Life Sciences Commons^™

Wrack Lines Spring-Summer 2026 Volume Number 1, Margaret Cozens, Johann Heupel, Owen Placido, Paul Salopek, Judy Benson

Wrack Lines

“Building community around the places we love,” is the theme of the Spring-Summer 2026 issue of Wrack Lines magazine. Learn about the work of the Six Lakes Park coalition in Hamden, Riverfront Recapture in Hartford, MyCoast in southeastern Connecticut and the statewide land conservation conference. Additional stories tell about the artistry and mission of photographer-videographer Tomas Koeck, and National Geographic explorer Paul Salopek, who is traveling the world on foot.

National Agricultural Library (Nal) Search., Leah Everitt, Sonya Lemke

Publications

SEARCH is the USDA National Agricultural Library (NAL)'s main discovery platform that provides integrated access to the NAL Digital Collections, Special Collections, PubAg and AGRICOLA. NAL SEARCH is a valuable tool for health science librarians, students, and professionals seeking veterinary science, nutrition, or animal experiment alternatives. This article aims to give users a comprehensive overview of this resource.

[2026 Winner] Seed Sovereignty Through The Lens Of Decolonization, Lily A. Marx

Ethnic Studies Research Paper Award

This paper explores the movement of seed sovereignty, a contemporary movement stemming from the history of theft, appropriation, and forced assimilation endured by indigenous peoples. This movement recognizes that consumers alone cannot mend the damage being done to our food systems, but instead encourages communities to take political action by saving seeds and rebuilding connections with the land.

University Of Nebraska At Omaha Division Of Biomechanics And Research Development Annual Report 2023-2025, Uno Biomechanics

Biomechanics Annual Report

This report contains:

A letter from the Director: Dr. Nick Stergiou

Highlights articles

Center for Cardiovascular Research in Biomechanics (CRiB) articles

The Center for Research in Human Movement Variability (MOVCENTR) articles

People of UNO Biomechanics

Student Centered articles

Education Initiative articles

Can Generative Ai Make Farming Decisions? Current Status And Future Pathways: A Case Study In Row Crop Production With Chatgpt, Nipuna Chamara, Yufeng Ge, Joe Luck, Yu Pan, Saleh Taghvaeian, Cory Walters, Christopher Proctor, Daran Rudnick, Daren Redfearn

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The agricultural decision-making process is experience-based, knowledge-dependent, time-sensitive, complex, and driven by historical data. Planting, fertilization, irrigation, and chemigation are key categories in farm decision-making, and currently there is no one-shot decision-support tool that covers all these activities. Generative Artificial Intelligence (AI) models are more advanced than traditional machine learning and deep learning models. These models have been trained on vast amounts of data from the internet, allowing them to accept unstructured data in various forms and generate human-like text, solutions to problems, and scenario predictions. Given this capability, we became interested in exploring the potential of generative AI in …

Neural Correlates Of Recognition Memory And Metamemory In Breast Cancer Survivors: An Event-Related Potential Study, Dishari Zaman Azad

Dissertations, Theses, and Capstone Projects

Breast cancer survivors (BCS) often report noticeable cognitive difficulties despite showing limited impairment on standardized neuropsychological tests. Some have theorized that this is simply an insensitivity of standardized testing to subtle cognitive changes (test-insensitivity hypothesis), whereas others have suggested there are early neural changes that are detected by patients but precede detection by these tests (early signal hypothesis) or that when they achieve normal performance, it is through saliently effortful compensatory processes (compensation hypothesis). The present study tested these theories by assessing metamemory and recognition memory retrieval in BCS and non-cancer controls (NCC) using both behavioral and event-related potential (ERP) …

A Predictive Coding Account Of Spatial Working Memory Following Prophylactic Levetiracetam Administration Prior To Traumatic Brain Injury, Omeima Mutwali

Dissertations, Theses, and Capstone Projects

Traumatic brain injury (TBI) symptom prevention and remediation is an important area of research that would benefit vulnerable groups, including active-duty and veteran soldiers. These patients can sustain penetrative forces in fields of combat or in training, which result in focal lesions that trigger inflammatory and degenerative processes in the brain. Both primary and secondary injuries are associated with changes to cognition, behavior and affective state. This disease poses increased risk of epileptogenesis, as well. Given these outcomes, prior research has evaluated levetiracetam (LEV) as a prophylactic treatment for seizures, cognitive deficits and negative emotionality. LEV acts as a presynaptic …

