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Articles 841 - 870 of 3160
Full-Text Articles in Life Sciences
Characterization Of Adiposity And Inflammation Genetic Pleiotropy Underlying Cardiovascular Risk Factors In Hispanics., Mohammad Yaser (Anwar)
Characterization Of Adiposity And Inflammation Genetic Pleiotropy Underlying Cardiovascular Risk Factors In Hispanics., Mohammad Yaser (Anwar)
Electronic Theses and Dissertations
The observed overlap between genetic variants associated with both adiposity and inflammatory markers suggests that changes in both adiposity and inflammation could be partially mediated by common pathways. The pervasive but sparsely characterized “pleiotropic” genetic variants associated with both adiposity and inflammation have been hypothesized to provide insight into the shared biology. This study explored and characterized the genetic pleiotropy underpinning adiposity and inflammation using genetic and phenotypic observations from the Cameron County Hispanic Cohort (CCHC). A total of 3,313 samples and >9 million single nucleotide polymorphisms (SNPs) were examined in this study. Mixed model genome-wide association studies (GWAS) were …
Investigating The Disorder And Compaction Of Designed Minielastin Using Nuclear Magnetic Resonance., Ma Faye Charmagne Aquino Carvajal
Investigating The Disorder And Compaction Of Designed Minielastin Using Nuclear Magnetic Resonance., Ma Faye Charmagne Aquino Carvajal
Electronic Theses and Dissertations
Minielastins are elastin-based proteins with alternating hydrophobic and cross-link modules similar to tropoelastin. Tropoelastin is the ~70 kDa soluble monomeric precursor of elastin. The extracellular matrix protein, elastin provides elasticity to tissues and organs such as lungs, arteries and ligaments. The elastic properties of natural elastin are believed to be entropic in origin. In vivo, the elastin matrix is approximately 50% water by weight. Without water, elastin is brittle and hard. Minielastins, like tropoelastin, undergo a liquid-liquid phase transition upon an increase in temperature. Factors such as hydrophobicity, chain length and concentration affect the coacervation temperature, Tc. The …
Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das
Statistical Approaches Of Gene Set Analysis With Quantitative Trait Loci For High-Throughput Genomic Studies., Samarendra Das
Electronic Theses and Dissertations
Recently, gene set analysis has become the first choice for gaining insights into the underlying complex biology of diseases through high-throughput genomic studies, such as Microarrays, bulk RNA-Sequencing, single cell RNA-Sequencing, etc. It also reduces the complexity of statistical analysis and enhances the explanatory power of the obtained results. Further, the statistical structure and steps common to these approaches have not yet been comprehensively discussed, which limits their utility. Hence, a comprehensive overview of the available gene set analysis approaches used for different high-throughput genomic studies is provided. The analysis of gene sets is usually carried out based on …
Modified-Half-Normal Distribution And Different Methods To Estimate Average Treatment Effect., Jingchao Sun
Modified-Half-Normal Distribution And Different Methods To Estimate Average Treatment Effect., Jingchao Sun
Electronic Theses and Dissertations
This dissertation consists of three projects related to Modified-Half-Normal distribution and causal inference. In my first project, a new distribution called Modified-Half-Normal distribution was introduced. I explored a few of its distributional properties, the procedures for generating random samples based on Bayesian approaches, and the parameter estimation based on the method of moments. The second project deals with the problem of selection bias of average treatment effect (ATE) if we use the observational data. I combined the propensity score based inverse probability of treatment weighting (IPTW) method and the directed acyclic graph (DAG) to solve this problem. The third project …
On The Straight And Narrow: How Cultural Beliefs About Sex/Gender Manifest In College Biology Learning Environments., Katherine Ray Kng
On The Straight And Narrow: How Cultural Beliefs About Sex/Gender Manifest In College Biology Learning Environments., Katherine Ray Kng
Electronic Theses and Dissertations
This dissertation focused on the ways that social beliefs about sex/gender and sexuality manifest in biology classrooms. Especially for health science students, classes include topics like sex, sexuality, sexual behaviors, or sex determination that forms the foundation of their understanding of human forms and behaviors. If the information they receive does not include the LGBTQIA+ community, their education will fail to adequately prepare them for the reality of healthcare practice where they will be expected to treat all patients with dignity and respect. There are three chapters in this dissertation. In chapter one, I asked what beliefs about and conceptions …
Determining The Physiological And Behavioral Responses To Elevated Salinity In The Freshwater Bivalves, Corbicula Fluminea And Lampsilis Ovata, John W. Roden
