Life Sciences Commons^™

Evaluation Of The Effect Of A Commercial Lippia Origanoides Essential Oil Extract On Salmonella Serovar Enteritidis As A Natural Alternative To Antibiotics In The Poultry Industry, Abdiel Atencio

Graduate Theses and Dissertations

The purpose of the present research was to evaluate the bactericidal activity of a microencapsulated Lippia origanoides essential oils (LOEOs) against Salmonella Enteritidis (SE) in an in vitro crop assay and in a prophylactic broiler chicken model using three low doses of the product: 75 ppm, 150 ppm and 300 ppm. Two trials of each assay were conducted. Day-of-hatch male Cobb-Vantress broiler chickens were randomly allotted to one of four groups: 1) positive control group; 2) 75 ppm LOEOs group; 3) 150 ppm LOEOs group; 4) 300 LOEOs group. Chicks were fed and watered ad libitum in heated brooder batteries …

Competition And Criticality In Cortical Neural Circuits Underlie Behavior And Optimize Working Memory, Jacob Harrison Barfield

Graduate Theses and Dissertations

One of the primary goals of neuroscience is to explain how brain function emerges from dynamic interactions among large populations of neurons. A long-standing hypothesis at the interface of physics and neuroscience posits that neural circuits may operate close to the critical point of a phase transition. In this dissertation, we will investigate a new form of criticality and the implications that it has in working memory and the generation of voluntary body movements. We will utilize this new form of criticality to investigate the functional benefits that can be harnessed by operating near the critical point when performing working …

Heterogenous Impacts Of Pathogenic Avian Diseases On Global Poultry Production, Elsbeth Hamilton

Graduate Theses and Dissertations

Globally, poultry is one of the most versatile and cost-effective sources of animal-based protein. Due to its wide variety of uses and variability of growing styles, poultry production is applicable in nearly every country. With the increase of scale and concentration of production, pathogenic diseases have decreased the efficiency of production through worsened feed conversion, morbidity, and mortality. In addition to physiological health, climate largely impacts the suitable conditions for growing. With more extreme climate events, locations once ideal for poultry are less efficient due to increased resource cost. This analysis seeks to determine the heterogeneity of production and the …

A Micro-Perspective Analysis Of The Demand For Greek And Non-Greek Yogurt In The United States Over Calendar Years 2018 To 2020, Oral Capps, Riuxin Jia, Vikas Mishra, Macson O. Ogieriakhi

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Using the Heckman framework, we develop profiles of households who purchase Greek yogurt and non-Greek yogurt and estimate own-price, cross-price, and income elasticities of demand. Attention is centered on the impacts of age, race, education, and ethnicity of the household head, household income, household size, region, the presence of children, and prices of Greek yogurt and non-Greek yogurt. This analysis rests on data acquired from Nielsen pertaining to 164,484 households over calendar years 2018–2020. Own-price elasticities are estimated to be −1.36 for Greek yogurt and −0.70 for non-Greek yogurt. Additionally, these yogurt products are not only substitutes but also necessities.

Genetic Dissection Of Diverse Seed Coat Patterns In Cowpea Through A Comprehensive Gwas Approach, Haizheng Xiong, Yilin Chen, Waltram Ravelombola, Beiquan Mou, Xiaolun Sun, Qingyang Zhang, Yiting Xiao, Yang Tian, Qun Luo, Ibtisam Alatawi, Kenani Edward Chiwina, Hanan Mohammedsaeed Alkabkabi, Ainong Shi

Poultry Science Faculty Publications and Presentations

This study investigates the genetic determinants of seed coat color and pattern variations in cowpea (Vigna unguiculata), employing a genome-wide association approach. Analyzing a mapping panel of 296 cowpea varieties with 110,000 single nucleotide polymorphisms (SNPs), we focused on eight unique coat patterns: (1) Red and (2) Cream seed; (3) White and (4) Brown/Tan seed coat; (5) Pink, (6) Black, (7) Browneye and (8) Red/Brown Holstein. Across six GWAS models (GLM, SRM, MLM, MLMM, FarmCPU from GAPIT3, and TASSEL5), 13 significant SNP markers were identified and led to the discovery of 23 candidate genes. Among these, four specific …