Kolonialisme Iklim Dan Tercerabutnya Pengetahuan Ekologi Tradisional: Sosio-Bioekonomi Sebagai Reorientasi Epistemologis, Viky Arthiando Putra

Antropologi Indonesia

Abstract The global climate change has brought with it a growing stack of conceptual proposals – from green economy to bioeconomy – each presenting itself as a non-extractive economic alternative. Unfortunately, these conceptual claims continue to reproduce colonial logic that subordinates local knowledge. The loss of Traditional Ecological Knowledge (TEK) is not merely an ecological setback: it is a systematic epistemological violence – a product of climate colonialism operating within the architecture of global green programs. This article traces the discourse of green economy, analyzes the loss of TEK as an epistemological problem, and proposes a socio-bioeconomy reorientation as a …

Reducing The Complexity Of The Experimental Design Attenuates Trait-Level Effects In Threat Safety Discrimination Learning, Justin M. Lazzarino

Dissertations, Theses, and Capstone Projects

Trait measures of negative emotionality have sometimes been shown to play a role in shaping threat learning, but findings are mixed. For example, Johnson et al (2023) showed that the inhibitory and prospective subscales of the Intolerance for Uncertainty Scale (IUS) were associated with diminished and enhanced threat-safety discrimination, respectively, during the acquisition phase of a Pavlovian fear conditioning task. This finding was subsequently replicated in an independent sample (Kinney-Petrucha, 2024, unpublished). However, these findings and other trait-level fear acquisition effects have not been consistently observed in the broader fear learning literature. Variation in the complexity of or uncertainty inherent …

Exercise Therapy For Mood Disorders In Retiring/Former Athletes, Christian Antos

Dissertations

This dissertation examined the potential integration of exercise therapy and psychotherapy as a treatment approach for mood-related difficulties experienced by former elite athletes during the transition out of competitive sport. Retirement from athletics is often associated with significant biopsychosocial challenges, including disruptions in identity, healthy routines, social support, and emotional well-being. Existing literature suggests that exercise may serve as an effective adjunctive intervention for improving mood and overall psychological functioning, though limited research has explored its application among retiring athletes within psychotherapeutic contexts. This literature review synthesized current research related to athletic retirement, neurobiological mechanisms associated with physical activity, and …

The Cultivation Of Public Perception: Cultivated Meat Narratives And Misinformation On Tiktok, Anna M. Balkus

Graduate Masters Theses

Cultivated meat is an emerging tissue engineering technology that has the potential to address major issues threatening food systems, including climate change, rapid population growth, and the spread of disease. Among technical challenges, public perception remains a significant barrier for the widespread adoption of cultivated meat. While social media has transformed communication globally, it has simultaneously contributed to corrupt online environments infected with misinformation—unintentional inaccuracies that differ from disinformation, which is spread with the intent to mislead. The way the public receives and digests information regarding new food technologies, like cultivated meat, will be shaped by their social media environment. …

The Effect Of Incompatibility Types On The Escalation Of Global Armed Conflicts, Michael Haratua Rajagukguk, Ruben Cornelius Siagian Rcs

Journal of Terrorism Studies

Global armed conflicts show variations in intensity influenced by the type of issue incompatibility. This study aims to analyze the influence of territorial, ideological, and combined incompatibilities on the probability of high-intensity conflict escalation, as well as its implications for conflict mitigation strategies. Global conflict dyadic data were analyzed using a multilevel logistic regression model with controls for time, region, and conflict type. The results show that ideology-based conflicts have a lower probability of reaching high intensity than territorial conflicts (OR ≈ 0.51, p < 0.05), while conflicts with a combination of ideology and territory tend to be at greater risk of high escalation (AM effect ≈ +26.6 points), although the effect is not yet statistically significant. Temporal analysis shows a downward trend in conflict intensity over time, especially in the post-Cold War period, while regional effects and conflict types show significant variation. These findings fill a gap in the literature on the dual interaction of ideological and territorial claims, showing that the highest escalation of violence occurs when symbolic and material dimensions are intertwined. In conclusion, conflict escalation is more influenced by a combination of issues and structural characteristics of conflict than by ideology alone. The novelty of this research lies in the identification of the strengthening effect of dual incompatibility and the downward trend in conflict intensity after the Cold War, which emphasizes the importance of a relational and temporal context-based mitigation approach in global conflict management.

