Life Sciences Commons^™

Identification Of Peptides For A Muc13 Cancer Vaccine, Abigail Olivia Gomez

Theses and Dissertations

Mucin 13 (MUC13) is a transmembrane glycoprotein that is frequently overexpressed in epithelial cancers. Its extracellular domains and cytoplasmic signaling potential contribute to disrupted cell adhesion, increased invasion, and cancer-promoting pathways, making MUC13 a promising target for immunotherapy. This project used an in-silico approach to identify MUC13-derived peptides predicted to bind HLA class I molecules and support CD8+ T cell-mediated immune responses. Bioinformatics tools were used to screen candidate epitopes for HLA binding affinity, antigenicity, toxicity, IFN-γ-inducing potential, and population coverage, allowing rational prioritization of peptide candidates for experimentation. Selected peptides were evaluated in THP-1-derived macrophages using RT-PCR, Western blotting, …

Linking North American Demographic Trends To Mexican Non-Breeding Grounds In A Migratory Warbler, Majuwana Gamage Dulanthi Dileka Kariyawasam

Theses and Dissertations

Migration enables species to exploit seasonal resources despite high energetic costs and mortality risks, making it a key focus for conservation under environmental change. I investigated migratory connectivity in Orange-crowned Warblers using stable hydrogen isotopes (δ²H) from feathers collected at nine non-breeding sites across Mexico. Results indicated generally weak connectivity (MC = 0.18), with most sites hosting individuals from six breeding clusters across Canada and the United States. However, one northwestern breeding group showed strong connectivity, suggesting crosswise migration to eastern Mexico. By integrating these findings with long-term Breeding Bird Survey data, I detected contrasting population trends, with Pacific Coast …

Emotional Intelligence Documentary - The Journey, Not The Destination: A Spain Reflection, Elise I. Palacios

Cultivating Emotional Intelligence through the Humanities in Spain

The Journey, Not the Destination follows my study abroad experience in Madrid and Toledo, Spain through a Medical Humanities course. Through art, history, culture, and personal reflection, I explore how travel broadened my understanding of the human experience and shaped my perspective as a future physician. More than a story about a place, this documentary is about growth, empathy, and the lessons we learn along the journey.

Low Methane Emissions From Nutrient-Rich Former River Channels In A Hydrologically Managed Dryland Delta, Siena Stassi, Jude A. Benavides, Chu-Lin Cheng, Marcelo Gomes Da Silva, Nicholas E. Ray, Nathan O. Barros, Rafael M. Almeida

School of Earth, Environmental, & Marine Sciences Faculty Publications

Anthropogenic stresses in dryland regions can alter hydrology, salinization, and biogeochemical processes. How these pressures influence methane (CH4) cycling and emissions from aquatic ecosystems remains poorly understood. Over the course of 1 year, we measured diffusive and ebullitive CH4 emissions from resacas—shallow, hydrologically managed distributary channels prevalent throughout the Lower Rio Grande Valley along the US–Mexico border. Despite warm, nutrient-rich waters, CH4 emissions from resacas were low, and more comparable to rates observed in estuarine systems. CH4 fluxes were positively related to temperature but negatively related to salinity and rainfall. Elevated salinity, driven by evaporation and source water from the …

Landscape Connectivity And Wildlife Access To Water Across An International Border: Barriers And Opportunities For Facilitating Transboundary Movement, Bogdan Chivoiu, Erin L. Koen, Michael J. Osland, Christopher A. Gabler, Jerald T. Garrett, Ernesto Reyes, Stephanie A. Bilodeau, Mitch A. Sternberg, Jude A. Benavides, James Martinez

School of Earth, Environmental, & Marine Sciences Faculty Publications

Rapid global acceleration in the construction of physical barriers along international borders has greatly influenced biodiversity and animal movement. Physical barriers can fragment landscapes, hinder access to essential resources, impact long-distance migrations, and inhibit dispersal and gene flow. The effects of physical barriers on animal movement and landscape connectivity can be exacerbated in dryland environments where access to water is a limiting factor. In recent decades, the construction of border barrier infrastructure has accelerated along the international boundary between the United States and Mexico. Here, we used a landscape connectivity model to investigate the effects of barriers on wildlife access …