Deoxynivalenol And Fumonisin Predispose Broilers To Bacterial Chondronecrosis With Osteomyelitis Lameness, Khawla Alharbi, Nnamdi Ekesi, Amer Hasan, Andi Asnayanti, Jundi Liu, Raj Murugesan, Shelby Ramirez, Samuel Rochell, Michael T. Kidd, Adnan Alrubaye

Poultry Science Faculty Publications and Presentations

Bacterial chondronecrosis with osteomyelitis (BCO) lameness is the most critical animal health and welfare issue facing the broiler industry worldwide. It is estimated that 1 to 2% of bird condemnation at marketing age is caused by BCO lameness, resulting in tens of millions of dollars in annual losses. Fast-growing broilers are prone to mechanical stress that triggers bacterial translocation across epithelial barriers into the bloodstream, followed by bacterial colonization in the growth plate of long bones, and eventually, bone necrosis and lameness. Mycotoxins (MTX) are secondary metabolites produced naturally by microfungi, of which deoxynivalenol (DON …

Potential Non-Invasive Detection Of Lesions In Broiler Femur Heads: Application Of The Dxa Imaging System, Alison Ramser, Elizabeth Greene, Robert Wideman, Sami Dridi

Poultry Science Faculty Publications and Presentations

Leg health is a significant economic and welfare concern for the poultry industry. Current methods of detection rely on visual assessment of the legs and gait scores and bone scoring during necropsy for full characterization. Additionally, the current scoring of femurs only examines the external surface of the femoral head. Through the use of the dual-energy X-ray absorptiometry (DXA) imaging system, we show the presence of a necrotic region in the femurs that would otherwise be considered healthy based on the current evaluation procedures. Importantly, these lesions were present in almost 60% (22 of 37) of femurs that scored normal …

Potential Consumer Response To The Healthy Symbol Proposed By The Us Food And Drug Administration, Jillian Hyink, Brandon R. Mcfadden, Brenna Ellison

Agricultural Economics and Agribusiness Faculty Publications and Presentations

The U.S. Food and Drug Administration (FDA) has proposed updates to the definition of “healthy,” including distinctions between types of sugar and fats and limits on added sugar, saturated fat, and sodium. To communicate the updated standards, the FDA is developing a Healthy symbol to display on food packages, which could reduce knowledge gaps by assisting U.S. consumers in meeting recommended nutritional guidelines. This study aimed to explore the potential for the label to increase consumers' ability to correctly identify a food product that met the FDA's criteria for a healthy symbol. To complete the study objective, 1018 adults were …

A Sublethal Concentration Of Chlorine Induces Antibiotic Resistance In Salmonella Via Production Of Reactive Oxygen Species, Mohammed Aljuwayd, Israa Abdullah Malli, Steven C. Ricke, Young Min Kwon

Poultry Science Faculty Publications and Presentations

Studies have shown that the production of reactive oxygen species (ROS) is triggered by bactericidal antibiotics, which contributes significantly to the killing of bacterial cells and increasing mutations in surviving cells. In this study, we hypothesized that exposure of Salmonella to sublethal concentrations of hypochlorite (NaOCl), a commonly used sanitizer in household and food industries increases mutation rates, leading to the development of antibiotic resistance. We found that a sublethal concentration (20 ppm) of NaOCl increased the mutation rates of S. typhimurium 14028s significantly (p < 0.05), which was prevented by the ROS scavenger thiourea, supporting that the increased mutation was due to NaOCl-triggered ROS production. We further found that the exposure of S. typhimurium 14028s to the same sublethal concentration of NaOCl increases resistance to kanamycin among the 3 antibiotics evaluated. The results of this study suggest that when NaOCl applied as a sanitizer fails to kill Salmonella due to diluted local concentrations or presence of organic materials, it can cause an adverse outcome of developing antibiotic resistance of the pathogen.