Electronic Theses and Dissertations
Salinization has been identified as an increasing threat to freshwater mussel diversity in recent years. Native mussels have been observed to display reduced salinity tolerance in comparison to some invasive bivalve species, but methods by which organismal tolerance is achieved are not well understood. This study was designed to compare the behavioral and physiological responses of the native Lampsilis ovata to that of the invasive Corbicula fluminea. Lampsilis were found to exhibit strong behavioral avoidance to salinity exposure, whereas Corbicula displayed very weak avoidance to comparable salinity concentrations followed by indications of osmotic conformation through physiological mechanisms. Prolonged valve …
Malaria, Microbes, And Mice: The Role Of The Gut Microbiota On The Immune Response To Plasmodium Infection And The Treatment Potential Of Microbiota Modulation., Morgan L. Waide
Electronic Theses and Dissertations
Plasmodium infection leads to over 200 million cases of malaria and 400,000 deaths worldwide each year. These deaths are largely in children under the age of five and pregnant women [1]. Caused by transmission of Plasmodium parasites by the female Anopheles mosquito, malaria poses a risk for over 40 percent of the world’s population [1]. Despite worldwide efforts to eradicate malaria leading to a decrease in malaria-associated mortalities in the early 2000s [2], growing resistance to the available antimalarials and the lack of an effective, long-lasting vaccine has caused this decrease to plateau in recent years [1, 3-6]. Furthermore, malaria …
Block Periodization Programming: Efficacy In Subjects Of Differing Strength Levels, Paul Moquin
Block Periodization Programming: Efficacy In Subjects Of Differing Strength Levels, Paul Moquin
Electronic Theses and Dissertations
Physiological muscle adaptations due to resistance training are still not fully known. The rate and area of hypertrophy could drastically help or hinder athletic performance. The purpose of this study was to observe the changes in lean body mass (and related factors), relative allometrically scaled strength and absolute strength through an 11-week block periodized resistance training program. The subjects (n = 15) realized an increase in total body water (pre = 49.77Kg; post = 51.70Kg), lean body mass (pre = 67.98Kg; post = 70.63Kg), adjusted lean body mass (pre = 20.35Kg; post = 21.03Kg) and cross sectional area (pre = …
Predator-Avoidance Of Larval Black-Bellied Salamanders (Desmognathus Quadramaculatus) In Response To Cues From Native And Nonnative Salmonids, Brian L. Dempsey
Predator-Avoidance Of Larval Black-Bellied Salamanders (Desmognathus Quadramaculatus) In Response To Cues From Native And Nonnative Salmonids, Brian L. Dempsey
Electronic Theses and Dissertations
The introduction of nonnative salmonids into Southern Appalachia may pose a threat to resident salamander populations. In recent years, the stocking and encroachment of rainbow trout (Oncorhynchus mykiss) into headwaters where the black-bellied salamander (Desmognathus quadramaculatus) and brook trout (Salvelinus fontinalis) naturally coexist has raised concerns. In aquatic prey, predator-avoidance responses are primarily influenced through the detection of chemical cues released from predators. The objective of this study was to determine how co-occurrence with a predator influences black-bellied salamander predator recognition behavior. To evaluate this, salamander activity metrics (general activity, number of movements, and latency to move) were recorded before …
Immune Activation Induces Telomeric Dna Damage, Reduces Memory Precursors, And Promotes Short-Lived Effector T Cell Differentiation In Chronic Hcv Infection, Lam Nguyen
Electronic Theses and Dissertations
Chronic hepatitis C virus (HCV) infection exhibits persistent high viral load, inducing T cells differentiation and dysfunction in chronically infected individuals. Recent longitude studies in both HCV specific- and bulk T cells reveal that chronic immune stimulation is the driving force for the impaired T cell functions, however, the underlying mechanisms remain elusive. Here, we show that peripheral CD4+ T cells from chronically HCV-infected patients exhibit lymphopenia with the reduction of naïve population and expansion of effector memory T cells. CD4+ T cells from HCV patient also display elevated activation markers. including HLA-DR, GLUT1, Granzyme B, and short-lived …
Prevention Of Chronic Inflammation By Targeting Macrophage Integrin Adb2, Cady Forgey
Prevention Of Chronic Inflammation By Targeting Macrophage Integrin Adb2, Cady Forgey
Electronic Theses and Dissertations
Macrophage integrin aDb2 promotes macrophage retention and accumulation within inflamed tissue, a key event in development of chronic inflammation. Recently, the P5 peptide was identified as a specific inhibitor for integrin aDb2 interaction with 2-(ω-carboxyethyl) pyrole (CEP), a ligand at inflammatory sites. This thesis aims to identify integrin aD I-domain amino acids involved in binding P5 peptide and likewise to CEP. We propose that non-conserved, basic amino acids of the integrin aDb2 I-domain are responsible for binding to P5 peptide and likewise to CEP. Eight amino acids were analyzed by …
