 10 …


Physical Education And Anti-Blackness, Brian Culp Dec 2020

Physical Education And Anti-Blackness, Brian Culp

Faculty and Research Publications

This commentary is not intended to be an all-inclusive “catch-all” but a starting point to inspire behavior change, cultural fluency, and an “ideological repositioning” of how we think about our professional work. In defining anti-Blackness, the article provides perspectives from educational literature, research, and personal observations before providing a challenge to SHAPE America and all professionals involved in efforts related to the promotion of quality physical education.


Physiological Differences Between Advanced Crossfit Athletes, Recreational Crossfit Participants, And Physically-Active Adults, Gerald Mangine, Matthew Stratton, Christian G. Almeda, Michael D. Roberts, Tiffany A. Esmat, Trisha Vandusseldorp, Yuri Feito Apr 2020

Physiological Differences Between Advanced Crossfit Athletes, Recreational Crossfit Participants, And Physically-Active Adults, Gerald Mangine, Matthew Stratton, Christian G. Almeda, Michael D. Roberts, Tiffany A. Esmat, Trisha Vandusseldorp, Yuri Feito

Faculty and Research Publications

This investigation examined anthropometric, hormonal, and physiological differences between advanced (ADV; n = 8, 27.8 ± 4.2 years, 170 ± 11 cm, 79.8 ± 13.3 kg) and recreational (REC; n = 8, 33.5 ± 8.1 years, 172 ± 14 cm, 76.3 ± 19.5 kg) CrossFit (CF) trained participants in comparison to physically-active controls (CON; n = 7, 27.5 ± 6.7 years, 171 ± 14 cm, 74.5 ± 14.3 kg). ADV and REC were distinguished by their past competitive success. REC and CON were resistance-trained (>2 years) and exercised on 3–5 days·wk-1 for the past year, but CON utilized …


Early And Late Rapid Torque Characteristics And Select Physiological Correlates In Middle-Aged And Older Males, Alex A. Olmos, Matthew T. Stratton, Phuong L. Ha, Benjamin E. Dalton, Trisha Vandusseldorp, Gerald Mangine, Yuri Feito, Micah J. Poisal, Joshua A. Jones, Tyler M. Smith, Garrett Hester Apr 2020

Early And Late Rapid Torque Characteristics And Select Physiological Correlates In Middle-Aged And Older Males, Alex A. Olmos, Matthew T. Stratton, Phuong L. Ha, Benjamin E. Dalton, Trisha Vandusseldorp, Gerald Mangine, Yuri Feito, Micah J. Poisal, Joshua A. Jones, Tyler M. Smith, Garrett Hester

Faculty and Research Publications

Purpose

The purpose of this study was to compare early and late rapid torque parameters of the plantar flexors (PFs) in middle-aged (MM) and older (OM) males, and determine the effect of normalization to peak torque (PT) and muscle cross-sectional area (CSA).

Methods

Twenty-nine healthy, MM (n = 14; 45 ± 2 yrs) and OM (n = 15; 65 ± 3 yrs) performed rapid, maximal isometric contractions of the PFs. PT, as well as rate of torque development and impulse during the early (0–50 ms; RTD0-50, IMP0-50) and late (100–200 ms; RTD100-200, IMP100-200 …


Self-Talk: Mentoring And Empowering Faculty To Contribute To Organizational Change, Brian Culp Mar 2020

Self-Talk: Mentoring And Empowering Faculty To Contribute To Organizational Change, Brian Culp

Faculty and Research Publications

We can effectively mentor if in possession of qualities to empower mentees, which include: effective communication skills, knowledge of the professional realm, enthusiasm, passion and the ability to create an equitable and supportive organizational environment with the mentee. The authors of this article propose that self-talk (ST) or inner speech is a helpful means of inspiring mentors, colleagues, teachers, and friends in navigating communication challenges with themselves and others. A three-step approach to implementing ST for the purpose of mentoring involves: (1) awareness of the ST they are currently using; (2) follow-up with the mentee’s active reflection of and recording …


The Larp1 La-Module Recognizes Both Ends Of Top Mrnas, Hiba A. Al-Ashtal, Courtney M. Rubottom, Thomas C. Leeper, Andrea J. Berman Oct 2019

