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Full-Text Articles in Life Sciences

การจัดการขยะหลังภัยพิบัติน้ำท่วม : บทเรียนจากประเทศญี่ปุ่นต่อการพัฒนานโยบายในประเทศไทย, วิไลลักษณ์ นิยมมณีรัตน์, มงคลชัย อัศวดิษฐเลิศ, กนกพร คุ้มภัย Jan 2026

การจัดการขยะหลังภัยพิบัติน้ำท่วม : บทเรียนจากประเทศญี่ปุ่นต่อการพัฒนานโยบายในประเทศไทย, วิไลลักษณ์ นิยมมณีรัตน์, มงคลชัย อัศวดิษฐเลิศ, กนกพร คุ้มภัย

Thai Environment

การศึกษาการจัดการขยะหลังภัยพิบัติน้ำท่วม โดยวิเคราะห์บทเรียนจากประเทศญี่ปุ่นเพื่อพัฒนานโยบายสำหรับประเทศไทย เนื่องจากประเทศไทยประสบปัญหาน้ำท่วมบ่อยครั้ง ทำให้เกิดขยะจำนวนมหาศาลซึ่งเกินขีดความสามารถของระบบจัดการขยะปกติ การศึกษาได้เปรียบเทียบกรณีศึกษาในประเทศญี่ปุ่นและประเทศไทย พร้อมทั้งเสนอแนวทางการจัดการขยะในแต่ละระยะของภัยพิบัติ รวมถึงข้อเสนอแนะเชิงนโยบายต่อประเทศไทยถึงความจำเป็นของการเตรียมความพร้อมด้านการจัดการขยะหลังภัยพิบัติ เพื่อเสริมสร้างความพร้อมและความยั่งยืนในการจัดการขยะหลังภัยพิบัติในประเทศไทย


Effects Of Replacing Antibiotics With Bacillus-Based Probiotics In The Diet Of Lactating Sows On Reproductive Performance, Feed Intake, Serum Immunoglobulin Levels, Milk Production, Oxidative Stress Markers, Fecal Short-Chain Fatty Acids, And Piglet Growth Performance, Chutikan Srisang, Tip-Apa Akkhaphan, Preechaphon Taechamaeteekul, Junpen Suwimonteerabutr, Rafa Boonprakob, Suparlark Nuntawan Na Ayudhya Dr, Lea Hübertz Birch Hansen Dr, Padet Tummaruk Dec 2025

Effects Of Replacing Antibiotics With Bacillus-Based Probiotics In The Diet Of Lactating Sows On Reproductive Performance, Feed Intake, Serum Immunoglobulin Levels, Milk Production, Oxidative Stress Markers, Fecal Short-Chain Fatty Acids, And Piglet Growth Performance, Chutikan Srisang, Tip-Apa Akkhaphan, Preechaphon Taechamaeteekul, Junpen Suwimonteerabutr, Rafa Boonprakob, Suparlark Nuntawan Na Ayudhya Dr, Lea Hübertz Birch Hansen Dr, Padet Tummaruk

The Thai Journal of Veterinary Medicine

This clinical trial investigated the effects of adding a Bacillus-based probiotic to the lactation diet of sows (without in-feed antibiotics) on maternal and piglet outcomes. A total of 109 Landrace × Yorkshire sows (parity 1–7) were assigned to either a control group (n = 61) or a treatment group (n = 48) receiving Bacillus subtilis – 541 and Bacillus amyloliquefaciens – 516. Piglets in the treatment group also received the probiotics via creep feed from day 3 until weaning. Blood samples were collected within 12 h after farrowing to assess serum immunoglobulins (IgG, IgA, and IgM) and malondialdehyde (MDA) …


Effect Of Ovarian Characteristics And Propylene Glycol Supplementation On Pregnancy Rates Per Ai In Suckled Beef Cows Subjected To A 7-Day Co-Synch Fixed-Time Ai Protocol Across Seasons, Body Condition Scores, And Postpartum Intervals, Pachara Pearodwong, Sarawanee Khunmanee, Kajohn Nitiwararuk, Thuwanon Boonkerd, Thananon Junsuri, Andrew A. Ponter, Winai Kaewlamun Dec 2025

Effect Of Ovarian Characteristics And Propylene Glycol Supplementation On Pregnancy Rates Per Ai In Suckled Beef Cows Subjected To A 7-Day Co-Synch Fixed-Time Ai Protocol Across Seasons, Body Condition Scores, And Postpartum Intervals, Pachara Pearodwong, Sarawanee Khunmanee, Kajohn Nitiwararuk, Thuwanon Boonkerd, Thananon Junsuri, Andrew A. Ponter, Winai Kaewlamun