Past, Current, And Future Potential Distributions Of Red Spruce And Fraser Fir Forests In The Southern Appalachians: Interpreting Possible Impacts Of Climate Change, Danika Mosher
Electronic Theses and Dissertations
Spruce-Fir forests are relicts from the Pleistocene and can only be found within the Southern Appalachians. Analyzing the relationships between species distribution, climatic parameters, topography, and biotic interactions through ecological niche modeling creates prediction maps for conservation efforts. Maxent, Boosted Regression, and Random Forest were utilized to compare which model and variable combinations best approximate the unique mountain forest environment. Maxent with a bias file produced optimal results and was used to examine distributional changes that may occur in the future and how these changes compare to paleo-environmental distributions. Fraser fir has shown evidence of being influenced by changing climates …
Analyzing The Longevity Of Sperm Within The Female Japanese Quail By Assessing Sperm Penetration Of The Perivitelline Layer Under Optimal And Suboptimal Conditions., Garret G. Ashabranner, Joey L. Bray
Analyzing The Longevity Of Sperm Within The Female Japanese Quail By Assessing Sperm Penetration Of The Perivitelline Layer Under Optimal And Suboptimal Conditions., Garret G. Ashabranner, Joey L. Bray
Electronic Theses and Dissertations
After mating, birds have the ability to store semen within the female reproductive tract. The sperm storage tubules will store and subsequently release semen to travel up the oviduct. Sperm cells that make the trek up the oviduct have a chance to fertilize the ovum. These sperm cells will bind to the perivitelline layer of the ovum and hydrolyze a hole in the perivitelline layer, where it has the possibility to fertilize the female sex cell. Analyzing the number of penetration points on the perivitelline layer is an effective way to analyze reproductive efficiency. Many environmental factor has its effect …
Evaluating The Biological Effects And Safety Of Exposure To Low, Putatively Safe Concentrations Of The Common Pesticide Chlorpyrifos Using An Anuran Model, Sara Mcclelland
Electronic Theses and Dissertations
In the US, over 1.1 billion pounds of pesticides are applied annually. Unfortunately, pesticides contaminate natural habitats affecting animal health. Chlorpyrifos (CPF) is an organophosphorous insecticide that contaminates surface waters. Few studies have assessed the impacts of CPF at low, ecologically realistic doses. I aimed to test the effects of low dose CPF exposures on biological parameters including body morphology, hormone levels, and brain development in Northern Leopard Frogs (Lithobates pipiens), a common vertebrate model. To determine if CPF exposure has direct impacts or indirectly impacts animals through the disruption of the food web, I examined CPF exposure …
Differential Expression Of Rna In The Rat Peripheral Nervous System Following Nerve Injury And Treatment With Pain-Relieving Celecoxib-Loaded Nanomedicine, Andrea Stevens
Electronic Theses and Dissertations
The neuroinflammatory response to peripheral nerve injury is associated with chronic pain and significant changes in the expression profiles of RNAs in neurons, glia and infiltrating immune cells: a neuro-immune triad. Chronic constriction injury (CCI) of the rat sciatic nerve provides an opportunity to mimic neuropathic injury and quantitatively assess behavior and differential gene expression in individual animals. Macrophages that phagocytose intravenously injected nanoemulsion carrying the non-steroidal anti-inflammatory, NSAID, Celecoxib, naturally accumulate at the site of injury resulting in relief of CCI behavioral hyper-sensitivity. It is not known beyond the inhibition of cyclooxygenase-2 (COX-2) activity and the reduction in prostaglandin …
Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria, Keren Solomon
Isolation, Structure Elucidation, And Synthesis Of Natural Products From Marine Cyanobacteria, Keren Solomon
Electronic Theses and Dissertations
This thesis describes the isolation, structure elucidation, and synthesis of natural products from marine cyanobacteria. A crude extract from a cyanobacterium collected in Curacao showed selective affinity for the dopamine D5 receptor in a screen against a panel of CNS receptors. Due to the high similarity of the D5 and D1 receptor, to date there are no known ligands that differentiate them. Attempts to purify the compound responsible for this affinity led to the isolation of the known compound caylobolide A. A second extract from a cyanobacterium collected in Panama underwent bioassay-guided fractionation and yielded the novel …
Use Of Multibeam And Split-Beam Sonar To Observe Changes In Fish School Biomass In Relation To Dolphin Abundance, Reece Eleanor Aponte
Use Of Multibeam And Split-Beam Sonar To Observe Changes In Fish School Biomass In Relation To Dolphin Abundance, Reece Eleanor Aponte
Electronic Theses and Dissertations
No abstract provided.