Analyzing Criteria Air Pollutants And Meteorological Parameters In The Rio Grande Valley, Laredo, And Corpus Christi Region Of South Texas, Angela Garcia

Theses and Dissertations

Recently, the Rio Grande Valley has experienced significant population growth due to economic opportunities, cross-border commerce, SpaceX, and the Rio Grande and Texas liquid natural export terminal presence. The Rio Grande Valley has an estimated population of 1,368,723. This region is largely understudied, along with nearby urban centers such as Laredo and Corpus Christi. The Rio Grande Valley and Laredo regions are a concern due to their population growth and heavy cross-border transportation. Data from the Texas Commission of Environmental Quality Continuous Ambient Monitoring Sites was collected from January 1st , 2024, to December 31st, 2024. Statistical analysis, such as …

Investigating The Ability Of Foxo1 To Maintain Stem Cells, Stella Aime Rios

Theses and Dissertations

Forkhead box O (Foxo) transcription factors are key regulators of stem cell identity and tumor aggressiveness. Prior work from our group and others demonstrates that Foxo factors maintain stem-like states across diverse biological systems; however, the mechanisms by which Foxo1 suppresses differentiation remain poorly defined.

Using C2C12 myoblasts as a model, we investigated whether Foxo1 preserves stem-like programs through regulation of the nuclear pore protein Nup210. RNA interference was used to generate Foxo1 knockdown cells, followed by qRT-PCR, RNA-sequencing, and fluorescence microscopy. Transcriptomic analysis revealed widespread gene expression changes involving metabolic, mitochondrial, and transcriptional pathways. Notably, Nup210 expression was significantly …

Men’S Preconception Diet Quality Patterns Predict Supportive Food Parenting Practices: Evidence From A Longitudinal Cohort Study, Mariane H. De Oliveira, Brian K. Lo, Matthew M. Lee, Stephanie Armbruster, Natalie Grafft, In Young Park, Alejandra Cantu-Aldana, Katherine W. Bauer, Rebekah Levine Coley, Sebastien Haneuse, Kirsten Davison, Jess Haines

Human Genetics Publications

Background: Food parenting practices play a vital role in shaping children's food intake, yet evidence linking fathers' earlier diet patterns to later parenting is limited. This study examined the association between fathers' diet quality patterns during their adolescence and food parenting practices during fatherhood.

Methods: Data were drawn from Fathers & Families (F&F), a father-based cohort that recruited participants from an ongoing cohort in the United States that has followed participants since adolescence. Participants (n = 584) reported their dietary intake during adolescence (ages 10-18) using a Youth/Adolescent Food Frequency Questionnaire across multiple survey waves (1996-2011), and reported their food …

Geospatial Assessment Of Agrivoltaic Opportunities And Land Use Requirements In Nigeria, Ifeoluwa Ezekiel Babarinde, Bashir Salisu, Jude A. Benavides, Engil Pereira, Steven M. Grodsky, Rafael M. Almeida

School of Earth, Environmental, & Marine Sciences Faculty Publications

Agrivoltaics, the co-location of agriculture and solar photovoltaic (PV) infrastructure, can deliver co-benefits like reduced plant drought stress and improved yields of shade-tolerant crops, particularly in water-scarce regions. Despite growing global interest, the technical potential and opportunities for agrivoltaics remain poorly understood in many regions facing both food and energy insecurity, such as sub-Saharan Africa. Here we provide a spatial assessment of agrivoltaic opportunities in Nigeria by integrating cropland distribution, solar resources, and water stress. We find that northern states—where cropland is abundant and water-stressed, solar irradiance is high, and electricity access remains low—offer the greatest potential for agrivoltaic systems …

Evaluation Of Sirna-Mediated Knockdown Of Heat Shock Protein 16.2 In Adult Acropora Cervicornis, Edward P. Gniffke, Benjamin D. Young, Keir J. Macartney, Michael S. Studivan, Ian C. Enochs, Erin E. Easton