Visualizing Ozone Pollution In The Denver Metro Area Using A Bioindicator Garden, Ella K. Mathews, Hillary Hamann, Julie Morris, Erica L. Larson

DU Undergraduate Research Journal Archive

Since the industrial revolution, widespread fossil fuel combustion has significantly increased atmospheric pollution. The combustion of fossil fuels releases nitrogen oxides (NOx) and volatile organic compounds (VOCs), which form tropospheric (ground-level) ozone when exposed to sunlight. Ozone directly harms plants by disrupting their ability to absorb carbon dioxide, release oxygen, and carry out photosynthesis. Bioindicator species are plants that have visible responses to environmental conditions, such as ozone, and can act as “canaries in the coal mine,” indicating the health of their environment. In this study, we used a garden of ozone bioindicator species (ozone garden) as a cost-effective tool …

Du Undergraduate Showcase Abstracts: Research, Scholarship, And Creative Works, Sophia Wismar, Henry Staats, Allison Metzler, Chloe Puckett, Rachel Levine, Christa Kilpatrick, Scott Wolf, Joe Walsh, Grace Doolittle, John Engebreston, Zoe Lopez, Christopher Aaby, Audrey Duff, Timothy Sisk, Katelyn Lamberton, Angela Narayan, Gilkah Argueta, Habiba Samir, Girena Tesfazghi, Genet Kenore, Sinit Tesfamariam, Effley Brooks, Abi Newell, Megan Doherty, Natalie Baer, Lexi Blood, Talya Riciputi, Jessica Jimenez, Devin Hernandez, Lynn Clark, Taj Kumar, Sunil Kumar, Allen Rutman, Mira Pronobis, Tess Carson, Anna Sher, Frankie Stroud, Tamra Pearson D'Estree, Alyssa Wilson, Emily Melnick, Jenalee Doom, Yihang Gao, Gwendolyn Geiger, Noah Gettle, Scott Nichols, Clare Ayoub, Cara Dienno, Sunny Walker, Zoe Hansen, Maya Wheeler, Addison Rice, Patrick Martin, Sanjana Acharya, Daniel Mcintosh, Amanda Mckellips, Calli Cain, Justin Blake, Peter Sokol-Hessner, Natalie Miller, Max Weisbuch, Sophia Dellota, John Macikas, Charlotte Snow, Mark Siemens, Zoe Lynch, Alex Huffman, Prachi Shah, Jason Roney, Halcyon Levi, Nicole Herzog, Andrea Koly, Daniel Linseman, Annie London, Xi Yang, Avery Zwisler, Jane Smith, Chaz Contag, Michael Kerwin, Lucy Rand, Grace Schroeder, Michelle Rozenman, Nissa Tapper, Guiming Zhang, Mateo Mazariego-Halpern, Keith Meyer, Julie Do, Dakota Park-Ozee, Travis Herink, Kara Neu, Jonathan Plomin, Eve-Odine Duchaufour, Debbie Gale Mitchell, Tennyson Anderson-Stricklin, Lily Treitz, Samantha Rosenberger, Sierra Griffith, Finley Joseph, Daniel Sampson, Emmy Davis, Skyler Kasnoff, Evon Lopez, Vivian Nguyen, Cassy Young, Franklin Sellner, Martin Tobon, Ila Graham, Zach Billings, Holden Hedit, Decatur Boland, Paul Kosempel, Cory Chandler, Jay Mahoney, Sam Dragan, Susan Dagget, Yarrow Ator, Heidi Vuletich, Owen Weber, Andrew Kloeppel, Petersen Gray, Mandi Schaeffer-Fry, Razleen Bassra, Bryanna Rodriguez, Christina Blue, Taubie Sanders, Rachel Epstein, Luke Milburn, Camryn Evans, Ezra Martinez, Mary Westwood, Gabri Notov, Robin Tinghitella, Lilou Cabrol, Eli Barbour, Juliet Mendik, Selma Myers, Zac Wise, Noah Fahlin, Michelle Knowles, Abigail Hopper, Michael Greenberger, Romi Laclair, Sarah Watamura, Sabrina Efroymson, Casey Barker, Sydney Seltzer, Bryn Yehle, Jennifer Hoffman, Sara Garcia, Ryuka Nagamine, Trevor Briggs, Remy Le Boeuf, Elena Krone, Eileen Farrell, Regan O'Rourke, Elena Roel, Greg Mortimer, Ali Ayoub, Stefani Langehennig, Caitlin Turk, Logan Scmid, Stefan Chavez-Norgaard, Karen Kim, Tatiana Peccedi, Courtney Cassidy, John Sebesta, Rhianna Lewis, Janice Bening-Lacek, Vivian Lawless, Mckenna Hanson, Jeffrey Amidon, Riya Joshi, Ram Ambre, Brady Worrell, Perrin Schneider, Ali Azadani, Brooke Agulnek, Lyndsie Salvagio, Elise Siemanowki, Yan Qin, Andre Allen, Melodie Nguyen, Megan Livengood, Abby Reams, Saffron Hartreeve, Bri Wylie, Sarah Brookman, Mariah Loiacono, Green Russo, Abhia Lodhi, Gabrielle Welsh, Nika Spehar, Shahked Levin, Evrim Baykal, Kimberly Chiew, Jocelyn Torres, Kailey Hicks, Mykaela Tanino-Springsteen, Audrey Bellows, Akam Chahal, Madeline Tepper, Shannon Murphy, Alexa Fonseca, Deborah Han, Cassandra Perez, Oluwatoyin Alaba, Julia Roncoroni, Vy Nguyen, Nana Burn, Sarah Sasse, Rubin Tuder, Anthony Gerber, Nancy Lorenzon, Christine Vohwinkel, Camryn Gunter, Tristan Weber, Sam Rommel, Brian Michel, Muskan Fatima, Alannah Oleson, Kira Frey, Edward Garrido, Beckett Morris, Kerstin Haring, Drew Middleton, Abigail Walpert, Liam Dee, Gabby Ishaw, Cole Carnes, Maddie Weiser, Claire Fox, Valeriia Vlasenko, Kateri Mcrae, Riley Smith, Abigail Templin, Kushani Rajapaksha