The Thai Journal of Veterinary Medicine

The present study evaluated the independent effects of ovarian characteristics and oral propylene glycol (PG) supplementation on pregnancy rates in suckled beef cows subjected to the 7-day CO-Synch + CIDR fixed-time AI (FTAI) protocol across different seasons, body condition scores (BCS; 5-point scale), and parturition-to-FTAI intervals. Cows received a CIDR insert and 10 μg GnRH on day -10, followed by 25 mg PGF2α at CIDR removal on day -3, and another 10 μg GnRH 72 h later (day 0). In Study 1, the ovarian characteristics of 36 cows were assessed transrectally on days -10 and 0 relative to the FTAI. …


Climate And Non-Genetic Effects On Goat Milk Quality And Casein Prediction Using Machine Learning, Ibrahima Mahamane Abdourhamane, Dilek Arsoy Nov 2025

Climate And Non-Genetic Effects On Goat Milk Quality And Casein Prediction Using Machine Learning, Ibrahima Mahamane Abdourhamane, Dilek Arsoy

The Thai Journal of Veterinary Medicine

Milk quality is becoming more and more crucial for farmers with the increasing use of component-based pricing systems in the sector. This study aimed to investigate the effects of climate-related and non-genetic factors on goat milk quality on the island of Northern Cyprus and to predict casein content using machine learning techniques. An analysis was performed on 21,695 goat milk samples collected between 2012 and 2018. Somatic cell count (SCC), standard plate count (SPC), and key milk components such as protein, casein, lactose, and fat were evaluated for different seasons, regions, farm sizes, and raw milk types. Five machine learning …


Commercial Laying Hen Farms' General Characteristics, Environmental Management, And Biosecurity Practices In The Sub-Arid Area Of Algeria, Yacine Kasmi, Nouzha Heleili, Zohra Ahmed Gaid, Brahim Hamad, Leyla Hadef, Manel Merradi Nov 2025

Commercial Laying Hen Farms' General Characteristics, Environmental Management, And Biosecurity Practices In The Sub-Arid Area Of Algeria, Yacine Kasmi, Nouzha Heleili, Zohra Ahmed Gaid, Brahim Hamad, Leyla Hadef, Manel Merradi

The Thai Journal of Veterinary Medicine

The success of commercial laying hen farms depends on the possibility of managing environmental conditions properly and performing strict biosecurity measures, which would increase productivity, enhance the performance of the flock, and save money, especially in regions characterized by challenging climatic conditions, such as the sub-arid and arid areas. There is, however, very little literature exploring these issues in the Algerian context. The objective of the study was to assess environmental management and biosecurity practices, and the relationship between these and farm size in the Algerian sub-arid area (northeast Algeria). The face-to-face interviews were conducted between January 2024 and April …


Milk Yield Performance Of Local Cows, Handling Practices, Physicochemical Properties, And Milk Production Constraints In Kucha District, Southern Ethiopia, Demissie Jorge, Seifu Birhanu, Yilkal Tadele Oct 2025

Milk Yield Performance Of Local Cows, Handling Practices, Physicochemical Properties, And Milk Production Constraints In Kucha District, Southern Ethiopia, Demissie Jorge, Seifu Birhanu, Yilkal Tadele

The Thai Journal of Veterinary Medicine

The study assessed milk production performance of local cows, milk handling practices, physicochemical properties, and milk production constraints in Kucha District, Southern Ethiopia. A purposive and random sampling technique was employed to select 138 respondents for the interview. For physicochemical property assessment, milk samples were collected from 90 interviewed households. Majorities (76.7%) of the respondents were males, and the average family size was 6.82±0.25. Mean daily milk yield (DMY) of 1.80±0.07, 1.94±0.06, and 1.52±0.09 liters was recorded for local cows, respectively, in early, mid, and late lactation stages. All respondents in the area use hand milking and wash their hands …


Extraction And Optimization Of Flavonoids From Elaeagnus Pungens Thunb And Its Potential Impact On Blood Plasma Cholesterol In A Mouse Model, Qunqing Lu, Haozhe Liu, Xinxin Zhang, Nourhan Nassar, Ibrar Khan, Haji Gul, Zaigui Wang Oct 2025

Extraction And Optimization Of Flavonoids From Elaeagnus Pungens Thunb And Its Potential Impact On Blood Plasma Cholesterol In A Mouse Model, Qunqing Lu, Haozhe Liu, Xinxin Zhang, Nourhan Nassar, Ibrar Khan, Haji Gul, Zaigui Wang