In Vitro And In Vivo Fermentation Models To Study The Function Of Dietary Fiber In Pig Nutrition, Weikang Huangfu, Hexi Cao, Shouren Li, Shuhang Zhang, Mengqi Liu, Boshuai Liu, Xiaoyan Zhu, Yalei Cui, Zhichang Wang, Jiangchao Zhao, Yinghua Shi

Animal Science Faculty Publications and Presentations

The importance of dietary fiber (DF) in animal diets is increasing with the advancement of nutritional research. DF is fermented by gut microbiota to produce metabolites, which are important in improving intestinal health. This review is a systematic review of DF in pig nutrition using in vitro and in vivo models. The fermentation characteristics of DF and the metabolic mechanisms of its metabolites were summarized in an in vitro model, and it was pointed out that SCFAs and gases are the important metabolites connecting DF, gut microbiota, and intestinal health, and they play a key role in intestinal health. At …

Contractile Vacuoles: A Rapidly Expanding (And Occasionally Diminishing?) Understanding, Kiran J. More, Harpreet Kaur, Alastair G.B. Simpson, Frederick W. Spiegel, Joel B. Dacks

Biological Sciences Faculty Publications and Presentations

Osmoregulation is the homeostatic mechanism essential for the survival of organisms in hypoosmotic and hyperosmotic conditions. In freshwater or soil dwelling protists this is frequently achieved through the action of an osmoregulatory organelle, the contractile vacuole. This endomembrane organelle responds to the osmotic challenges and compensates by collecting and expelling the excess water to maintain the cellular osmolarity. As compared with other endomembrane organelles, this organelle is underappreciated and under-studied. Here we review the reported presence or absence of contractile vacuoles across eukaryotic diversity, as well as the observed variability in the structure, function, and molecular machinery of …

Exploring Leaf Anthocyanin Concentrations And Light Effects On Lettuce Growth, Peyton Lou Palsha, Marc W. Van Iersel, Ryan Dickson, Lynn Seymour, Melanie Yelton, Rhuanito Soranz Ferrarezi

Horticulture Faculty Publications and Presentations

Anthocyanins are secondary metabolites classified as water-soluble, non-photosynthetic pigments with the potential ability to shield chloroplasts from excess light energy. This study investigated the morphological and physiological responses of six lettuce (Lactuca sativa) cultivars with different leaf anthocyanin contents grown in a greenhouse under different supplemental photosynthetic photon flux densities (PPFD). Cultivars ‘Cherokee’, ‘Teodore’, ‘Rex’, and ‘Rouxai’ decreased in specific leaf area with increasing PPFD, respectively. We observed that growth in cultivars with higher leaf anthocyanin content (‘Cherokee’ and ‘Rouxai’) increased with increasing PPFD. Light use efficiency (LUE) is an important physiological parameter affecting biomass accumulation, and cultivars ‘Cherokee’, ‘Rex’, …

Genomic Insights Into Oxalate Content In Spinach: A Genome-Wide Association Study And Genomic Prediction Approach, Haizheng Xiong, Kenani Chiwina, Waltram Ravelombola, Yilin Chen, Ibtisam Alatawi, Qun Luo, Theresa M. Phiri, Beiquan Mou, Ainong Shi

Horticulture Faculty Publications and Presentations

Oxalate content in spinach is a key trait of interest due to its relevance to human health. Understanding the genetic basis of it can facilitate the development of spinach varieties with reduced oxalate levels. In pursuit of understanding the genetic determinants, a diverse panel comprising 288 spinach accessions underwent thorough phenotyping of oxalate content and were subjected to whole-genome resequencing, resulting in a comprehensive dataset encompassing 14 386 single-nucleotide polymorphisms (SNPs). Leveraging this dataset, we conducted a genome-wide association study (GWAS) to identify noteworthy SNPs associated with oxalate content. Furthermore, we employed genomic prediction (GP) via cross-prediction, utilizing five GP …