The Influence Of Environmental Variables On The Height Growth Of Loblolly Pine (Pinus Taeda) In The Western Gulf, Osakpamwan Edo-Iyasere
The Influence Of Environmental Variables On The Height Growth Of Loblolly Pine (Pinus Taeda) In The Western Gulf, Osakpamwan Edo-Iyasere
Electronic Theses and Dissertations
Understanding the effects of environmental factors on stand growth is important in optimizing forest management plans. This study investigated the effects of soil and climate factors on the height growth (site index) of loblolly pine (Pinus Taeda L.) using data collected from permanent plots established in intensively-managed plantations across East Texas and Western Louisiana. The Chapman-Richards model was selected as the base model to describe the height-age relationships and important soil and climate variables were incorporated into the models as model parameter coefficient adjustors. Our results showed that the most important factors for predicting site index were nitrogen …
Evaluation Of Groundwater Sodium And Sodium Uptake In Taxodium And Its Hybrids On Galveston Island, Texas, Daniel Morgan
Evaluation Of Groundwater Sodium And Sodium Uptake In Taxodium And Its Hybrids On Galveston Island, Texas, Daniel Morgan
Electronic Theses and Dissertations
In September 2008, Hurricane Ike swept through the Gulf of Mexico striking the Gulf Coast, claiming hundreds of lives and causing billions of dollars in damage. The hurricane left behind elevated sea salt concentrations in the soil and groundwater, preventing the unaided return of live oaks and other species to the island. To determine effective ways to ameliorate the elevated Na+ concentrations in the soil, eight treatments were applied to the soil and combinations of three species of plants, live oak (Quercus virginiana), hybrid bald cypress (Taxodium ‘T406’), and yellow hibiscus (Hibiscus hamabo …
Surface Levels, Keisha Brathwaite
Surface Levels, Keisha Brathwaite
Electronic Theses and Dissertations
Surface Levels are depictions of unobserved and imperceptible realities of many phytoplankton exteriors. The exhibition explores various structures, textures, and repetitious forms from microscopic surfaces of objects that cannot be seen with unaided eyes. Electron microscopy is used to perceive and analyze these otherwise unseeable surfaces in depth. Magnifications provide a reference in creating three- and two-dimensional works that are minimalistic and abstract at a visible level. This abstract 3D/2D image collection is translated into material expressions using acrylic sheets, acrylic ink, and wood as the main media for construction of individual works. Collectively, they serve to make the invisible …
The Relationship Between Cell-Free Dna And Resistance Training, Henry Lang
The Relationship Between Cell-Free Dna And Resistance Training, Henry Lang
Electronic Theses and Dissertations
The primary purposes of this dissertation were to explore relationship between cell free DNA (cf-DNA), creatine kinase (CK), C-reactive protein (CRP), vertical jump testing delayed onset muscle soreness (DOMS) in response to a high-volume resistance training protocol, and to assess the sensitivity of cf-DNA to different resistance training volume loads. The secondary purpose was to examine the relationship between cf-DNA and relative strength. Study 1 was an exploratory attempt to discover relationships between cf-DNA, CK, CRP, delayed onset muscle soreness, and performance variables. Seventeen resistance trained males were recruited, 9 were randomly assigned to receive BCAAs while 8 received a …
Comparative Secretomics And Functional Analysis Of Effectors Utilized By The Microbotryum Genus Of Anther-Smut Fungal Pathogens, And Their Role In Host-Specificity., William Christopher Beckerson
Comparative Secretomics And Functional Analysis Of Effectors Utilized By The Microbotryum Genus Of Anther-Smut Fungal Pathogens, And Their Role In Host-Specificity., William Christopher Beckerson
Electronic Theses and Dissertations