DU Undergraduate Research Journal Archive

Abstracts from the DU Undergraduate Research Showcase.

The Role Of Media In Enhancing The Awareness Of Jordanian University Students About The Risks Of Energy Drinks, Rasha Salameh, R. Abuhasirah

Middle East Journal of Communication Studies

This article aimed to explore the role of media in enhancing the awareness of Jordanian university students regarding the health risks associated with energy drink consumption. The article employed a media audience survey method, applied to a Quota sample of 300 students from diverse academic disciplines (humanities, health sciences, and natural sciences) at Yarmouk University (public) and Middle East University (private). Data were collected between March 10 and April 15, 2025. The results indicated that energy drink consumption was higher among Middle East University students (55.4%) compared to Yarmouk University students (44.6%). Furthermore, students in the humanities reported higher consumption …

The Role Of Artificial Intelligence In Developing Science Journalism Strategies And Enhancing Political Awareness, Enad Akif Al-Jallad

Middle East Journal of Communication Studies

This study aimed to analyze the role of artificial intelligence in developing science journalism strategies and enhancing its capacity to raise political awareness. The study adopted a descriptive-analytical methodology through a review of relevant literature and an analysis of scientific content related to artificial intelligence technologies and their media applications. It also relied on a set of applied experiences in science journalism, including The Guardian’s coverage of climate issues and Al Jazeera Net’s reporting on the COVID-19 pandemic and its connection to health policies.

The findings revealed that science journalism serves as a fundamental tool for transferring knowledge to the …

The Use Of Social Media By Jordanian Science Journalists And Its Implications For The Accuracy Of Journalistic Content, Farah Yahya Zaatreh

Middle East Journal of Communication Studies

This study aimed to explore the use of social media by Jordanian science journalists and its implications for the accuracy of journalistic content. The descriptive-analytical method was adopted, utilizing a questionnaire as the primary research tool. The study sample consisted of 178 journalists, all members of the Jordanian Press Association who use social media in covering scientific issues. The results revealed that the majority of journalists primarily rely on social media to gather scientific information, with Facebook being the most preferred platform (61.8%). Furthermore, the spread of unverified scientific news was identified as a significant threat to journalistic credibility, with …

The Role Of Public Relations Practitioners In Jordanian Hospitals In Managing The Covid-19 Crisis In 2020., Dana Khalil Basheer Al-Shloul

Middle East Journal of Communication Studies

This study aimed to identify the departments and divisions that contributed to public relations in Jordanian hospitals during the COVID-19 pandemic, as well as to determine the procedures undertaken by public relations practitioners and the challenges they faced. Utilizing a descriptive-survey methodology guided by the Crisis and Emergency Risk Communication (CERC) model, the research collected data from a comprehensive sample of 16 individuals using a questionnaire.