The Thai Journal of Veterinary Medicine

Elaeagnus pungens Thunb is a significant source of flavonoids with biological function. This study aims to develop orthogonal tests and alkali alcohol extraction methods for extracting flavonoids from leaves of E. pungens. The levels of factors in the orthogonal test were determined by pre-experiment, and the physiological efficacy was verified by the in vivo test. The results indicated that the optimal extraction yield was 4.07% when the solid-to-liquid ratio was 1:40, the concentration of ethanol was 60%, the extraction temperature was 80℃, and the extraction time was five h. The alkalialcohol extraction results demonstrated that the extraction yield of …


Polysaccharide From Schisandra Chinensis Alleviates Ulcerative Colitis By Improving Intestinal Microbiota Abundance And Inhibiting The Tlr4/P65/Iκbα Pathway In Dextran Sodium Sulfate-Induced Mice, Caihong Wu, Yang Yang, Peng Liu, Bin Zhang, Hui Lu Oct 2025

Polysaccharide From Schisandra Chinensis Alleviates Ulcerative Colitis By Improving Intestinal Microbiota Abundance And Inhibiting The Tlr4/P65/Iκbα Pathway In Dextran Sodium Sulfate-Induced Mice, Caihong Wu, Yang Yang, Peng Liu, Bin Zhang, Hui Lu

The Thai Journal of Veterinary Medicine

Schisandra chinensis polysaccharides (SCP) are isolated from Schisandra chinensis with a mean molecular weight of 32.401 kDa. Previous studies have demonstrated that Schisandra chinensis extract effectively prevented colitis and modulated gut microbiota in dextran sulfate sodium (DSS)-induced mice. In this study, 3% DSS was used to induce acute ulcerative colitis in mice, and then the SCP with different doses (50 mg/kg, 100 mg/kg, 200 mg/kg) and 5- aminosalicylic acid (5-ASA) were used to treat mice by oral gavage for one week. Here, we report for the first time that SCP presents outstanding protective effects on colon damage induced by DSS …


Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang Oct 2025

Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang

The Thai Journal of Veterinary Medicine

Blastocystis is the most ubiquitous intestinal protozoan parasite found in humans and animals worldwide. Commonly, ST7 and ST6 are the major Blastocystis subtypes reported in birds, and their frequencies fluctuate greatly with various factors. However, little literature is available on the prevalence and subtype characteristics of this parasite in free-living wild birds in the same city. For this purpose, a total of 114 fresh fecal specimens were collected from wild free-living birds in urban districts of Xinxiang city and tested for Blastocystis using PCR of the barcoding region of the small subunit ribosomal RNA (SSU rRNA) gene. The positive isolates …


Efficiency And Clinical Outcomes Of Platelet-Rich Plasma Therapy On Canine Coxofemoral Osteoarthritis, Patama Arunrattanakul, Kumpanart Soontornvipart Sep 2025

Efficiency And Clinical Outcomes Of Platelet-Rich Plasma Therapy On Canine Coxofemoral Osteoarthritis, Patama Arunrattanakul, Kumpanart Soontornvipart

The Thai Journal of Veterinary Medicine

The purpose of this study was to find out the optimal technique to prepare plasma with the highest platelet concentration in platelet rich plasma (PRP), as well as determine the result of autologous PRP from the dogs with osteoarthritis (OA) condition. It was shown that the PRP could reduce inflammation, cell regeneration and enhance angiogenesis to support the injured tissue. This study was composed of two phases; the first phase aimed to find the best centrifugation speed and time that could be able to produce the plasma with the highest platelet concentration by conducting the experiment from a total of …


Paediatric Fixed Drug Eruption: A Case Report Of Ofloxacin As The Culprit, Ambika Nand Jha, Varsha Ratan Gaikwad, Rabia Alam, Shivanshu Sharma, Ashok Kumar Gupta Aug 2025

Paediatric Fixed Drug Eruption: A Case Report Of Ofloxacin As The Culprit, Ambika Nand Jha, Varsha Ratan Gaikwad, Rabia Alam, Shivanshu Sharma, Ashok Kumar Gupta

Chulalongkorn Medical Journal

Ofloxacin, a second-generation fluoroquinolone, is a relatively rare but documented cause of fixed drug eruption (FDE), a localized cutaneous hypersensitivity reaction marked by recurrent, well-demarcated erythematous patches or macules that may develop into blisters upon re-exposure to the offending agent. The underlying mechanism is immune-mediated, involving T-cell activation, cytokine release, and keratinocyte apoptosis. A 5-year-old boy weighing 15 kg was prescribed Ofloxacin syrup (7.5 ml twice daily) and Paracetamol suspension (5 ml twice daily) for suspected enteric fever. Within two days, he developed several annular erythematous lesions on his hands and back, associated with intense itching, raising suspicion of a …


