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Thymoquinone Decreases Oxidative Dna Damage (8-Ohdg) In Dmba Treated Female Sprague Dawley Rats, Abrar A. Sindi
Thymoquinone Decreases Oxidative Dna Damage (8-Ohdg) In Dmba Treated Female Sprague Dawley Rats, Abrar A. Sindi
EWU Masters Thesis Collection
"Tamoxifen (TAM) is used widely for treatment and prevention of breast cancer. However, TAM has been reported to have a negative effect on glutathione (GSH) levels and 8-hydroxydeoxyguanosine (8-OHdG). Thymoquinone (TQ), the main active ingredient of Nigella sativa, or Black seeds, is used in the Middle East for treatment of several diseases, especially cancer. The aim of my research was to investigate the role of thymoquinone in improving 8-OHdG and GSH compared with tamoxifen in female Sprague Dawley rats treated with 7,12 dimethylbenz (a)anthracene (DMBA, a drug that induces mammary cancer). 8-OHdG is the most commonly assayed fingerprint of free …
Efficacy Of Tamoxifen And Thymoquinone On Tumor Development, Lipid Peroxidation, And Total Antioxidant Capacity In Dmba Induced Mammary Carcinoma In Female Sprague-Dawley Rats, Nadiah S. Alotaibi
Efficacy Of Tamoxifen And Thymoquinone On Tumor Development, Lipid Peroxidation, And Total Antioxidant Capacity In Dmba Induced Mammary Carcinoma In Female Sprague-Dawley Rats, Nadiah S. Alotaibi
EWU Masters Thesis Collection
"Tamoxifen (TAM) is a drug used for treatment and prevention of breast cancer. However, TAM has been reported to induce liver tumors in several animal models due to overproduction of free radicals and lipid peroxidation. Thymoquinone (TQ), from Nigella sativa seeds, is a Middle East natural medicine and it has been used to treat a number of diseases, including cancer. The aim of my study was to investigate the effect of TQ and TAM on tumor development, lipid peroxidation level, and total antioxidant capacity in DMBA treated female Sprague-Dawley rats. Five groups of 10 rats (control, DMBA, TAM, TQ, and …