The findings revealed that senior management’s participation in pandemic management in the surveyed hospitals was 37.93%, followed by the Ministry of Health at 27.59%. The public relations department’s actions varied by phase. Before the …

Jordanian Digital Media Organizations Rely On Artificial Intelligence To Produce Scientific Content, Baraa Kamal Abdul Latif Abu Humam

Middle East Journal of Communication Studies

The research aims to identify the extent to which workers in Jordanian digital media organizations rely on artificial intelligence in the production of scientific content, by knowing the extent of Jordanian digital media's coverage of scientific content, and the most prominent types of scientific content that rely on artificial intelligence techniques in its production, what are the most prominent roles that artificial intelligence plays during the production of scientific content, and what are the most prominent artificial intelligence techniques used in the production of scientific content, and the  study belongs to descriptive research, and relies on the field survey method, …

Improving Human-Wildlife Coexistence: An Ecological And Educational Approach To Rewilding Grizzly Bears (Ursus Arctos Horribilis) In California, Amanda C. D. Rosales

Master's Projects and Capstones

Megafauna extinction during the Holocene has been both caused and amplified by climatic changes and human influence. By the last half century, large carnivores were diminished in Europe and the United States, but policies increasingly addressed species decline and their territories expanded. This research examined large carnivore rewilding across the European Union and United States, specifically for rewilding brown bears, Ursus arctos, in historic habitat. Next, case studies for the health status of climate-impacted whitebark pine, Pinus albicaulis, a high energy food for bears, was assessed. Ultimately, research case studies, human perspective surveys, and the California Department of Education content …

Kev's Dinghy Boat Workshops, Ruiyang Xiao

Masters Theses

In a culture where convenience replaces process, this project argues that making — even when inefficient, imperfect, or unnecessary — enables forms of engagement that buying cannot.

Technologies and Services nowadays are able to fulfill human’s desire to travel and explore at ease. However, this convenience proposes a mode of engagement based only in deeper knowledge of context and thus our experience with the world around us is hence diminished. Our engagement with the world becomes heavily mediated, regulated and controlled.

This project investigates how hands-on engagement with water can reintroduce + restore our sense of joy, curiosity, consequence, and …

The Marathon Without Running: Experiencing A Runner's Sensorial Journey, Harin Kim

Masters Theses

The marathon is defined not by motion alone, but by the changing conditions a body moves through—and remains within—over time. Breath, cadence, heat, sound, crowd compression and attention fluctuate, producing phases that structure the race from within. These interior states are difficult to access by spectators from the sidelines, yet they are precisely what shape the runner’s experience.

This thesis begins with a simple but unconventional question: How can an exhibition translate the runner’s physical sensations and emotions into a multidimensional experience for spectators who do not run? Through a sequence of pop-up exhibitions placed along the New York City …

Environmental Mercury Alters Immune Pathways Linked To Autoimmune Risk In Mice Mirroring Humans, Maurgan Lee, Paul Stemmer, Randall Gill, Allen Rosenspire, Anil Aranha, Heather Gibson

Medical Student Research Symposium

Background and Purpose: Mercury is a pervasive environmental contaminant, and human epidemiologic studies have linked chronic low-level exposure to increased autoimmune disease-risk. Dysregulated lymphocyte activation and impaired signaling tolerance are central mechanisms in human autoimmunity. Protein phosphorylation governs lymphocyte differentiation and function, alterations in phosphoproteomic networks may represent a signature of immune disruption. This study evaluates how low dose mercury exposure modifies B and T cell abundance and intracellular signaling patterns in BALB/c and Diversity Outbred (DO) mice.

Methods: BALB/c and DO mice were exposed to low dose HgCl2 in their water for two weeks or provided standard water controls. …

Sustainable Choices, Generational Voices: Unraveling The Green Buying Behavior Of Millennials And Zoomers Using The Theory Of Planned Behavior, Bhadra Thulaseedharan Pillai, Aishwarya Nagarathinam, Shikha Bhagat, Senthilmurugan Paramasivan

Journal of Environmental Science and Sustainable Development

Younger generations have begun to change their purchasing behaviour in response to growing environmental concerns and global sustainability efforts. This research evaluates the eco-friendly shopping habits of Zoomers (born 1997–2012) and Millennials (born 1981–1996) in India. The research employs the Theory of Planned Behaviour (TPB) to analyse how the stewardship model, subjective norms, perceived consumer effectiveness, environmental attitudes and ecological values influence green product buying behaviour. A quantitative research design was adopted, and data were collected from 391 respondents across urban, semi-urban, and rural regions using a structured questionnaire. The relationship between the constructs were examined using structural equation modelling …

Community-Based Participatory Research In Developing Online Nutrition Tools: A Pathway To Relevance And Engagement, Laura Justice, Stacy Phillips

EFNEP

This article explains how Community-Based Participatory Research (CBPR) can strengthen the design of digital nutrition tools by ensuring they are culturally relevant, accessible, and grounded in community needs. By engaging participants as equal partners, CBPR enhances trust, usability, and long-term impact. The approach aligns with EFNEP’s mission to deliver inclusive, community-driven nutrition education and provides a framework for developing sustainable, adaptable tools that reflect the lived experiences of the families Extension serves.