The Larp1 La-Module Recognizes Both Ends Of Top Mrnas, Hiba A. Al-Ashtal, Courtney M. Rubottom, Thomas C. Leeper, Andrea J. Berman

Faculty and Research Publications

La-Related Protein 1 (LARP1) is an RNA-binding protein that regulates the stability and translation of mRNAs encoding the translation machinery, including ribosomal proteins and translation factors. These mRNAs are characterized by a 5ʹ-terminal oligopyrimidine (TOP) motif that coordinates their temporal and stoichiometric expression. While LARP1 represses TOP mRNA translation via the C-terminal DM15 region, the role of the N-terminal La-Module in the recognition and translational regulation of TOP mRNAs remains elusive. Herein we show that the LARP1 La-Module also binds TOP motifs, although in a cap-independent manner. We also demonstrate that it recognizes poly(A) RNA. Further, our data reveal that …


Identification And Characterization Of Preferred Dna-Binding Sites For The Thermus Thermophilus Hb8 Transcriptional Regulator Ttha0973, James Shell Cox, Kristi Moncja, Mykala Mckinnes, Michael W. Van Dyke Jul 2019

Identification And Characterization Of Preferred Dna-Binding Sites For The Thermus Thermophilus Hb8 Transcriptional Regulator Ttha0973, James Shell Cox, Kristi Moncja, Mykala Mckinnes, Michael W. Van Dyke

Faculty and Research Publications

Advances in genomic sequencing have allowed the identification of a multitude of genes encoding putative transcriptional regulatory proteins. Lacking, often, is a fuller understanding of the biological roles played by these proteins, the genes they regulate or regulon. Conventionally this is achieved through a genetic approach involving putative transcription factor gene manipulation and observations of changes in an organism’s transcriptome. However, such an approach is not always feasible or can yield misleading findings. Here, we describe a biochemistry-centric approach, involving identification of preferred DNA-binding sequences for the Thermus thermophilus HB8 transcriptional repressor TTHA0973 using the selection method Restriction Endonuclease Protection, …


Time-Restricted Feeding Plus Resistance Training In Active Females: A Randomized Trial, Grant M. Tinsley, M. Lane Moore, Austin J. Graybeal, Trisha A. Vandusseldorp Jul 2019

Time-Restricted Feeding Plus Resistance Training In Active Females: A Randomized Trial, Grant M. Tinsley, M. Lane Moore, Austin J. Graybeal, Trisha A. Vandusseldorp

Faculty and Research Publications

Background A very limited amount of research has examined intermittent fasting (IF) programs, such as time-restricted feeding (TRF), in active populations. Objective Our objective was to examine the effects of TRF, with or without β-hydroxy β-methylbutyrate (HMB) supplementation, during resistance training (RT). Methods This study employed a randomized, placebo-controlled, reduced factorial design and was double-blind with respect to supplementation in TRF groups. Resistance-trained females were randomly assigned to a control diet (CD), TRF, or TRF plus 3 g/d HMB (TRFHMB). TRF groups consumed all calories between 1200 h and 2000 h, whereas the CD group ate regularly from breakfast until …


Beyond The Black Box: Promoting Mathematical Collaborations For Elucidating Interactions In Soil Ecology, Alison E. Bennett, Antonio Golubski, Et Al. Jul 2019

Beyond The Black Box: Promoting Mathematical Collaborations For Elucidating Interactions In Soil Ecology, Alison E. Bennett, Antonio Golubski, Et Al.

Faculty and Research Publications

Understanding soil systems is critical because they form the structural and nutritional foundation for plants and thus every terrestrial habitat and agricultural system. In this paper, we encourage increased use of mathematical models to drive forward understanding of interactions in soil ecological systems. We discuss several distinctive features of soil ecosystems and empirical studies of them. We explore some perceptions that have previously deterred more extensive use of models in soil ecology and some advances that have already been made using models to elucidate soil ecological interactions. We provide examples where mathematical models have been used to test the plausibility …


Pilates Training Induces Changes In The Trunk Musculature Of Adolescents, Noelia González-Gálvez, María Carrasco Poyatos, Pablo Jorge Marcos-Pardo, Yuri Feito Jun 2019