Life Of Moo Deng, The Internet Sensation Pygmy Hippopotamus: An Overview Of The Biology And Conservation Breeding Program In Thailand, Ampika Thongphakdee, Atthapon Nundee, Umaporn Maikeaw, Narongwit Chodchoy, Chainarong Punkong, Kaywalee Chatdarong Jul 2025

Life Of Moo Deng, The Internet Sensation Pygmy Hippopotamus: An Overview Of The Biology And Conservation Breeding Program In Thailand, Ampika Thongphakdee, Atthapon Nundee, Umaporn Maikeaw, Narongwit Chodchoy, Chainarong Punkong, Kaywalee Chatdarong

The Thai Journal of Veterinary Medicine

The hippopotamus, commonly known as the hippo, is classified into two extant species: the common hippopotamus (Hippopotamus amphibius) and the pygmy hippopotamus (Choeropsis liberiensis). Pygmy hippos are fascinating creatures native to the forests and swamps of West Africa. Their survival is increasingly threatened by habitat loss resulting from agricultural expansion and urban development. As the population declines, zoological institutions play a crucial role in conservation by acting as genetic reservoirs and promoting public awareness of wildlife and environmental protection. “Moo Deng”, a pygmy hippo, whose name in Thai has gained international recognition, represents a notable success …


Antioxidant Activity Of Caesalpinia Sappan Heartwood Extracts Against Hydrogen Peroxide-Induced Oxidative Damage In Mrc-5 Cell Lines, Supranee Kongkham, Aylada Kaenu Jun 2025

Antioxidant Activity Of Caesalpinia Sappan Heartwood Extracts Against Hydrogen Peroxide-Induced Oxidative Damage In Mrc-5 Cell Lines, Supranee Kongkham, Aylada Kaenu

Chulalongkorn Medical Journal

Background: C. sappan heartwood extract is a good antioxidant potential natural compound against oxidative stress. A few data have been reported with those of value using cell base assay, especially in normal human lung fibroblast cells.

Objective: The heartwood extracts of C. sappan were obtained with different ethanol concentrations and investigated on the antioxidant capacity on human lung fibroblast MRC-5.

Method: The crude extracts were subjected to antioxidant activity assays based on free radical scavenging activity by Chemi-based assay and cell-based assay (in-vitro lipid peroxidation, CAT and SOD) using MRC-5 cells.

Result: The study shown that …


Association Of Glucose Kinase (Gck) Rs1799884 And Glucokinase Regulatory Protein (Gckr) Rs780094 Gene Polymorphism And Type 2 Diabetes Mellitus (T2dm) Susceptibility In Asian Population: A Meta-Analysis, Sharon Benita Stephen, Jayakanthan Saravanan, Gowtham Kumar Subbaraj Jun 2025

Association Of Glucose Kinase (Gck) Rs1799884 And Glucokinase Regulatory Protein (Gckr) Rs780094 Gene Polymorphism And Type 2 Diabetes Mellitus (T2dm) Susceptibility In Asian Population: A Meta-Analysis, Sharon Benita Stephen, Jayakanthan Saravanan, Gowtham Kumar Subbaraj

Chulalongkorn Medical Journal

Background: Type 2 diabetes mellitus (T2DM) is a condition where the body struggles to regulate blood sugar levels. The GCK (Glucose kinase) and GCKR (Glucokinase regulatory protein) genes play a crucial role in glucose metabolism. GCK produces an enzyme essential for glucose sensing and insulin production, while GCKR regulates this enzyme's activity.

Objective: The meta-analysis aimed to investigate GCK rs1799884 and GCKR rs780094 gene polymorphisms and their association with T2DM in an Asian population.

Methods: Researchers observed articles for two genetic variations (GCK rs1799884 and GCKR rs780094) and their link to type 2 diabetes. We searched online databases like Scopus …


The Factors Affecting The Distribution Of Scorpions (Arachnida: Scorpions) In Iran, Hassan Nasirian Jun 2025

The Factors Affecting The Distribution Of Scorpions (Arachnida: Scorpions) In Iran, Hassan Nasirian

Chulalongkorn Medical Journal

Background: The distribution of scorpions is influenced by various factors that determine their presence and abundance in different regions. Understanding these factors is crucial for comprehending scorpion ecology and predicting their potential impact on ecosystems. Objective: These subtopics aim to provide an overview of the distribution of scorpions within Iran and the factors affecting their distribution, highlighting their ecological preferences and adaptations to different regions.