Understanding how pathogens evolve in response to changes in their host is paramount to combating the spread of emergent strains of disease. This is particularly true for plant pathogens that cause billions of dollars of damages to crops globally, every year. Understanding the molecular interactions between pathogens and their hosts therefore sheds light on the coevolutionary arms race that can result in host-specificity and host-shifts in plant pathogens. This research approaches the question of how fungal pathogens interact with their plant hosts utilizing both unique and shared arsenals of secreted proteins (SPs) during infection, and addresses the question of whether …
Tissue-Resident Myeloid-Derived Suppressor Cells Modulate Immune Homeostasis In Healthy Adipose., Katlin Brooke Stivers
Tissue-Resident Myeloid-Derived Suppressor Cells Modulate Immune Homeostasis In Healthy Adipose., Katlin Brooke Stivers
Electronic Theses and Dissertations
Our goal with this study was to gain insight into the homeostatic immune cell network in healthy adipose tissue. Specifically, we sought to determine if the immature myeloid cells found in healthy and inflamed adipose were, in fact, tissue-resident myeloid-derived suppressor cells (MDSCs). Using various in vitro and in vivo methods, we have uncovered a population of CD11bHi Ly6CHi Ly6G- MDSCs resident in healthy adipose tissue. To the best of our knowledge this is the first time that these cells have been investigated and described in healthy adipose tissue. Systemic MDSC depletion lead to the accumulation of …
A Novel Role For Rassf1a In The Regulation Of Ras Activation., Desmond Ramón Harrell Stewart
A Novel Role For Rassf1a In The Regulation Of Ras Activation., Desmond Ramón Harrell Stewart
Electronic Theses and Dissertations
Ras is the most frequently activated oncogene in human cancer. It is not only the most frequently mutated oncogene, but is also rendered hyperactive in the wild-type form by aberrant regulation. Ras drives transformation and contributes to tumor aggressiveness by activating multiple downstream mitogenic effectors. Ras also possesses the paradoxical ability to induce apoptosis and senescence. Ras-induced apoptosis is not well understood, but has been largely attributed to the RASSF tumor suppressors, particularly RASSF1A. RASSF1A mediates Ras-induced apoptosis by activating pro-apoptotic proteins such as the MST kinases and BAX. RASSF1A is among the most frequently inactivated tumor suppressors in human …
Analyzing The Management Practices Of East Texas Beef Cattle Producers, Hiliary Cheyenne Swor
Analyzing The Management Practices Of East Texas Beef Cattle Producers, Hiliary Cheyenne Swor
Electronic Theses and Dissertations
A survey of East Texas beef cattle producers was designed to evaluate the management practices that were prevalent in the area. Demographic and cattle operation data from 103 respondents were analyzed using SPSS (Version 25; Chicago, IL). This electronic-based survey was distributed through Qualtrics. Respondents were located in Angelina, Nacogdoches, or Cherokee county. Most producers (38.8%) had a Bachelor’s degree. A negative correlation was established between castration method and weaning weight (p = - 0.204). Calves were weaned 50 pounds heavier when band or surgically castrated. Females were less likely to castrate their calves or utilize a mineral program. Approximately, …
Costs And Benefits Of Hipv-Mediated Eavesdropping Under Field Conditions., Grace Ellin Freundlich
Costs And Benefits Of Hipv-Mediated Eavesdropping Under Field Conditions., Grace Ellin Freundlich
Electronic Theses and Dissertations
Eavesdropping is defined as the act of an organism taking advantage of a cue that was not originally intended for them for their own gain. Plant-mediated eavesdropping is a widely documented phenomenon and eavesdropping cues range from oviposition cues to airborne volatile compounds. Eavesdropping is predicted to be widespread because eavesdropping confers a fitness advantage. In plants, eavesdropping on herbivore-induced plant volatiles (HIPVs) often results in enhanced resistance profiles upon herbivory. As a result of this enhanced resistance, it is predicted that eavesdropping alone incurs minor costs due to resource shifts towards inducible defense responses. Although HIPV-mediated eavesdropping is widely …