Nutrient Transformations Based On Sampling Scheme And Cropping System Following Subsurface-Banded Poultry Litter, Amanda Ashworth, H. Amorim, P. A. Moore, T. A. Adams, C. Nieman, P. R. Owens

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Poultry litter (PL) is an excellent source of micro- and macronutrients. However, surface applications result in greater nutrient runoff and nitrogen loss via ammonia volatilization. Subsurface banding PL is a promising technology for combating these challenges, but scant information exists on proper soil sampling techniques and management recommendations for subsurface-applied PL. Therefore, objectives were to quantify the nutrient status based on sampling depth (0–15 cm and 15–30 cm) and schema (systematic [0, 3, 7, and 10 cm from PL bands] and composite) to develop subsurface PL recommendations per system (annual cropping and perennial pasture). Soil samples were collected during PL …

A Histological And Dicect-Derived 3d Reconstruction Of The Avian Visual Thalamofugal Pathway, Parker J. Straight, Paul M. Gignac, Wayne Kuenzel

Poultry Science Faculty Publications and Presentations

Amniotes feature two principal visual processing systems: the tectofugal and thalamofugal pathways. In most mammals, the thalamofugal pathway predominates, routing retinal afferents through the dorsolateral geniculate complex to the visual cortex. In most birds, the thalamofugal pathway often plays the lesser role with retinal afferents projecting to the principal optic thalami, a complex of several nuclei that resides in the dorsal thalamus. This thalamic complex sends projections to a forebrain structure called the Wulst, the terminus of the thalamofugal visual system. The thalamofugal pathway in birds serves many functions such as pattern discrimination, spatial memory, and navigation/migration. A comprehensive analysis …

Development Of Real-Time Pcr Assay For Quantitative Detection Of Clostridium Septicum, Bishnu Adhikari, Guillermo Tellez-Isaias, Tieshan Jiang, Brian Wooming, Young Min Kwon

Poultry Science Faculty Publications and Presentations

Cellulitis is an important disease in commercial turkey farms associated with significant economic loss. Although the etiology of cellulitis is not fully elucidated, Clostridium septicum (C. septicum) is one of the main causes of this infectious disease. In this study, we report the development of a quantitative real-time PCR (qRT PCR) assay targeting the alpha-toxin gene (csa), which involves a prior 15-cyle PCR using a nested pair of primers to increase the detection sensitivity. Additionally, the TaqMan probe was employed to increase the target-specificity of the assay. The performance of our nested qRT-PCR assay …

Corn And Soybean Growth As Affected By Wastewater-Derived Struvite-Phosphorus Sources And Irrigation Water Types, Machaela Morrison, Kristofor R. Brye, Gerson L. Drescher, Jennie Popp, Lisa Wood

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Struvite (MgNH₄PO₄·6H₂O) produced synthetically from a stock solution of known phosphorus (P) and nitrogen (N) concentrations has been shown to be an effective, alternative fertilizer-P source for various crops, but little is known about the potential agronomic effectiveness of struvite created from an actual municipal wastewater source. The objective of this study was to evaluate the effects of soil [i.e., Creldon silt loam (Oxyaquic Fragiudalf) and Calloway silt loam (Aquic Fraglossudalf) series], fertilizer-P source [i.e., synthetically produced electrochemically precipitated struvite (ECSTsyn), real-wastewater-derived ECST (ECSTreal), chemically precipitated struvite (CPST), monoammonium phosphate …

Winners And Losers: Emotional Shifts Across Elections Are Conveyed By A Politician’S Smile, Carl Senior, Patrick A. Stewart, Erik Bucy, Nick Lee

Political Science Faculty Publications and Presentations

The human smile can convey both rewarding and affiliative social intent and thus has significant utility in politics, where the ability to bond with and reassure voters is vital to electoral success. We examine experimental evidence from the 2019 UK general election to investigate the influence of a politician’s reward or affiliative smile on voter emotions. It was hypothesised that the winner’s affiliative smile would engender positive affect across all partisan groups compared to the winner’s reward smile display. Participants from a nationally representative sample were shown campaign footage containing both types of smiles from the leaders of the main …