Methods: Forty-nine documents were collected from well-known indexing services, including Elsevier, Google Scholar, PubMed, ScienceDirect, Scopus, Springer, and Web of Science. After carefully studying the documents, they were classified into specific topics and discussed.

Results: …


Seroprevalence And Associated Risk Factors Of Caprine Arthritis Encephalitis (Cae) And Peste Des Petits Ruminants (Ppr) Among Deer In An Institutional Farm In Malaysia, Krishnan Nair Balakrishnan, Faez Firdaus Abdullah Jesse, Bura Thlama Paul, Shalonagiftsal Stephen C Charles, Ummul Rifhan Najiha Noor Zaman, Eric Lim Teik Chung, Nur Amira Azhar, Abdirahman Barre, Muhammed Mikail, Mohd Azmi Mohd Lila May 2025

Seroprevalence And Associated Risk Factors Of Caprine Arthritis Encephalitis (Cae) And Peste Des Petits Ruminants (Ppr) Among Deer In An Institutional Farm In Malaysia, Krishnan Nair Balakrishnan, Faez Firdaus Abdullah Jesse, Bura Thlama Paul, Shalonagiftsal Stephen C Charles, Ummul Rifhan Najiha Noor Zaman, Eric Lim Teik Chung, Nur Amira Azhar, Abdirahman Barre, Muhammed Mikail, Mohd Azmi Mohd Lila

The Thai Journal of Veterinary Medicine

Caprine arthritis encephalitis (CAE) and peste des petits ruminants (PPR) are significant viral diseases impacting small ruminants, leading to substantial economic losses and posing a potential threat to livestock health. Although seroprevalence evidence of these viruses has been documented in ruminants, there is a lack of data regarding their presence among farmed deer in Malaysia. This preliminary study aimed to determine the seroprevalence and associated risk factors for CAEV and PPRV infections among deer in Malaysia. A total of ninety-two blood sera from an institutional deer farm were screened for CAEV and PPRV antibodies using commercially available indirect ELISA test …


Survey And Analysis Of Rumen Microbiota In Yaks At Different Growth Stages, Shengwei Jin, Xinyue Liu, Yin-Cang Han, Yong-Gang Sun, Wei-Qin Ding, Ya-Qian Liu, Fa-Jie Gou, Jian-Yu Chen Apr 2025

Survey And Analysis Of Rumen Microbiota In Yaks At Different Growth Stages, Shengwei Jin, Xinyue Liu, Yin-Cang Han, Yong-Gang Sun, Wei-Qin Ding, Ya-Qian Liu, Fa-Jie Gou, Jian-Yu Chen

The Thai Journal of Veterinary Medicine

This study investigated changes in the richness and composition of the rumen microbiome in yaks at various developmental stages. Eighteen healthy male yaks at the ages of 5 months (M5), 12 months (M12), and 24 months (M24) had samples of their rumen digesta taken for 16S rRNA gene sequencing. The 11087 amplicon sequence variations (ASVs) in total were found; the M5, M12, and M24 groups had 3585, 1146 and 5545 distinct ASVs, respectively. Alpha diversity indices Chao, Shannon, Sobs, and ace indicated significant differences among the groups. The principal coordinate analysis (PCoA) indicated significant changes in microbial community composition across …


Advantages, Disadvantages, And Factors Influencing The Reproductive Performance Of Gilts And Sows Raised In Gestational Group Housing And Free-Farrowing Systems, Natchanon Dumniem Dr., Thomas D. Parsons, Padet Tummaruk Apr 2025

Advantages, Disadvantages, And Factors Influencing The Reproductive Performance Of Gilts And Sows Raised In Gestational Group Housing And Free-Farrowing Systems, Natchanon Dumniem Dr., Thomas D. Parsons, Padet Tummaruk

The Thai Journal of Veterinary Medicine

In the modern global pig industry, there is a growing interest in animal-friendly agriculture, encouraging farmers to prioritize humane practices and meet the welfare needs of their animals. In developed countries, consumers are increasingly concerned about animal welfare, particularly regarding pigs as social animals, advocating for their housing in groups that reflect their natural behaviors in the wild. There is significant societal pressure to eliminate the use of crate systems, which cause discomfort to animals in commercial farming. In these systems, breeding females are often restricted in movement throughout the reproductive cycle. As a result, alternative husbandry and housing systems …


