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Articles 1 - 10 of 10
Full-Text Articles in Life Sciences
Influence Of Env And Long Terminal Repeat Sequences On The Tissue Tropism Of Avian Leukosis Viruses, David Brown, Harriet Robinson
Influence Of Env And Long Terminal Repeat Sequences On The Tissue Tropism Of Avian Leukosis Viruses, David Brown, Harriet Robinson
David C. Brown
Adsorption and penetration of retroviruses into eucaryotic cells is mediated by retroviral envelope glycoproteins interacting with host receptors. Recombinant avian leukosis viruses (ALVs) differing only in envelope determinants that interact with host receptors for subgroup A or E ALVs have been found to have unexpectedly distinctive patterns of tissue-specific replication. Recombinants of both subgroups were highly expressed in bursal lymphocytes as well as in cultured chicken embryo fibroblasts. In contrast, the subgroup A but not subgroup E host range allowed high levels of expression in skeletal muscle, while subgroup E but not subgroup A envelope glycoproteins permitted efficient replication in …
Adjustment Of Value Productivity Estimates To Changes In Price And Technical Relationships , David Brown
Adjustment Of Value Productivity Estimates To Changes In Price And Technical Relationships , David Brown
David C. Brown
No abstract provided.
Holocene Climatic Change And Past Irish Societal Response, David Brown, M. Baillie, J. Palmer, Christian Turney
Holocene Climatic Change And Past Irish Societal Response, David Brown, M. Baillie, J. Palmer, Christian Turney
David C. Brown
No abstract provided.
Lower Extremity Passive Range Of Motion In Community-Ambulating Stroke Survivors, Sheila Schindler-Ivens, Davalyn Desimone, Sarah Grubich, Carolyn Kelley, Namita Sanghvi, David Brown
Lower Extremity Passive Range Of Motion In Community-Ambulating Stroke Survivors, Sheila Schindler-Ivens, Davalyn Desimone, Sarah Grubich, Carolyn Kelley, Namita Sanghvi, David Brown
David C. Brown
Background: Physical therapists may prescribe stretching exercises for individuals with stroke to improve joint integrity and to reduce the risk of secondary musculoskeletal impairment. While deficits in passive range of motion (PROM) exist in stroke survivors with severe hemiparesis and spasticity, the extent to which impaired lower extremity PROM occurs in community-ambulating stroke survivors remains unclear. This study compared lower extremity PROM in able-bodied individuals and independent community-ambulatory stroke survivors with residual stroke-related neuromuscular impairments. Our hypothesis was that the stroke group would show decreased lower extremity PROM in the paretic but not the nonparetic side and that decreased PROM …
Infection Of Peripancreatic Lymph Nodes But Not Islets Precedes Kilham Rat Virus-Induced Diabetes In Bb/Wor Rats, David Brown, Raymond Welsh, Arthur Like
Infection Of Peripancreatic Lymph Nodes But Not Islets Precedes Kilham Rat Virus-Induced Diabetes In Bb/Wor Rats, David Brown, Raymond Welsh, Arthur Like
David C. Brown
A parvovirus serologically identified as Kilham rat virus (KRV) reproducibly induces acute type I diabetes in diabetes-resistant BB/Wor rats. The tissue tropism of KRV was investigated by in situ hybridization with a digoxigenin-labelled plasmid DNA probe containing approximately 1.6 kb of the genome of the UMass isolate of KRV. Partial sequencing of the KRV probe revealed high levels of homology to the sequence of minute virus of mice (89%) and to the sequence of H1 (99%), a parvovirus capable of infecting rats and humans. Of the 444 bases sequenced, 440 were shared by H1. KRV mRNA and DNA were readily …
Rural Juvenile Delinquency: Problems And Needs In East Tennessee, William Bolton, David Brown
Rural Juvenile Delinquency: Problems And Needs In East Tennessee, William Bolton, David Brown
David C. Brown
No abstract provided.
An Annotated Bibliography Of References To Historical Distributions Of Pronghorn In Southern And Baja California, David Brown, Jorge Cancino, Kevin Clark, Myrna Smith, Jim Yoakum
An Annotated Bibliography Of References To Historical Distributions Of Pronghorn In Southern And Baja California, David Brown, Jorge Cancino, Kevin Clark, Myrna Smith, Jim Yoakum
David C. Brown
Recent pronghorn (Antilocapra americana) translocations to southern California and the establishment of captive populations of endangered desert pronghorn have revived interest in the historical occurrence of pronghorn in the Californias. Adding to this interest is the recent widespread replacement of coastal sage scrub vegetation in southern California by annual grasslands more favorable to pronghorn. We have searched the scientific and popular literature, as well as museum collections, to locate pronghorn antelope occurrences from below San Francisco Bay southward through the Baja California peninsula. Our results show that pronghorn were widely distributed, and often abundant, on nearly all of the plains …
Rural People In Skilled Industrial Work: Experience Of Graduates Of A Manpower Training Program In Appalachia, David Brown, Samuel Cooper
Rural People In Skilled Industrial Work: Experience Of Graduates Of A Manpower Training Program In Appalachia, David Brown, Samuel Cooper
David C. Brown
No abstract provided.
Cd4+ Regulatory T Cells Require Ctla-4 For The Maintenance Of Systemic Tolerance, Randall Friedline, David Brown, Hai Nguyen, Hardy Kornfeld, Jinhee Lee, Yi Zhang, Mark Appleby, Sandy Der, Joonsoo Kang, Cynthia Chambers
Cd4+ Regulatory T Cells Require Ctla-4 For The Maintenance Of Systemic Tolerance, Randall Friedline, David Brown, Hai Nguyen, Hardy Kornfeld, Jinhee Lee, Yi Zhang, Mark Appleby, Sandy Der, Joonsoo Kang, Cynthia Chambers
David C. Brown
Cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in negatively regulating T cell responses and has also been implicated in the development and function of natural FOXP3(+) regulatory T cells. CTLA-4-deficient mice develop fatal, early onset lymphoproliferative disease. However, chimeric mice containing both CTLA-4-deficient and -sufficient bone marrow (BM)-derived cells do not develop disease, indicating that CTLA-4 can act in trans to maintain T cell self-tolerance. Using genetically mixed blastocyst and BM chimaeras as well as in vivo T cell transfer systems, we demonstrate that in vivo regulation of Ctla4(-/-) T cells in trans by CTLA-4-sufficient T cells is …
Organizational Problems Of Small Watersheds, David Brown, Joseph Winsett
Organizational Problems Of Small Watersheds, David Brown, Joseph Winsett
David C. Brown
No abstract provided.