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Full-Text Articles in Life Sciences
Dynamic Interplay Between The Co-Opted Fis1 Mitochondrial Fission Protein And Membrane Contact Site Proteins In Supporting Tombusvirus Replication, Wenwu Lin, Zhike Feng, K. Reddisiva Prasanth, Yuyan Liu, Peter D. Nagy
Dynamic Interplay Between The Co-Opted Fis1 Mitochondrial Fission Protein And Membrane Contact Site Proteins In Supporting Tombusvirus Replication, Wenwu Lin, Zhike Feng, K. Reddisiva Prasanth, Yuyan Liu, Peter D. Nagy
Plant Pathology Faculty Publications
Plus-stranded RNA viruses have limited coding capacity and have to co-opt numerous pro-viral host factors to support their replication. Many of the co-opted host factors support the biogenesis of the viral replication compartments and the formation of viral replicase complexes on subverted subcellular membrane surfaces. Tomato bushy stunt virus (TBSV) exploits peroxisomal membranes, whereas the closely-related carnation Italian ringspot virus (CIRV) hijacks the outer membranes of mitochondria. How these organellar membranes can be recruited into pro-viral roles is not completely understood. Here, we show that the highly conserved Fis1 mitochondrial fission protein is co-opted by both TBSV and CIRV via …