Reproductive Performances Of Bali Cattle Under Different Management Systems For Designing Their Breeding Strategies, Dwi Hariyono, Panjono Panjono, Dwi Priyadi, Adisti Rastosari, Eny Endrawati, Tety Hartatik Apr 2025

Reproductive Performances Of Bali Cattle Under Different Management Systems For Designing Their Breeding Strategies, Dwi Hariyono, Panjono Panjono, Dwi Priyadi, Adisti Rastosari, Eny Endrawati, Tety Hartatik

The Thai Journal of Veterinary Medicine

Reproductive performance is an economically important trait in beef cattle breeding and improvement programs, as it directly influences overall productivity. Key performance indicators, such as age at puberty (AP), age at first mating (AFM), age at first calving (AFC), calving intervals (CI), days open (DO), number of services per conception (NSC), conception rate (CR), and gestation length (GL), can be used to assess reproductive performance. This review summarized findings from previous studies on the reproductive performance of Bali cattle under various management conditions in Indonesia. The literature indicated a range of reproductive performances in Bali cattle, with AP varying from …


Antituberculosis Potential Of Borrelidin Derivatives: An In Silico Molecular Docking And Molecular Dynamic Approach, Teni Ernawati, Donny Ramadhan, Faris Hermawan, Sasmito Wulyoadi, Bambang Marwoto, Ahmad Wibisana, Bambang Srijanto Mar 2025

Antituberculosis Potential Of Borrelidin Derivatives: An In Silico Molecular Docking And Molecular Dynamic Approach, Teni Ernawati, Donny Ramadhan, Faris Hermawan, Sasmito Wulyoadi, Bambang Marwoto, Ahmad Wibisana, Bambang Srijanto

The Thai Journal of Pharmaceutical Sciences

Background: The present tuberculosis (TB) treatment requires a significant time commitment, often lasting from 6 months to 2 years, with strict daily adherence. Non-compliance leads to drug resistance and suboptimal outcomes. Present research indicates that borrelidin shows potential activity against Mycobacterium tuberculosis, including strains that are resistant to first-line medications. Borrelidin has shown remarkable activity against M. tuberculosis H37Rv, with a minimum inhibitory concentration value of 3.12 μg/mL. Therefore, investigating the inhibition activity of borrelidin derivatives was essential for finding new anti-TB candidates. Objectives: This study aims to investigate the effects of 31 borrelidin derivative compounds …


Preparation And Evaluation Of Mesoporous Celecoxib For Improved Antiarthritic Activity In Rodents, Reena I. Fernandaes, Sayani Bhattacharyya Mar 2025

Preparation And Evaluation Of Mesoporous Celecoxib For Improved Antiarthritic Activity In Rodents, Reena I. Fernandaes, Sayani Bhattacharyya

The Thai Journal of Pharmaceutical Sciences

Background: Celecoxib, a model anti-inflammatory drug, used in the management of arthritis exhibits limited oral bioavailability and slow onset of action due to its poor solubility. Objective: The present study explores a mesoporous drug delivery of celecoxib to investigate the efficacy of its antiarthritic activity in animal models, and develops a low-oral dose therapy. Materials and Methods: The solvent evaporation method was employed for the preparation of mesoporous delivery of celecoxib, using Syloid®, and Neusilin®, at a molar ratio of silica/ drug 1:2.5. The formulations were characterized for drug loading, in vitro drug release, and material …


Enhancing Topical Drug Delivery Of Apremilast Through Niosomal Gel Formulation: Ex Vivo Skin Permeation And In Vivo Evaluation For Psoriasis, Megha Shyam Matlapudi, Anka Rao Areti, Yukti Jaiswal, Veeresh Bantal, Raghavender Medishetti Mar 2025

Enhancing Topical Drug Delivery Of Apremilast Through Niosomal Gel Formulation: Ex Vivo Skin Permeation And In Vivo Evaluation For Psoriasis, Megha Shyam Matlapudi, Anka Rao Areti, Yukti Jaiswal, Veeresh Bantal, Raghavender Medishetti

The Thai Journal of Pharmaceutical Sciences

Background: Psoriasis is a dynamic and chronic disease characterized by inflammatory changes and an increased rate of keratinocyte proliferation leading to the formation of erythematous scleroderma plaques with a silvery sheen. The existing therapies come with shortcomings in terms of effectiveness and leave behind a trail of side effects. Hence, there is a need of alternative therapeutic measures. Objectives: This study aimed to assess the therapeutic potential of Apremilast Niosomal Gel (APR Nio Gel) in treating psoriasis, comparing its effectiveness with conventional gel (APR Gel) and oral suspension (APR Oral) formulations. Materials and Methods: Apremilast niosomes were prepared by thin …