Beyond Stabilization: Biological Healing, Structural Exclusion, And The Recovery Gap After Border-Fall Trauma At The U.S.-Mexico Border, Julia Robinson

Undergraduate Honors Theses

This honors thesis examines the biochemical, ethical, and public health consequences of insufficient post-operative follow-up care for undocumented immigrants injured in border falls. Discussing pathways of inflammation resolution, wound healing, and bone remodeling, this thesis argues that recovery depends on tightly regulated molecular and cellular processes that are highly vulnerable to disruption without continued monitoring and rehabilitation (Loi et al., 2016; Maruyama et al., 2020). When follow-up care is absent, these processes can be predicted to derail, leading to infection, impaired healing, and permanent disability (Chung & Sohn, 2025; Howard et al., 2020; Kruidenier et al., 2018). Framed through principles …

Barn To Brain: Relationship Between Farm Animal Interaction And Well-Being In Rural Adults, Tiffany N. Hendershot

Doctoral Dissertations and Projects

This study examined the relationship between naturally occurring farm animal interactions and overall well-being among rural adults living in the central Appalachian region, specifically western Maryland, south-central Pennsylvania, and the eastern panhandle of West Virginia. A cross-sectional, correlational design was used to compare adults with at least five hours of naturally occurring farm animal contact per week to those with less than one hour of contact per week. Overall well-being was measured with the PERMA-Profiler, and heart rate variability (HRV) was measured using wearable devices as a physiological indicator of autonomic health. Grounded in polyvagal theory, the biophilia hypothesis, and …

When Faced With Persistent Crying, Will Adults Follow The Advice To Take A Break?, Lauren J. Duplessis, Remington K. Asta, Benjamin N. Witts

InnovateHER Meeting 2026

Inconsolable crying in early infancy can have detrimental effects on caregiver mental health, the caregiver-infant relationship, and infant safety. Professionals often advise caregivers to walk away and take a break. This study used n-of-1 methodology to examine how frequently undergraduate students will follow this advice when tasked with calming a simulated inconsolable infant. Results are mixed, but suggest active training prior to the baby’s arrival might yield promising outcomes

Global Health Financing Of Diagonal Interventions: Building Resilient And Sustainable Health Systems In Sub-Saharan Africa, Lucy Kim

Master in Public Policy Theses

Background: Global health financing has historically prioritized disease-specific “vertical” programs over broader “horizontal” strengthening of general health systems. Vertical programs in HIV have led to unprecedented reductions in mortality worldwide, but HIV remains a significant public health threat in sub-Saharan Africa, where vertical strategies have long been criticized for creating fragmented health systems. In response, global health strategies have shifted towards combining vertical investments with broader horizontal activities, commonly referred to as “diagonal” programming. While evidence suggests that diagonal programming has the potential to create more resilient and sustainable health systems, evaluating its value for money is challenging due to …

Acute And Chronic Oral Administration Of Cannabidiol-Dominant Cannabis Products: Sex- And Formulation-Dependent Effects On Anxiety-Like Behavioral Patterns In Rats, Carlos R. Maestas-Olguin

Psychology ETDs

Interest in the anxiolytic-like effects of cannabidiol (CBD), the non-intoxicating phytocannabinoid found within the genus, Cannabis, has grown significantly in recent years. However, preclinical investigations of CBD’s anxiolytic potential often elect to forgo translationally relevant models that maximize external validity in favor of greater internal and mechanistic validity. As a result, the effects of relatively low dose (< 3mg/kg) oral CBD administration on anxiety-like behaviors are not yet fully characterized. The present studies examined the impact of two orally delivered CBD-dominant cannabis products – a “full-spectrum” formulation derived from the whole plant and a CBD isolate derived from the same chemovar – on innate defensive behaviors exhibited by adult male and female rats in various tests of anxiety. Results indicated that acute and chronic low dose oral CBD administration attenuated anxiety-like behavior in rats, regardless of sex or formulation. These findings extend the growing corpus of literature describing anxiolytic-like effects of CBD.