School of Earth, Environmental, & Marine Sciences Faculty Publications

Acropora cervicornis is a critically endangered Caribbean coral species facing a precipitous decline due to disease and thermal bleaching. To combat the loss of ecologically important reef-building corals, novel molecular approaches can be used to understand mechanisms of resilience and ultimately provide a means to modulate coral performance. In this study, we tested a recently developed method for gene knockdown in adult corals that utilizes short interfering RNAs (siRNAs) and the RNA interference pathway. The Heat Shock Protein 16.2 (HSP16.2) gene in fragments of adult A. cervicornis was targeted for knockdown using a single siRNA construct. RT-qPCR analysis of HSP16.2 …

Cross-Sectional Associations Of Metabolically Healthy Obesity, Lifestyle Factors, And Steatotic Liver Disease In Adults From The Fels Longitudinal Study, Ariana L. Garza, Audrey C. Choh, John Blangero, Cici X. Bauer, Stefan A. Czerwinski, Miryoung Lee

School of Medicine Publications

Objective: To examine the associations of metabolic health and obesity phenotypes with liver fat accumulation and hepatic steatosis in adults. Methods: We analyzed 676 non-Hispanic white adults (18–95 years; 55.8% female) from the Fels Longitudinal Study using a cross-sectional design. Participants were classified into metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO) phenotypes. Metabolically unhealthy status was defined as the presence of ≥1 metabolic dysfunction, consistent with prior epidemiological definitions; secondary analyses using ≥2 were also performed. Obesity was defined using DXA-derived body fat percentage. Liver fat (%) was …

Identification Of Lipid Quantitative Trait Loci Linked With Cardiometabolic Disease In Asian Indians And Europeans: A Genome-Wide Association Study And Mendelian Randomization, Madhusmita Rout, Christopher E. Aston, Ravindranath Duggirala, Harald H. H. Goring, Oliver Fiehn, Dharambir K. Sanghera

School of Medicine Publications

Background: Genetic mechanisms that predispose people to type 2 diabetes (T2D) and cardiovascular disease (CVD) remain poorly understood, partly because of a lack of sufficient data on non-European ethnic groups. Extending these evaluations to diverse cohorts is essential for gaining insights into the molecular pathways involved in disease development among human populations. In this study, we aimed to evaluate the genetic connection between the human lipidome and cardiometabolic disorders. We conducted a metabolite genome-wide association study (mGWAS) in a Punjabi population from India, along with multi-layer replication studies using the UK Biobank and other independent European and non-European cohorts.

Methods …

Molecular Adaptation Of Sweet Potato To Martian Soil Simulant: Insights From Mrna And Long Non-Coding Rna Analyses, Subramanyam Reddy Chinreddy, Karthik Chinnannan, Purushothaman Natarajan, Vaibhavi Patel, Gwonjin Lee, Manohar Chakrabarti, Padma Nimmakayala, Umesh K. Reddy

School of Integrative Biological & Chemical Sciences Faculty Publications

Introduction: Understanding how crops adapt to extraterrestrial environments is essential for sustainable space agriculture. Sweet potato (Ipomoea batatas), a nutritionally rich and stress-resilient crop, is a promising candidate for cultivation under Martian-like conditions, characterized by high salinity, heavy metal contamination, and poor water retention.

Objective: This study aimed to elucidate the molecular mechanisms underlying sweet potato adaptation to Martian soil analog conditions using Mars Global Simulant-1 (MGS-1).