Pilates Training Induces Changes In The Trunk Musculature Of Adolescents, Noelia González-Gálvez, María Carrasco Poyatos, Pablo Jorge Marcos-Pardo, Yuri Feito

Faculty and Research Publications

Introduction The Pilates Method may be an appropriate form of exercise for improving trunk muscle strength, which can be a predictor of pain and musculoskeletal problems. Objective The objective of this study was to assess the effects of the Pilates Method on muscle strength and endurance of the extensor and flexor muscles of the trunk in a group of adolescents. Methods The sample consisted of 101 high-school students divided into two groups: an experimental group (EG=81) and a control group (CG=20). The intervention was carried out twice a week for six weeks. Each session lasted 55 minutes, and was divided …


Genistein Has Antiviral Activity Against Herpes B Virus And Acts Synergistically With Antiviral Treatments To Reduce Effective Dose, Julia C. Lecher, Nga Diep, Peter W. Krug, Julia K. Hilliard May 2019

Genistein Has Antiviral Activity Against Herpes B Virus And Acts Synergistically With Antiviral Treatments To Reduce Effective Dose, Julia C. Lecher, Nga Diep, Peter W. Krug, Julia K. Hilliard

Faculty and Research Publications

Herpes B virus is a deadly zoonotic agent that can be transmitted to humans from the macaque monkey, an animal widely used in biomedical research. Currently, there is no cure for human B virus infection and treatments require a life-long daily regimen of antivirals, namely acyclovir and ganciclovir. Long-term antiviral treatments have been associated with significant debilitating side effects, thus, there is an ongoing search for alternative efficacious antiviral treatment. In this study, the antiviral activity of genistein was quantified against B virus in a primary cell culture model system. Genistein prevented plaque formation of B virus and reduced virus …


Agreement Between The Open Barbell And Tendo Linear Position Transducers For Monitoring Barbell Velocity During Resistance Exercise, Adam M. Gonzalez, Gerald T. Mangine, Robert W. Spitz, Jamie J. Ghigiarelli May 2019

Agreement Between The Open Barbell And Tendo Linear Position Transducers For Monitoring Barbell Velocity During Resistance Exercise, Adam M. Gonzalez, Gerald T. Mangine, Robert W. Spitz, Jamie J. Ghigiarelli

Faculty and Research Publications

To determine the agreement between the Open Barbell (OB) and Tendo weightlifting analyzer (TWA) for measuring barbell velocity, eleven men (19.4 ± 1.0 y) performed one set of 2–3 repetitions at four sub-maximal percentage loads, [i.e., 30, 50, 70, and 90% one-repetition maximum (1RM)] in the back (BS) and front squat (FS) exercises. During each repetition, peak and mean barbell velocity were recorded by OB and TWA devices, and the average of the 2–3 repetitions was used for analyses. Although the repeated measures analysis of variance revealed significantly (p ≤ 0.005) greater peak and mean velocity scores from OB across …


Individual Differences Influence Exercise Behavior: How Personality, Motivation, And Behavioral Regulation Vary Among Exercise Mode Preferences, Allyson G. Box, Yuri Feito, Chris Brown, Steven J. Petruzzello Apr 2019

Individual Differences Influence Exercise Behavior: How Personality, Motivation, And Behavioral Regulation Vary Among Exercise Mode Preferences, Allyson G. Box, Yuri Feito, Chris Brown, Steven J. Petruzzello

Faculty and Research Publications

Personality traits, participatory motives, and behavior regulation have been linked to physical activity engagement. It is possible that these dimensions are associated with the type of physical activity one chooses to engage. Thus, the purpose of this study was to examine individual differences in those participating in various primary modes of physical activity (PMA) and determine which individual differences are predictive of exercise frequency. Methods 403 adults (36.3 ± 11.6 yrs, 35.5% male) completed an online survey. The survey included questions related to their PMA, items for the Big Five Inventory (BFI), Exercise Motivation Inventory (EMI-2), and the Behavioral Regulation …


High Intensity Functional Training (Hift) And Competitions: How Motives Differ By Length Of Participation, Allyson G. Box, Yuri Feito, Chris Brown, Katie M. Heinrich Mar 2019