Exploring The Intestinal Microbial Community Of Lantang Pigs Through Metagenome-Assembled Genomes And Carbohydrate Degradation Genes, Jianbo Yang, Ying Fan, Rui Jin, Yunjuan Peng, Jianmin Chai, Xiaoyuan Wei, Yunxiang Zhao, Feilong Deng, Jiangchao Zhao, Ying Li

Animal Science Faculty Publications and Presentations

High-fiber, low-cost agricultural byproducts offer a sustainable alternative for mitigating the competition for crops between humans and livestock. Pigs predominantly utilize dietary fibers through the process of microbial fermentation within the gut. This study explored the gut microbiota and the capacity for carbohydrate degradation in 30 individual Lantang pigs, a breed indigenous to China. Through metagenomic analysis, a total of 671 metagenome-assembled genomes (MAGs) were assembled and assigned into 14 bacterial and 1 archaeal phylum, including 97 species from uncultured microbes. The phylum with the highest abundance were identified as Bacillota_A, Bacteroidota, and Bacillota. Remarkably, the investigation revealed nearly 10,000 …

Phenotypic And Functional Characterization Of Bovine Adipose-Derived Mesenchymal Stromal Cells, Vitali V. Maldonado, Sriya Pokharel, Jeremy G. Powell, Rebekah M. Samsonraj Dr.

Animal Science Faculty Publications and Presentations

Background: Mesenchymal stem cells (MSCs) are increasingly trialed in cellular therapy applications in humans. They can also be applied to treat a range of diseases in animals, particularly in cattle to combat inflammatory conditions and aging-associated degenerative disorders. We sought to demonstrate the feasibility of obtaining MSCs from adipose tissue and characterizing them using established assays. Methods: Bovine adipose MSCs (BvAdMSCs) were isolated using in-house optimized tissue digestion protocols and characterized by performing a colony formation assay, cell growth assessments, cell surface marker analysis by immunocytochemistry and flow cytometry, osteogenic and adipogenic differentiation, and secretion of indoleamine 2,3-dioxygenease (IDO). Results: …

Evaluating Supplementation Programs For Growing Calves Grazing Bermudagrass Pastures, A. M. Womack, Beth Kegley, Shane Gadberry, T. Hess, D. Hubbell, P. A. Beck

Animal Science Faculty Publications and Presentations

Objective

Materials and Methods

Brainlife.Io: A Decentralized And Open-Source Cloud Platform To Support Neuroscience Research, Soichi Hayashi, Bradley A. Caron, Anibal Solon Heinsfeld, Sophia Vinci-Booher, Brent Mcpherson, Daniel N. Bullock, Giulia Berto, Guiomar Niso, Sandra Hanekamp, Daniel Levitas, Kimberly Ray, Anne Mackenzie, Paolo Avesani, Lindsey Kitchell, Josiah K. Leong, Filipi Nascimento-Silva, Serge Koudoro, Hanna Willis, Jasleen K. Jolly, Derek Pisner, Taylor R. Zuidema, Jan W. Kurzawski, Kyriaki Mikellidou, Aurore Bussalb, Maximilien Chaumon, Nathalie George, Christopher Rorden, Conner Victory, Dheeraj Bhatia, Dogu Baran Aydogan, Fang-Chen F. Yeh, Franco Delogu, Javier Guaje, Jelle Veraart, Jeremy Fischer, Joshua Faskowitz, Ricardo Fabrega, David Hunt, Shawn Mckee, Shawn T. Brown, Stephanie Heyman, Vittorio Iacovella, Amanda F. Mejia, Daniele Marinazzo, R. Cameron Craddock, Emanuale Olivetti, Jamie L. Hanson, Eleftherios Garyfallidis, Dan Stanzione, James Carson, Robert Henschel, David Y. Hancock, Craig A. Stewart, David Schnyer, Damian O. Eke, Russell A. Poldrack, Steffen Bollmann, Ashley Stewart, Holly Bridge, Ilaria Sani, Winrich A. Freiwald, Aina Puce, Nicholas L. Port, Franco Pestilli