Methods: Leaf, shoot, and storage root tissues of sweet potato grown in MGS-1 were subjected to RNA sequencing. Differentially expressed mRNAs and long non-coding RNAs (lncRNAs) were identified, and functional enrichment analyses were …

High Germinability Can Facilitate Recovery Of Adelia Vaseyi (Euphorbiaceae), An Imperiled Tamaulipan Thornscrub Shrub, Saroj Dhakal, Bashira Chowdhury, Alejandro Fierro-Cabo

School of Earth, Environmental, & Marine Sciences Faculty Publications

While critical to maintaining dryland biodiversity and drought resilience, reforestation has been limited in subtropical dry forests because of knowledge gaps in seed biology that must be filled to upscale seedling production and ensure recovery of imperiled endemic plants. We characterized seed germination, dormancy, and storage needs for Adelia vaseyi, a threatened endemic shrub commonly included in planting mixes to restore Tamaulipan thornscrub, an imperiled subtropical forest spanning South Texas and Northeastern Mexico. We found A. vaseyi seeds have high germinability (82.0%) and a short mean germination time (3.04 ± 0.08 days). A delia vaseyi seed does not appear …

Brown Pelican (Pelecanus Occidentalis) Groundings On A Four-Lane Divided Highway In South Texas: A Comparative Study Using Citizen Science, Bradley Evan Beer, Kevin W. Ryer, Md. Saydur Rahman, John H. Young Jr., Richard J. Kline

School of Integrative Biological & Chemical Sciences Faculty Publications

The population of the once-endangered brown pelican (Pelecanus occidentalis) has increased over the past several decades and is now considered fully recovered. However, in south Texas, the combined effects of weather patterns, transportation infrastructure, and brown pelican biology have led to road mortalities on State Highway 48 (SH 48) at the Carl “Joe” Gayman Bridge. To mitigate these mortalities, the Texas Department of Transportation modified traffic barriers on SH 48. We aimed to examine the effect of the barrier change and determine which weather variables influence brown pelican groundings on SH 48. Citizen scientists monitored sections of SH …

Applications Of Machine Learning In Enhancing Evaporation Estimation For Small Reservoirs: A Case Study In Semi-Arid South Texas, Syed Muhammad F Abdullah, Chu-Lin Cheng, Jude A. Benavides, Jungseok Ho, Rafael M. Almeida

School of Earth, Environmental, & Marine Sciences Faculty Publications

Small reservoirs in semi-arid regions experience substantial evaporative losses but are rarely monitored at daily scales. A multi-reservoir machine learning (ML) framework was developed to estimate daily open-water evaporation. Empirical models (Penman, Penman-Monteith, Priestley-Taylor, Bowen Ratio Energy Budget) andabenchmark combination method (Daily Lake Evaporation Model-DLEM) were compared against ML models. Predictors combined gridded meteorology (gridMET) with reservoir attributes (surface area, average depth, maximum depth, and fetch). ML models (Random Forest-RF, Decision Tree-DT, K-Nearest Neighbor-KNN, and Support Vector Regression-SVR) were trained on four reservoirs using data from 2018 to 2025. Results from ML models were further validated using both DLEM and …

Morphology, Phylogeny And Distribution Of Scaeurgus (Cephalopoda: Octopoda) In Southeast Pacific Seamounts, Sergio A. Carrasco, Christian M. Ibáñez, Andrea I. Varela, Jan M. Tapia-Guerra, Erin E. Easton, Javier Sellanes

School of Earth, Environmental, & Marine Sciences Faculty Publications

Octopuses of the genus Scaeurgus inhabit upper bathyal benthic habitats and are composed of five recognized species. In this study, we conducted morphological and molecular phylogenetic analyses of two individuals of Scaeurgus and provided additional field observations of the genus in seamounts of the Nazca and Salas y Gómez ridges (southeast Pacific Ocean) over the last six years. Specifically, two specimens of Scaeurgus were collected at 234 m depth in 2019 during the EPIC oceanographic cruise onboard the R/V Mirai (JAMSTEC, Japan), and five other specimens were video recorded at depths between 210 and 340 m during three oceanographic expeditions …

Snapshot Usa 2024: Year 6 Of The Coordinated National Camera Trap Survey Of The United States, Brigit Rooney, Roland Kays, Michael V. Cove, Alex Jensen, Daniel J. Herrera, Camilla Price, Phuong-Thao Nguyen-Nu, Katrina Adamczyk, Peter D. Alexander, Drew R. Davis

School of Integrative Biological & Chemical Sciences Faculty Publications

Motivation: SNAPSHOT USA is an annual, multi-contributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of species interactions on daily activity patterns.