High Intensity Functional Training (Hift) And Competitions: How Motives Differ By Length Of Participation, Allyson G. Box, Yuri Feito, Chris Brown, Katie M. Heinrich

Faculty and Research Publications

High Intensity Functional Training (HIFT) is a unique fitness method that promotes an active lifestyle and has seen exponential and continual growth over the last two decades. Motivation to exercise is likely to change over time as individuals’ motives to initiate exercise may be different than those which motivate them to maintain an exercise program. The purpose of this study was to examine the motivational factors reported by individuals who actively engage in HIFT with varying length of participation and competition levels. 737 adults (32.4 ± 8.2 years) with more than three-months of HIFT experience completed an online version of …


Effects Of Eight Weeks Of High Intensity Functional Training On Glucose Control And Body Composition Among Overweight And Obese Adults, Yuri Feito, Pratik Patel, Andrea Sal Redondo, Katie M. Heinrich Feb 2019

Effects Of Eight Weeks Of High Intensity Functional Training On Glucose Control And Body Composition Among Overweight And Obese Adults, Yuri Feito, Pratik Patel, Andrea Sal Redondo, Katie M. Heinrich

Faculty and Research Publications

High-intensity exercise has been found to positively influence glucose control, however, the effects of high-intensity functional training (HIFT) for overweight and obese sedentary adults without diabetes is unknown. The purpose of this study was to examine changes in body composition and glucose control from eight weeks of aerobic and resistance training (A-RT) compared to HIFT. Session time spent doing daily workouts was recorded for each group. Baseline and posttest measures included height, weight, waist circumference, dual X-ray absorptiometry (body fat percentage, fat mass, lean mass), and fasting blood glucose. Participants completing the intervention (78%, n = 9 per group) were …


Monitoring Training Load, Well-Being, Heart Rate Variability, And Competitive Performance Of A Functional-Fitness Female Athlete: A Case Study, Ramires Alsamir Tibana, Nuno Manuel Frade De Sousa, Jonato Prestes, Yuri Feito Feb 2019

Monitoring Training Load, Well-Being, Heart Rate Variability, And Competitive Performance Of A Functional-Fitness Female Athlete: A Case Study, Ramires Alsamir Tibana, Nuno Manuel Frade De Sousa, Jonato Prestes, Yuri Feito

Faculty and Research Publications

The aim of this case study was to quantify the magnitude of internal load, acute/chronic workload ratio (ACWR), well-being perception, and heart rate variability (HRV) following 38 weeks of functional-fitness training in a female elite athlete. The internal load was obtained with session rating perceived exertion (session-RPE) while the ACWR was calculated by dividing the acute workload by the chronic workload (four-week average). Furthermore, HRV measurements were analyzed via a commercially available smartphone (HRV4training) each morning upon waking whilst in a supine position. The magnitude of internal load was: the weekly mean total during the 38 weeks was 2092 ± …


Citrus Aurantium And Caffeine Complex Versus Placebo On Biomarkers Of Metabolism: A Double Blind Crossover Design, Brian Kliszczewicz, Emily Bechke, Cassie Williamson, Zackery Green Feb 2019

Citrus Aurantium And Caffeine Complex Versus Placebo On Biomarkers Of Metabolism: A Double Blind Crossover Design, Brian Kliszczewicz, Emily Bechke, Cassie Williamson, Zackery Green

Faculty and Research Publications

BACKGROUOND: The purpose of this study was to examine resting the metabolic response to the ingestion of a complex containing Citrus Aurantium + Caffeine (CA + C) and if its consumption influences metabolic recovery following a high-intensity anaerobic exercise bout in habitual caffeine users. METHODS: Ten physically active males (25.1 ± 3.9 years; weight 78.71 ± 9.53 kg; height 177.2 ± 4.6 cm; body fat 15.5 ± 3.13%) participated in this study. This study was performed in a double-blind, randomized crossover fashion consisting of two exhaustive exercise protocols. On each visit the participants consumed either a CA + C (100 …


Pasnet: Pathway-Associated Sparse Deepneural Network For Prognosis Prediction From High-Throughput Data, Jie Hao, Youngsoon Kim, Tae-Kyung Kim, Mingon Kang Dec 2018