Psychological Science Faculty Publications and Presentations

Neuroscience is advancing standardization and tool development to support rigor and transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable and reusable) access. brainlife.io was developed to democratize neuroimaging research. The platform provides data standardization, management, visualization and processing and automatically tracks the provenance history of thousands of data objects. Here, brainlife.io is described and evaluated for validity, reliability, reproducibility, replicability and scientific utility using four data modalities and 3,200 participants.

Asynchronous Video Directly Observed Therapy To Monitor Short-Course Latent Tuberculosis Infection Treatment: Results Of A Randomized Controlled Trial, Richard S. Garfein, Lin Liu, Javier Cepeda, Susannah Graves, Stacie San Miguel, Antonette Antonio, Jazmine Cuevas-Mota, Valerie Mercer, Mckayla Miller, Donald G. Cantazaro, Phillip Rios, Fredric Raab, Constance A. Benson

Biological Sciences Faculty Publications and Presentations

Background

Observing medication ingestion through self-recorded videos (video directly observed therapy [VDOT]) has been shown to be a cost-effective alternative to in-person directly observed therapy (DOT) for monitoring adherence to treatment for tuberculosis disease. VDOT could be a useful tool to monitor short-course latent tuberculosis infection (LTBI) treatment.

Methods

We conducted a prospective randomized controlled trial comparing VDOT (intervention) and clinic-based DOT (control) among patients newly diagnosed with LTBI who agreed to a once-weekly 3-month treatment regimen of isoniazid and rifapentine. Study outcomes were treatment completion and patient satisfaction. We also assessed costs. Pre- and posttreatment interviews were conducted.

Results …

Notes On The Ecological Distribution Of The Myxomycete Arcyria Globosa, Steven L. Stephenson, Rollins W. Rollins, Theda Win Coco, Randy G. Darrah

Biological Sciences Faculty Publications and Presentations

Abstract

Prior to the virtual elimination of American chestnut (Castanea dentata) from the forests of eastern North America by the chestnut blight fungus, Arcyria globosa was commonly found on old chestnut burs that had fallen to the ground. The association of this myxomycete with chestnut burs was not absolute, but occurrences on other substrates appear to have been rare. During field collecting carried out in a forest in northern Thailand, it was noticed that old fallen cupules (burs) of Castanopsis indica often had scattered fruiting bodies of A. globosa present. Castanea and Castanopsis belong to the same family (Fagaceae) and …

Analytic-Holistic Cognitive Styles Affect Consumer Responses To Food And Beverage Samples During Sensory Evaluation, Thadeus L. Beekman, Han-Seok Seo

Food Science Faculty Publications and Presentations

Recent studies have shown that the analytic-holistic theory is applicable in sensory science-related areas. Analytic and holistic cognitive style groups have been found to have significantly different perceptions and behaviors within food-related scenarios. These differences were further investigated and identified within the current study, focusing on specific areas of common sensory tests and analyses where analytic and holistic cognitive style groups may differ from one another. Before the main study, 419 volunteers were classified into three groups based on their scores to the Analysis-Holism Scale (AHS). The extreme groups (65 adults for each) were identified as the “analytic” and “holistic” …

A Hypothesis-Based Hop Microbiology Laboratory Module Testing The Plausibility Of The Mythical Origin Of The India Pale Ale, Julio Molina Pineda, Amanda N. Scholes, Jeffrey A. Lewis