Main Types of Variables Contained: SNAPSHOT USA 2024 contains 377,427 records of camera trap image sequence data and 3127 records of camera trap deployment metadata.

Spatial Location …

Bacillus Subtilis Parb C-Terminal Lysine Residues Are Essential For Dimerization And In Vivo Function, Indicating Their Roles In Dna Sliding, Aleksey Aleshintsev, Lindsey E. Way, Ngoc Khanh Lai, Bianca Guerra, Paloma Dorantes, Lois Akosua Serwaa, Sealtiel Anulao, Miranda Molina, Xindan Wang, Hyeongjun Kim

Physics & Astronomy Faculty Publications

The broadly conserved ParB protein performs crucial functions in bacterial chromosome segregation and replication regulation. The cellular function of ParB requires it to dimerize, recognize parS DNA sequences, clamp on DNA, then slide to adjacent sequences through nonspecific DNA binding. How ParB coordinates nonspecific DNA binding and sliding remains elusive. Here, we combine multiple in vitro biophysical and computational tools and in vivo approaches to address this question. We found that five conserved lysine residues in the C-terminal domain (CTD) of ParB play distinct roles. While the two central rigid lysine residues provide the structural platform for the CTD, the …

Genetic Variants And Molecular Components Associated With Metabolic Dysfunctional-Associated Steatotic Liver Disease And Depression: Shared Association Of Adamts7 And Thrap3, Eron G. Manusov, Vincent P. Diego, Marcio A. Almeida, Jacob A. Galan, Kathryn Herklotz, Edwardo Abrego Ii, Habiba Sultana, Luis A. Peña Marquez, Marco Arriaga, Marcelo Leandro, Juan M. Peralta, Ana C. Leandro, Tom Howard, Joanne Curran, Sandra Laston, John Blangero, Sarah Williams-Blangero

Human Genetics Publications

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and depression frequently occur together. Identifying the genes that influence both MASLD and depression may facilitate the discovery of biological pathways associated with disease risk.

Methods: We recruited 525 participants from Mexican American families living in the Rio Grande Valley of south Texas. We collected clinical data, biometric measurements, hepatic health assessments using Vibration-Controlled Transient Elastography (VCTE), and depression evaluations determined with the Beck Depression Inventory-II. We estimated the heritability (h2) of MASLD-related measures, depression status, aspartate aminotransferase (AST), alanine aminotransferase (ALT), the AST/ALT ratio, and Vibration-Controlled Transient Elastography measurements. For each gene, …

Structural Brain Analysis In Focal Upper Limb Dystonia, Danilo Donizete De Faria, Artur José Marques Paulo, Joselisa Péres Queiroz De Paiva, Anderson M. Winkler, Vanderci Borges, Sonia Maria Azevedo Silva, Henrique Ballalai Ferraz, Patricia De Carvalho Aguiar

Human Genetics Publications

Prior structural magnetic resonance imaging (MRI) studies that investigated structural alterations in focal dystonia have reported inconsistent findings, potentially due to methodological limitations or sample heterogeneity. This work investigates gray and white matter changes in patients with upper limb dystonia using T1-weighted images and diffusion tensor imaging (DTI). Imaging data collected with MRI at 3T from 28 right-handed individuals with right upper limb dystonia and 29 healthy controls were analyzed. T1-weighted images were analyzed using FreeSurfer to examine cortical thickness, volume and area. DTI data were assessed using tract-based spatial statistics, regions of interest (ROI) analysis and probabilistic tractography. ROI …

Species Sorting And Spatial Effects In Hyporheic Invertebrate Functional Groups, Benjamin T. Hutchins, Zoey B. Chanin, Kathryn E. Perez, Peter H. Diaz, Benjamin F. Schwartz