Pasnet: Pathway-Associated Sparse Deepneural Network For Prognosis Prediction From High-Throughput Data, Jie Hao, Youngsoon Kim, Tae-Kyung Kim, Mingon Kang

Faculty and Research Publications

Background: Predicting prognosis in patients from large-scale genomic data is a fundamentally challenging problem in genomic medicine. However, the prognosis still remains poor in many diseases. The poor prognosis maybe caused by high complexity of biological systems, where multiple biological components and their hierarchical relationships are involved. Moreover, it is challenging to develop robust computational solutions with high-dimension, low-sample size data. Results: In this study, we propose a Pathway-Associated Sparse Deep Neural Network (PASNet) that not only predicts patients’ prognoses but also describes complex biological processes regarding biological pathways for prognosis. PASNet models a multilayered, hierarchical biological system of genes …


Autophagy And Aging: Maintaining The Proteome Through Exercise And Caloric Restriction, Kurt A. Escobar, Nathan H. Cole, Christine M. Mermier, Trisha A. Vandusseldrop Nov 2018

Autophagy And Aging: Maintaining The Proteome Through Exercise And Caloric Restriction, Kurt A. Escobar, Nathan H. Cole, Christine M. Mermier, Trisha A. Vandusseldrop

Faculty and Research Publications

Accumulation of dysfunctional and damaged cellular proteins and organelles occursduring aging, resulting in a disruption of cellular homeostasis and progressive degen-eration and increases the risk of cell death. Moderating the accrual of these defunctcomponents is likely a key in the promotion of longevity. While exercise is knownto promote healthy aging and mitigate age‐related pathologies, the molecular under-pinnings of this phenomenon remain largely unclear. However, recent evidencessuggest that exercise modulates the proteome. Similarly, caloric restriction (CR), aknown promoter of lifespan, is understood to augment intracellular protein quality.Autophagy is an evolutionary conserved recycling pathway responsible for thedegradation, then turnover of cellular proteins …


A 4-Year Analysis Of The Incidence Of Injuries Among Crossfit-Trained Participants, Yuri Feito, Evanette K. Burrows, Loni Phillip Tabb Oct 2018

A 4-Year Analysis Of The Incidence Of Injuries Among Crossfit-Trained Participants, Yuri Feito, Evanette K. Burrows, Loni Phillip Tabb

Faculty and Research Publications

Background: High-intensity functional training (HIFT) is a new training modality that merges high-intensity exercise with functional (multijoint) movements. Even though others exist, CrossFit training has emerged as the most common form of HIFT. Recently, several reports have linked CrossFit training to severe injuries and/or life-threatening conditions, such as rhabdomyolysis.Empirical evidence regarding the safety of this training modality is currently limited. Purpose: To examine the incidence of injuries related to CrossFit participation and to estimate the rate of injuries in a large cross-sectional convenience sample of CrossFit participants from around the world. Study Design: Descriptive epidemiology study. Methods: A total of …


Effect Of Branched-Chain Amino Acid Supplementationon Recovery Following Acute Eccentric Exercise, Trisha A. Vandusseldorp, Kurt A. Escobar, Kelly E. Johnson, Matthew T. Stratton, Terence Moriarty, Nathan Cole, James J. Mccormick, Chad M. Kersick, Roger A. Vaughan, Karol Dokladny, Len Kravitz, Christine M. Mermier Oct 2018

Effect Of Branched-Chain Amino Acid Supplementationon Recovery Following Acute Eccentric Exercise, Trisha A. Vandusseldorp, Kurt A. Escobar, Kelly E. Johnson, Matthew T. Stratton, Terence Moriarty, Nathan Cole, James J. Mccormick, Chad M. Kersick, Roger A. Vaughan, Karol Dokladny, Len Kravitz, Christine M. Mermier