N-Acetyltranserase 2 (Nat2) Genotype Polymorphism In Cryopreserved Human Hepatocytes And Chinese Hamster Ovary (Cho) Cells., Mariam Refaat Zaky Habil
N-Acetyltranserase 2 (Nat2) Genotype Polymorphism In Cryopreserved Human Hepatocytes And Chinese Hamster Ovary (Cho) Cells., Mariam Refaat Zaky Habil
Electronic Theses and Dissertations
Arylamine N-acetyltransferases, NAT1 and NAT2, catalyze the detoxification and/or activation of drugs and aromatic amine carcinogens. Single nucleotide polymorphisms or SNPs result in different human NAT2 genotypes thus dividing the population into rapid, intermediate, and slow acetylators. We hypothesize allelic variants of NAT2 genotype will decrease levels of N-acetylation, cytotoxicity, oxidative stress, DNA adduct formation, and mutagenesis compared to the reference allele NAT2*4. Cryopreserved human hepatocytes expressing different NAT2 genotypes and NER-deficient Chinese hamster ovary (CHO) cells transfected with human CYP1A2 and human NAT2*4, NAT2*5B or NAT2*7B have been used to investigate N-acetylation of different xenobiotics. In …
Genes Involved In Nitrogen Assimilation In Ustilago Maydis., Sunita Khanal
Genes Involved In Nitrogen Assimilation In Ustilago Maydis., Sunita Khanal
Electronic Theses and Dissertations
U. maydis can utilize nitrate as a source of nitrogen from its environment, a process requiring a nitrate transporter to bring the nitrate inside the cell. This is followed by a two-step reduction of nitrate to ammonium. At first, nitrate reductase reduces nitrate into nitrite; in the second reaction, nitrite is reduced to ammonium by nitrite reductase. The goal of the study was to identify the nitrate transporter and nitrite reductase genes in U. maydis and characterize them based on their role in mating and virulence. The genes um03848 and um03849 were identified bioinformatically as encoding, respectively, the nitrite reductase …
Plasmodium Impairs Antibacterial Innate Immunity To Systemic Infections In Part Through Hemozoin-Bound Bioactive Molecules., Christopher Lynn Harding
Plasmodium Impairs Antibacterial Innate Immunity To Systemic Infections In Part Through Hemozoin-Bound Bioactive Molecules., Christopher Lynn Harding
Electronic Theses and Dissertations
Despite efforts to decrease the global health burden of malaria, infections with Plasmodium species continue to cause over 200 million episodes of malaria each year which resulted in 405,000 deaths in 2018 [1]. One complication of malaria is increased susceptibility to invasive bacterial infections. Plasmodium infections impair host immunity to non-Typhoid Salmonella (NTS) through activities of heme oxygenase I (HO-I) )-induced release of immature granulocytes and myeloid cell-derived IL-10. Yet, it is not known if these mechanisms are specific to NTS. We show here, that Plasmodium yoelii 17XNL (Py) infected mice had impaired clearance of systemic Listeria monocytogenes (Lm) during …
Identification And Structural Characterization Functional Motifs In The Porphyromonas Gingivalis Mfa1 Short Fimbria., Mohammad K. Roky
Identification And Structural Characterization Functional Motifs In The Porphyromonas Gingivalis Mfa1 Short Fimbria., Mohammad K. Roky
Electronic Theses and Dissertations
Porphyromonas gingivalis is a causative agent of periodontal disease, initially colonizes the oral cavity by adhering to commensal streptococci. Adherence requires the interaction of the minor fimbrial protein (Mfa1) of P. gingivalis with streptococcal antigen I/II (Ag I/II). A peptide derived from Ag I/II peptide has been well characterized and shown to significantly reduce P. gingivalis colonization and bone loss in vivo, suggesting that this interaction represents a potential target for therapeutic intervention. However, the functional motifs of Mfa1 involved in the interaction with Ag I/II remain uncharacterized. A series of N- and C-terminal peptide fragments of Mfa1 were …