School of Integrative Biological & Chemical Sciences Faculty Publications

Invertebrate communities in the hyporheic zone are structured by metacommunity processes including environmental filtering and spatial effects (e.g., dispersal). We investigated how these processes differentially influence two functional groups: groundwater-obligate invertebrates (stygobionts) and benthic insects. We predicted that environmental filtering would dominate for insects, while spatial effects would prevail for stygobionts. We collected 76 samples from 28 hyporheic sites along 109 km of the Rio Grande, Texas, USA, enumerating 54,508 individuals across 80 taxa. Concordance analysis and RDA revealed two communities: one dominated by insects, and another by crustaceans and soft-bodied organisms, including all stygobionts. In linear models, insect richness …

Systematic Synthesis Of Crispr/Cas Applications For Enhancing Salt Tolerance In Crops: A Decade Of Progress And Challenges, Xindi Sun, Fusheng Wu, Zhuanzhuan Ma, Guohao Liang, Shumei Chen, Xutong Hu, Shugao Fan, Ying Zhao

School of Mathematical & Statistical Sciences Faculty Publications

Soil salinity is a major constraint on global crop productivity, driving the need for salt-tolerant varieties. While CRISPR-Cas genome editing offers targeted solutions for trait improvement, significant biological and technical bottlenecks limit its application in conferring salt stress resilience. This systematic summarizes findings from 83 peer-reviewed studies (2015–2024) employing CRISPR/Cas technologies to improve salt tolerance in five major crops (rice, wheat, maize, sorghum, barley). Our systematic review reveals that early single-gene edits achieved modest gains (30–50% Na⁺ exclusion) but often showed limited yield gains in field settings, potentially due to compensatory regulation and environmental variation. The literature suggests that multiplex …

Cellstaar: Incorporating Single-Cell-Sequencing-Based Functional Data To Boost Power In Rare Variant Association Testing Of Noncoding Regions, Eric Van Buren, Yi Zhang, Xihao Li, Margaret Sunitha Selvaraj, Zilin Li, Nicholette D. Palmer, Donna K. Arnett, John Blangero, Eric Boerwinkle, Joanne E. Curran, Ravi Duggirala

School of Medicine Publications

Understanding how rare genetic variants influence complex traits remains a major challenge, particularly when these variants lie in noncoding regions of the genome. The effects of variants within candidate cis-regulatory elements (cCREs) often depend on the cell type, making interpretation difficult. Here we introduce cellSTAAR, which integrates whole-genome sequencing data with single-cell assay for transposase-accessible chromatin using sequencing data to capture variability in chromatin accessibility across cell types via the construction of cell-type-specific functional annotations and regulatory elements. To reflect the uncertainty in cCRE–gene linking, cellSTAAR uses a comprehensive strategy to link cCREs to their target genes. We applied …

Drought × Herbivory Induce Leaf Trichomes In Soybean With Differential Impact On Its Major Herbivore Soybean Looper Chrysodeixis Includens, Manish Gautam, Karen Alanis, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences Faculty Publications

Trichomes have been well studied as a physical defense against stress. With climate change, stressors like drought and/or herbivory can have exacerbated effects on crop morpho-physiology. However, the interactive effects of such stressors on physical defenses like trichomes and their effects on herbivores is poorly understood. To examine this, soybean plants were exposed to a major herbivore, soybean looper (SBL) (Chrysodeixis includens Walker), under simulated drought conditions to examine the interactive effects of drought and herbivory (D × H) on leaf trichomes. Additionally, SBL growth traits were monitored under different leaf diet concentrations (10% and 20%) and trichome enriched diets …

Weather Conditions Associated With Citrus Canker Incidence Caused By Aw Strain In The Lower Rio Grande Valley Of South Texas, Amit Sharma, Teresa Patricia Feria-Arroyo, George Yanev, Madhurababu Kunta

School of Integrative Biological & Chemical Sciences Faculty Publications

Citrus canker, caused by bacterium Xanthomonas citri subsp. citri (Xcc), affects the citrus industry by making the fruit unmarketable due to unsightly lesions on the fruit. Citrus canker caused by a relatively new AWstrain of Xcc was reported on the citrus trees in the residential areas of the Lower Rio Grande Valley (LRGV) of South Texas. Xcc AW has a limited host range, predominantly affecting limes and a few other citrus species. Previous work has reported prevailing environmental conditions that influence the incidence and spread of the citrus canker caused by the Asiatic A strain. However, no information is available …