Faculty and Research Publications

This study investigated the effect of branched-chain amino acid (BCAA) supplementationon recovery from eccentric exercise. Twenty males ingested either a BCAA supplement or placebo(PLCB) prior to and following eccentric exercise. Creatine kinase (CK), vertical jump (VJ), maximalvoluntary isometric contraction (MVIC), jump squat (JS) and perceived soreness were assessed.No significant (p> 0.05) group by time interaction effects were observed for CK, soreness, MVIC, VJ,or JS. CK concentrations were elevated above baseline (p< 0.001) in both groups at 4, 24, 48 and 72 hr,while CK was lower (p= 0.02) in the BCAA group at 48 hr compared to PLCB. Soreness increasedsignificantly from baseline (p< 0.01) in both groups at all time-points; however, BCAA supplementedindividuals reported less soreness (p< 0.01) at the 48 and 72 hr time-points. MVIC force outputreturned to baseline levels (p> 0.05) at 24, 48 and 72 hr for BCAA individuals. No significant differencebetween groups (p> 0.05) was detected for VJ or JS. BCAA supplementation may mitigate musclesoreness following muscle-damaging …


Resistance Training Does Not Induce Uniform Adaptations To Quadriceps, Gerald T. Mangine, Michael J. Redd, Adam M. Gonzalez, Jeremy R. Townsend, Adam J. Wells, Adam R. Jajtner, Kyle S. Beyer, Carleigh H. Boone, Michael B. La Monica, Jeffrey R. Stout, David H. Fukuda, Nicholas R. Ratamess, Jay R. Hoffman Aug 2018

Resistance Training Does Not Induce Uniform Adaptations To Quadriceps, Gerald T. Mangine, Michael J. Redd, Adam M. Gonzalez, Jeremy R. Townsend, Adam J. Wells, Adam R. Jajtner, Kyle S. Beyer, Carleigh H. Boone, Michael B. La Monica, Jeffrey R. Stout, David H. Fukuda, Nicholas R. Ratamess, Jay R. Hoffman

Faculty and Research Publications

Resistance training may differentially affect morphological adaptations along the length of uni-articular and bi-articular muscles. The purpose of this study was to compare changes in muscle morphology along the length of the rectus femoris (RF) and vastus lateralis (VL) in response to resistance training. Following a 2-wk preparatory phase, 15 resistance-trained men (24.0 ± 3.0 y, 90.0 ± 13.8 kg, 174.9 ± 20.7 cm) completed pre-training (PRE) assessments of muscle thickness (MT), pennation angle (PA), cross-sectional area (CSA), and echo-intensity in the RF and VL at 30, 50, and 70% of each muscle’s length; fascicle length (FL) was estimated from …


Normative Values For Self-Reported Benchmark Workout Scores In Crossfit® Practitioners, Gerald T. Mangine, Brant Cebulla, Yuri Feito Aug 2018

Normative Values For Self-Reported Benchmark Workout Scores In Crossfit® Practitioners, Gerald T. Mangine, Brant Cebulla, Yuri Feito

Faculty and Research Publications

Background: CrossFit® practitioners commonly track progress by monitoring their ability to complete a variety of standardized benchmark workouts within a typical class setting. However, objective assessment of progress is challenging because normative data does not currently exist for any of these benchmark workouts. Therefore, the purpose of this study was to develop normative values for five common benchmark workouts (i.e., Fran, Grace, Helen, Filthy-50 [F50], and Fight-Gone-Bad [FGB]). Methods: Performance data from 133,857 male (M) and female (F) profiles located on a publicly available website were collected and sorted by sex (i.e., male [M] and female [F]) and competitive age …


High-Intensity Functional Training (Hift): Definition And Research Implications For Improved Fitness, Yuri Feito, Katie M. Heinrich, Scotty J. Butcher, Walker S. Carlos Poston Aug 2018

High-Intensity Functional Training (Hift): Definition And Research Implications For Improved Fitness, Yuri Feito, Katie M. Heinrich, Scotty J. Butcher, Walker S. Carlos Poston

Faculty and Research Publications

High-intensity functional training (HIFT) is an exercise modality that emphasizes functional,multi-joint movements that can be modified to any fitness level and elicit greater muscle recruitmentthan more traditional exercise. As a relatively new training modality, HIFT is often compared tohigh-intensity interval training (HIIT), yet the two are distinct. HIIT exercise is characterized byrelatively short bursts of repeated vigorous activity, interspersed by periods of rest or low-intensityexercise for recovery, while HIFT utilizes constantly varied functional exercises and various activitydurations that may or may not incorporate rest. Over the last decade, studies evaluating theeffectiveness of HIIT programs have documented improvements in metabolic and …