Biological Sciences Faculty Publications and Presentations

As one of the most famous fermented drinks in the world, beer is an especially relatable topic for microbiology courses. Here, we describe a short and easily adaptable module based on the antibacterial properties of hops used in brewing. By the 15th century, beer recipes included hops (the flower of the Humulus lupulus plant) as a bittering agent and antimicrobial. By the 19th century, the highly hopped Indian Pale Ale (IPA) became popular, and a modern myth has emerged that IPAs were invented to survive long ocean voyages such as from Britain to India. With that myth in mind, we …

Investigation Of Potential Gut Health Biomarkers In Broiler Chicks Challenged By Campylobacter Jejuni And Submitted To A Continuous Water Disinfection Program, Tilemachos Mantzios, Despoina E. Kiousi, Georgia D. Brellou, Georgios A. Papadopoulos, Vangelis Economou, Marili Vasilogianni, Elisavet Kanari, Evanthia Petridou, Ilias Giannenas, Guillermo Tellez-Isaias, Aglaia Pappa, Alex Galanis, Vasilios Tsiouris

Poultry Science Faculty Publications and Presentations

The exploration of novel biomarkers to assess poultry health is of paramount importance, not only to enhance our understanding of the pathogenicity of zoonotic agents but also to evaluate the efficacy of novel treatments as alternatives to antibiotics. The present study aimed to investigate potential gut health biomarkers in broiler chicks challenged by Campylobacter jejuni and subjected to a continuous water disinfection program. A total of 144 one-day-old hatched broiler chicks were randomly allocated to four treatment groups with four replicates each, according to the following experimental design: Group A received untreated drinking water; Group B received drinking water treated …

Low-Dimensional Criticality Embedded In High-Dimensional Awake Brain Dynamics, Antonio J. Fontenele, J. Samuel Sooter, V. Kindler Norman, Shree Hari Gautam, Woodrow L. Shew

Physics Faculty Publications and Presentations

Whether cortical neurons operate in a strongly or weakly correlated dynamical regime determines fundamental information processing capabilities and has fueled decades of debate. We offer a resolution of this debate; we show that two important dynamical regimes, typically considered incompatible, can coexist in the same local cortical circuit by separating them into two different subspaces. In awake mouse motor cortex, we find a low-dimensional subspace with large fluctuations consistent with criticality—a dynamical regime with moderate correlations and multi-scale information capacity and transmission. Orthogonal to this critical subspace, we find a high-dimensional subspace containing a desynchronized dynamical regime, which may optimize …

Exercise-Induced Myc As An Epigenetic Reprogramming Factor That Combats Skeletal Muscle Aging, Ronald G. Jones Iii, Ferdinand Von Walden, Kevin A. Murach

Health, Human Performance and Recreation Faculty Publications and Presentations

Of the “Yamanaka factors” Oct3/4, Sox2, Klf4, and c-Myc (OSKM), the transcription factor c-Myc (Myc) is the most responsive to exercise in skeletal muscle and is enriched within the muscle fiber. We hypothesize that the pulsatile induction of MYC protein after bouts of exercise can serve to epigenetically reprogram skeletal muscle toward a more resilient and functional state.

Comparative Analyses Of The Banded Alder Borer (Rosalia Funebris) And Asian Longhorned Beetle (Anoplophora Glabripennis) Genomes Reveal Significant Differences In Genome Architecture And Gene Content Among These And Other Cerambycidae, Terrence Sylvester, Richard Adams, Robert F. Mitchell, Anne M. Way, Rongron Shen, Na Ra Shin, Duane D. Mckenna

Entomology Faculty Publications and Presentations

Rosalia funebris (RFUNE; Cerambycidae), the banded alder borer, is a longhorn beetle whose larvae feed on the wood of various economically and ecologically significant trees in western North America. Adults are short-lived and not known to consume plant material substantially. We sequenced, assembled, and annotated the RFUNE genome using HiFi and RNASeq data. We documented genome architecture and gene content, focusing on genes putatively involved in plant feeding (phytophagy). Comparisons were made to the well-studied genome of the Asian longhorned beetle (AGLAB; Anoplophora glabripennis) and other Cerambycidae. The 814 Mb RFUNE genome assembly was distributed across 42 contigs, with …