Genome-Wide Association Study Identifies Novel Variants In Olfactory, Vitamin A, Vitamin B, And Cadherin Pathways Associated With Learning And Memory, Lloyd N. Hopkins, Nesli Avgan, Heidi G. Sutherland, Francesca E. Fernandez, Emma M. Knowles, Larisa M. Haupt, John Blangero, David C. Glahn, David H. K. Shum, Rod A. Lea, Lyn R. Griffiths

Human Genetics Publications

Learning and memory, as fundamental components of human cognition, are heritable traits that are highly variable between individuals and within populations. Investigation into the genetic basis of cognition is a prominent area of research, with genetic associations being previously reported for a wide range of cognitive phenotypes. Here we utilise a genome-wide association study (GWAS) approach to evaluate the contribution of genetic variation to learning and memory phenotypes in a comprehensively phenotyped, well-characterised, healthy, and unrelated cohort of individuals (n = 613). Cognitive phenotypes were assessed using nine comprehensive test batteries consisting of twenty-one cognitive performance assessments including IQ, five …

Spatiotemporal Analysis Of Genetic Perturbations Reveals A Genetic Cascade Driving Tribolium Gap Gene Initialization, Mahla Ahmadi, Heike Rudolf, Christine Mau, Jimena Garcia-Guillen, Ezzat El-Sherif

School of Integrative Biological & Chemical Sciences Faculty Publications

The ‘French flag’ model has long served as the prevailing framework for explaining how morphogen gradients generate spatial domains during embryonic development. However, recent evidence indicates that many tissues establish patterns by translating the sequential activation of genes into spatial domains. While the sequential nature of this process is becoming clear, the mechanisms that mediate these temporal dynamics and translate them into stable spatial boundaries remain debated. Using the gap gene network in the flour beetle Tribolium castaneum [which mediates the regionalization of the anterior-posterior (AP) axis into different axial fates through the regulation of downstream Hox genes] as a …

Structural Brain Differences Associated With Panic Disorder: An Enigma-Anxiety Working Group Mega-Analysis Of 4924 Individuals Worldwide, Laura K. M. Han, Willem B. Bruin, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Kevin Hilbert, Anderson M. Winkler, André Zugman, Takeshi Asami, Jacques P. Barber, Francesco Benedetti

Human Genetics Publications

Neuroanatomical findings on panic disorder (PD) are typically difficult to replicate, with inconsistent effects. These concerns prompted a paradigm shift towards large-scale collaborations, focused on harmonized data extraction and processing for robust examination of PD brain correlates. Hence, leveraging the largest-ever multi-site neuroimaging database on PD (Age: 10–66 years; global sites: 28), compiled by the ENIGMA-Anxiety Working Group, we report on cortical and subcortical differences in individuals with PD (N = 1146) versus healthy controls (HC: N = 3778). The analyses revealed lower thickness and smaller cortical surface area within fronto-temporo-parietal regions in PD (Cohen’s ds: −0.08–0.13), along with lower …

Changes In Phenology Mediate Vertebrate Population Responses To Temperature Globally, Viktoriia Radchuk, Carys V. Jones, Nina Mclean, Anne Charmantier, Céline Teplitsky, Ray Alisauskas, Sergio Ancona, Tycho Anker-Nilssen, Peter Arcese, Karl S. Berg

School of Integrative Biological & Chemical Sciences Faculty Publications

Phenotypic responses to climate affect individual fitness, but the extent to which this translates into effects on population dynamics remains poorly understood. We assemble 213 time series on phenotypes and population sizes of wild vertebrates globally and match them with local climate data. Our meta-analysis shows that morphological traits are mostly climate insensitive. However, phenology is earlier in warmer-than-average years, which contributes positively to population growth in most species. At lower latitudes, temperature has weaker effects on phenology but stronger direct negative effects on population growth, likely because these populations are less capable of tracking climate via plasticity. Variation in …