Antibiotic Resistance Profile Of Enterobacteriaceae Isolated From Healthy Pigs In The Republic Of Armenia, Yura Shirvanyan, Irma Artushyan, Lilit Hovsepyan, Ashkhen Shirvanyan, Elmira Ghazaryan, Tigran Markosyan Mar 2025

Antibiotic Resistance Profile Of Enterobacteriaceae Isolated From Healthy Pigs In The Republic Of Armenia, Yura Shirvanyan, Irma Artushyan, Lilit Hovsepyan, Ashkhen Shirvanyan, Elmira Ghazaryan, Tigran Markosyan

The Thai Journal of Veterinary Medicine

The rising prevalence of antimicrobial resistance (AMR) among Enterobacteriaceae in livestock presents a significant threat to both animal and human health. This study investigates the antibiotic resistance profiles of Enterobacteriaceae isolated from 160 samples collected from the lymph nodes of healthy pigs in Armenia. Fifty isolates were identified, including Escherichia coli (24), Klebsiella spp. (10), Salmonella spp. (6), Raoultella ornithinolytica (4), Pseudomonas aeruginosa (4), and Proteus mirabilis (2). Resistance was evaluated using the disk diffusion method against 22 antibiotics from nine classes. Alarmingly, 94.5% of isolates were resistant to clarithromycin and 90.3% to erythromycin, while resistance to cephalothin and amoxicillin …


First Record Of Nesting Ecology And Tumor-Forming Disease In Endangered Green Turtles (Chelonia Mydas) On Taiping Island, Taiwan, Tsung-Hsien Li, Po-Yu Wu, Ming-An Tsai Mar 2025

First Record Of Nesting Ecology And Tumor-Forming Disease In Endangered Green Turtles (Chelonia Mydas) On Taiping Island, Taiwan, Tsung-Hsien Li, Po-Yu Wu, Ming-An Tsai

The Thai Journal of Veterinary Medicine

Taiping Island is an important sea turtle nesting site in Taiwan. However, information on the nesting ecology on Taiping Island is still limited. The present study was conducted between 26 April and 3 June 2023 with the objective of collecting primary data on the sea turtle species that nest on the island. A total of 20 individual nesting green turtles were identified. No other sea turtle species were recorded nesting during this period. Five percent of nesting sea turtles had external tumors. The mean curved carapace length of all nesting female turtles was 98.2 cm. A total of 28 clutches …


Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr. Mar 2025

Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr.

Chulalongkorn Medical Journal

Abstract:

Background: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by inflammation and joint damage.

Objective: This study aimed to evaluate the antiarthritic activity of Trigonella foenum-graecum (TFG) Transferosomal gel in a Freund’s adjuvant-induced arthritic rat model and compare it with Diclofenac gel, a standard anti-inflammatory drug.

Methods: Arthritis was induced in rats by injecting a 0.1 mL (1mg/ml) CFA suspension into the left hind foot in the subplantar region, allowing them to develop arthritis for 21 days.

Results: Arthritis induction led to a significant increase in paw volume, indicative of inflammation. Treatment with both TFG-transferosomal gel and Diclofenac …


External Jugular Vein Catheterization Technique For Continuous Blood Sampling In Gilts, Preechaphon Taechamaeteekul, Yosua Kristian Adi, Chutikan Srisang, Pirada Virankabutra, Natchanon Dumniem, Jinda Singlor, Padet Tummaruk Mar 2025

External Jugular Vein Catheterization Technique For Continuous Blood Sampling In Gilts, Preechaphon Taechamaeteekul, Yosua Kristian Adi, Chutikan Srisang, Pirada Virankabutra, Natchanon Dumniem, Jinda Singlor, Padet Tummaruk

The Thai Journal of Veterinary Medicine

External jugular vein blood collection is common in gilts and sows, but continuous sampling for hormonal and pharmacokinetic research requires catheterization. The standard protocol has remained largely unchanged for nearly 40 years. This study aimed to develop a modified external jugular vein catheterization technique in gilts. Ten gilts (72.0 ± 3.4 kg) underwent surgery under general anesthesia after 12-hour fasting. Sedation was induced with intramuscular Xylazine (4.4 mg/kg) and Tiletamine–Zolazepam (2.2 mg/kg), followed by intravenous Thiopental sodium (10 mg/kg). Once anesthetized, gilts were placed in dorsal recumbency, and the external jugular fossa was prepared under sterile conditions. A 10 cm …


Restricted Feeding Of Goats During The Last Third Of Gestation And Trans-Generational Effects On Plasma Progesterone In Their Female Offspring, Andrew A. Ponter, Bérengère Laporte, Sabine Roussel, Winai Kaewlamun, Pascale Chavatte-Palmer, Christine Duvaux-Ponter Mar 2025

Restricted Feeding Of Goats During The Last Third Of Gestation And Trans-Generational Effects On Plasma Progesterone In Their Female Offspring, Andrew A. Ponter, Bérengère Laporte, Sabine Roussel, Winai Kaewlamun, Pascale Chavatte-Palmer, Christine Duvaux-Ponter

The Thai Journal of Veterinary Medicine

Feeding levels can vary in goat farms for several reasons. Underfeeding of gestating dairy goats can occur and may influence fetal follicle development and future reproductive performance in their offspring. The objective of this experiment was to study the effect of restricted feeding during the last third of gestation on some reproductive parameters in female offspring (F1). Two feeding groups were formed using 60 Alpine and Saanen dairy goats to produce the F1 female offspring. The control group (C, n = 30) was fed to requirements. The restricted group (R, n = 30) was given the same diet, but the …


Stepwise Regression Analysis To Assess Various Factors Affecting On Fresh Sperm Quality In Ouled Djellal Ram, Yamina Belkhiri, Souheyla Benbia, Farida Bouzebda-Afri, Zoubir Bouzebda, Ramzi Lamraoui Mar 2025

Stepwise Regression Analysis To Assess Various Factors Affecting On Fresh Sperm Quality In Ouled Djellal Ram, Yamina Belkhiri, Souheyla Benbia, Farida Bouzebda-Afri, Zoubir Bouzebda, Ramzi Lamraoui

The Thai Journal of Veterinary Medicine

The aim of this study was to evaluate the effect of various factors on fresh semen quality in Ouled Djellal rams. Specifically, we examined the impact of semen collection method, season, ram age, testosterone levels, body weight , and testicular weight. Twelve mature Ouled Djellal rams were used in the trial. Six rams were trained for semen collection using an artificial vagina (AV), while semen from the other six rams was collected using an electroejaculator (EE) biweekly throughout the year. Stepwise regression analysis showed that 62.50% of the variation in sperm volume, 48.60% of the variation in mass motility, 62.70% …


Local Tissue Damage Treatment Of Snake Venom, Suchitra Khunsap Jan 2025

Local Tissue Damage Treatment Of Snake Venom, Suchitra Khunsap

The Thai Journal of Veterinary Medicine

Local tissue damage caused by snake envenomation was a medical problem that caused morbidity and mortality for more than a decade, with no defined treatment guidelines. Nowadays, antivenom is the primary treatment for snakebite, which substantially reduces systemic venom but not significantly reducing local symptoms. We compiled a list of local damage therapies, including antivenom medication, surgery and skin grafting, small molecule medicines, and alternative therapies. Although each was not approved as a standard treatment, it may be a treatment option for tissue damage caused by snake venom. However, antivenoms and most resistant compounds may not be the best strategy …


The Use Of Ethyl Lauroyl Arginate Encapsulated In Organic Nanoparticles Within Boar Semen Extenders To Control Bacterial Growth And Preserve Sperm Quality During Short-Term Storage Without Antibiotics, Congbang Ngo, Naiyaphat Nittayasut, Teerapong Yata, Junpen Suwimonteerabutr, Nuvee Prapasarakul, Jane M. Morrell, Padet Tummaruk Jan 2025

The Use Of Ethyl Lauroyl Arginate Encapsulated In Organic Nanoparticles Within Boar Semen Extenders To Control Bacterial Growth And Preserve Sperm Quality During Short-Term Storage Without Antibiotics, Congbang Ngo, Naiyaphat Nittayasut, Teerapong Yata, Junpen Suwimonteerabutr, Nuvee Prapasarakul, Jane M. Morrell, Padet Tummaruk

The Thai Journal of Veterinary Medicine

The aim of the present study was to investigate the effect of adding ethyl lauroyl arginate (ELA), encapsulated in organic nanoparticles, to a semen extender without antibiotics on sperm quality and bacterial load during short-term storage. Three ejaculates from Duroc boars were divided into four equal portions and diluted with Beltsville Thawing Solution to produce semen doses containing 3 billion spermatozoa in 80 ml. The extended semen did not include antibiotics but instead incorporated different concentrations of ELA nanoparticles into the extenders: 0 ppm, 5 ppm, 10 ppm, and 15 ppm. The semen doses were stored for 4 days, with …